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Publications until 2015

Molekulare Medizin - All Publications
2014 Lutz A, Sanwald J, Thomas M, Feuer R, Sawodny O, Ederer M, Borner C, Humar M, Merfort I. Interleukin-1β Enhances FasL-Induced Caspase-3/-7 Activity without Increasing Apoptosis in Primary Mouse Hepatocytes. PLoS One. 2014 Dec 31;9(12):e115603. doi: 10.1371/journal.pone.0115603. eCollection 2014. Pubmed25551609
  Avci D, Fuchs S, Schrul B, Fukumori A, Breker M, Frumkin I, Chen CY, Biniossek ML, Kremmer E, Schilling O, Steiner H, Schuldiner M, Lemberg MK. The Yeast ER-Intramembrane Protease Ypf1 Refines Nutrient Sensing by Regulating Transporter Abundance. Mol Cell. 2014 Dec 4;56(5):630-40. doi: 10.1016/j.molcel.2014.10.012. Epub 2014 Nov 13. Pubmed25454947
  Yaktapour N, Meiss F, Mastroianni J, Zenz T, Andrlova H, Mathew NR, Claus R, Hutter B, Fröhling S, Brors B, Pfeifer D, Pantic M, Bartsch I, Spehl TS, Meyer PT, Duyster J, Zirlik K, Brummer T, Zeiser R. BRAF inhibitor-associated ERK activation drives development of chronic lymphocytic leukemia. J Clin Invest. 2014 Nov 3;124(11):5074-5084. doi: 10.1172/JCI76539.. PMID: 25329694
  Petrera A, Lai ZW, Schilling O. Carboxyterminal Protein Processing in Health and Disease: Key Actors and Emerging Technologies.
J Proteome Res. 2014 Nov 7;13(11):4497-504. doi: 10.1021/pr5005746. Epub 2014 Sep 19. Pubmed25204196
  Bronsert P, Enderle-Ammour K, Bader M, Timme S, Kuehs M, Csanadi A, Kayser G, Kohler I, Bausch D, Hoeppner J, Hopt U, Keck T, Stickeler E, Passlick B, Schilling O, Reiss C, Vashist Y, Brabletz T, Berger J, Lotz J, Olesch J, Werner M, Wellner U. Cancer cell invasion and EMT marker expression - a three-dimensional study of the human cancer-host interface - J Pathol. 2014 Nov;234(3):410-22. doi: 10.1002/path.4416. Pubmed25081610
  Lindenboim L, Sasson T, Worman HJ, Borner C, Stein R. Cellular stress induces Bax-regulated nuclear bubble budding and rupture followed by nuclear protein release. Nucleus. 2014 Nov 2;5(6):527-41. doi: 10.4161/19491034.2014.970105. Pubmed25482068
  Waldera-Lupa DM, Kalfalah F, Florea AM, Sass S, Kruse F, Rieder V, Tigges J, Fritsche E, Krutmann J, Busch H, Boerries M, Meyer HE, Boege F, Theis F, Reifenberger G, Stühler K. Proteome-wide analysis reveals an age-associated cellular phenotype of in situ aged human fibroblasts. Aging (Albany NY). 2014 Oct;6(10):856-78. Pubmed25411231
  Lindner SE, Wissler M, Gründer A, Aumann K, Ottina E, Peintner L, Brauns-Schubert P, Preiss F, Herzog S, Borner C, Charvet C, Villunger A, Pahl HL, Maurer U. Increased leukocyte survival and accelerated onset of lymphoma in the absence of MCL-1 S159-phosphorylation.Oncogene. 2014 Oct 30;33(44):5221-4. doi: 10.1038/onc.2013.469. Epub 2013 Nov 11. Pubmed24213575
  Bronsert P, Weißer J, Biniossek ML, Kuehs M, Mayer B, Drendel V, Timme S, Shahinian H, Küsters S, Wellner UF, Lassmann S, Werner M, Schilling O. Impact of Routinely Employed Procedures for Tissue Processing on the Proteomic Analysis of Formalin-Fixed Paraffin-Embedded Tissue. Proteomics Clin Appl. 2014 Oct;8(10):796-804. doi: 10.1002/prca.201300082. Epub 2014 Jul 24. Pubmed24888792
  Volceanov L, Herbst K, Biniossek M, Schilling O, Haller D, Nölke T, Subbarayal P, Rudel T, Zieger B, Häcker G. Septins Arrange F-Actin-Containing Fibers on the Chlamydia trachomatis Inclusion and Are Required for Normal Release of the Inclusion by Extrusion.
MBio. 2014 Oct 7;5(5). pii: e01802-14. doi: 10.1128/mBio.01802-14. Pubmed25293760
  Akkari L, Gocheva V, Kester JC, Hunter KE, Quick ML, Sevenich L, Wang HW, Peters C, Tang LH, Klimstra DS, Reinheckel T, Joyce JA. Distinct functions of macrophage-derived and cancer cell-derived cathepsin Z combine to promote tumor malignancy via interactions with the extracellular matrix. Genes Dev. 2014 Oct 1;28(19):2134-50. doi: 10.1101/gad.249599.114. Pubmed25274726
  Kowalewski B, Lübke T, Kollmann K, Braulke T, Reinheckel T, Dierks T, Damme M. Molecular characterization of arylsulfatase G - Molecular characterization of arylsulfatase G - expression, processing, glycosylation, transport and activity. J Biol Chem. 2014 Oct 3;289(40):27992-8005. doi: 10.1074/jbc.M114.584144. Pubmed25135642
  Tamhane T, Arampatzidou M, Gerganova V, Tacke M, Illukkumbura R, Dauth S, Schaschke N, Peters C, Reinheckel T, Brix K. The activity and localization patterns of cathepsins B and X in cells of the mouse gastrointestinal tract differ along its length. Biol Chem. 2014 Oct 1;395(10):1201-19. doi: 10.1515/hsz-2014-0151. PMID: 25205730
  Tholen M, Hillebrand LE, Tholen S, Sedelmeier O, Arnold SJ, Reinheckel T. Out-of-frame start codons prevent translation of truncated nucleo-cytosolic cathepsin L in vivo. Nat Commun. 2014 Sep 15;5:4931. doi: 10.1038/ncomms5931. Pubmed25222295
  Gonzalez-Leal IJ, Röger B, Schwarz A, Schirmeister T, Reinheckel T, Lutz MB, Moll H. Cathepsin B in Antigen-Presenting Cells Controls Mediators of the Th1 Immune Response during Leishmania major Infection. PLoS Negl Trop Dis. 2014 Sep 25;8(9):e3194. doi: 10.1371/journal.pntd.0003194. eCollection 2014 Sep. Pubmed25255101
  Bischoff A, Huck B, Keller B, Strotbek M, Schmid S, Boerries M, Busch H, Müller D, Olayioye MA. miR-149 functions as a tumor suppressor by controlling breast epithelial cell migration and invasion. Cancer Res. 2014 Sep 15;74(18):5256-65. doi: 10.1158/0008-5472.CAN-13-3319. Epub 2014 Jul 17. Pubmed25035394
Möller Y, Siegemund M, Beyes S, Herr R, Lecis D, Delia D, Kontermann R, Brummer T, Pfizenmaier K, Olayioye MA. EGFR-Targeted TRAIL and a Smac Mimetic Synergize to Overcome Apoptosis Resistance in KRAS Mutant Colorectal Cancer Cells. PLoS One. 2014 Sep 8;9(9):e107165. doi: 10.1371/journal.pone.0107165. eCollection 2014. PMID: 25198428
Bengsch F, Buck A, Günther SC, Seiz JR, Tacke M, Pfeifer D, von Elverfeldt D, Sevenich L, Hillebrand LE, Kern U, Sameni M, Peters C, Sloane BF, Reinheckel T. Cell type-dependent pathogenic functions of overexpressed human cathepsin B in murine breast cancer progression. Oncogene. 2014 Sep 4;33(36):4474-84. doi: 10.1038/onc.2013.395. Epub 2013 Sep 30. Pubmed24077280
  Pensa S, Neoh K, Resemann HK, Kreuzaler PA, Abell K, Clarke NJ, Reinheckel T, Kahn CR, Watson CJ. The PI3K regulatory subunits p55α and p50α regulate cell death in vivo.Cell Death Differ.2014 Sep;21(9):1442-50. doi: 10.1038/cdd.2014.59. Epub 2014 Jun 6. Pubmed24902901
  Hayashi Y, Koga Y, Zhang X, Peters C, Yanagawa Y, Wu Z, Yokoyama T, Nakanishi H. Autophagy in superficial spinal dorsal horn accelerates the cathepsin B-dependent morphine antinociceptive tolerance. Neuroscience. 2014 Sep 5;275:384-94. doi: 10.1016/j.neuroscience.2014.06.037. Epub 2014 Jun 26. Pubmed24973657
Sprissler C, Belenki D, Maurer H, Aumann K, Pfeifer D, Klein C, Müller TA, Kissel S, Hülsdünker J, Alexandrovski J, Brummer T, Jumaa H, Duyster J, Dierks C. Depletion of STAT5 blocks TEL-SYK-induced APMF-type leukemia with myelofibrosis and myelodysplasia in mice. Blood Cancer J. 2014 Aug 22;4:e240. doi: 10.1038/bcj.2014.53. PMID: 25148222
Fløyel T, Brorsson C, Nielsen LB, Miani M, Bang-Berthelsen CH, Friedrichsen M, Overgaard AJ, Berchtold LA, Wiberg A, Poulsen P, Hansen L, Rosinger S, Boehm BO, Ram R, Nguyen Q, Mehta M, Morahan G, Concannon P, Bergholdt R, Nielsen JH, Reinheckel T, von Herrath M, Vaag A, Eizirik DL, Mortensen HB, Størling J, Pociot F. CTSH regulates β-cell function and disease progression in newly diagnosed type 1 diabetes patients. Proc Natl Acad Sci U S A. 2014 Jul 15;111(28):10305-10. doi: 10.1073/pnas.1402571111. Epub 2014 Jun 30. Pubmed24982147
  Bronsert P, Kohler I, Timme S, Kiefer S, Werner M, Schilling O, Vashist Y, Makowiec F, Brabletz T, Hopt UT, Bausch D, Kulemann B, Keck T, Wellner UF. Prognostic significance of Zinc finger E-box binding homeobox 1 (ZEB1) expression in cancer cells and cancer-associated fibroblasts in pancreatic head cancer. Surgery. 2014 Jul;156(1):97-108. doi: 10.1016/j.surg.2014.02.018. Epub 2014 Feb 28. Pubmed24929761
  Weinberg F, Schulze E, Fatouros C, Schmidt E, Baumeister R, Brummer T. Expression pattern and first functional characterization of riok-1 in Caenorhabditis elegans. Gene Expr Patterns. 2014 Jul;15(2):124-34. doi: 10.1016/j.gep.2014.05.005. Epub 2014 Jun 12. PMID: 24929033
Grahammer F, Haenisch N, Steinhardt F, Sander L, Roerden M, Arnold F, Cordts T, Wanner N, Reichardt W, Kerjaschki D, Ruegg MA, Hall MN, Moulin P, Busch H, Boerries M, Walz G, Artunc F, Huber TB. mTORC1 maintains renal tubular homeostasis and is essential in response to ischemic stress. Proc Natl Acad Sci U S A. 2014 Jun 23. pii: 201402352. Pubmed24958889
  Timme S, Ihde S, Fichter CD, Waehle V, Bogatyreva L, Atanasov K, Kohler I, Schöpflin A, Geddert H, Faller G, Klimstra D, Tang L, Reinheckel T, Hauschke D, Busch H, Boerries M, Werner M, Lassmann S. STAT3 expression, activity and functional consequences of STAT3 inhibition in esophageal squamous cell carcinomas and Barrett's adenocarcinomas.Oncogene. 2014 Jun 19;33(25):3256-66. doi: 10.1038/onc.2013.298. Epub 2013 Aug 5. Pubmed23912451
  Butinar M, Prebanda MT, Rajković J, Jerič B, Stoka V, Peters C, Reinheckel T, Krüger A, Turk V, Turk B, Vasiljeva O. Stefin B deficiency reduces tumor growth via sensitization of tumor cells to oxidative stress in a breast cancer model.Oncogene. 2014 Jun 26;33(26):3392-400. doi: 10.1038/onc.2013.314. Epub 2013 Aug 19. Pubmed23955077
Videm P, Gunasekaran D, Schröder B, Mayer B, Biniossek ML, Schilling O. Automated peptide mapping and protein-topographical annotation of proteomics data.BMC Bioinformatics. 2014 Jun 19;15:207. doi: 10.1186/1471-2105-15-207. Pubmed24946880
  Schilling O, Findeisen P. Proteases and disease. Proteomics Clin Appl. 2014 Jun;8(5-6):296-8. doi: 10.1002/prca.201470035. Pubmed24913842
Rohde D, Schön C, Boerries M, Didrihsone I, Ritterhoff J, Kubatzky KF, Völkers M, Herzog N, Mähler M, Tsoporis JN, Parker TG, Linke B, Giannitsis E, Gao E, Peppel K, Katus HA, Most P. S100A1 is released from ischemic cardiomyocytes and signals myocardial damage via Toll-like receptor 4. EMBO Mol Med. 2014 May 15;6(6):778-94. doi: 10.15252/emmm.201303498. Pubmed24833748
Neumann J, Boerries M, Köhler R, Giaisi M, Krammer PH, Busch H, Li-Weber M. The natural anticancer compound rocaglamide selectively inhibits the G1-S-phase transition in cancer cells through the ATM/ATR-mediated Chk1/2 cell cycle checkpoints. Int J Cancer. 2014 Apr 15;134(8):1991-2002. doi: 10.1002/ijc.28521. Epub 2013 Oct 21. Pubmed24150948
 

Maurer U, Preiss F, Brauns-Schubert P, Schlicher L, Charvet C.
GSK-3 - at the crossroads of cell death and survival. J Cell Sci. 2014 Apr 1;127(Pt 7):1369-78. doi: 10.1242/jcs.138057. Pubmed24687186

  Jägle S, Rönsch K, Timme S, Andrlová H, Bertrand M, Jäger M, Proske A, Schrempp M, Yousaf A, Michoel T, Zeiser R, Werner M, Lassmann S, Hecht A. Silencing of the EPHB3 tumor-suppressor gene in human colorectal cancer through decommissioning of a transcriptional enhancer. Proc Natl Acad Sci U S A. 2014 Apr 1;111(13):4886-91. doi: 10.1073/pnas.1314523111. Epub 2014 Mar 18. Pubmed24707046
  Kalfalah F, Sobek S, Bornholz B, Götz-Rösch C, Tigges J, Fritsche E, Krutmann J, Köhrer K, Deenen R, Ohse S, Boerries M, Busch H, Boege F. Inadequate mito-biogenesis in primary dermal fibroblasts from old humans is associated with impairment of PGC1A-independent stimulation. Exp Gerontol. 2014 Mar 31. pii: S0531-5565(14)00089-8. doi: 10.1016/j.exger.2014.03.017. Pubmed24699405
Tholen S, Biniossek ML, Gansz M, Ahrens TD, Schlimpert M, Kizhakkedathu JN, Reinheckel T, Schilling O. Double deficiency of cathepsins B and L results in massive secretome alterations and suggests a degradative cathepsin-MMP axis. Cell Mol Life Sci. 2014 Mar;71(5):899-916. doi: 10.1007/s00018-013-1406-1. Epub 2013 Jun 29. Pubmed23811845
  El Maadidi S, Faletti L, Berg B, Wenzl C, Wieland K, Chen ZJ, Maurer U, Borner C. A novel mitochondrial MAVS/Caspase-8 platform links RNA virus-induced innate antiviral signaling to Bax/Bak-independent apoptosis. J Immunol. 2014 Feb 1;192(3):1171-83. doi: 10.4049/jimmunol.1300842. Epub 2014 Jan 3. Pubmed24391214
  Borner C, Andrews DW. The apoptotic pore on mitochondria: are we breaking through or still stuck? Cell Death Differ. 2014 Feb;21(2):187-91. doi: 10.1038/cdd.2013.169. No abstract available. Pubmed24413197
Shahinian H, Loessner D, Biniossek ML, Kizhakkedathu JN, Clements JA, Magdolen V, Schilling O. Secretome and degradome profiling shows that Kallikrein-related peptidases 4, 5, 6, and 7 induce TGFβ-1 signaling in ovarian cancer cells. Mol Oncol. 2014 Feb;8(1):68-82. doi: 10.1016/j.molonc.2013.09.003. Epub 2013 Oct 1.. Pubmed24120346
  Löffek S, Hurskainen T, Jackow J, Sigloch FC, Schilling O, Tasanen K, Bruckner-Tuderman L, Franzke CW. Transmembrane Collagen XVII Modulates Integrin Dependent Keratinocyte Migration via PI3K/Rac1 Signaling. PLoS One. 2014 Feb 5;9(2):e87263. doi: 10.1371/journal.pone.0087263. eCollection 2014. Pubmed24505282
  Ebeling S, Naumann K, Pollok S, Wardecki T, Vidal-Y-Sy S, Nascimento JM, Boerries M, Schmidt G, Brandner JM, Merfort I. From a traditional medicinal plant to a rational drug: understanding the clinically proven wound healing efficacy of birch bark extract. PLoS One. 2014 Jan 22;9(1):e86147. doi: 10.1371/journal.pone.0086147. eCollection 2014 Jan 22.Pubmed24465925
  Hamson EJ, Keane FM, Tholen S, Schilling O, Gorrell MD. Understanding Fibroblast Activation Protein (FAP): substrates, activities, expression and targeting for cancer therapy. Proteomics Clin Appl. 2014 Jan 28. doi: 10.1002/prca.201300095. Pubmed24470260
Müller S, Faulhaber A, Sieber C, Pfeifer D, Hochberg T, Gansz M, Deshmukh SD, Dauth S, Brix K, Saftig P, Peters C, Henneke P, Reinheckel T. The endolysosomal cysteine cathepsins L and K are involved in macrophage-mediated clearance of Staphylococcus aureus and the concomitant cytokine induction. FASEB J. 2014 Jan;28(1):162-75. doi: 10.1096/fj.13-232272. Pubmed24036885
2013 Fuellen G, Boerries M, Busch H, de Grey AD, Hahn U, Hiller T, Hoeflich A, Jansen L, Janssens GE, Kaleta C, Meinema AC, Schäuble S, Schofield PN, Smith B, Sühnel J, Vera J, Wagner W, Wönne EC, Wuttke D, Simm A. In-Silico-Approaches and the Role of Ontologies in Aging Research. Rejuvenation Res. 2013 Dec;16(6):540-6. doi: 10.1089/rej.2013.1517. Pubmed24188080
  Liszewski MK, Kolev M, Le Friec G, Leung M, Bertram PG, Fara AF, Subias M, Pickering MC, Drouet C, Meri S, Arstila TP, Pekkarinen PT, Ma M, Cope A, Reinheckel T, Rodriguez de Cordoba S, Afzali B, Atkinson JP, Kemper C. Intracellular Complement Activation Sustains T Cell Homeostasis and Mediates Effector Differentiation.Immunity. 2013 Dec 3. pii: S1074-7613(13)00509-8. doi: 10.1016/j.immuni.2013.10.018. Pubmed24315997
  Stevens GB, Silver DA, Zgaga-Griesz A, Bessler WG, Vashist SK, Patel P, Achazi K, Strotmeier J, Worbs S, Dorner MB, Dorner BG, Pauly D, Rummel A, Urban GA, Krueger M. Bioluminescence assay for the highly sensitive detection of botulinum neurotoxin A activity.Analyst. 2013 Oct 21;138(20):6154-62. doi: 10.1039/c3an00525a. Pubmed23971072
  Biniossek ML, Lechel A, Rudolph KL, Martens UM, Zimmermann S. Quantitative proteomic profiling of tumor cell response to telomere dysfunction using isotope-coded protein labeling (ICPL) reveals interaction network of candidate senescence markers. J Proteomics. 2013 Oct 8;91:515-35. doi: 10.1016/j.jprot.2013.08.007. Epub 2013 Aug 19. Pubmed23969227
  Geissler A, Haun F, Frank DO, Wieland K, Simon MM, Idzko M, Davis RJ, Maurer U, Borner C. Apoptosis induced by the fungal pathogen gliotoxin requires a triple phosphorylation of Bim by JNK. Cell Death Differ. 2013 Oct;20(10):1317-29. doi: 10.1038/cdd.2013.78. Epub 2013 Jul 5.. Pubmed23832115
  Aldahmesh MA, Khan AO, Alkuraya H, Adly N, Anazi S, Al-Saleh AA, Mohamed JY, Hijazi H, Prabakaran S, Tacke M, Al-Khrashi A, Hashem M, Reinheckel T, Assiri A, Alkuraya FS. Mutations in LRPAP1 Are Associated with Severe Myopia in Humans. Am J Hum Genet. 2013 Aug 8;93(2):313-20. doi: 10.1016/j.ajhg.2013.06.002. Epub 2013 Jul 3.. Pubmed23830514
  Yaktapour N, Ubelhart R, Schüler J, Aumann K, Dierks C, Burger M, Pfeifer D, Jumaa H, Veelken H, Brummer T, Zirlik K. Insulin-like growth factor 1 receptor (IGF1R) as a novel target in chronic lymphocytic leukemia. Blood. 2013 Aug 29;122(9):1621-33. doi: 10.1182/blood-2013-02-484386. Epub 2013 Jul 17. PMID: 23863897
  Huai J, Vögtle FN, Jöckel L, Li Y, Kiefer T, Ricci JE, Borner C. TNFα-induced lysosomal membrane permeability (LMP) is downstream of MOMP and triggered by caspase-mediated p75 cleavage and ROS formation. J Cell Sci. 2013 Sep 1;126(Pt 17):4015-25. doi: 10.1242/jcs.129999. Epub 2013 Jun 20. Pubmed23788428
  Reinheckel T. On the road to inflammation: Linking lysosome disruption, lysosomal protease release and necrotic death of immune cells. Cell Cycle. 2013 Jul 1;12(13):1994. doi: 10.4161/cc.25316. Epub 2013 Jun 11. Pubmed23759575
Karlsson M, Lienemann PS, Sprossmann N, Heilmann K, Brummer T, Lutolf MP, Ehrbar M, Weber W. A generic strategy for pharmacological caging of growth factors for tissue engineering. Chem Commun (Camb). 2013 Jul 7;49(53):5927-9. doi: 10.1039/c3cc41616j. PMID: 23715175
  Bühler A, Berger S, Werner F, Martin G, Han H, Vierkotten S, Pielen A, Boehringer D, Schlunck G, Fauser S, Agostini HT, Reinheckel T, Stahl A. Cathepsin proteases promote angiogenic sprouting and laser-induced choroidal neovascularisation in mice. Exp Eye Res. 2013 Oct;115:73-8. doi: 10.1016/j.exer.2013.06.014. Epub 2013 Jun 22. Pubmed23800510
  Sprenger A, Weber S, Zarei M, Engelke R, Nascimento JM, Gretzmeier C, Hilpert M, Boerries M, Has C, Busch H, Bruckner-Tuderman L, Dengjel J. Consistency of the proteome in primary human keratinocytes with respect to gender, age, and skin localization. Mol Cell Proteomics. 2013 Sep;12(9):2509-21. doi: 10.1074/mcp.M112.025478. Epub 2013 May 30 Pubmed23722187
  Lindenboim L, Ferrando-May E, Borner C, Stein R. Non-canonical function of Bax in stress-induced nuclear protein redistribution. Cell Mol Life Sci. 2013 Aug;70(16):3013-27. doi: 10.1007/s00018-013-1306-4. Epub 2013 Mar 9. Pubmed23475110
  Ploen D, Hafirassou ML, Himmelsbach K, Sauter D, Biniossek ML, Weiss TS, Baumert TF, Schuster C, Hildt E.TIP47 plays a crucial role in the life cycle of hepatitis C virus. J Hepatol. 2013 Jun;58(6):1081-8. doi: 10.1016/j.jhep.2013.01.022. Epub 2013 Jan 24. Pubmed 23354285
  Shahinian H, Tholen S, Schilling O. Proteomic identification of protease cleavage sites: cell-biological and biomedical applications. Expert Rev Proteomics. 2013 Oct;10(5):421-33. doi: 10.1586/14789450.2013.841547. Pubmed24117201
  Ruffell B, Affara NI, Cottone L, Junankar S, Johansson M, Denardo DG, Korets L, Reinheckel T, Sloane BF, Bogyo M, Coussens LM. Cathepsin C is a tissue-specific regulator of squamous carcinogenesis. Genes Dev. 2013 Oct 1;27(19):2086-98. doi: 10.1101/gad.224899.113. Epub 2013 Sep 24. Pubmed24065739
  Godoy P, Hewitt NJ, Albrecht U, Andersen ME, Ansari N, Bhattacharya S, Bode JG, Bolleyn J, Borner C, Böttger J, Braeuning A, Budinsky RA, Burkhardt B, Cameron NR, Camussi G, Cho CS, Choi YJ, Craig Rowlands J, Dahmen U, Damm G, Dirsch O, Donato MT, Dong J, Dooley S, Drasdo D, Eakins R, Ferreira KS, Fonsato V, Fraczek J, Gebhardt R, Gibson A, Glanemann M, Goldring CE, Gómez-Lechón MJ, Groothuis GM, Gustavsson L, Guyot C, Hallifax D, Hammad S, Hayward A, Häussinger D, Hellerbrand C, Hewitt P, Hoehme S, Holzhütter HG, Houston JB, Hrach J, Ito K, Jaeschke H, Keitel V, Kelm JM, Kevin Park B, Kordes C, Kullak-Ublick GA, LeCluyse EL, Lu P, Luebke-Wheeler J, Lutz A, Maltman DJ, Matz-Soja M, McMullen P, Merfort I, Messner S, Meyer C, Mwinyi J, Naisbitt DJ, Nussler AK, Olinga P, Pampaloni F, Pi J, Pluta L, Przyborski SA, Ramachandran A, Rogiers V, Rowe C, Schelcher C, Schmich K, Schwarz M, Singh B, Stelzer EH, Stieger B, Stöber R, Sugiyama Y, Tetta C, Thasler WE, Vanhaecke T, Vinken M, Weiss TS, Widera A, Woods CG, Xu JJ, Yarborough KM, Hengstler JG. Recent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in investigating mechanisms of hepatotoxicity, cell signaling and ADME. Arch Toxicol. 2013 Aug;87(8):1315-530. doi: 10.1007/s00204-013-1078-5. Epub 2013 Aug 23. Pubmed23974980
  Krueger S, Bernhardt A, Kalinski T, Baldensperger M, Zeh M, Teller A, Adolf D, Reinheckel T, Roessner A, Kuester D. Induction of premalignant host responses by cathepsin x/z-deficiency in helicobacter pylori-infected mice. PLoS One. 2013 Jul 30;8(7):e70242. doi: 10.1371/journal.pone.0070242. Print 2013. Pubmed23936173
  Ortiz-Padilla C, Gallego-Ortega D, Browne BC, Hochgräfe F, Caldon CE, Lyons RJ, Croucher DR, Rickwood D, Ormandy CJ, Brummer T, Daly RJ. Functional characterization of cancer-associated Gab1 mutations. Oncogene. 2013 May 23;32(21):2696-702. doi: 10.1038/onc.2012.271. Epub 2012 Jul 2. Pubmed22751113
  Halbach S, Rigbolt KT, Wöhrle FU, Diedrich B, Gretzmeier C, Brummer T, Dengjel J. Alterations of Gab2 signalling complexes in imatinib and dasatinib treated chronic myeloid leukaemia cells. Cell Commun Signal. 2013 Apr 22;11(1):30. doi: 10.1186/1478-811X-11-30. Pubmed23607741
  Küttner V, Mack C, Rigbolt KT, Kern JS, Schilling O, Busch H, Bruckner-Tuderman L, Dengjel J. Global remodelling of cellular microenvironment due to loss of collagen VII. Mol Syst Biol. 2013 Apr 16;9:657. doi: 10.1038/msb.2013.17. Pubmed23591773
  Busch H, Boerries M, Bao J, Hanke ST, Hiss M, Tiko T, Rensing SA. Network theory inspired analysis of time-resolved expression data reveals key players guiding P. patens stem cell development. PLoS One. 2013 Apr 18;8(4):e60494. doi: 10.1371/journal.pone.0060494. Print 2013. Pubmed23637751
  Elfert S, Weise A, Bruser K, Biniossek ML, Jägle S, Senghaas N, Hecht A. Acetylation of human TCF4 (TCF7L2) proteins attenuates inhibition by the HBP1 repressor and induces a conformational change in the TCF4::DNA complex. PLoS One. 2013 Apr 15;8(4):e61867. doi: 10.1371/journal.pone.0061867. Print 2013. Pubmed23613959
  Ohkouchi S, Shibata M, Sasaki M, Koike M, Safig P, Peters C, Nagata S, Uchiyama Y. Biogenesis and Proteolytic Processing of Lysosomal DNase II. PLoS One. 2013;8(3):e59148. doi: 10.1371/journal.pone.0059148. Epub 2013 Mar 13. Pubmed23516607
  Weber M, Gawanbacht A, Habjan M, Rang A, Borner C, Schmidt AM, Veitinger S, Jacob R, Devignot S, Kochs G, García-Sastre A, Weber F. Incoming RNA Virus Nucleocapsids Containing a 5'-Triphosphorylated Genome Activate RIG-I and Antiviral Signaling. Cell Host Microbe. 2013 Mar 13;13(3):336-46. doi: 10.1016/j.chom.2013.01.012. Pubmed23498958
  Tholen S, Biniossek ML, Gansz M, Gomez-Auli A, Werner F, Noel A, Kizhakkedathu JN, Boerries M, Busch H, Reinheckel T, Schilling O. Deletion of cysteine cathepsins B or L yields differential impacts on murine skin proteome and degradome. Mol Cell Proteomics. 2013 Mar;12(3):611-25. doi: 10.1074/mcp.M112.017962. Epub 2012 Dec 10. Pubmed23233448
  Koike M, Shibata M, Ezaki J, Peters C, Saftig P, Kominami E, Uchiyama Y. Differences in expression patterns of cathepsin C/dipeptidyl peptidase I in normal, pathological and aged mouse central nervous system. Eur J Neurosci. 2013 Mar;37(5):816-30. doi: 10.1111/ejn.12096. Epub 2012 Dec 20. Pubmed23279039
  Deswal S, Meyer A, Fiala GJ, Eisenhardt AE, Schmitt LC, Salek M, Brummer T, Acuto O, Schamel WW. Kidins220/ARMS Associates with B-Raf and the TCR, Promoting Sustained Erk Signaling in T Cells.J Immunol. 2013 Mar 1;190(5):1927-35. doi: 10.4049/jimmunol.1200653. Epub 2013 Jan 28. Pubmed23359496
  Benary U, Kofahl B, Hecht A, Wolf J. Modeling Wnt/β-Catenin Target Gene Expression in APC and Wnt Gradients Under Wild Type and Mutant Conditions. Front Physiol. 2013;4:21. doi: 10.3389/fphys.2013.00021. Epub 2013 Feb 25. Pubmed23508686
  Kienzle C, Eisler SA, Villeneuve J, Brummer T, Olayioye MA, Hausser A. PKD controls mitotic Golgi complex fragmentation through a Raf-MEK1 pathway. Mol Biol Cell. 2013 Feb;24(3):222-33. doi: 10.1091/mbc.E12-03-0198. Epub 2012 Dec 14. Pubmed23242995
  Lai ZW, Nice EC, Schilling O. Glycocapture-based proteomics for secretome analysis. Proteomics. 2013 Feb;13(3-4):512-25. doi: 10.1002/pmic.201200414. Pubmed23197367
  Wöhrle FU, Halbach S, Aumann K, Schwemmers S, Braun S, Auberger P, Schramek D, Penninger JM, Laßmann S, Werner M, Waller CF, Pahl HL, Zeiser R, Daly RJ, Brummer T. Gab2 signaling in chronic myeloid leukemia cells confers resistance to multiple Bcr-Abl inhibitors. Leukemia. 2013 Jan;27(1):118-29. doi: 10.1038/leu.2012.222. Epub 2012 Aug 3.Pubmed22858987
  Tholen S., Koczorowska M., Lai Z., Dengjel J., Schilling O.: Limited and Degradative Proteolysis in the Context of Posttranslational Regulatory Networks: Current Technical and Conceptional Advances. In: K. Brix and W. Stöcker (eds.): Proteases: Structure and Function, Springer Science, cap. 5. 2013 / Buchbeitrag
  Gansz M., Kern U., Peters C. and Reinheckel T. : Exploring Systemic Functions of Lysomal Proteases: The Perspective of Genetically Modified Mouse Models. In: K. Brix and W. Stöcker (eds.): Proteases: Structure and Function, Springer Science, cap. 6. 2013 / Buchbeitrag
2012 Kalyuga M, Gallego-Ortega D, Lee HJ, Roden DL, Cowley MJ, Caldon CE, Stone A, Allerdice SL, Valdes-Mora F, Launchbury R, Statham AL, Armstrong N, Alles MC, Young A, Egger A, Au W, Piggin CL, Evans CJ, Ledger A, Brummer T, Oakes SR, Kaplan W, Gee JM, Nicholson RI, Sutherland RL, Swarbrick A, Naylor MJ, Clark SJ, Carroll JS, Ormandy CJ. ELF5 Suppresses Estrogen Sensitivity and Underpins the Acquisition of Antiestrogen Resistance in Luminal Breast Cancer. PLoS Biol. 2012 Dec;10(12):e1001461. doi: 10.1371/journal.pbio.1001461. Epub 2012 Dec 27. Pubmed23300383
  Andrea Marzi, Thomas Reinheckel, Heinz Feldmann. Cathepsin B & L Are Not Required for Ebola Virus Replication. PLoS Negl Trop Dis. 2012 December; 6(12): e1923. Published online 2012 December 6. doi: 10.1371/journal.pntd.0001923 PMCID: Pubmed3516577
Unno T, Wakamori M, Koike M, Uchiyama Y, Ishikawa K, Kubota H, Yoshida T, Sasakawa H, Peters C, Mizusawa H, Watase K. Development of Purkinje cell degeneration in a knockin mouse model reveals lysosomal involvement in the pathogenesis of SCA6.Proc Natl Acad Sci U S A. 2012 Oct 23;109(43):17693-8. doi: 10.1073/pnas.1212786109. Pubmed23054835
  Schurigt U, Eilenstein R, Gajda M, Leipner C, Sevenich L, Reinheckel T, Peters C, Wiederanders B, Bräuer R. Decreased arthritis severity in cathepsin L-deficient mice is attributed to an impaired T helper cell compartment. Inflamm Res. Sep;61(9):1021-9. Pubmed22674323
  Sun L, Wu Z, Hayashi Y, Peters C, Tsuda M, Inoue K, Nakanishi H. Microglial cathepsin B contributes to the initiation of peripheral inflammation-induced chronic pain. J Neurosci. 2012 Aug 15;32(33):11330-42. Pubmed22895716
Wallmen B, Schrempp M, Hecht A.Intrinsic properties of Tcf1 and Tcf4 splice variants determine cell-type-specific Wnt/β-catenin target gene expression. Nucleic Acids Res. 2012 Oct 1;40(19):9455-69. doi: 10.1093/nar/gks690. Pubmed22859735
  Lu WD, Funkelstein L, Toneff T, Reinheckel T, Peters C, Hook V. Cathepsin H Functions as an Aminopeptidase in Secretory Vesicles for Production of Enkephalin and Galanin Peptide Neurotransmitters. J Neurochem. 2012 Aug;122(3):512-22. doi: 10.1111/j.1471-4159.2012.07788.x. Pubmed22582844
Reinheckel T, Peters C, Krüger A, Turk B, Vasiljeva O. Differential Impact of Cysteine Cathepsins on Genetic Mouse Models of De novo Carcinogenesis: Cathepsin B as Emerging Therapeutic Target. Front Pharmacol. 2012;3:133. Epub 2012 Jul 11. Pubmed22798952
  Pilzner C, Bühling F, Reinheckel T, Chwieralski C, Rathinasamy A, Lauenstein HD, Wex T, Welte T, Braun A, Groneberg DA.Allergic Airway Inflammation in Mice Deficient for the Antigen-Processing Protease Cathepsin E. Int Arch Allergy Immunol. 2012 Jul 26;159(4):367-383. Pubmed22846634
Jo J, Bengsch B, Seigel B, Rau SJ, Schmidt J, Bisse E, Aichele P, Aichele U, Joeckel L, Royer C, Ferreira KS, Borner C, Baumert TF, Blum HE, Lohmann V, Fischer R, Thimme R.Low perforin expression of early differentiated HCV-specific CD8+ T cells limits their hepatotoxic potential. J Hepatol. 2012 Jul;57(1):9-16. Pubmed22425625
  Joeckel LT, Wallich R, Metkar SS, Froelich CJ, Simon MM, Borner C. IL-1R signaling is essential for induction of pro-apoptotic CD8 T cells, viral clearance and pathology during LCMV infection in mice.J Virol. 2012 Aug;86(16):8713-9.Pubmed22674984
Steenhuis P, Froemming J, Reinheckel T, Storch S. Proteolytic cleavage of the disease-related lysosomal membrane glycoprotein CLN7. Biochim Biophys Acta. 2012 Oct;1822(10):1617-28. Pubmed22668694
Biniossek ML, Schilling O. Enhanced identification of peptides lacking basic residues by LC-ESI-MS/MS analysis of singly charged peptides. Proteomics. 2012 May;12(9):1303-9. doi: 10.1002/pmic.201100569. Pubmed22589179
Funkelstein L, Lu WD, Koch B, Mosier C, Toneff T, Taupenot L, O'Connor DT, Reinheckel T, Peters C, Hook V. Human cathepsin V protease participates in the production of enkephalin and NPY neurotransmitters. J Biol Chem. 2012May 4;287(19):15232-41. Pubmed22393040
Perera NC, Schilling O, Kittel H, Back W, Kremmer E, Jenne DE. NSP4, an elastase-related protease in human neutrophils with arginine specificity. Proc Natl Acad Sci U S A. 2012 Apr 17;109(16):6229-34. Pubmed22474388
Diederich S, Sauerhering L, Weis M, Altmeppen H, Schaschke N, Reinheckel T, Erbar S, Maisner A. Activation of the Nipah virus fusion protein in MDCK cells is mediated by cathepsin B within the endosomal-recycling compartment. J Virol. 2012 Apr;86(7):3736-45. Pubmed22278224
  Vogel S, Raulf N, Bregenhorn S, Biniossek ML, Maurer U, Czabotar P, Borner C. Cytosolic Bax: Does it require binding proteins to keep its pro-apoptotic activity in check? J Biol Chem. 2012Mar 16;287(12):9112-27. Pubmed22277657
Ferreira KS, Kreutz C, Macnelly S, Neubert K, Haber A, Bogyo M, Timmer J, Borner C. Caspase-3 feeds back on caspase-8, Bid and XIAP in type I Fas signaling in primary mouse hepatocytes. Apoptosis. 2012 May;17(5):503-15. doi: 10.1007/s10495-011-0691-0. Pubmed22246639
Grimm S, Horlacher M, Catalgol B, Hoehn A, Reinheckel T, Grune T. Cathepsins D and L reduce the toxicity of advanced glycation end products. Free Radic Biol Med. 2012 Mar 15;52(6):1011-23. PubMed22245096
Bildl W, Haupt A, Mueller CS, Biniossek ML, Thumfart JO, Hueber B, Fakler B, Schulte U. Extending The Dynamic Range Of Label-Free Mass Spectrometric Quantification Of Affinity Purifications. Mol Cell Proteomics. 2012 Feb;11(2):M111.007955. Epub 2011 Nov 8. PubMed22067099
  Müller S, Dennemärker J, Reinheckel T. Specific functions of lysosomal proteases in endocytic and autophagic pathways.Biochim Biophys Acta. 2012 Jan;1824(1):34-43. Epub 2011 Jul 13. PubMed21767668
Gopinathan A, Denicola GM, Frese KK, Cook N, Karreth FA, Mayerle J, Lerch MM, Reinheckel T, Tuveson DA. Cathepsin B promotes the progression of pancreatic ductal adenocarcinoma in mice Gut. 2012 Jun;61(6):877-84. Epub 2011 Dec 9.PubMed22157328
Leprivier G, Rufini A, García-Sáez AJ, Borner C, Rotblat B. 7th Tuscany Retreat on Cancer Research: Genetic profiling, resistance mechanism and novel treatment concepts in cancer. Cell Death Differ. 2012 Mar;19(3):546-8. doi: 10.1038/cdd.2011.186. Epub 2011 Dec 16. Pubmed22179574
Schlatter R, Philippi N, Wangorsch G, Pick R, Sawodny O, Borner C, Timmer J, Ederer M, Dandekar T. Integration of Boolean models exemplified on hepatocyte signal transduction. Brief Bioinform. 2012 May;13(3):365-76. Epub 2011 Oct 20 Pubmed22016404
  Werner F., Sachse K. and Reinheckel T. Secreted Cysteine Cathepsins - Versatile Players in Extracellular Proteolysis. In: Niels Behrendt (ed.): Matrix Proteases in Health and Disease, Wiley-VCH, cap. 11. 2012 / Buchbeitrag
2011 Biniossek ML, Nägler DK, Becker-Pauly C, Schilling O. Proteomic Identification of Protease Cleavage Sites Characterizes Prime and Non-prime Specificity of Cysteine Cathepsins B, L, and S. JProteome Res. 2011 Dec 2;10(12):5363-73. PubMed21967108
  Charvet C, Maurer U.GSK-3 turns p53 deadly. Cell Cycle. 2011 Nov 1;10(21):3621-2. Pubmed22033176
Sun J, Sukhova GK, Zhang J, Chen H, Sjöberg S, Libby P, Xiang M, Wang J, Peters C, Reinheckel T, Shi GP. Cathepsin L activity is essential to elastase perfusion-induced abdominal aortic aneurysms in mice. Arterioscler Thromb Vasc Biol. 2011 Nov;31(11):2500-8. PubMed21868704
Schilling O, dem Keller UA, Overall CM. Factor Xa subsite mapping by proteome-derived peptide libraries improved using WebPICS, a resource for proteomic identification of cleavage sites. Biol Chem. 2011 Nov;392(11):1031-7. PubMed21846260
  Schilling O, Huesgen PF, Barré O, Overall CM. Identification and relative quantification of native and proteolytically generated protein C-termini from complex proteomes: C-terminome analysis. Methods Mol Biol. 2011;781:59-69. PubMed21877277
  Tholen S, Biniossek ML, Geßler AL, Müller S, Weißer J, Kizhakkedathu JN, Reinheckel T, Schilling O. Contribution of cathepsin L to secretome composition and cleavage pattern of mouse embryonic fibroblasts. Biol Chem. 2011 Nov;392(11):961-971. PubMed21972973
  Arampatzidou M, Mayer K, Iolyeva ME, Asrat SG, Ravichandran M, Günther T, Schüle R, Reinheckel T, Brix K. Studies of intestinal morphology and cathepsin B expression in a transgenic mouse aiming at intestine-specific expression of Cath B-EGFP. Biol Chem. 2011 Nov;392(11):983-93. PubMed21871011
  Bühling F, Kouadio M, Chwieralski CE, Kern U, Hohlfeld JM, Klemm N, Friedrichs N, Roth W, Deussing JM, Peters C, Reinheckel T. Gene targeting of the cysteine peptidase cathepsin h impairs lung surfactant in mice. PLoS One. 2011;6(10):e26247. Epub 2011 Oct 12. PubMed22022579
  Yaddanapudi S, Altintas MM, Kistler AD, Fernandez I, Möller CC, Wei C, Peev V, Flesche JB, Forst AL, Li J, Patrakka J, Xiao Z, Grahammer F, Schiffer M, Lohmüller T, Reinheckel T, Gu C, Huber TB, Ju W, Bitzer M, Rastaldi MP, Ruiz P, Tryggvason K, Shaw AS, Faul C, Sever S, Reiser J. CD2AP in mouse and human podocytes controls a proteolytic program that regulates cytoskeletal structure and cellular survival. J Clin Invest. 2011 Oct 3;121(10):3965-80. doi: 10.1172/JCI58552. Epub 2011 Sep 12. PubMed21911934
  Savalas LR, Gasnier B, Damme M, Lübke T, Wrocklage C, Debacker C, Jezegou A, Reinheckel T, Hasilik A, Saftig P, Schröder BA. "Disrupted in renal carcinoma 2" (DIRC2) - a novel transporter of the lysosomal membrane - is proteolytically processed by cathepsin L.Biochem J. 2011 Oct 1;439(1):113-28. PubMed21692750
  Czibere L, Baur LA, Wittmann A, Gemmeke K, Steiner A, Weber P, Pütz B, Ahmad N, Bunck M, Graf C, Widner R, Kühne C, Panhuysen M, Hambsch B, Rieder G, Reinheckel T, Peters C, Holsboer F, Landgraf R, Deussing JM. Profiling trait anxiety: transcriptome analysis reveals cathepsin B (Ctsb) as a novel candidate gene for emotionality in mice. PLoS One. 2011;6(8):e23604. Epub 2011 Aug 29. PubMed21897848
  Becker-Pauly C, Barre O, Schilling O, Auf dem Keller U, Ohler A, Broder C, Schuette A, Kappelhoff R, Stoecker W, Overall CM. Proteomic analyses reveal an acidic prime side specificity for the astacin metalloprotease family reflected by physiological substrates. Mol Cell Proteomics. 2011 Sep;10(9):M111.009233. Epub 2011 Jun 21. PubMed21693781
  Jefferson T, Causevic M, Auf dem Keller U, Schilling O, Isbert S, Geyer R, Maier W, Tschickardt S, Jumpertz T, Weggen S, Bond JS, Overall CM, Pietrzik CU, Becker-Pauly C. Metalloprotease Meprin {beta} Generates Nontoxic N-terminal Amyloid Precursor Protein Fragments in Vivo. J Biol Chem. 2011 Aug 5;286(31):27741-50. PubMed21646356
  Mikhaylov G, Mikac U, Magaeva AA, Itin VI, Naiden EP, Psakhye I, Babes L, Reinheckel T, Peters C, Zeiser R, Bogyo M, Turk V, Psakhye SG, Turk B, Vasiljeva O. Ferri-liposomes as an MRI-visible drug-delivery system for targeting tumours and their microenvironment. Nat Nanotechnol. 2011 Aug 7;6(9):594-602.doi:10.1038/nnano. .2011.112. PubMed21822252
  Kraus S, Bunsen T, Schuster S, Cichoń MA, Tacke M, Reinheckel T, Sommerhoff CP, Jochum M, Nägler DK. Cellular senescence induced by cathepsin X downregulation. Eur J Cell Biol. 2011 Aug;90(8):678-86. Epub 2011 May 26. PubMed21616554
Vor dem Esche U, Huber M, Zgaga-Griesz A, Grunow R, Beyer W, Hahn U, Bessler WG. Passive vaccination with a human monoclonal antibody: generation of antibodies and studies for efficacy in Bacillus anthracis infections. Immunobiology. 2011 Jul;216(7):847-53. PubMed21397977
Löffek S, Schilling O, Franzke CW. Biological role of matrix metalloproteinases: a critical balance. Eur Respir J. 2011 Jul;38(1):191-208. Epub 2010 Dec 22. PubMed21177845
  Schilling O, auf dem Keller U, Overall CM. Protease specificity profiling by tandem mass spectrometry using proteome-derived Peptide libraries. Methods Mol Biol. 2011;753:257-72. PubMed21604128
  Charvet C, Wissler M, Brauns-Schubert P, Wang SJ, Tang Y, Sigloch FC, Mellert H, Brandenburg M, Lindner SE, Breit B, Green DR, McMahon SB, Borner C, Gu W, Maurer U.Phosphorylation of Tip60 by GSK-3 Determines the Induction of PUMA and Apoptosis by p53. Mol Cell. 2011 Jun 10;42(5):584-96. Pubmed21658600
  Miller G, Matthews SP, Reinheckel T, Fleming S, Watts C. Asparagine endopeptidase is required for normal kidney physiology and homeostasis. FASEB J. 2011 May;25(5):1606-17. PubMed21292981
  Luckert K, Götschel F, Sorger PK, Hecht A, Joos TO, Pötz O.Snapshots of Protein Dynamics and Post-translational Modifications In One Experiment--{beta}-Catenin and Its Functions. Mol Cell Proteomics. 2011 May;10(5):M110.007377. PubMed21378377
 

Rönsch K, Jäger M, Schöpflin A, Danciu M, Laßmann S, Hecht A.Class I and III HDACs and loss of active chromatin features contribute to epigenetic silencing of CDX1 and EPHB tumor suppressor genes in colorectal cancer. Epigenetics. 2011 May;6(5):610-22. PubMed21393996

  Lindenboim L, Borner C, Stein R. Nuclear proteins acting on mitochondria. Biochim Biophys Acta. 2011 Apr;1813(4):584-96 Pubmed21130123
  Häcker G, Borner C. Preface to Mitochondria: the deadly organelle.Biochim Biophys Acta. 2011 Apr;1813(4):507. Pubmed21419936
  Joeckel LT, Wallich R, Martin P, Sanchez-Martinez D, Weber FC, Martin SF, Borner C, Pardo J, Froelich C, Simon MM. Mouse granzyme K has pro-inflammatory potential. Cell Death Differ. 2011 Jul;18(7):1112-9. doi: 10.1038/cdd.2011.5. Epub 2011 Feb 11. Pubmed21311565
  Carrasco-Marín E, Fernández-Prieto L, Rodriguez-Del Rio E, Madrazo-Toca F, Reinheckel T, Saftig P, Alvarez-Dominguez C.LIMP-2 links late phagosomal trafficking with the onset of the innate immune response to Listeria monocytogenes: a role in macrophage activation. J Biol Chem. 2011 Feb 4;286(5):3332-41. PubMed21123180
Heeg S, Hirt N, Queisser A, Schmieg H, Thaler M, Kunert H, Quante M, Goessel G, von Werder A, Harder J, Beijersbergen R, Blum HE, Nakagawa H, Opitz OG. EGFR overexpression induces activation of telomerase via PI3K/AKT-mediated phosphorylation and transcriptional regulation through Hif1-alpha in a cellular model of oral-esophageal carcinogenesis. Cancer Sci. 2011 Feb;102(2):351-60. doi: 10.1111/j.1349-7006.2010.01796.x. Epub 2010 Dec 12. PubMed21156006
  Schmich K, Schlatter R, Corazza N, Ferreira KS, Ederer M, Brunner T, Borner C, Merfort I. Tumor necrosis factor α sensitizes primary murine hepatocytes to Fas/CD95-induced apoptosis in a Bim- and Bid-dependent manner.Hepatology. 2011 Jan; 53(1):282-92. Pubmed20872776
  Schilling O, Huesgen PF, Barré O, Auf dem Keller U, Overall CM. Characterization of the prime and non-prime active site specificities of proteases by proteome-derived peptide libraries and tandem mass spectrometry. Nat Protoc. 2011 Jan;6(1):111-20. PubMed21212787
Sevenich L, Werner F, Gajda M, Schurigt U, Sieber C, Müller S, Follo M, Peters C, Reinheckel T. Transgenic expression of human cathepsin B promotes progression and metastasis of polyoma-middle-T-induced breast cancer in mice. Oncogene. 2011 Jan 6;30(1):54-64. PubMed20818432.
  Masset A, Maillard C, Sounni N, Jacobs N, Bruyère F, Delvenne P, Tacke M, Reinheckel T, Foidart JM, Coussens L, Noël A. Unimpeded skin carcinogenesis in K14-HPV16 transgenic mice deficient for plasminogen activator inhibitor. Int J Cancer. 2011 Jan 15;128(2):283-93. Pubmed20232379
2010 Goncalves JA, South K, Ahuja S, Zaitseva E, Opefi CA, Eilers M, Vogel R, Reeves PJ, Smith SO. Highly conserved tyrosine stabilizes the active state of rhodopsin. Proc Natl Acad Sci U S A. 2010 Nov 16;107(46):19861-6. Pubmed21041664
  Bessler WG, Vogler M, Störmer H, Gerthsen D, Utz A, Weber A, Ivers-Tiffée E. Model anodes and anode models for understanding the mechanism of hydrogen oxidation in solid oxide fuel cells. Phys Chem Chem Phys. 2010 Nov 14;12(42):13888-903. Pubmed20820576
  Auf dem Keller U, Schilling O. Proteomic Techniques and Activity-based Probes for the System-wide Study of Proteolysis. Biochimie. 2010 Nov;92(11):1705-14. Pubmed20493233
  Konjar S, Sutton VR, Hoves S, Repnik U, Yagita H, Reinheckel T, Peters C, Turk V, Turk B, Trapani JA, Kopitar-Jerala N. Human and mouse perforin are processed in part through cleavage by the lysosomal cysteine proteinase cathepsin L. Immunology. 2010 Oct;131(2):257-67. Pubmed20497254
  Reiser J, Adair B, Reinheckel T. Specialized roles for cysteine cathepsins in health and disease. J Clin Invest. 2010 Oct 1;120(10):3421-31. Pubmed20921628
  Zaitseva E, Saavedra M, Banerjee S, Sakmar TP, Vogel R. SEIRA spectroscopy on a membrane receptor monolayer using lipoprotein particles as carriers. Biophys J. 2010 Oct 6;99(7):2327-35. Pubmed20923668
  Bernhardt A, Kuester D, Roessner A, Reinheckel T, Krueger S. Cathepsin X deficient gastric epithelial cells in coculture with macrophages-characterization of cytokine response and migration capability after H. pylori infection. J Biol Chem. 2010 Oct 29;285(44):33691-700. Pubmed20736174
  Zeeuwen PL, van Vlijmen-Willems IM, Cheng T, Rodijk-Olthuis D, Hitomi K, Hara-Nishimura I, John S, Smyth N, Reinheckel T, Hendriks WJ, Schalkwijk J. The cystatin M/E-cathepsin L balance is essential for tissue homeostasis in epidermis, hair follicles, and cornea. FASEB J. 2010 Oct;24(10):3744-55. Pubmed20495178
  Bessler WG, vor dem Esche U, Zgaga-Griesz A, Ataullakhanov R. Immunostimulatory properties of the bacterial extract OM-89 in vitro and in vivo. Arzneimittelforschung. 2010;60(6):324-9. Pubmed20648922
  Bessler WG, Vor dem Esche U, Masihi N.The bacterial extract OM-85 BV protects mice against influenza and Salmonella infection. Int Immunopharmacol. 2010 Sep;10(9):1086-90. Pubmed20601184
  Grimm S, Ernst L, Grötzinger N, Höhn A, Breusing N, Reinheckel T, Grune T. Cathepsin D is one of the major enzymes involved in intracellular degradation of AGE-modified proteins. Free Radic Res. 2010 Sep;44(9):1013-26. Pubmed20560835
  Sprenger A, Küttner V, Biniossek ML, Gretzmeier C, Boerries M, Mack C, Has C, Bruckner-Tuderman L, Dengjel J. Comparative quantitation of proteome alterations induced by aging or immortalization in primary human fibroblasts and keratinocytes for clinical applications. Mol Biosyst. 2010 Sep;6(9):1579-82. Pubmed20454738
  Sun L, Wu Z, Baba M, Peters C, Uchiyama Y, Nakanishi H. Cathepsin B-dependent motor neuron death after nerve injury in the adult mouse. Biochem Biophys Res Commun. 2010 Aug 27;399(3):391-5. Pubmed20673755
  Dennemärker J, Lohmüller T, Müller S, Aguilar SV, Tobin DJ, Peters C, Reinheckel T. Impaired turnover of autophagolysosomes in cathepsin L deficiency. Biol Chem. 2010 Aug;391(8):913-22. Pubmed20536383
  Gocheva V, Chen X, Peters C, Reinheckel T, Joyce JA. Deletion of cathepsin H perturbs angiogenic switching, vascularization and growth of tumors in a mouse model of pancreatic islet cell cancer. Biol Chem. 2010 Aug;391(8):937-45.Pubmed2031543
  Oberle C, Huai J, Reinheckel T, Tacke M, Rassner M, Ekert PG, Buellesbach J, Borner C. Lysosomal membrane permeabilization and cathepsin release is a Bax/Bak-dependent, amplifying event of apoptosis in fibroblasts and monocytes. Cell Death Differ. 2010 Jul;17(7):1167-78. Pubmed20094062
  Schilling O, Barré O, Huesgen PF, Overall CM.Proteome-wide analysis of protein carboxy termini: C terminomics. Nat Methods. 2010 Jul;7(7):508-11. Pubmed20526347
  D'Angelo ME, Bird PI, Peters C, Reinheckel T, Trapani JA, Sutton VR. Cathepsin H is an additional convertase of pro-granzyme B. J Biol Chem. 2010 Jul 2;285(27):20514-9. Pubmed20435891
  Huai J, Jöckel L, Schrader K, Borner C. Role of caspases and non-caspase proteases in cell death. F1000 Biol Rep. 2010 Jun 23;2. pii: 48. Pubmed20948786
  Schrader K, Huai J, Jöckel L, Oberle C, Borner C. Non-caspase proteases: triggers or amplifiers of apoptosis? Cell Mol Life Sci. 2010 May;67(10):1607-18. Review. Pubmed20169397
  Tacke M, Ball CR, Schmidt M, Klingenberg S, Maurer B, Fessler S, Eaves C, von Kalle C, Glimm H. The inherent differentiation program of short term hematopoietic repopulating cells changes during human ontogeny. Stem Cells Dev. 2010 May;19(5):621-8. Pubmed19788397
  Ye S, Zaitseva E, Caltabiano G, Schertler GF, Sakmar TP, Deupi X, Vogel R. Tracking G-protein-coupled receptor activation using genetically encoded infrared probes. Nature. 2010 Apr 29;464(7293):1386-9. Pubmed20383122
  Zaitseva E, Brown MF, Vogel R. Sequential rearrangement of interhelical networks upon rhodopsin activation in membranes: the Meta II(a) conformational substate. J Am Chem Soc. 2010 Apr 7;132(13):4815-21.Pubmed20230054
  Sevenich L, Hagemann S, Stoeckle C, Tolosa E, Peters C, Reinheckel T. Expression of human cathepsin L or human cathepsin V in mouse thymus mediates positive selection of T helper cells in cathepsin L knock-out mice. Biochimie. 2010 Nov;92(11):1674-80. Pubmed20347002
  Shimada N, Ohno-Matsui K, Iseki S, Koike M, Uchiyama Y, Wang J, Yoshida T, Sato T, Peters C, Mochizuki M, Morita I. Cathepsin L in bone marrow-derived cells is required for retinal and choroidal neovascularization. Am J Pathol. 2010 May;176(5):2571-80. Epub 2010 Mar 19. Pubmed20304958
  Kleifeld O, Doucet A, auf dem Keller U, Prudova A, Schilling O, Kainthan RK, Starr AE, Foster LJ, Kizhakkedathu JN, Overall CM. Isotopic labeling of terminal amines in complex samples identifies protein N-termini and protease cleavage products. Nat Biotechnol. 2010 Mar;28(3):281-8. Pubmed20208520
  Matthews SP, Werber I, Deussing J, Peters C, Reinheckel T, Watts C. Distinct protease requirements for antigen presentation in vitro and in vivo. J Immunol. 2010 Mar 1;184(5):2423-31. Pubmed20164435
  Wartmann T, Mayerle J, Kähne T, Sahin-Tóth M, Ruthenbürger M, Matthias R, Kruse A, Reinheckel T, Peters C, Weiss FU, Sendler M, Lippert H, Schulz HU, Aghdassi A, Dummer A, Teller S, Halangk W, Lerch MM. Cathepsin L inactivates human trypsinogen, whereas cathepsin L-deletion reduces the severity of pancreatitis in mice. Gastroenterology. 2010 Feb;138(2):726-37. Pubmed19900452
  Oberle C, Huai J, Reinheckel T, Tacke M, Rassner M, Ekert PG, Buellesbach J, Borner C. Lysosomal membrane permeabilization and cathepsin release is a Bax/Bak-dependent, amplifying event of apoptosis in fibroblasts and monocytes. Cell Death Differ. 2010 Jul;17(7):1167-78. Pubmed20094062
  Sevenich L, Schurigt U, Sachse K, Gajda M, Werner F, Müller S, Vasiljeva O, Schwinde A, Klemm N, Deussing J, Peters C, Reinheckel T. Synergistic antitumor effects of combined cathepsin B and cathepsin Z deficiencies on breast cancer progression and metastasis in mice. Proc Natl Acad Sci U S A. 2010 Feb 9;107(6):2497-502. Pubmed20133781
  Minokadeh A, Funkelstein L, Toneff T, Hwang SR, Beinfeld M, Reinheckel T, Peters C, Zadina J, Hook V. Cathepsin L participates in dynorphin production in brain cortex, illustrated by protease gene knockout and expression. Mol Cell Neurosci. 2010 Jan;43(1):98-107. Pubmed19837164
  Terada K, Yamada J, Hayashi Y, Wu Z, Uchiyama Y, Peters C, Nakanishi H. Involvement of cathepsin B in the processing and secretion of interleukin-1beta in chromogranin A-stimulated microglia. Glia. 2010 Jan 1;58(1):114-24. Pubmed19544382
  Dennemärker J, Lohmüller T, Mayerle J, Tacke M, Lerch MM, Coussens LM, Peters C, Reinheckel T. Deficiency for the cysteine protease cathepsin L promotes tumor progression in mouse epidermis.Oncogene. 2010 Mar 18;29(11):1611-21. Pubmed20023699
  Weise A, Bruser K, Elfert S, Wallmen B, Wittel Y, Wöhrle S, Hecht A. Alternative splicing of Tcf7l2 transcripts generates protein variants with differential promoter-binding and transcriptional activation properties at Wnt/ß-catenin targets. Nucleic Acids Res. 2010 Apr;38(6):1964-81. PMID20044351
  Gebhardt R, Lerche KS, Götschel F, Günther R, Kolander J, Teich L, Zellmer S, Hofmann HJ, Eger K, Hecht A, Gaunitz F. 4-Amino-ethyl-amino-emodin - a novel potent inhibitor of GSK-3beta - acts as an insulin-sensitizer avoiding downstream effects of activated beta-catenin. J Cell Mol Med. 2010 Jun;14(6A):1276-93. Pubmed19228266
  Lindenboim L, Blacher E, Borner C, Stein R. Regulation of stress-induced nuclear protein redistribution: a new function of Bax and Bak uncoupled from Bcl-x(L). Cell Death Differ. 2010 Feb;17(2):346-59. Pubmed19816507
  Jabbour AM, Daunt CP, Green BD, Vogel S, Gordon L, Lee RS, Silke N, Pearson RB, Vandenberg CJ, Kelly PN, Nutt SL, Strasser A, Borner C, Ekert PG. Myeloid progenitor cells lacking p53 exhibit delayed up-regulation of Puma and prolonged survival after cytokine deprivation. Blood. 2010 Jan 14;115(2):344-52. Pubmed19965665
2009 Schlatter R, Schmich K, Avalos Vizcarra I, Scheurich P, Sauter T, Borner C, Ederer M, Merfort I, Sawodny O. ON/OFF and beyond--a boolean model of apoptosis. PLoS Comput Biol. 2009 Dec;5(12):e1000595. Pubmed20011108
Bessler WG, Puce K, vor dem Esche U, Kirschning C, Huber M. Immunomodulating effects of OM-89, a bacterial extract from Escherichia coli, in murine and human leukocytes. Arzneimittelforschung. 2009;59(11):571-7. Pubmed20066966
  Xiao K, Jehle F, Peters C, Reinheckel T, Schirmer RH, Dandekar T. CA/C1 peptidases of the malaria parasites Plasmodium falciparum and P. berghei and their mammalian hosts--a bioinformatical analysis. Biol Chem. 2009 Nov;390(11):1185-97. Pubmed19663681
  Zimmermann S, Biniossek ML, Maurer C, Münzer P, Pantic M, Veelken H, Martens UM. Proteomic profiling in distinct cellular compartments of tumor cells reveals p53-dependent upregulation of S100A6 upon induction of telomere dysfunction. Proteomics. 2009 Nov;9(22):5175-87. PMID: Pubmed19834903
  Lindenboim L, Blacher E, Borner C, Stein R. Regulation of stress-induced nuclear protein redistribution: a new function of Bax and Bak uncoupled from Bcl-x(L). Cell Death Differ. 2009 Oct 9. Pubmed19816507
Sugita S, Horie S, Nakamura O, Maruyama K, Takase H, Usui Y, Takeuchi M, Ishidoh K, Koike M, Uchiyama Y, Peters C, Yamamoto Y, Mochizuki M. Acquisition of T regulatory function in cathepsin L-inhibited T cells by eye-derived CTLA-2alpha during inflammatory conditions. J Immunol. 2009 Oct 15;183(8):5013-22. Pubmed19801522
  Schuy S, Schäfer E, Yoder NC, Kumar K, Vogel R, Janshoff A. Lipopeptides derived from HIV and SIV mimicking the prehairpin intermediate of gp41 on solid supported lipid bilayers. J Struct Biol. 2009 Oct;168(1):125-36. Pubmed19406246
  Beinfeld MC, Funkelstein L, Foulon T, Cadel S, Kitagawa K, Toneff T, Reinheckel T, Peters C, Hook V. Cathepsin L plays a major role in cholecystokinin production in mouse brain cortex and in pituitary AtT-20 cells: protease gene knockout and inhibitor studies. Peptides. 2009 Oct;30(10):1882-91. Pubmed19589362
  Philippi N, Walter D, Schlatter R, Ferreira KS, Ederer M, Sawodny O, Timmer J, Borner C, Dandekar T. Modeling system states in liver cells: Survival, apoptosis and their modifications in response to viral infection. BMC Syst Biol. 2009 Sep 22;3(1):97. Pubmed19772631
  Baudot AD, Jeandel PY, Mouska X, Maurer U, Tartare-Deckert S, Raynaud SD, Cassuto JP, Ticchioni M, Deckert M. The tyrosine kinase Syk regulates the survival of chronic lymphocytic leukemia B cells through PKCdelta and proteasome-dependent regulation of Mcl-1 expression. Oncogene. 2009 Sep 17;28(37):3261-73. Pubmed19581935
Wolf AM, Eller K, Zeiser R, Dürr C, Gerlach UV, Sixt M, Markut L, Gastl G, Rosenkranz AR, Wolf D. The sphingosine 1-phosphate receptor agonist FTY720 potently inhibits regulatory T cell proliferation in vitro and in vivo. J Immunol. 2009 Sep 15;183(6):3751-60. Pubmed19692647
  Olson JA, Zeiser R, Beilhack A, Goldman JJ, Negrin RS. Tissue-specific homing and expansion of donor NK cells in allogeneic bone marrow transplantation. J Immunol. 2009 Sep 1;183(5):3219-28. Pubmed19657090
  Jost PJ, Grabow S, Gray D, McKenzie MD, Nachbur U, Huang DC, Bouillet P, Thomas HE, Borner C, Silke J, Strasser A, Kaufmann T. XIAP discriminates between type I and type II FAS-induced apoptosis. Nature. 2009 Aug 20;460(7258):1035-9. Pubmed19626005
  Galluzzi L, Aaronson SA, Abrams J, Alnemri ES, Andrews DW, Baehrecke EH, Bazan NG, Blagosklonny MV, Blomgren K, Borner C, Bredesen DE, Brenner C, Castedo M, Cidlowski JA, Ciechanover A, Cohen GM, De Laurenzi V, De Maria R, Deshmukh M, Dynlacht BD, El-Deiry WS, Flavell RA, Fulda S, Garrido C, Golstein P, Gougeon ML, Green DR, Gronemeyer H, Hajnóczky G, Hardwick JM, Hengartner MO, Ichijo H, Jäättelä M, Kepp O, Kimchi A, Klionsky DJ, Knight RA, Kornbluth S, Kumar S, Levine B, Lipton SA, Lugli E, Madeo F, Malomi W, Marine JC, Martin SJ, Medema JP, Mehlen P, Melino G, Moll UM, Morselli E, Nagata S, Nicholson DW, Nicotera P, Nuñez G, Oren M, Penninger J, Pervaiz S, Peter ME, Piacentini M, Prehn JH, Puthalakath H, Rabinovich GA, Rizzuto R, Rodrigues CM, Rubinsztein DC, Rudel T, Scorrano L, Simon HU, Steller H, Tschopp J, Tsujimoto Y, Vandenabeele P, Vitale I, Vousden KH, Youle RJ, Yuan J, Zhivotovsky B, Kroemer G. Guidelines for the use and interpretation of assays for monitoring cell death in higher eukaryotes. Cell Death Differ. 2009 Aug;16(8):1093-107. Review. Pubmed19373242
  Hook VY, Kindy M, Reinheckel T, Peters C, Hook G. Genetic cathepsin B deficiency reduces beta-amyloid in transgenic mice expressing human wild-type amyloid precursor protein. Biochem Biophys Res Commun. 2009 Aug 21;386(2):284-8. Pubmed19501042
  Ye S, Huber T, Vogel R, Sakmar TP. FTIR analysis of GPCR activation using azido probes. Nat Chem Biol. 2009 Jun;5(6):397-9. Pubmed19396177
  Vreemann A, Qu H, Mayer K, Andersen LB, Stefana MI, Wehner S, Lysson M, Farcas AM, Peters C, Reinheckel T, Kalff J, Brix K. Cathepsin B release from rodent intestine mucosa due to mechanical injury results in extracellular matrix damage in early post-traumatic phases.Biol Chem. 2009 May-Jun;390(5-6):481-92. Pubmed19335208
  Anel A, Bleackley C, Borner C, Golstein P, Krammer PH, Müllbacher A, Pardo J, Simon MM, Trapani JA. EMBO workshop on cytotoxicity, cell death and the immune system. Cell Death Differ. 2009 May;16(5):790-3. No abstract available. Pubmed19369941
  Zeiser R, Maas K, Youssef S, Dürr C, Steinman L, Negrin RS. Regulation of different inflammatory diseases by impacting the mevalonate pathway. Immunology. 2009 May;127(1):18-25. Review. Pubmed19191903
  Caglic D, Kosec G, Bojic L, Reinheckel T, Turk V, Turk B. Murine and human cathepsin B exhibit similar properties: possible implications for drug discovery. Biol Chem. 2009 Feb;390(2):175-9. Erratum in: Biol Chem. 2009 May-Jun;390(5-6):517. Pubmed19040356
  Pardo J, Aguilo JI, Anel A, Martin P, Joeckel L, Borner C, Wallich R, Müllbacher A, Froelich CJ, Simon MM. The biology of cytotoxic cell granule exocytosis pathway: granzymes have evolved to induce cell death and inflammation. Microbes Infect. 2009 Apr;11(4):452-9. Review. Pubmed19249384
  Zeiser R, Zerweck A, Bertz H, Finke J. Allogeneic hematopoietic cell transplantation for t-AML following liver transplantation from the same haploidentical donor. Bone Marrow Transplant. 2009 Apr;43(7):589-90. No abstract available. Pubmed18978821
Schuy S, Schäfer E, Yoder NC, Hobe S, Kumar K, Vogel R, Janshoff A. Coiled-coil lipopeptides mimicking the prehairpin intermediate of glycoprotein gp41. Angew Chem Int Ed Engl. 2009;48(4):751-4. No abstract available. Pubmed19090512
  Lüdeke S, Mahalingam M, Vogel R. Rhodopsin activation switches in a native membrane environment. Photochem Photobiol. 2009 Mar-Apr;85(2):437-41. Review. Pubmed19267869
  Shen ZJ, Esnault S, Schinzel A, Borner C, Malter JS. The peptidyl-prolyl isomerase Pin1 facilitates cytokine-induced survival of eosinophils by suppressing Bax activation. Nat Immunol. 2009 Mar;10(3):257-65. Pubmed19182807
  Zimmermann S, Biniossek ML, Pantic M, Pfeifer D, Veelken H, Martens UM. Proteomic profiling of tumor cells after induction of telomere dysfunction. Proteomics. 2009 Feb;9(3):521-34. Pubmed19132685
  Ryppa C, Mann-Steinberg H, Biniossek ML, Satchi-Fainaro R, Kratz F. In vitro and in vivo evaluation of a paclitaxel conjugate with the divalent peptide E-[c(RGDfK)2] that targets integrin alpha v beta 3. Int J Pharm. 2009 Feb 23;368(1-2):89-97. Pubmed18992308
Ajaj KA, Biniossek ML, Kratz F. Development of protein-binding bifunctional linkers for a new generation of dual-acting prodrugs. Bioconjug Chem. 2009 Feb;20(2):390-6. Pubmed19199576
  Schwinté P, Gärtner W, Sharda S, Mroginski MA, Hildebrandt P, Siebert F. The photoreactions of recombinant phytochrome CphA from the cyanobacterium Calothrix PCC7601: a low-temperature UV-Vis and FTIR study. Photochem Photobiol. 2009 Jan-Feb;85(1):239-49. Pubmed18764898
  Ai WZ, Hou JZ, Zeiser R, Czerwinski D, Negrin RS, Levy R. Follicular lymphoma B cells induce the conversion of conventional CD4+ T cells to T-regulatory cells. Int J Cancer. 2009 Jan 1;124(1):239-44. Pubmed18814264
  Wilson SR, Peters C, Saftig P, Brömme D. Cathepsin K activity-dependent regulation of osteoclast actin ring formation and bone resorption. J Biol Chem. 2009 Jan 23;284(4):2584-92. Pubmed19028686
  Vogel, S., Kiefer, T., Raulf, N., Sterz, K., Manoharan, A. & Borner, C. Mechanisms of Bax/Bak activation: is there any light at the end of the tunnel? Gastroenterology and Hepatology from Bed to Bench 2, S11-S18.(2009).
2008 Funkelstein L, Toneff T, Mosier C, Hwang SR, Beuschlein F, Lichtenauer UD, Reinheckel T, Peters C, Hook V. Major Role of Cathepsin L for Producing the Peptide Hormones ACTH, {beta}-Endorphin, and {alpha}-MSH, Illustrated by Protease Gene Knockout and Expression. J BiolChem. 2008 Dec19; 283(51):356529. Pubmed18849346
  Walter D, Schmich K, Vogel S, Pick R, Kaufmann T, Hochmuth FC, Haber A, Neubert K, McNelly S, von Weizsäcker F, Merfort I, Maurer U, Strasser A, Borner C. Switch from type II to I Fas/CD95 death signaling on in vitro culturing of primary hepatocytes. Hepatology. 2008 Dec;48(6):1942-53. Pubmed19003879
  Mahalingam M, Martínez-Mayorga K, Brown MF, Vogel R. Two protonation switches control rhodopsin activation in membranes.Proc Natl Acad Sci U S A. 2008 Nov 18;105(46):17795-800. Pubmed18997017
Ryppa C, Mann-Steinberg H, Satchi-Fainaro R, Biniossek ML, Kratz F. In vitro and in vivo evaluation of a paclitaxel conjugate with the divalent peptide E-[c(RGDfK)(2)] that targets integrin alpha(v)beta(3). Int J Pharm. 2008 Oct 17. Pubmed18992308
  Urban C, Rhême C, Maerz S, Berg B, Pick R, Nitschke R, Borner C. Apoptosis induced by Semliki Forest virus is RNA replication dependent and mediated via Bak. Cell Death Differ. 2008 Sep;15(9):1396-407. Pubmed18437160
  Jiang X, Zaitseva E, Schmidt M, Siebert F, Engelhard M, Schlesinger R, Ataka K, Vogel R, Heberle Resolving voltage-dependent structural changes of a membrane photoreceptor by surface-enhanced IR difference spectroscopy. J. Proc Natl Acad Sci U S A. 2008 Aug 26;105(34):12113-7. Pubmed18719097
Halle A, Hornung V, Petzold GC, Stewart CR, Monks BG, Reinheckel T, Fitzgerald KA, Latz E, Moore KJ, Golenbock DT. The NALP3 inflammasome is involved in the innate immune response to amyloid-beta. Nat Immunol. 2008 Aug;9(8):857-65.Pubmed18604209
Schurigt U, Sevenich L, Vannier C, Gajda M, Schwinde A, Werner F, Stahl A, von Elverfeldt D, Becker AK, Bogyo M, Peters C, Reinheckel T. Trial of the cysteine cathepsin inhibitor JPM-OEt on early and advanced mammary cancer stages in the MMTV-PyMT-transgenic mouse model. Biol Chem. 2008 Aug;389(8):1067-74.Pubmed18710344
Denayer T, Locker M, Borday C, Deroo T, Janssens S, Hecht A, van Roy F, Perron M, Vleminckx K. Canonical Wnt signaling controls proliferation of retinal stem/progenitor cells in postembryonic Xenopus eyes. Stem Cells. 2008 Aug;26(8):2063-74. Pubmed18556512
  Ryppa C, Mann-Steinberg H, Fichtner I, Weber H, Satchi-Fainaro R, Biniossek ML, Kratz F. In vitro and in vivo evaluation of doxorubicin conjugates with the divalent peptide E-[c(RGDfK)2] that targets integrin alphavbeta3. Bioconjug Chem. 2008 Jul;19(7):1414-22. 26.Pubmed18578486
  Funkelstein L, Toneff T, Hwang SR, Reinheckel T, Peters C, Hook V. Cathepsin L participates in the production of neuropeptide Y in secretory vesicles, demonstrated by protease gene knockout and expression. J Neurochem. 2008 Jul;106(1):384-91. Pubmed18410501
  Funkelstein L, Toneff T, Hwang SR, Reinheckel T, Peters C, Hook V. Cathepsin L participates in the production of neuropeptide Y in secretory vesicles, demonstrated by protease gene knockout and expression. J Neurochem. 2008 Jul;106(1):384-91. Pubmed18410501
  Vasiljeva O, Korovin M, Gajda M, Brodoefel H, Bojic L, Krüger A, Schurigt U, Sevenich L, Turk B, Peters C, Reinheckel T. Reduced tumour cell proliferation and delayed development of high-grade mammary carcinomas in cathepsin B-deficient mice. Oncogene. 2008 Jul 10;27(30):4191-9. Pubmed18345026
  Vogel R, Mahalingam M, Lüdeke S, Huber T, Siebert F, Sakmar TP. Functional role of the "ionic lock"--an interhelical hydrogen-bond network in family A heptahelical receptors. J Mol Biol. 2008 Jul 18;380(4):648-55. Pubmed18554610
  Schuy S, Faiss S, Yoder NC, Kalsani V, Kumar K, Janshoff A, Vogel R. Structure and thermotropic phase behavior of fluorinated phospholipid bilayers: a combined attenuated total reflection FTIR spectroscopy and imaging ellipsometry study. J Phys Chem B. 2008 Jul 17;112(28):8250-6. Pubmed18563929
  Schilling O, Overall CM. Proteome-derived, database-searchable peptide libraries for identifying protease cleavage sites. Nat Biotechnol. 2008 Jun;26(6):685-94. Pubmed18500335
  Standfuss J, Zaitseva E, Mahalingam M, Vogel R. Structural impact of the E113Q counterion mutation on the activation and deactivation pathways of the G protein-coupled receptor rhodopsin. J Mol Biol. 2008 Jun 27;380(1):145-57. Pubmed18511075
  Harder J, Opitz OG, Brabender J, Olschewski M, Blum HE, Nomoto S, Usadel H.Quantitative promoter methylation analysis of hepatocellular carcinoma, cirrhotic and normal liver. Int J Cancer. 2008 Jun 15;122(12):2800-4. Pubmed18351580
  Götschel F, Kern C, Lang S, Sparna T, Markmann C, Schwager J, McNelly S, von Weizsäcker F, Laufer S, Hecht A, Merfort I Inhibition of GSK3 differentially modulates NFκB, CREB, AP-1 and β-catenin signaling in hepatocytes, but fails to to promote TNF-α -induced apoptosis. Exp. Cell. Res. 2008 April 1; 314 (6): 1351-1366Pubmed18261723
  Conus S, Perozzo R, Reinheckel T, Peters C, Scapozza L, Yousefi S, Simon HU. Caspase-8 is activated by cathepsin D initiating neutrophil apoptosis during the resolution of inflammation. J Exp Med. 2008 Mar 17;205(3):685-98. Pubmed18299403
  Pardo J, Wallich R, Martin P, Urban C, Rongvaux A, Flavell RA, Müllbacher A, Borner C, Simon MM. Granzyme B-induced cell death exerted by ex vivo CTL: discriminating requirements for cell death and some of its signs. Cell Death Differ. 2008 Mar;15(3):567-79. Pubmed18064039
  Pardo J, Wallich R, Martin P, Urban C, Rongvaux A, Flavell RA, Muellbacher A, Borner C, Simon MM. Granzyme B-induced cell death exerted by ex vivo CTL: discriminating requirements for cell death and some of its signs. Cell Death Differ. 2008 Mar;15(3):567-79. Epub 2007 Dec 7.Pubmed18064039
  Wolf P, Alt K, Bühler P, Katzenwadel A, Wetterauer U, Tacke M, Elsässer-Beile U. Anti-PSMA immunotoxin as novel treatment for prostate cancer? High and specific antitumor activity on human prostate xenograft tumors in SCID mice. Prostate. 2008 Feb 1;68(2):129-38. Pubmed18044731
  Zeiser R, Leveson-Gower DB, Zambricki EA, Kambham N, Beilhack A, Loh J, Hou JZ, Negrin RS. Differential impact of mammalian target of rapamycin inhibition on CD4+CD25+Foxp3+ regulatory T cells compared with conventional CD4+ T cells. Blood. 2008 Jan 1;111(1):453-62. Pubmed17967941
  Bühler P, Wolf P, Gierschner D, Schaber I, Katzenwadel A, Schultze-Seemann W, Wetterauer U, Tacke M, Swamy M, Schamel WW, Elsässer-Beile U. A bispecific diabody directed against prostate-specific membrane antigen and CD3 induces T-cell mediated lysis of prostate cancer cells. Cancer Immunol Immunother. 2008 Jan;57(1):43-52. Pubmed17579857
  Reinheckel, T., Gocheva, V., Peters, C., Joyce, J.A.:Roles of Cysteine Proteases in Tumor Progression: Analysis of Cysteine Cathepsin Knockout Mice in Cancer Models. In: D. Edwards et al. (eds.): The Cancer Degradome, Springer Science, cap. 15. 2008 / Buchbeitrag
2007 Wöhrle S, Wallmen B, Hecht A.:Differential control of Wnt target genes involves epigenetic mechanisms and selective promoter occupancy by TCFs. Mol Cell Biol. 2007 Dec;27(23):8164-8177 Pubmed17923689
  Bojic L, Petelin A, Stoka V, Reinheckel T, Peters C, Turk V, Turk B. Cysteine cathepsins are not involved in Fas/CD95 signalling in primary skin fibroblasts. FEBS Lett. 2007 Nov 13;581(27):5185-90. Pubmed1950288
  Spira D, Stypmann J, Tobin DJ, Petermann I, Mayer C, Haggemann S, Vasiljeva O, Günther T, Schüle R, Peters C, Reinheckel T. Cell type-specific functions of the lysosomal protease cathepsin L in the heart. J Biol Chem. 2007 Oct 17. Pubmed17942402
  Yamasaki R, Zhang J, Koshiishi I, Sastradipura Suniarti DF, Wu Z, Peters C, Schwake M, Uchiyama Y, Kira J, Saftig P, Utsumi H, Nakanishi H. Involvement of lysosomal storage-induced p38 MAP kinase activation in the overproduction of nitric oxide by microglia in cathepsin D-deficient mice.Mol Cell Neurosci. 2007 Aug;35(4):573-84. Pubmed17570679
  Yoder NC, Kalsani V, Schuy S, Vogel R, Janshoff A, Kumar K. Nanoscale patterning in mixed fluorocarbon-hydrocarbon phospholipid bilayers. J Am Chem Soc. 2007 Jul 25;129(29):9037-43. Pubmed17602478
  Colell A, Ricci JE, Tait S, Milasta S, Maurer U, Bouchier-Hayes L,
Fitzgerald P, Guio-Carrion A, Waterhouse NJ, Li CW, Mari B, Barbry P, Newmeyer DD, Beere HM, Green DR. GAPDH and autophagy preserve survival after apoptotic cytochrome c release in the absence of caspase activation. Cell. 2007 Jun 1;129(5):983-97. Pubmed17540177
  Tiwari N, Garbi N, Reinheckel T, Moldenhauer G, Hämmerling GJ, Momburg F. A transporter associated with antigen-processing independent vacuolar pathway for the MHC class I-mediated presentation of endogenous transmembrane proteins..J Immunol. 2007 Jun 15;178(12):7932-42. Pubmed17548631
  Sanjuán Szklarz LK, Kozjak-Pavlovic V, Voegtle FN, Chacinska A, Milenkovic D, Vogel S, Dürr M, Westermann B, Guiard B, Martinou JC, Borner C, Pfanner N, Meisinger C. Preprotein transport machineries of yeast mitochondrial outer membrane are not required for Bax-induced release of intermembrane space proteins. J Mol Biol. 2007 Apr 20;368(1):44-54. Pubmed17335847
  Kitamoto S, Sukhova GK, Sun J, Yang M, Libby P, Love V, Duramad P, Sun C, Zhang Y, Yang X, Peters C, Shi GP. Cathepsin L deficiency reduces diet-induced atherosclerosis in low-density lipoprotein receptor-knockout mice. Circulation. 2007 Apr 17;115(15):2065-75. Epub 2007 Apr 2. Pubmed17404153
  Bartl FJ, Vogel R. Structural and functional properties of metarhodopsin III: recent spectroscopic studies on deactivation pathways of rhodopsin. Phys Chem Chem Phys. 2007 Apr 14;9(14):1648-58. Review. Pubmed17396175
  Vasiljeva O, Reinheckel T, Peters C, Turk D, Turk V, Turk B. Emerging roles of cysteine cathepsins in disease and their potential as drug targets. Curr Pharm Des. 2007;13(4):387-403. Pubmed17311556
  Vogel R, Sakmar TP, Sheves M, Siebert F. Coupling of protonation switches during rhodopsin activation. Photochem Photobiol. 2007 Mar-Apr;83(2):286-92. Review. Pubmed17576345
  Vogel R, Martell S, Mahalingam M, Engelhard M, Siebert F. Interaction of a G protein-coupled receptor with a G protein-derived peptide induces structural changes in both peptide and receptor: a Fourier-transform infrared study using isotopically labeled peptides. J Mol Biol. 2007 Mar 9;366(5):1580-8. Pubmed17217962
  Hirsch C, Campano LM, Wohrle S, Hecht A. Canonical Wnt signaling transiently stimulates proliferation and enhances neurogenesis in neonatal neural progenitor cultures. Exp Cell Res. 2007 Feb 1;313(3):572-87. Pubmed17198701
2006 Rocken C, Fandrich M, Stix B, Tannert A, Hortschansky P, Reinheckel T, Saftig P, Kahne T, Menard R, Ancsin JB, Buhling F. Cathepsin protease activity modulates amyloid load in extracerebral amyloidosis. J Pathol. 2006 Dec;210(4):478-87. Pubmed17068745
  Sciortino MT, Perri D, Medici MA, Grelli S, Serafino A, Borner C, Mastino A. Role of Bcl-2 expression for productive herpes simplex virus 2 replication. Virology. 2006 Dec 5-20;356(1-2):136-46.
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  Schepsky A, Bruser K, Gunnarsson GJ, Goodall J, Hallsson JH, Goding CR, Steingrimsson E, Hecht A. The microphthalmia-associated transcription factor Mitf interacts with beta-catenin to determine target gene expression. Mol Cell Biol. 2006 Dec;26(23):8914-27.
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Klingmuller U, Bauer A, Bohl S, Nickel PJ, Breitkopf K, Dooley S, Zellmer S, Kern C, Merfort I, Sparna T, Donauer J, Walz G, Geyer M, Kreutz C, Hermes M, Gotschel F, Hecht A, Walter D, Egger L, Neubert K, Borner C, Brulport M, Schormann W, Sauer C, Baumann F, Preiss R, MacNelly S, Godoy P, Wiercinska E, Ciuclan L, Edelmann J, Zeilinger K, Heinrich M, Zanger UM, Gebhardt R, Maiwald T, Heinrich R, Timmer J, von Weizsacker F, Hengstler JG. Primary mouse hepatocytes for systems biology approaches: a standardized in vitro system for modelling of signal transduction pathways. Syst Biol (Stevenage). 2006 Nov;153(6):433-47. Pubmed17186705
  Waterkamp DA, Muller OJ, Ying Y, Trepel M, Kleinschmidt JA.
Isolation of targeted AAV2 vectors from novel virus display libraries. J Gene Med. 2006 Nov;8(11):1307-19. Pubmed16955542
  Modlich U, Bohne J, Schmidt M, von Kalle C, Knoss S, Schambach A, Baum C. Cell-culture assays reveal the importance of retroviral vector design for insertional genotoxicity. Blood. 2006 Oct 15;108(8):2545-53. Pubmed16825499
  Charvet C, Canonigo AJ, Becart S, Maurer U, Miletic AV, Swat W, Deckert M, Altman A. Vav1 promotes T cell cycle progression by linking TCR/CD28 costimulation to FOXO1 and p27kip1 expression. J Immunol. 2006 Oct 15;177(8):5024-31. Pubmed17015685
Baran K, Ciccone A, Peters C, Yagita H, Bird PI, Villadangos JA, Trapani JA. Cytotoxic T lymphocytes from cathepsin B-deficient mice survive normally in vitro and in vivo after encountering and killing target cells. J Biol Chem. 2006 Oct 13;281(41):30485-91. Pubmed16914553
  Perez-Amodio S, Jansen DC, Schoenmaker T, Vogels IM, Reinheckel T, Hayman AR, Cox TM, Saftig P, Beertsen W, Everts V. Calvarial osteoclasts express a higher level of tartrate-resistant acid phosphatase than long bone osteoclasts and activation does not depend on cathepsin K or L activity. Calcif Tissue Int. 2006 Oct;79(4):245-54. Pubmed17033726
  Worsham DN, Schuesler T, von Kalle C, Pan D. In vivo gene transfer into adult stem cells in unconditioned mice by in situ delivery of a lentiviral vector. Mol Ther. 2006 Oct;14(4):514-24. Pubmed16893684
  Binder M, Otto F, Mertelsmann R, Veelken H, Trepel M.
The epitope recognized by rituximab. Blood. 2006 Sep15;108(6):1975-8. Pubmed16705086
  Everts V, Korper W, Hoeben KA, Jansen ID, Bromme D, Cleutjens KB, Heeneman S, Peters C, Reinheckel T, Saftig P, Beertsen W.
Osteoclastic bone degradation and the role of different cysteine proteinases and matrix metalloproteinases: differences between calvaria and long bone. J Bone Miner Res. 2006 Sep;21(9):1399-408. Pubmed16939398
  Fischer M, Schmidt M, Klingenberg S, Eaves CJ, von Kalle C, Glimm H.
Short-term repopulating cells with myeloid potential in human mobilized peripheral blood do not have a side population (SP) phenotype. Blood. 2006 Sep 15;108(6):2121-3.
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  Ekert PG, Jabbour AM, Manoharan A, Heraud JE, Yu J, Pakusch M, Michalak EM, Kelly PN, Callus B, Kiefer T, Verhagen A, Silke J, Strasser A, Borner C, Vaux DL. Cell death provoked by loss of Interleukin-3 signalling is independent of Bad, Bim, and PI3 Kinase, but depends in part on Puma. Blood. 2006 Sep 1;108(5):1461-8. Pubmed16705087
  Mollmann H, Nef HM, Kostin S, von Kalle C, Pilz I, Weber M, Schaper J, Hamm CW, Elsasser A. Bone marrow-derived cells contribute to infarct remodelling.Cardiovasc Res. 2006 Sep 1;71(4):661-71. Pubmed16854401
  Borner C. In memoriam of a prominent composer of the Bcl-2 family symphony. Cell Death Differ. 2006 Aug;13(8):1248-9. Pubmed16838034
  Klingmüller, U. Bauer, A., Breitkopf, K., Bohl, S., Dooley, S., Zellmer, S., Kern, C., Merfort, I., Sparna, T., Donauer, J., Walz, G., Geyer, M., Kreutz, C., Hermes, M., Walter, D., Egger, L., Neubert, K., Borner, C., Götschel, F., Hecht, A., Brulport, M., Schormann, W., Sauer, C., Baumann, F., Preiss, R., Illes, P., Nickel, P. J., MacNelly, S., Godoy, P., Wiercinska, E., Ciuclan, L., Zeilinger, K., Heinrich, M., Zanger, U. M., Reuss, M., Bader, A., Gebhardt, R., Maiwald, T., Timmer, J., von Weizsäcker, F., und Hengstler, J. G. “Primary mouse hepatocytes for systems biology approaches: a standardized in vitro system for modelling of signal transduction pathways”.IEE Proc. Systems Biology, 153, 433-447. Pubmed17186705
  Manoharan A, Kiefer T, Leist S, Schrader K, Urban C, Walter D, Maurer U, Borner C. Identification of a 'genuine' mammalian homolog of nematodal CED-4: is the hunt over or do we need better guns? Cell Death Differ. 2006 Aug;13(8):1310-7. Pubmed16691212
  Pardo, J., Urban, C., Galvez, E. M., Müller U., Kwon-Chung, J., Lobigs, M., Müllbacher, A. Wallich, R., Borner, C. & Simon, M. Bak is key in gliotoxin-induced apoptosis and a critical host factor of A. fumigatus virulence in mice. J. Cell Biology, Pubmed16893972
  Sevenich L, Pennacchio LA, Peters C, Reinheckel T. Human cathepsin L rescues the neurodegeneration and lethality in cathepsin B/L double-deficient mice. Biol Chem. 2006 Jul;387(7):885-91. Pubmed16913838
  Cheng T, Hitomi K, van Vlijmen-Willems IM, de Jongh GJ, Yamamoto K, Nishi K, Watts C, Reinheckel T, Schalkwijk J, Zeeuwen PL. Cystatin M/E is a high affinity inhibitor of cathepsin V and cathepsin L by a reactive site that is distinct from the legumain-binding site. A novel clue for the role of cystatin M/E in epidermal cornification.
J Biol Chem. 2006 Jun 9;281(23):15893-9. Pubmed16565075
  Petermann I, Mayer C, Stypmann J, Biniossek ML, Tobin DJ, Engelen MA, Dandekar T, Grune T, Schild L, Peters C, Reinheckel T.
Lysosomal, cytoskeletal, and metabolic alterations in cardiomyopathy of cathepsin L knockout mice. FASEB J. 2006 Jun;20(8):1266-8. Pubmed16636100
 

Montini E, Cesana D, Schmidt M, Sanvito F, Ponzoni M, Bartholomae C, Sergi Sergi L, Benedicenti F, Ambrosi A, Di Serio C, Doglioni C, von Kalle C, Naldini L. Hematopoietic stem cell gene transfer in a tumor-prone mouse model uncovers low genotoxicity of lentiviral vector integration.Nat Biotechnol. 2006 Jun;24(6):687-96. Pubmed16732270

  Nowrouzi A, Dittrich M, Klanke C, Heinkelein M, Rammling M, Dandekar T, von Kalle C, Rethwilm A. Genome-wide mapping of foamy virus vector integrations into a human cell line. J Gen Virol. 2006 May;87(Pt 5):1339-47. Pubmed16603537
  Kim S, Xu X, Hecht A, Boyer TG. Mediator is a transducer of Wnt/beta-catenin signaling. J Biol Chem. 2006 May19;281(20): 14066-75. Pubmed16565090
  Schambach A, Galla M, Modlich U, Will E, Chandra S, Reeves L, Colbert M, Williams DA, von Kalle C, Baum C. Lentiviral vectors pseudotyped with murine ecotropic envelope: increased biosafety and convenience in preclinical research. Exp Hematol. 2006 May;34(5):588-92. Pubmed16647564
  Seggewiss R, Pittaluga S, Adler RL, Guenaga FJ, Ferguson C, Pilz IH, Ryu B, Sorrentino BP, Young WS 3rd, Donahue RE, von Kalle C, Nienhuis AW, Dunbar CE. Acute myeloid leukemia is associated with retroviral gene transfer to hematopoietic progenitor cells in a rhesus macaque. Blood. 2006 May 15;107(10):3865-7. Pubmed16439674
  Vasiljeva O, Papazoglou A, Kruger A, Brodoefel H, Korovin M, Deussing J, Augustin N, Nielsen BS, Almholt K, Bogyo M, Peters C, Reinheckel T. Tumor cell-derived and macrophage-derived cathepsin B promotes progression and lung metastasis of mammary cancer. Cancer Res. 2006 May 15;66(10):5242-50. Pubmed16707449
  Thakar J, Schleinkofer K, Borner C, Dandekar T. RIP death domain structural interactions implicated in TNF-mediated proliferation and survival. Proteins. 2006 May 15;63(3):413-23. Pubmed16470584
  Hajitou A, Trepel M, Lilley CE, Soghomonyan S, Alauddin MM, Marini FC 3rd, Restel BH, Ozawa MG, Moya CA, Rangel R, Sun Y, Zaoui K, Schmidt M, von Kalle C, Weitzman MD, Gelovani JG, Pasqualini R, Arap W. A hybrid vector for ligand-directed tumor targeting and molecular imaging. Cell. 2006 Apr 21;125(2):385-98. Pubmed16630824
  Ott MG, Schmidt M, Schwarzwaelder K, Stein S, Siler U, Koehl U, Glimm H, Kuhlcke K, Schilz A, Kunkel H, Naundorf S, Brinkmann A, Deichmann A, Fischer M, Ball C, Pilz I, Dunbar C, Du Y, Jenkins NA, Copeland NG, Luthi U, Hassan M, Thrasher AJ, Hoelzer D, von Kalle C, Seger R, Grez M. Correction of X-linked chronic granulomatous disease by gene therapy, augmented by insertional activation of MDS1-EVI1, PRDM16 or SETBP1. Nat Med. 2006 Apr;12(4):401-9. Pubmed16582916
  Woods NB, Bottero V, Schmidt M, von Kalle C, Verma IM. Gene therapy: therapeutic gene causing lymphoma. Nature. 2006 Apr 27;440(7088):1123. Pubmed16641981
  Maurer U, Charvet C, Wagman AS, Dejardin E, Green DR. Glycogen synthase kinase-3 regulates mitochondrial outer membrane permeabilization and apoptosis by destabilization of MCL-1. Mol Cell. 2006 Mar 17;21(6):749-60.Pubmed16543145
  Gocheva V, Zeng W, Ke D, Klimstra D, Reinheckel T, Peters C, Hanahan D, Joyce JA. Distinct roles for cysteine cathepsin genes in multistage tumorigenesis. Genes Dev. 2006 Mar 1;20(5):543-56. Pubmed16481467
  Schulte U, Thumfart JO, Klocker N, Sailer CA, Bildl W, Biniossek M, Dehn D, Deller T, Eble S, Abbass K, Wangler T, Knaus HG, Fakler B.
The epilepsy-linked lgi1 protein assembles into presynaptic kv1 channels and inhibits inactivation by kvbeta1.
Neuron. 2006 Mar 2;49(5):697-706. Pubmed1650494
  Yanez-Munoz RJ, Balaggan KS, MacNeil A, Howe SJ, Schmidt M, Smith AJ, Buch P, MacLaren RE, Anderson PN, Barker SE, Duran Y, Bartholomae C, von Kalle C, Heckenlively JR, Kinnon C, Ali RR, Thrasher AJ. Effective gene therapy with nonintegrating lentiviral vectors. Nat Med. 2006 Mar;12(3):348-53. Pubmed16491086
2005 Darie CC, Biniossek ML, Gawinowicz MA, Milgrom Y, Thumfart JO, Jovine L, Litscher ES, Wassarman PM. Mass spectrometric evidence that proteolytic processing of rainbow trout egg vitelline envelope proteins takes place on the egg. J Biol Chem. 2005 Nov 11;280(45):37585-98. Pubmed16157586
Calmels B, Ferguson C, Laukkanen MO, Adler R, Faulhaber M, Kim HJ, Sellers S, Hematti P, Schmidt M, von Kalle C, Akagi K, Donahue RE, Dunbar CE. Recurrent retroviral vector integration at the MDS1-EVI1 locus in non-human primate hematopoietic cells. Blood. 2005 Oct 1;106(7):2530-3. Pubmed15933056
  Themis M, Waddington SN, Schmidt M, von Kalle C, Wang Y, Al-Allaf F, Gregory LG, Nivsarkar M, Themis M, Holder MV, Buckley SM, Dighe N, Ruthe AT, Mistry A, Bigger B, Rahim A, Nguyen TH, Trono D, Thrasher AJ, Coutelle C. Oncogenesis following delivery of a nonprimate lentiviral gene therapy vector to fetal and neonatal mice. Mol Ther. 2005 Oct;12(4):763-71. Pubmed16084128
  Glimm H, Schmidt M, Fischer M, Schwarzwaelder K, Wissler M, Klingenberg S, Prinz C, Waller CF, Lange W, Eaves CJ, von Kalle C.
Efficient marking of human cells with rapid but transient repopulating activity in autografted recipients. Blood. 2005 Aug 1;106(3):893-8. Pubmed15845903
  Reinheckel T, Hagemann S, Dollwet-Mack S, Martinez E, Lohmuller T, Zlatkovic G, Tobin DJ, Maas-Szabowski N, Peters C. The lysosomal cysteine protease cathepsin L regulates keratinocyte proliferation by control of growth factor recycling. J Cell Sci. 2005 Aug 1;118(Pt 15):3387-95. Pubmed16079282
  Lindenboim L, Kringel S, Braun T, Borner C, Stein R.
Bak but not Bax is essential for Bcl-xS-induced apoptosis.
Cell Death Differ. 2005 Jul;12(7):713-23. Pubmed15861188
  Podsakoff GM, Engel BC, Carbonaro DA, Choi C, Smogorzewska EM, Bauer G, Selander D, Csik S, Wilson K, Betts MR, Koup RA, Nabel GJ, Bishop K, King S, Schmidt M, von Kalle C, Church JA, Kohn DB.
Selective survival of peripheral blood lymphocytes in children with HIV-1 following delivery of an anti-HIV gene to bone marrow CD34(+) cells. Mol Ther. 2005 Jul;12(1):77-86. Pubmed15963923
  Loop T, Dovi-Akue D, Frick M, Roesslein M, Egger L, Humar M, Hoetzel A, Schmidt R, Borner C, Pahl HL, Geiger KK, Pannen BH.
Volatile anesthetics induce caspase-dependent, mitochondria-mediated apoptosis in human T lymphocytes in vitro.
Anesthesiology. 2005 Jun;102(6):1147-57. Pubmed15915027
  Modlich U, Kustikova OS, Schmidt M, Rudolph C, Meyer J, Li Z, Kamino K, von Neuhoff N, Schlegelberger B, Kuehlcke K, Bunting KD, Schmidt S, Deichmann A, von Kalle C, Fehse B, Baum C. Leukemias following retroviral transfer of multidrug resistance 1 (MDR1) are driven by combinatorial insertional mutagenesis. Blood. 2005 Jun 1;105(11):4235-46. Pubmed15713797
  Darie CC, Biniossek ML, Winter V, Mutschler B, Haehnel W. Isolation and structural characterization of the Ndh complex from mesophyll and bundle sheath chloroplasts of Zea mays. FEBS J. 2005 Jun;272(11):2705-16. Pubmed15943805
  Thrasher AJ, Hacein-Bey-Abina S, Gaspar HB, Blanche S, Davies EG, Parsley K, Gilmour K, King D, Howe S, Sinclair J, Hue C, Carlier F, von Kalle C, de Saint Basile G, le Deist F, Fischer A, Cavazzana-Calvo M.
Failure of SCID-X1 gene therapy in older patients. Blood. 2005 Jun 1;105(11):4255-7. Pubmed15687233
Henningsson F, Yamamoto K, Saftig P, Reinheckel T, Peters C, Knight SD, Pejler G. A role for cathepsin E in the processing of mast-cell carboxypeptidase A. J Cell Sci. 2005 May 1;118(Pt 9):2035-42. Pubmed15860733
Schmidt M, Hacein-Bey-Abina S, Wissler M, Carlier F, Lim A, Prinz C, Glimm H, Andre-Schmutz I, Hue C, Garrigue A, Le Deist F, Lagresle C, Fischer A, Cavazzana-Calvo M, von Kalle C. Clonal evidence for the transduction of CD34+ cells with lymphomyeloid differentiation potential and self-renewal capacity in the SCID-X1 gene therapy trial. Blood. 2005 Apr 1;105(7):2699-706. Pubmed15585650
Stemmler MP, Hecht A, Kemler R. E-cadherin intron 2 contains cis-regulatory elements essential for gene expression.Development. 2005 Mar;132(5):965-76. Pubmed15673570
Laukkanen MO, Kuramoto K, Calmels B, Takatoku M, von Kalle C, Donahue RE, Dunbar CE. Low-dose total body irradiation causes clonal fluctuation of primate hematopoietic stem and progenitor cells. Blood. 2005 Feb 1;105(3):1010-5. Pubmed15383461
Urbich C, Heeschen C, Aicher A, Sasaki KI, Bruhl T, Farhadi MR, Vajkoczy P, Hofmann WK, Peters C, Pennacchio LA, Abolmaali ND, Chavakis E, Reinheckel T, Zeiher AM, Dimmeler S. Cathepsin L is required for endothelial progenitor cell-induced neovascularization.
Nat Med. 2005 Feb;11(2):206-13. Pubmed15665831
  Yao VJ, Ozawa MG, Trepel M, Arap W, McDonald DM, Pasqualini R.
Targeting pancreatic islets with phage display assisted by laser pressure catapult microdissection. Am J Pathol. 2005 Feb;166(2):625-36. Pubmed15681844
  Milsom MD, Duxbury R, Gagen D, Humphries RK, Schmidt M, von-Kalle C, Fairbairn LJ. Overexpression of HOXB4 confers a myelo-erythroid differentiation delay in vitro. Leukemia. 2005 Jan;19(1):148-53. (Letter) Pubmed15496973
  Glimm H, Schmidt M, Fischer M, Klingenberg S, Lange W, Waller CF, Eaves CJ, von Kalle C. Evidence of similar effects of short-term culture on the initial repopulating activity of mobilized peripheral blood transplants assessed in NOD/SCID-beta2microglobulin(null) mice and in autografted patients. Exp Hematol. 2005 Jan;33(1):20-5. Pubmed15661394
2004 Hematti P, Hong BK, Ferguson C, Adler R, Hanawa H, Sellers S, Holt IE, Eckfeldt CE, Sharma Y, Schmidt M, von Kalle C, Persons DA, Billings EM, Verfaillie CM, Nienhuis AW, Wolfsberg TG, Dunbar CE, Calmels B. Distinct genomic integration of MLV and SIV vectors in primate hematopoietic stem and progenitor cells. PLoS Biol. 2004 Dec;2(12):e423. Pubmed15550989
  Gaspar HB, Parsley KL, Howe S, King D, Gilmour KC, Sinclair J, Brouns G, Schmidt M, Von Kalle C, Barington T, Jakobsen MA, Christensen HO, Al Ghonaium A, White HN, Smith JL, Levinsky RJ, Ali RR, Kinnon C, Thrasher AJ. Gene therapy of X-linked severe combined immunodeficiency by use of a pseudotyped gammaretroviral vector. Lancet. 2004 Dec 18;364(9452):2181-7. Pubmed15610804
  Hagemann S, Gunther T, Dennemarker J, Lohmuller T, Bromme D, Schule R, Peters C, Reinheckel T. The human cysteine protease cathepsin V can compensate for murine cathepsin L in mouse epidermis and hair follicles. Eur J Cell Biol. 2004 Dec;83(11-12):775-80. Pubmed15679121
  von Kalle C, Fehse B, Layh-Schmitt G, Schmidt M, Kelly P, Baum C.
Stem cell clonality and genotoxicity in hematopoietic cells: gene activation side effects should be avoidable. Semin Hematol. 2004 Oct;41(4):303-18. Pubmed15508116
  von Kalle C, Baum C, Williams DA. Lenti in red: progress in gene therapy for human hemoglobinopathies. J Clin Invest. 2004 Oct;114(7):889-91. Pubmed15467825
  Lindenboim L, Schlipf S, Kaufmann T, Borner C, Stein R.
Bcl-x(S) induces an NGF-inhibitable cytochrome c release.
Exp Cell Res. 2004 Jul 15;297(2):392-403. Pubmed15212942
  Wille A, Gerber A, Heimburg A, Reisenauer A, Peters C, Saftig P, Reinheckel T, Welte T, Buhling F. Cathepsin L is involved in cathepsin D processing and regulation of apoptosis in A549 human lung epithelial cells. Biol Chem. 2004 Jul;385(7):665-70. Pubmed15318816
  Fischer A, Abina SH, Thrasher A, von Kalle C, Cavazzana-Calvo M.
LMO2 and gene therapy for severe combined immunodeficiency.
N Engl J Med. 2004 Jun 10;350(24):2526-7; author reply 2526-7. (Comment) Pubmed15190153
  Darie CC, Biniossek ML, Jovine L, Litscher ES, Wassarman PM.
Structural Characterization of Fish Egg Vitelline Envelope Proteins by Mass Spectrometry. Biochemistry. 2004 Jun 15;43(23):7459-7478. Pubmed15182189
  Kuramoto K, Follmann DA, Hematti P, Sellers S, Agricola BA, Metzger ME, Donahue RE, von Kalle C, Dunbar CE. Effect of chronic cytokine therapy on clonal dynamics in nonhuman primates. Blood. 2004 Jun 1;103(11):4070-7. Pubmed14962906
  Hook V, Yasothornsrikul S, Greenbaum D, Medzihradszky KF, Troutner K, Toneff T, Bundey R, Logrinova A, Reinheckel T, Peters C, Bogyo M.
Cathepsin L and Arg/Lys aminopeptidase: a distinct prohormone processing pathway for the biosynthesis of peptide neurotransmitters and hormones. Biol Chem. 2004 Jun;385(6):473-80. Pubmed15255178
  Schinzel A, Kaufmann T, Borner C.
Bcl-2 family members: intracellular targeting, membrane-insertion, and changes in subcellular localization.
Biochim Biophys Acta. 2004 Mar 1;1644(2-3):95-105. Pubmed14996494
  Schinzel A, Kaufmann T, Schuler M, Martinalbo J, Grubb D, Borner C.
Conformational control of Bax localization and apoptotic activity by Pro168.
J Cell Biol. 2004 Mar 29;164(7):1021-32. Pubmed15037603
  Kiem HP, Sellers S, Thomasson B, Morris JC, Tisdale JF, Horn PA, Hematti P, Adler R, Kuramoto K, Calmels B, Bonifacino A, Hu J, von Kalle C, Schmidt M, Sorrentino B, Nienhuis A, Blau CA, Andrews RG, Donahue RE, Dunbar CE. Long-term clinical and molecular follow-up of large animals receiving retrovirally transduced stem and progenitor cells: no progression to clonal hematopoiesis or leukemia. Mol Ther. 2004 Mar;9(3):389-95. Pubmed15006605
  Faller D, Reinheckel T, Wenzler D, Hagemann S, Xiao K, Honerkamp J, Peters C, Dandekar T, Timmer J. An open source protein gel documentation system for proteome analyses. J Chem Inf Comput Sci. 2004 Jan-Feb;44(1):168-9. Pubmed14741024
  Baum C, von Kalle C, Staal FJ, Li Z, Fehse B, Schmidt M, Weerkamp F, Karlsson S, Wagemaker G, Williams DA. Chance or necessity? Insertional mutagenesis in gene therapy and its consequences.
Mol Ther. 2004 Jan;9(1):5-13. Pubmed14741772
  Kaufmann T, Schinzel A, Borner C.
Bcl-w(edding) with mitochondria.
Trends Cell Biol. 2004 Jan;14(1):8-12. Pubmed14729175 
2003 Schild L, Reinheckel T, Reiser M, Horn TF, Wolf G, Augustin W. 
Nitric oxide produced in rat liver mitochondria causes oxidative stress and impairment of respiration after transient hypoxia. 

FASEB J. 2003 Dec;17(15):2194-201. Pubmed14656981
  Gao C, Kang EM, Kuramoto K, Agricola BA, Metzger M, von Kalle C, Donahue RE, Tisdale JF. Retrovirally transduced muscle-derived cells contribute to hematopoiesis at very low levels in the nonhuman primate model. Mol Ther. 2003 Dec;8(6):974-80. Pubmed14664800
  Strauch OF, Stypmann J, Reinheckel T, Martinez E, Haverkamp W, Peters C. Cardiac and ocular pathologies in a mouse model of mucopolysaccharidosis type VI. Pediatr Res. 2003 Nov;54(5):701-8. Pubmed12904606
  Shah S, Hecht A, Pestell R, Byers SW. Trans-repression of beta-Catenin Activity by Nuclear Receptors.  
J Biol Chem. 2003 Nov 28;278(48):48137-48145. Pubmed12972427
  Neff T, Horn PA, Peterson LJ, Thomasson BM, Thompson J, Williams DA, Schmidt M, Georges GE, von Kalle C, Kiem HP. Methylguanine methyltransferase-mediated in vivo selection and chemoprotection of allogeneic stem cells in a large-animal model. J Clin Invest. 2003 Nov;112(10):1581-8. Pubmed14617759
  Egger L, Schneider J, Rheme C, Tapernoux M, Hacki J, Borner C.
Serine proteases mediate apoptosis-like cell death and phagocytosis under caspase-inhibiting conditions.
Cell Death Differ. 2003 Oct;10(10):1188-1203. Pubmed14502242
  Hacein-Bey-Abina S, Von Kalle C, Schmidt M, McCormack MP, Wulffraat N, Leboulch P, Lim A, Osborne CS, Pawliuk R, Morillon E, Sorensen R, Forster A, Fraser P, Cohen JI, de Saint Basile G, Alexander I, Wintergerst U, Frebourg T, Aurias A, Stoppa-Lyonnet D, Romana S, Radford-Weiss I, Gross F, Valensi F, Delabesse E, Macintyre E, Sigaux F, Soulier J, Leiva LE, Wissler M, Prinz C, Rabbitts TH, Le Deist F, Fischer A, Cavazzana-Calvo M. LMO2-associated clonal T cell proliferation in two patients after gene therapy for SCID-X1.
Science. 2003 Oct 17;302(5644):415-9. Pubmed14564000
  Houseweart MK, Pennacchio LA, Vilaythong A, Peters C, Noebels JL, Myers RM. Cathepsin B but not cathepsins L or S contributes to the pathogenesis of Unverricht-Lundborg progressive myoclonus epilepsy (EPM1). J Neurobiol. 2003 Sep 15;56(4):315-27.
  Muller OJ, Kaul F, Weitzman MD, Pasqualini R, Arap W, Kleinschmidt JA, Trepel M. Random peptide libraries displayed on adeno-associated virus to select for targeted gene therapy vectors. 
Nat Biotechnol. 2003 Sep;21(9):1040-6. Pubmed12897791
  McCaw SE, Schneider J, Liao EH, Zimmermann W, Gray-Owen SD.
Immunoreceptor tyrosine-based activation motif phosphorylation during engulfment of Neisseria gonorrhoeae by the neutrophil-restricted CEACAM3 (CD66d) receptor.
Mol Microbiol. 2003 Aug;49(3):623-37. Pubmed12864848
  Yasothornsrikul S, Greenbaum D, Medzihradszky KF, Toneff T, Bundey R, Miller R, Schilling B, Petermann I, Dehnert J, Logvinova A, Goldsmith P, Neveu JM, Lane WS, Gibson B, Reinheckel T, Peters C, Bogyo M, Hook V. Cathepsin L in secretory vesicles functions as a prohormone-processing enzyme for production of the enkephalin peptide neurotransmitter. 
Proc Natl Acad Sci U S A. 2003 Aug 5;100(16):9590-5. Pubmed12869695
  Huber TB, Hartleben B, Kim J, Schmidts M, Schermer B, Keil A, Egger L, Lecha RL, Borner C, Pavenstädt H, Shaw A, Walz G, Benzing T.
Nephrin and CD2AP associate with phosphoinositide 3-OH kinase and stimulate AKT-dependent signaling.
Mol Cell Biol. 2003 Jul;23(14):4917-28. Pubmed12832477
  Lohmuller T, Wenzler D, Hagemann S, Kiess W, Peters C, Dandekar T, Reinheckel T. Toward computer-based cleavage site prediction of cysteine endopeptidases.  Biol Chem. 2003 Jun;384(6):899-909. Pubmed12887057
  Friedrichs B, Tepel C, Reinheckel T, Deussing J, von Figura K, Herzog V, Peters C, Saftig P, Brix K. Thyroid functions of mouse cathepsins B, K, and L. J Clin Invest. 2003 Jun;111(11):1733-45. Pubmed12782676
  Stemmler MP, Hecht A, Kinzel B, Kemler R. Analysis of regulatory elements of E-cadherin with reporter gene constructs in transgenic mouse embryos. Dev Dyn. 2003 Jun;227(2):238-45 Pubmed12761851
  Gianinazzi C, Grandgirard D, Imboden H, Egger L, Meli DN, Bifrare YD, Joss PC, Tauber MG, Borner C, Leib SL.
Caspase-3 mediates hippocampal apoptosis in pneumococcal meningitis.
Acta Neuropathol (Berl) 2003 May;105(5):499-507. Pubmed12677451
  Schmidt M, Glimm H, Wissler M, Hoffmann G, Olsson K, Sellers S, Carbonaro D, Tisdale JF, Leurs C, Hanenberg H, Dunbar CE, Kiem HP, Karlsson S, Kohn DB, Williams D, Von Kalle C. Efficient characterization of retro-, lenti-, and foamyvector-transduced cell populations by high-accuracy insertion site sequencing. Ann N Y Acad Sci. 2003 May;996:112-21. Pubmed12799289
  Leurs C, Jansen M, Pollok KE, Heinkelein M, Schmidt M, Wissler M, Lindemann D, Von Kalle C, Rethwilm A, Williams DA, Hanenberg H.
Comparison of three retroviral vector systems for transduction of nonobese diabetic/severe combined immunodeficiency mice repopulating human CD34+ cord blood cells. Hum Gene Ther. 2003 Apr 10;14(6):509-19. Pubmed12718762
  Schmidt M, Carbonaro DA, Speckmann C, Wissler M, Bohnsack J, Elder M, Aronow BJ, Nolta JA, Kohn DB, von Kalle C. Clonality analysis after retroviral-mediated gene transfer to CD34+ cells from the cord blood of ADA-deficient SCID neonates. Nat Med. 2003 Apr;9(4):463-8. Pubmed12640448
  Tamm I, Trepel M, Cardó-Vila M, Sun Y, Welsh K, Cabezas E, Swatterthwait A, Arap W, Reed JC, Pasqualini R. Peptides targeting caspase inhibitors. J Biol Chem. 2003 Apr 18;278(16):14401-5. Pubmed12538646
  Baum C, Düllmann J, Li Z, Fehse B, Meyer J, Williams DA, von Kalle C.
Side effects of retroviral gene transfer into hematopoietic stem cells. Blood. 2003 Mar 15;101(6):2099-114. Pubmed12511419
  Woods NB, Muessig A, Schmidt M, Flygare J, Olsson K, Salmon P, Trono D, von Kalle C, Karlsson S. Lentiviral vector transduction of NOD/SCID repopulating cells results in multiple vector integrations per transduced cell: risk of insertional mutagenesis.
Blood. 2003 Feb 15;101(4):1284-9. Pubmed12393514
  Hecht A, Stemmler MP. Identification of a promoter-specific transcriptional activation domain at the C terminus of the Wnt effector protein T-cell factor 4. J Biol Chem. 2003 Feb 7;278(6):3776-85. Pubmed12446687
  Hacein-Bey-Abina S, von Kalle C, Schmidt M, Le Deist F, Wulffraat N, McIntyre E, Radford I, Villeval JL, Fraser CC, Cavazzana-Calvo M, Fischer A. A serious adverse event after successful gene therapy for X-linked severe combined immunodeficiency. 
N Engl J Med. 2003 Jan 16;348(3):255-6. Pubmed12529469
  Borner C.
The Bcl-2 protein family: sensors and checkpoints for life-or-death decisions.
Mol Immunol 2003 Jan;39(11):615-47, Pubmed12493639
  Kaufmann T, Schlipf S, Sanz J, Neubert K, Stein R, Borner C.
Characterization of the signal that directs Bcl-x(L), but not Bcl-2, to the mitochondrial outer membrane.
J Cell Biol 2003 Jan 6;160(1):53-64. Pubmed12515824
  Baum C, von Kalle C. Gene therapy targeting hematopoietic cells: better not leave it to chance. Acta Haematol. 2003;110(2-3):107-9. Pubmed14583670
2002 Nishimura F, Naruishi H, Naruishi K, Yamada T, Sasaki J, Peters C, Uchiyama Y, Murayama Y. Cathepsin-L, a key molecule in the pathogenesis of drug-induced and I-cell disease-mediated gingival overgrowth: a study with cathepsin-L-deficient mice.  
Am J Pathol 2002 Dec;161(6):2047-52 Pubmed12466121
  Ailles L, Schmidt M, Santoni de Sio FR, Glimm H, Cavalieri S, Bruno S, Piacibello W, Von Kalle C, Naldini L. Molecular evidence of lentiviral vector-mediated gene transfer into human self-renewing, multi-potent, long-term NOD/SCID repopulating hematopoietic cells. 
Mol Ther 2002 Nov;6(5):615-26 Pubmed12409260
  Schmidt M, Zickler P, Hoffmann G, Haas S, Wissler M, Muessig A, Tisdale JF, Kuramoto K, Andrews RG, Wu T, Kiem HP, Dunbar CE, von Kalle C. Polyclonal long-term repopulating stem cell clones in a primate model. Blood 2002 Oct 15;100(8):2737-43 Pubmed12351380
  Neff T, Horn PA, Valli VE, Gown AM, Wardwell S, Wood BL, von Kalle C, Schmidt M, Peterson LJ, Morris JC, Richard RE, Clackson T, Kiem HP, Blau CA. Pharmacologically regulated in vivo selection in a large animal. Blood 2002 Sep 15;100(6):2026-31 Pubmed12200362
  Ebert DH, Deussing J, Peters C, Dermody TS. Cathepsin L and cathepsin B mediate reovirus disassembly in murine fibroblast cells. J Biol Chem 2002 Jul 5;277(27):24609-17 Pubmed11986312
  Glimm H, Tang P, Clark-Lewis I, von Kalle C, Eaves C. Ex vivo treatment of proliferating human cord blood stem cells with stroma-derived factor-1 enhances their ability to engraft NOD/SCID mice. 
Blood 2002 May 1;99(9):3454-7 Pubmed11964317
  Honey K, Nakagawa T, Peters C, Rudensky A. Cathepsin L regulates CD4+ T cell selection independently of its effect on invariant chain: a role in the generation of positively selecting peptide ligands.  
J Exp Med 2002 May 20;195(10):1349-58 Pubmed12021314
  Tobin DJ, Foitzik K, Reinheckel T, Mecklenburg L, Botchkarev VA, Peters C, Paus R. The lysosomal protease cathepsin L is an important regulator of keratinocyte and melanocyte differentiation during hair follicle morphogenesis and cycling. Am J Pathol 2002 May;160(5):1807-21 Pubmed12000732
  Li Z, Dullmann J, Schiedlmeier B, Schmidt M, von Kalle C, Meyer J, Forster M, Stocking C, Wahlers A, Frank O, Ostertag W, Kuhlcke K, Eckert HG, Fehse B, Baum C. Murine leukemia induced by retroviral gene marking. Science 2002 Apr 19;296(5567):497 Pubmed11964471
  Stypmann J, Glaser K, Roth W, Tobin DJ, Petermann I, Matthias R, Monnig G, Haverkamp W, Breithardt G, Schmahl W, Peters C, Reinheckel T. Dilated cardiomyopathy in mice deficient for the lysosomal cysteine peptidase cathepsin L. Proc Natl Acad Sci U S A 2002 Apr 30;99(9):6234-9, Pubmed11972068, http://www.pnas.org/cgi/content/full/99/9/6234
  Schmidt S, Bork P, Dandekar T. A versatile structural domain analysis server using profile weight matrices.  J Chem Inf Comput Sci 2002 Mar-Apr;42(2):405-7 Pubmed11911710
  Schuster S, Pfeiffer T, Moldenhauer F, Koch I, Dandekar T. Exploring the pathway structure of metabolism: decomposition into subnetworks and application to Mycoplasma pneumoniae.  Bioinformatics 2002 Feb;18(2):351-361, Pubmed11847093
  Nishioku T, Hashimoto K, Yamashita K, Liou SY, Kagamiishi Y, Maegawa H, Katsube N, Peters C, von Figura K, Saftig P, Katunuma N, Yamamoto K, Nakanishi H. Involvement of cathepsin E in exogenous antigen processing in primary cultured murine microglia.  
J Biol Chem 2002 Feb 15;277(7):4816-22 Pubmed11719510
  Billker O, Popp A, Brinkmann V, Wenig G, Schneider J, Caron E, Meyer TF. Distinct mechanisms of internalization of Neisseria gonorrhoeae by members of the CEACAM receptor family involving Rac1- and Cdc42-dependent and -independent pathways.
EMBO J 2002 Feb 15;21(4):560-571. Pubmed11847104 http://emboj.oupjournals.org/cgi/reprint/21/4/560.pdf
  Schempp CM, Kirkin V, Simon-Haarhaus B, Kersten A, Kiss J, Termeer CC, Gilb B, Kaufmann T, Borner C, Sleeman JP, Simon JC.
Inhibition of tumour cell growth by hyperforin, a novel anticancer drug from St. John's wort that acts by induction of apoptosis.
Oncogene 2002 Feb 14;21(8):1242-50. Pubmed11850844
  Deussing J, Kouadio M, Rehman S, Werber I, Schwinde A, Peters C. 
Identification and characterization of a dense cluster of placenta-specific cysteine peptidase genes and related genes on mouse chromosome 13.
Genomics 2002 Feb;79(2):225-40 Pubmed11829493
  Dandekar T, Sauerborn R. Comparative genome analysis and pathway reconstruction. Pharmacogenomics 2002; 3(2):243-254 Pubmed11972445
  Zwad O, Kubler B, Roth W, Scharf JG, Saftig P, Peters C, Braulke T. 
Decreased intracellular degradation of insulin-like growth factor binding protein-3 in cathepsin L-deficient fibroblasts.
FEBS Lett 2002 510(3), 211-215 Pubmed11801256
2001 Dandekar T, Du F, Schirmer RH, Schmidt S. Medical target prediction from genome sequence: combining different sequence analysis algorithms with expert knowledge and input from artificial intelligence approaches. Comput Chem 2001 Dec;26(1):15-21 Pubmed11765847
  Nishioku T, Hashimoto K, Yamashita K, Liou SY, Kagamiishi Y, Maegawa H, Katsube N, Peters C, von Figura K, Saftig P, Katunuma N, Yamamoto K, Nakanishi H. Involvement of cathepsin E in exogenous antigen processing in primary cultured murine microglia.  J Biol Chem 2001 Nov 21; Pubmed1171951
  Lindenboim L, Borner C, Stein R.
Bcl-x(S) can form homodimers and heterodimers and its apoptotic activity requires localization of Bcl-x(S) to the mitochondria and its BH3 and loop domains. 
Cell Death Differ 2001 Sep;8(9):933-942. Pubmed11526448
  Schmidt M, Glimm H, Lemke N, Muessig A, Speckmann C, Haas S, Zickler P, Hoffmann G, Von Kalle C. A model for the detection of clonality in marked hematopoietic stem cells. Ann N Y Acad Sci 2001 Jun;938:146-55; discussion 155-6 Pubmed11458502
  Glimm H, Tang P, Clark-Lewis I, von Kalle C., Eaves C. Ex vivo treatment of proliferating human cord blood stem cells with stroma-derived factor-1 enhances their ability to engraft NOD/SCID mice.  Blood 2002 May 1;99(9):3454-7 Pubmed11964317 http://www.bloodjournal.org/cgi/content/full/99/9/3454 
  Gilgenast O, Brandt-Nedelev B, Wiswedel I, Lippert H, Halangk W, Reinheckel T. Differential oxidative injury in extrapancreatic tissues during experimental pancreatitis: modification of lung proteins by 4- hydroxynonenal. Dig Dis Sci 2001 Apr;46(4):932-937 PubMed11330437
  Honey K, Duff M, Beers C, Brissette WH, Elliott EA, Peters C, Maric M, Cresswell P, Rudensky A. (2001) Cathepsin S regulates the expression of cathepsin L and the turnover of gamma-interferon-inducible lysosomal thiol reductase in B lymphocytes. J Biol Chem 276(25), 22573-8 Pubmed11306582
 

Nakanishi H, Zhang J, Koike M, Nishioku T, Okamoto Y, Kominami E, von Figura K, Peters C, Yamamoto K, Saftig P, Uchiyama Y. (2001) 
Involvement of nitric oxide released from microglia-macrophages in pathological changes of cathepsin D-deficient mice.
J Neurosci  21(19), 7526-33 Pubmed11567042

  Reinheckel T, Deussing J, Roth W, Peters C. Towards specific functions of lysosomal cysteine peptidases: phenotypes of mice deficient for cathepsin B or cathepsin L. Biol Chem 382(5), 735-41 Pubmed11517926
  Reinheckel T, Grune T. Regulation of the degradation of oxidized proteins. In: Nesaretnam K., Packer L. (Hrsg): Micronutrients and Health: Molecular Biological Mechanisms. AOCS Press, 2001; chap 17
  Schulz HU, Böhm AK, Halangk W, Lippert H, Reinheckel T.  Insertions-Deletions-Polymorphismus im humanen T6 Trypsinogen-Gen: Bedeutung für die Entwicklung einer chronischen Pankreatitis.  
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2000 Pross M, Schulz HU, Flechsig A, Manger T, Halangk W, Augustin W, Lippert H, Reinheckel T. 
Oxidative stress in lung tissue induced by CO(2) pneumoperitoneum in the rat. 

Surg Endosc 2000 Dec;14(12):1180-4 Pubmed11148794
  Conus S, Rossé T, Borner C.
Failure of Bcl-2 family members to interact with Apaf-1 in normal and apoptotic cells. 
Cell Death Differ 2000 Oct;7(10):947-954. Pubmed11279541
  Bosse R, Kulmburg P, von Kalle C, Engelhardt M, Dwenger A, Rosenthal F, Schulz G. 
Production of stem-cell transplants according to good manufacturing practice. 
Ann Hematol 2000 Sep;79(9):469-76 PubMed 11043417
  Dandekar T, Huynen M, Regula JT, Ueberle B, Zimmermann CU, Andrade MA, Doerks T, Sanchez-Pulido L, Snel B, Suyama M, Yuan YP, Herrmann R, Bork P. 
Re-annotating the mycoplasma pneumoniae genome sequence: adding value, function and reading frames. 
Nucleic Acids Res. 2000 Sep 1;28(17):3278-88 Pubmed10954595
  Kenealy MR, Flouriot G, Sonntag-Buck V, Dandekar T, Brand H, Gannon F. 
The 3'-untranslated region of the human estrogen receptor alpha gene mediates rapid messenger ribonucleic acid turnover. 
Endocrinology. 2000 Aug;141(8):2805-13 Pubmed10919266
  Tribble G, Ahn YT, Lee J, Dandekar T, Jayaram M. 
DNA recognition, strand selectivity, and cleavage mode during integrase family site-specific recombination. 
J Biol Chem. 2000 Jul 21;275(29):22255-67 Pubmed10748094
  Foyouzi-Youssefi R, Arnaudeau S, Borner C, Kelley WL, Tschopp J, Lew DP, Demaurex N, Krause KH.
Bcl-2 decreases the free Ca2+ concentration within the endoplasmic reticulum.
Proc Natl Acad Sci U S A 2000 May 23;97(11):5723-8
http://www.pnas.org/cgi/content/full/97/11/5723
  Häcki J, Egger L, Monney L, Conus S, Rossé T, Fellay I, Borner C.
Apoptotic crosstalk between the endoplasmic reticulum and mitochondria controlled by Bcl-2.
Oncogene 2000 May 4;19(19):2286-95. Pubmed10822379
  Reinheckel T, Ullrich O, Sitte N, Grune T. 
Differential impairment of 20S and 26S proteasome activities in human hematopoietic K562 cells during oxidative stress. 
Arch Biochem Biophys 2000 May 1;377(1):65-8 Pubmed10775442
  Conus S, Kaufmann T, Fellay I, Otter I, Rossé T, Borner C.
Bcl-2 is a monomeric protein: prevention of homodimerization by structural constraints.
EMBO J 2000 Apr 3;19(7):1534-44. Pubmed10747022
  Reinheckel T, Körn S, Möhring S, Augustin W, Halangk W, Schild L. 
Adaptation of protein carbonyl detection to the requirements of proteome analysis demonstrated for hypoxia/reoxygenation in isolated rat liver mitochondria. 
Arch Biochem Biophys 2000 Apr 1;376(1):59-65 Pubmed10729190
  Vieira O, Escargueil-Blanc I, Jürgens G, Borner C, Almeida L, Salvayre R, Negre-Salvayre A.
Oxidized LDLs alter the activity of the ubiquitin-proteasome pathway: potential role in oxidized LDL-induced apoptosis.
FASEB J 2000 Mar;14(3):532-42
http://www.fasebj.org/cgi/content/abstract/14/3/532
  Schuster S, Fell DA, Dandekar T. 
A general definition of metabolic pathways useful for systematic organization and analysis of complex metabolic networks. 
Nat Biotechnol. 2000 Mar;18(3):326-32 Pubmed10700151
  Glimm H, Eisterer W, Lee K, Cashman J, Holyoake TL, Nicolini F, Shultz LD, von Kalle C, Eaves CJ. 
Previously undetected human hematopoietic cell populations with short-term repopulating activity selectively engraft NOD/SCID-beta2 microglobulin-null mice. 
J Clin Invest 2001 Jan;107(2):199-206 http://www.jci.org/cgi/content/full/107/2/199?view=full&pmid=11160136
  Pross M, Manger T, Reinheckel T, Mirow L, Kunz D, Lippert H. 
Endoscopic treatment of clinically symptomatic leaks of thoracic esophageal anastomoses. 
Gastrointest Endosc 2000 Jan;51(1):73-6 Pubmed10625803
  Deussing, J., von Olshausen, I., and Peters, C. (2000). 
Murine and Human Cathepsin Z: cDNA-cloning, characterization of the genes and chromosomal localization.
 
Biochim. Biophys. Acta 1491, 93-106 Pubmed10760573
  Deussing, J., Tisljar, K., Papazoglou, A., and Peters, C. (2000). 
Mouse Cathepsin F: cDNA cloning, genomic organization and chromosomal assignment of the gene.
 
Gene 251(2):165-73 Pubmed10876093
  Guicciardi, M.E., Deussing, J., Miyoshi, H., Bronk, S.F., Svingen, P.A., Peters, C., Kaufmann, S.H., and Gores, G.J. (2000) 
Cathepsin B contributes to TNF-alpha-mediated hepatocyte apoptosis by promoting mitochondrial release of cytochrome c.
 
J. Clin. Invest. 106, 1127-37 Pubmed11067865
  Halangk, W., Lerch, M.M., Brandt-Nedelev, B., Roth, W., Ruthenbuerger, M., Reinheckel, T., Domschke, W., Lippert, H., Peters, C., and Deussing, J. (2000). 
Role of cathepsin B in intracellular trypsinogen activation and the onset of acute pancreatitis.
 J. Clin. Invest. 106, 773-81 http://www.jci.org/cgi/content/full/106/6/773?view=full&pmid=10995788 Pubmed10995788
  Heinrich, M., Wickel, M., Winoto-Morbach, S., Schneider-Brachert, W., Weber, T., Brunner, J., Saftig, P., Peters, C., Krönke, M., and Schütze, S. (2000). 
Ceramide as an activator lipid of cathepsin D (Review).
 
Adv. Exp. Med. Biol. 477, 305-15 Pubmed10849758
  Hrabe de Angelis, M.H., Flaswinkel, H., Fuchs, H., Rathkolb, B., Soewarto, D., Marschall, S., Heffner, S., Pargent, W., Wuensch, K., Jung, M., Reis, A., Richter, T., Alessandrini, F., Jakob, T., Fuchs, E., Kolb, H., Kremmer, E., Schaeble, K., Rollinski, B., Roscher, A., Peters, C., Meitinger, T., Strom, T., Steckler, T., Holsboer, F., Klopstock T. Gekeler, F., Schindewolf, C., Jung, T., Avraham, K., Behrendt, H., Ring, J., Zimmer, A., Schughart, K., Pfeffer, K., Wolf, E., and Balling, R. (2000) 
Genome-wide, large-scale production of mutant mice by ENU mutagenesis.

Nat. Genet. 25, 444-7 Pubmed10932192
  Koike, M., Nakanishi, H., Saftig, P., Ezaki, J., Isahara, K., Ohsawa, Y., Schulz-Schaeffer, W., Watanabe, T., Waguri, S., Kametaka, S., Shibata, M., Yamamoto, K., Kominami, E., Peters, C., von Figura, K., and Uchiyama, Y. (2000). 
Cathepsin D deficiency induces lysosomal storage with ceroid lipofuscin in mouse CNS neurons.
 
J. Neurosci. 20, 6898-906 Pubmed10995834
  Moin, K., Demchik, L., Mai, J., Deussing, J., Peters, C., and Sloane, B.F. (2000). 
Observing proteases in living cells (Review).
 
Adv. Exp. Med. Biol. 477, 391-401 Pubmed10849765
  Roth, W., Deussing, J., Botchkarev, V.A., Pauly-Evers, M., Saftig, P., Hafner, A., Schmidt, P., Schmahl, W., Scherer, J., Anton-Lamprecht, I., von Figura, K., Paus, R., and Peters, C. (2000). 
Cathepsin L deficiency as molecular defect of furless: hyperproliferation of keratinocytes and pertubation of hair follicle cycling.
FASEB J., 14, 2075-86 Pubmed11023992
  Tatnell, P.J., Cook, M., Peters, C., and Kay, J. (2000) 
Molecular organization, expression and chromosomal localization of the mouse pronapsin gene.
 
Eur. J. Biochem. 267, 6921-30 Pubmed11082205
  Reinheckel T, Grune T, Davies KJ. 
The measurement of protein degradation in response to oxidative stress.
Methods Mol Biol 2000;99:49-60 Pubmed10909076
  Botchkareva, N.V., Botchkarev, V.A., Welker, P., Airaksinen, M., Roth, W., Suvanto, P., Müller-Röver, S., Hadshiew, I.M., Peters, C., and Paus, R. (2000). 
New roles for glial cell line-derived neurotrophic factor and neurturin: involvement in hair cycle control.
 
Am. J. Pathol. 156, 1041-53 Pubmed10702420
1999 Dandekar T, Schuster S, Snel B, Huynen M, Bork P. 
Pathway alignment: application to the comparative analysis of glycolytic enzymes. 

Biochem J. 1999 Oct 1;343 Pt 1:115-24 Pubmed10493919
  Nickel R, Ott C, Dandekar T, Leippe M. 
Pore-forming peptides of Entamoeba dispar. Similarity and divergence to amoebapores in structure, expression and activity. 

Eur J Biochem. 1999 Nov;265(3):1002-7 Pubmed10518795
  Struttmann T, Fabro M, Romieu G, de Roquefeuil G, Touchon J, Dandekar T, Ritchie K. 
Quality-of-life assessment in the old using the WHOQOL 100: differences between patients with senile dementia and patients with cancer. 
Int Psychogeriatr. 1999 Sep;11(3):273-9 Pubmed10547127
  Ullrich O, Reinheckel T, Sitte N, Grune T. 
Degradation of hypochlorite-damaged glucose-6-phosphate dehydrogenase by the 20S proteasome. 
Free Radic Biol Med 1999 Sep;27(5-6):487-92 Pubmed10490267
  Sugimoto C, Fujieda S, Seki M, Sunaga H, Fan GK, Tsuzuki H, Borner C, Saito H, Matsukawa S.
Apoptosis-promoting gene (bax) transfer potentiates sensitivity of squamous cell carcinoma to cisplatin in vitro and in vivo.
Int J Cancer 1999 Sep 9;82(6):860-7. Pubmed10446454
  Borner C, Schlagbauer Wadl H, Fellay I, Selzer E, Polterauer P, Jansen B.
Mutated N-ras upregulates Bcl-2 in human melanoma in vitro and in SCID mice.
Melanoma Res 1999 Aug;9(4):347-50. Pubmed10504052
  Huynen MA, Dandekar T, Bork P. 
Variation and evolution of the citric-acid cycle: a genomic perspective. 
Trends Microbiol. 1999 Jul;7(7):281-91. Review Pubmed10390638
  Borner C, Monney L.
Apoptosis without caspases: an inefficient molecular guillotine?
Cell Death Differ 1999 Jun;6(6):497-507. Pubmed10381652
  Ullrich O, Reinheckel T, Sitte N, Hass R, Grune T, Davies KJ. 
Poly-ADP ribose polymerase activates nuclear proteasome to degrade oxidatively damaged histones. 
Proc Natl Acad Sci U S A 1999 May 25;96(11):6223-8 http://www.pnas.org/cgi/content/full/96/11/6223
  Reinheckel T, Bohne M, Halangk W, Augustin W, Gollnick H. 
Evaluation of UVA-mediated oxidative damage to proteins and lipids in extracorporeal photoimmunotherapy. 
Photochem Photobiol 1999 May;69(5):566-70 Pubmed10333762
  Konig R, Dandekar T. 
Improving genetic algorithms for protein folding simulations by systematic crossover. 

Biosystems. 1999 Apr;50(1):17-25 Pubmed10235648
  Liu Z, Song D, Kramer A, Martin AC, Dandekar T, Schneider-Mergener J, Bautz EK, Dubel S. 
Fine mapping of the antigen-antibody interaction of scFv215, a recombinant antibody inhibiting RNA polymerase II from Drosophila melanogaster. 
J Mol Recognit. 1999 Mar-Apr;12(2):103-11 Pubmed10398401
  Keese MA, Saffrich R, Dandekar T, Becker K, Schirmer RH. 
Microinjected glutathione reductase crystals as indicators of the redox status in living cells. 
FEBS Lett. 1999 Mar 26;447(2-3):135-8 Pubmed10214933
  Borner C, Monney L, Olivier R, Rossé T, Häcki J, Conus S.
Life and death in a medieval atmosphere.
Cell Death Differ 1999 Feb;6(2):201-6. Pubmed10200567
  Schuster S, Dandekar T, Fell DA. 
Detection of elementary flux modes in biochemical networks: a promising tool for pathway analysis and metabolic engineering. 
Trends Biotechnol. 1999 Feb;17(2):53-60. Review Pubmed10087604
  Reinheckel T, Prause J, Nedelev B, Augustin W, Schulz HU, Lippert H, Halangk W. 
Oxidative stress affects pancreatic proteins during the early pathogenesis of rat caerulein pancreatitis. 
Digestion 1999 Jan-Feb;60(1):56-62 Pubmed9892799
  Heinrich, M., Wickel, M., Schneider-Brachert, W., Sandberg, C., Gahr, J., Schwandner, R., Weber, T., Brunner, J., Saftig, P., Peters, C., Brunner, J., Krönke, M., and Schütze, S. (1999). 
Cathepsin D targeted by acid sphingomyelinase-derived ceramide.
 EMBO J. 18, 5252-63 Pubmed10508159
  Tisljar, K., Deussing, J., and Peters, C. (1999). 
Cathepsin J, a novel murine cysteine protease of the papain family with a placenta-restricted expression.
 
FEBS Lett. 459, 299-304 Pubmed10526153
  Botchkarev, V.A., Botchkareva, N.V., Roth, W., Nakamura, M., Chen, L.-H., Herzog, W., Lindner, G., McMahon, J.A., Peters, C., Lauster, R., McMahon, A.P., and Paus, R. (1999). 
Noggin is a mesenchymally derived stimulator of hair follicle induction.
Nat. Cell Biol. 1, 158-64 Pubmed10559902

Villadangos, J.A., Bryant, R.A., Deussing, J., Driessen, C., Lennon-Dumenil, A.M., Riese, R.J., Roth, W., Saftig, P., Shi, G.P., Chapman, H.A., Peters, C., and Ploegh, H.L. (1999). 
Proteases involved in MHC class II antigen presentation. (Review).
Immunol. Rev. 172, 109-20 Pubmed10631941
1998 Grandgirard D, Studer E, Monney L, Belser T, Fellay I, Borner C, Michel MR.
Alphaviruses induce apoptosis in Bcl-2-overexpressing cells: evidence for a caspase-mediated, proteolytic inactivation of Bcl-2.
EMBO J 1998 Aug 10;17(5):1268-78
http://www.emboj.org/cgi/content/full/17/5/1268
  Monney L, Otter I, Olivier R, Ozer HL, Haas AL, Omura S, Borner C.
Defects in the ubiquitin pathway induce caspase-independent apoptosis blocked by Bcl-2.
J Biol Chem 1998 Mar 13;273(11):6121-31
http://www.jbc.org/cgi/content/full/273/11/6121
  Otter I, Conus S, Ravn U, Rager M, Olivier R, Monney L, Fabbro D, Borner C.
The binding properties and biological activities of Bcl-2 and Bax in cells exposed to apoptotic stimuli.
J Biol Chem 1998 Mar 13;273(11):6110-20
http://www.jbc.org/cgi/content/full/273/11/6110
  Monney L, Olivier R, Otter I, Jansen B, Poirier GG, Borner C.
Role of an acidic compartment in tumor-necrosis-factor-alpha-induced production of ceramide, activation of caspase-3 and apoptosis.
Eur J Biochem 1998 Jan 15;251(1-2):295-303
http://www.blackwell-synergy.com/Journals/member/institutions/processfree2.asp? contentid=ejb.1998.23&filetype=abstracts&article=25391
  Rossé T, Olivier R, Monney L, Rager M, Conus S, Fellay I, Jansen B, Borner C.
Bcl-2 prolongs cell survival after Bax-induced release of cytochrome c.
Nature 1998 Jan 29;391(6666):496-9. Pubmed9461218
  Deussing, J., Roth, W., Saftig, P., Peters, C., Ploegh, H.L., and Villadangos, J.A. (1998). 
Cathepsins B and D are dispensable for major histocompatibility complex class II-mediated antigen presentation.
 
Proc. Natl. Acad. Sci. USA 95, 4516-21 Pubmed9539769

Nakagawa, T., Roth, W., Wong, P., Nelson, A., Farr, A., Deussing, J., Villadangos, J.A., Ploegh, H., Peters, C., and Rudensky, A. (1998). 
Cathepsin L: critical role in Ii degradation and CD4 T cell selection in the thymus.
 Science 280, 450-3   Pubmed9545226
  Tatnell, P.J., Roth, W., Deussing, J., Peters, C., and Kay, J. (1998). 
Mouse procathepsin E gene: molecular organisation and chromosomal localisation.
 
Biochim. Biophys. Acta 1398(1), 57-66 Pubmed9602058
  Wu, G. S., Saftig, P., Peters, C., and El-Deiry, W. S. (1998). 
Potential role for cathepsin D in p53-dependent tumor suppression and chemosensitivity.
 
Oncogene 16, 2177-83 Pubmed9619826
1997
Deussing, J., Pauly-Evers, M., Roth, W., Saftig, P., and Peters, C. (1997). 
Manipulating the Mouse Genome (Review).
 Futura 12, 162-71 
  Deussing, J., Roth, W., Rommerskirch, W., Wiederanders, B., von Figura, K., and Peters, C. (1997). 
The genes of the lysosomal cysteine proteinases cathepsin B, H, L, and S map to different mouse chromosomes.
 
Mamm. Genome 8, 241-5 Pubmed9096102
  Saftig, P., Hartmann, D., Lüllmann-Rauch, R., Wolff, J., Evers, M., Köster, A., Hetman, M., von Figura, K., and Peters, C. (1997). 
Mice deficient in lysosomal acid phosphatase develop lysosomal storage in the kidney and central nervous system.
 
J. Biol. Chem. 272, 18628-35 Pubmed9228031
  Villadangos, J.A., Riese, R.J., Peters, C., Chapman, H.A., and Ploegh, H.L. (1997). 
Degradation of mouse invariant chain: roles of cathepsins S and D and the influence of major histocompatibility complex polymorphism.
J. Exp. Med. 186, 549-60 Pubmed9254653
  Ye Q, Wei Y, Fischer R, Borner C, Berchtold MW.
Expression of calmodulin and calmodulin binding proteins in rat fibroblasts stably transfected with protein kinase C and oncogenes.
Biochim Biophys Acta 1997 Oct 30;1359(1):89-96. Pubmed9398089
  Olivier R, Otter I, Monney L, Wartmann M, Borner C.
Bcl-2 does not require Raf kinase activity for its death-protective function.
Biochem J 1997 May 15;324 ( Pt 1):75-83
http://www.biochemj.org/bj//324/0075/bj3240075.htm
  Pourzand C, Rossier G, Reelfs O, Borner C, Tyrrell RM.
Overxpression of Bcl-2 inhibits UVA-mediated immediate apoptosiinrat 6 fibroblasts: evidence for the involvement of Bcl-2 as an antioxidant.
Cancer Res 1997 Apr 15;57(8):1405-11. Pubmed9108435
  Weinstein IB, Kahn SM, O'Driscoll K, Borner C, Bang D, Jiang W, Blackwood A, Nomoto K.
The role of protein kinase C in signal transduction, growth control and lipid metabolism.
Adv Exp Med Biol 1997;400A:313-21. Pubmed9547573
1996
Braulke, T., Claussen, M., Saftig, P., Wendland, M., Neifer, K., Schmidt, B., Zapf, J., von Figura, K., and Peters, C. (1996). 
Proteolysis of IGFBPs by cathepsin D in vitro and in cathepsin D-deficient mice (Review).
 
Prog. Growth Factor Res. 6, 265-71 Pubmed8817669
  Evers, M., Saftig, P., Schmidt, P., Hafner, A., McLoghlin, D.B., Schmahl, W., Hess, B., von Figura, K., and Peters, C. (1996). 
Targeted disruption of the arylsulfatase B gene results in mice resembling the phenotype of mucopolysaccharidosis VI.
 
Proc. Natl. Acad. Sci. USA 93, 8214-9  Pubmed8710849
  Hess, B., Saftig, P., Hartmann, D., Coenen, R., Lüllmann-Rauch, R., Goebel, H. H., Evers, M., von Figura, K., D´Hooge, R., Nagels, G., DeDeyn, P., Peters, C., and Gieselmann, V. (1996). 
Phenotype of arylsulfatase A-deficient mice: relationship to human metachromatic leukodystrophy.
 
Proc. Natl. Acad. Sci. USA 93, 14821-6 Pubmed8962139
  Isbrandt, D., Hopwood, J.J., von Figura, K., and Peters, C. (1996). 
Two novel frameshift mutations causing premature stop codons in a patient with the severe form of Maroteaux-Lamy syndrome.
 
Hum. Mutat. 7, 361-3   Pubmed8723688
  Litjens, T., Brooks, D.A., Peters, C., Gibson, G.J., and Hopwood, J.J. (1996). 
Identification, expression, and biochemical characterization of N-acetylgalactosamine-4-sulfatase mutations and relationship with clinical phenotype in MPS-VI patients.
 
Am. J. Hum. Genet. 58, 1127-34 Pubmed8651289
  Saftig, P., Peters, C., von Figura, K., Craessaerts, K., van Leuven, F., and De Strooper, B. (1996). 
Amyloidogenic processing of human amyloid precursor protein in hippocampal neurons devoid of cathepsin D.
 
J. Biol. Chem. 271, 27241-4 Pubmed8910296
  Borner C.
Diminished cell proliferation associated with the death-protective activity of Bcl-2.
J Biol Chem 1996 May 31;271(22):12695-8
http://www.jbc.org/cgi/content/full/271/22/12695
  Zhang J, Alter N, Reed JC, Borner C, Obeid LM, Hannun YA.
Bcl-2 interrupts the ceramide-mediated pathway of cell death.
Proc Natl Acad Sci U S A 1996 May 28;93(11):5325-8
http://www.pnas.org/cgi/reprint/93/11/5325
  Monney L, Otter I, Olivier R, Ravn U, Mirzasaleh H, Fellay I, Poirier GG, Borner C.
Bcl-2 overexpression blocks activation of the death protease CPP32/Yama/apopain.
Biochem Biophys Res Commun 1996 Apr 16;221(2):340-5. Pubmed8619857
1995 Brooks, D.A., Robertson, D.A., Bindloss, C., Litjens, T., Anson, D.S., Peters, C., Morris, C.P., and Hopwood, J.J. (1995). 
Two site-directed mutations abrogate enzyme activity but have different effects on the conformation and cellular content of the N-acetylgalactosamine 4-sulphatase protein.
 
Biochem. J. 307, 457-463 Pubmed7733883
  Saftig, P., Hetman, M., Schmahl, W., Weber, K., Heine, L., Mossmann, H., Köster, A., Hess, B., Evers, M., von Figura, K., and Peters, C. (1995). 
Mice deficient for the lysosomal proteinase cathepsin D exhibit progressive atrophy of the intestinal mucosa and profound destruction of lymphoid cells.

EMBO J. 14, 3599-608   Pubmed7641679
  Schröter M, Lowin B, Borner C, Tschopp J.
Regulation of Fas(Apo-1/CD95)- and perforin-mediated lytic pathways of primary cytotoxic T lymphocytes by the protooncogene bcl-2.
Eur J Immunol 1995 Dec;25(12):3509-13. Pubmed8566045
  Borner C, Ueffing M, Jaken S, Parker PJ, Weinstein IB.
Two closely related isoforms of protein kinase C produce reciprocal effects on the growth of rat fibroblasts. Possible molecular mechanisms.
J Biol Chem 1995 Jan 6;270(1):78-86
http://www.jbc.org/cgi/content/full/270/1/78
1994 Arlt, G., Brooks, D.A., Isbrandt, D., Hopwood, J.J., Bielicki, J., Bradford, T.M., Bindloss-Petherbridge, C.A., von Figura, K., and Peters, C. (1994). 
Juvenile form of mucopolysaccharidosis VI (Maroteaux-Lamy syndrome). A C-terminal extension causes instability but increases catalytic efficiency of arylsulfatase B.
 
J. Biol. Chem. 269, 9638-43 Pubmed8144552
  von Figura, K., Hille-Rehfeld, A., Lehmann, L., Peters, C., and Prill, V.  
Signal-Mediated Targeting of Lysosomal Membrane Glycoproteins (Review).
 
44. Colloquium Mosbach 1993, DNA Replication and the Cell Cycle, Springer-Verlag Berlin Heidelberg pp. 33-44
  Hetman, M., Perschl, A., Saftig, P., von Figura, K., and Peters, C. (1994). 
Mouse cathepsin D gene: molecular organization, characterization of the promoter, and chromosomal localization.
 
DNA Cell Biol. 13, 419-27 Pubmed8011168
  Isbrandt, D., Arlt, G., Brooks, D.A., Hopwood, J.J., von Figura, K., and Peters, C. (1994). 
Mucopolysaccharidosis VI (Maroteaux-Lamy syndrome): six unique arylsulfatase B gene alleles causing variable disease phenotypes.
Am. J. Hum. Genet. 54, 454-63 Pubmed8116615
  Peters, C., and von Figura, K. (1994). 
Biogenesis of lysosomal membranes (Review).
 
FEBS Lett. 346, 108-14 Pubmed8206148
  Voskoboeva, E., Isbrandt, D., von Figura, K., Krasnopolskaya, X., and Peters, C. (1994). 
Four novel mutant alleles of the arylsulfatase B gene in two patients with intermediate form of mucopolysaccharidosis VI (Maroteaux-Lamy Syndrome).

Hum. Genet. 93, 259-64 Pubmed8125475
  Kahn SM, O'Driscoll KR, Jiang W, Borner C, Xu DB, Blackwood MA, Zhang YJ, Nomoto K, Weinstein IB.
Suppression of mitogenic activity by stable expression of the regulatory domain of PKC beta.
Carcinogenesis 1994 Dec;15(12):2919-25. Pubmed8001256
  Borner C, Olivier R, Martinou I, Mattmann C, Tschopp J, Martinou JC.
Dissection of functional domains in Bcl-2 alpha by site-directed mutagenesis.
Biochem Cell Biol 1994 Nov-Dec;72(11-12):463-9. Pubmed7654319
  Borner C, Martinou I, Mattmann C, Irmler M, Schaerer E, Martinou JC, Tschopp J.
The protein bcl-2 alpha does not require membrane attachment, but two conserved domains to suppress apoptosis.
J Cell Biol 1994 Aug;126(4):1059-68. Pubmed8051205
1993 Brömme, D., Bonneau, P.R., Lachance, P., Wiederanders, B., Kirschke, H., Peters, C., Thomas, D.Y., Storer, A.C., and Vernet, T. (1993). 
Functional expression of human cathepsin S in Saccharomyces cerevisiae: purification and characterization of the recombinant enzyme.
J. Biol. Chem. 268, 4832-8 Pubmed8444861
  Köster, A., Saftig, P., Matzner, U., von Figura, K., Peters, C., and Pohlmann, R. (1993). 
Targeted disruption of the M(r) 46,000 mannose 6-phosphate receptor gene in mice results in misrouting of lysosomal proteins.
 
EMBO J. 12, 5219-23 Pubmed8262064
  Modaressi, S., Rupp, K., von Figura, K., and Peters, C. (1993). 
Structure of the human arylsulfatase B gene.
 
Biol. Chem. Hoppe Seyler 374, 327-35 Pubmed7687847
  Prill, V., Lehmann, L., von Figura, K., and Peters, C. (1993). 
The cytoplasmic tail of lysosomal acid phosphatase contains overlapping but distinct signals for basolateral sorting and rapid internalization in polarized MDCK cells.
 
EMBO J. 12, 2181-93 Pubmed8491206
  Peitsch MC, Borner C, Tschopp J.
Sequence similarity of phospholipase A2 activating protein and the G protein beta-subunits: a new concept of effector protein activation in signal transduction?
Trends Biochem Sci 1993 Aug;18(8):292-3. Pubmed8236442
  Fabbro, D. & Borner, C. (1993) Protein kinase C.
Human protein data EMBL (A. Haeberli, ed.) VHC Verlags GmBH, Weinheim
  Weinstein, I. B., Borner, C., Guadagno Nichols, S., O'Driscoll, K., Cacace, A. & Fabbro, D. (1993) The roles of specific isoforms of protein kinase C (PKC) in growth control, oncogene-induced cell transformation, and differentiation (Review)
In: The pharmacology of cell differentiation. R. A. Rifkind (ed.); Elsevier Science Publishers, B. V., pp. 15-23.
  Kahn, S. M., O'Driscoll, K., Borner, C., Bang, D., Jiang, W., Blackwood, A., Nomoto, K. & Weinstein, I. B. (1993) Inhibition of diacylglycerol production in rat 6 cells that stably express only the regulatory domain of protein kinase CbI.
In: Advances in polyunsaturated fatty acid research. T. Yasugi, H. Nakamura, and M. Soma (eds.); Elsevier Science Publishers, B. V., pp. 45-50.
1992 Anson, D.S., Taylor, J.A., Bielicki, J., Harper, G.S., Peters, C., Gibson, G.J., and Hopwood, J.J. (1992). 
Correction of human mucopolysaccharidosis type VI fibroblasts with recombinant N-acetylgalactosamine- 4-sulphatase.
 
Biochem. J. 284, 789-94 Pubmed1320379
  Bresciani, R., Peters, C., and von Figura, K. (1992). 
Lysosomal acid phosphatase is not involved in the dephosphorylation of mannose 6-phosphate containing lysosomal proteins.
Eur. J. Cell Biol. 58, 57-61 Pubmed1353723
  Hille, A., Klumperman, J., Geuze, H.J., Peters, C., Brodsky, F.M., and von Figura, K. (1992). 
Lysosomal acid phosphatase is internalized via clathrin-coated pits.
 Eur. J. Cell Biol. 59, 106-15 Pubmed1468434
  Lehmann, L.E., Eberle, W., Krull, S., Prill, V., Schmidt, B., Sander, C., von Figura, K., and Peters, C. (1992). 
The internalization signal in the cytoplasmic tail of lysosomal acid phosphatase consists of the hexapeptide PGYRHV.  
EMBO J. 11, 4391-4399 Pubmed1425575
  Litjens, T., Morris, C.P., Robertson, E.F., Peters, C., von Figura, K., and Hopwood, J.J. (1992). 
An N-acetylgalactosamine- 4-sulfatase mutation (delta G238) results in a severe Maroteaux-Lamy phenotype.
 
Hum. Mutat. 1, 397-402  Pubmed1301949
  Peters, C., Braun, M., Weber, B., Wendland, M., Schmidt, B., Pohlmann, R., Waheed, A. and von Figura, K. (1992). 
The nineteen amino acid cytoplasmic tail of lysosomal acid phosphatase contains an endocytosis signal necessary and sufficient for targeting to lysosomes (Review).
 
in: Endocytosis. Ed.: P.J. Courtoy. NATO ASI Series, Vol. H 62, Springer-Verlag Berlin Heidelberg. 
  Wiederanders, B., Brömme, D., Kirschke, H., von Figura, K., Schmidt, B., and Peters, C. (1992). 
Phylogenetic conservation of cysteine proteinases. Cloning and expression of a cDNA coding for human cathepsin S.
 
J. Biol. Chem. 267, 13708-13 Pubmed1377692
  Borner C, Guadagno Nichols S, Fabbro D, Weinstein IB.
Expression of four protein kinase C isoforms in rat fibroblasts. I. Distinct subcellular distribution and regulation by calcium and phorbol esters.
J Biol Chem 1992 Jun 25;267(18):12892-9. Pubmed1618787
  Borner C, Guadagno Nichols S, Hsiao WW, Fabbro D, Barr M, Weinstein IB.
Expression of four protein kinase C isoforms in rat fibroblasts. II. Differential alterations in ras-, src-, and fos-transformed cells.
J Biol Chem 1992 Jun 25;267(18):12900-10. Pubmed1618788
  Tulchin N, Ornstein L, Harpaz N, Guillem J, Borner C, O'Toole K.
c-myc protein distribution. Neoplastic tissues of the human colon.
Am J Pathol 1992 Mar;140(3):719-29. Pubmed1372161
  Guadagno Nichols S, Borner C, Weinstein IB.
Altered regulation of a major substrate of protein kinase C in rat 6 fibroblasts overproducing PKC beta I.
J Biol Chem 1992 Feb 5;267(4):2697-707. Pubmed1370830
  Fabbro D, Küng W, Costa SD, Borner C, Regenass U, Eppenberger U.
Involvement of protein kinase C in the growth regulation of human breast cancer cells.
Cancer Treat Res 1992;61:229-48. Pubmed1360235
  Borner, C. & Fabbro, D. (1992) PKC and Cellular Transformation (Review)
In: Protein kinase C: Current concepts and perspectives. R. Epand and D. Lester (eds.); Ellis Horwood Publisher, Sussex, England, pp. 296-352.
  O'Driscoll, K. R., Kahn, S. M., Borner, C. M., Jiang, W. & Weinstein, I. B. (1992) Studies on the role of protein kinase C in multistage carcinogenesis and their relevance to risk extrapolation (Review).
In: Oncogene and transgenic correlates of cancer risk assessments. C. Zervos (ed.); Plenum Press, New York, pp. 43-59.
1991 Eberle, W., Sander, C., Klaus, W., Schmidt, B., von Figura, K., and Peters, C. (1991). 
The essential tyrosine of the internalization signal in lysosomal acid phosphatase is part of a beta turn.
 
Cell 67, 1203-9 Pubmed1760845
  Peters, C., Rommerskirch, W., Modaressi, S., and von Figura, K. (1991). 
Restoration of arylsulfatase B activity in human mucopolysaccharidosis- type-VI fibroblasts by retroviral-vector-mediated gene transfer.
Biochem. J. 276, 499-504 Pubmed1904721
  Rommerskirch, W., Fluharty, A.L., Peters, C., von Figura, K., and Gieselmann, V. (1991). 
Restoration of arylsulfatase A activity in human-metachromatic- leukodystrophy fibroblasts via retroviral-vector-mediated gene transfer.
 Biochem. J. 280, 459-61 Pubmed1684103
  Wicker, G., Prill, V., Brooks, D., Gibson, G., Hopwood, J., von Figura, K., and Peters, C. (1991). 
Mucopolysaccharidosis VI (Maroteaux-Lamy Syndrome): An intermediate clinical phenotype caused by substitution of valine for glycine at position 137 of arylsulfatase B.
 
J. Biol. Chem. 266, 21386-91 Pubmed1718978 
  Borner C, Filipuzzi I, Weinstein IB, Imber R.
Failure of wild-type or a mutant form of protein kinase C-alpha to transform fibroblasts.
Nature 1991 Sep 5;353(6339):78-80. Pubmed1881450
  Fabbro, D., Küng, W., Costa, S. D., Borner, C., Regenass, U. & Eppenberger, U. (1991) Involvement of protein kinase C in the growth regulation of human breast cancer cells.
In: Genes, Oncogenes, and Hormones: Advances in Cellular and Molecular Biology of Breast Cancer. R. B. Dickson & M. E. Lippman (eds.); Kluwer Academic Publishers, Boston, pp. 229-248.
1990 Peters, C., Braun, M., Weber, B., Wendland, M., Schmidt, B., Pohlmann, R., Waheed, A., and von Figura, K. (1990). 
Targeting of a lysosomal membrane protein: a tyrosine-containing endocytosis signal in the cytoplasmic tail of lysosomal acid phosphatase is necessary and sufficient for targeting to lysosomes.
  EMBO J. 9, 3497-506 Pubmed2209556
  Peters, C., Schmidt, B., Rommerskirch, W., Rupp, K., Zühlsdorf, M., Vingron, M., Meyer, H.E., Pohlmann, R., and von Figura, K. (1990). 
Phylogenetic conservation of arylsulfatases. cDNA cloning and expression of human arylsulfatase B.
 
J. Biol. Chem. 265, 3374-81 Pubmed2303452
  Borner C, Guadagno Nichols S, Hsieh LL, Hsiao WL, Weinstein IB.
Transformation by a ras oncogene causes increased expression of protein kinase C-alpha and decreased expression of protein kinase C-epsilon.
Cell Growth Differ 1990 Dec;1(12):653-60. Pubmed2288879
  Rotenberg SA, Krauss RS, Borner CM, Weinstein IB.
Characterization of a specific form of protein kinase C overproduced by a C3H 10T1/2 cell line.
Biochem J 1990 Feb 15;266(1):173-8. Pubmed2310371, Portland Press
  Krauss RS, Housey GM, Hsiao WL, Johnson MK, Rotenberg SA, Borner CM, Weinstein IB.
The role of protein kinase C in signal transduction and cellular transformation.
Prog Clin Biol Res 1990;340D:175-82, Review. Pubmed2196578
  Weinstein IB, Borner C, Krauss R, O'Driscoll K, Choi P, Moritomi M, Hoshina S, Hsieh L-L, Tchou-Wong K-M, Guadagno Nichols S, Ueffing M, Guillem J.
Pleiotropic effects of protein kinase C and the concept of carcinogenesis as a progressive disorder in signal transduction.
Adv in Second Messenger and Phosphoprotein Res 1990; 26:182-96.
  Kahn SM, Jiang W, Borner C, O'Driscoll K, Weinstein IB.
Construction of defined deletion mutants by thermal cycled fusion: Applications to protein kinase C.
Technique 1990; 2:27-30.
1989 Peters, C., Geier, C., Pohlmann, R., Waheed, A., von Figura, K., Roiko, K., Virkkunen, P., Henttu, P., and Vihko, P. (1989). 
High degree of homology between primary structure of human lysosomal acid phosphatase and human prostatic acid phosphatase.
Biol. Chem. Hoppe Seyler 370, 177-81 Pubmed2706086
  Peters, C., Kruse, U., Pollwein, R., Grzeschik, K.H., and Sippel, A.E. (1989). The human lysozyme gene. Sequence organization and chromosomal localization. 
Eur. J. Biochem. 182, 507-16 Pubmed2546758
  Borner C, Filipuzzi I, Wartmann M, Eppenberger U, Fabbro D.
Biosynthesis and posttranslational modifications of protein kinase C in human breast cancer cells.
J Biol Chem 1989 Aug 15;264(23):13902-9. Pubmed2474538
1988 Bonifer, C., Hecht, A., Peters, C., and Sippel. A.E. (1988). 
Rat antibodies as probes for the characterization of progesterone receptor A and B proteins from laying hen oviduct cytosol.
 
Biochim. Biophys. Acta 968, 96-108 Pubmed3337848
  Borner C, Eppenberger U, Wyss R, Fabbro D.
Continuous synthesis of two protein-kinase-C-related proteins after down-regulation by phorbol esters.
Proc Natl Acad Sci U S A 1988 Apr;85(7):2110-4. Pubmed3353368
  Fabbro D, Mazurek N, Borner C, Conscience JF, Erne P.
Role of protein kinase C (PKC) in short- and long-term cellular responses: inhibition of agonist-mediated calcium transients and down-regulation of PKC.
J Cardiovasc Pharmacol 1988;12 Suppl 5:S73-9. Pubmed2469882
1987 Peters, C., Sippel, A.E., Vingron, M., and Klempnauer K.H. (1987). 
Drosophila and vertebrate myb proteins share two conserved regions, one of which functions as a DNA-binding domain.
 
EMBO J. 6, 3085-90 Pubmed3121304
  Borner C, Wyss R, Regazzi R, Eppenberger U, Fabbro D.
Immunological quantitation of phospholipid/Ca2+-dependent protein kinase of human mammary carcinoma cells: inverse relationship to estrogen receptors.
Int J Cancer 1987 Sep 15;40(3):344-8. Pubmed3623717
  Wyss R, Fabbro D, Regazzi R, Borner C, Takahashi A, Eppenberger U.
Phorbol ester and epidermal growth factor receptors in human breast cancer.
Anticancer Res 1987 Jul-Aug;7(4B):721-7. Pubmed3499860
  Mazurek N, Regazzi R, Borner C, Wyss R, Conscience JF, Erne P, Eppenberger U, Fabbro D.
Altered protein kinase C in a mast cell variant defective in exocytosis.
Proc Natl Acad Sci U S A 1987 Mar;84(5):1277-81. Pubmed3493490
  Erne P, Mazurek N, Borner C, Conscience JF, Eppenberger U, Fabbro D.
Translocation of protein kinase C is not required to inhibit the antigen-induced increase of cytosolic calcium in a mast cell line.
Biochem Biophys Res Commun 1987 Feb 27;143(1):252-9. Pubmed3103618
  Fabbro D, Regazzi R, Costa SD, Borner C, Eppenberger U.
Protein kinase C desensitization by phorbol esters and its impact on growth of human breast cancer cells.
Year Book of Cancer 1987; 545-546.
1986 Regazzi R, Fabbro D, Costa SD, Borner C, Eppenberger U.
Effects of tumor promoters on growth and on cellular redistribution of phospholipid/Ca2+-dependent protein kinase in human breast cancer cells.
Int J Cancer 1986 May 15;37(5):731-7. Pubmed3084390
  Fabbro D, Regazzi R, Costa SD, Borner C, Eppenberger U.
Protein kinase C desensitization by phorbol esters and its impact on growth of human breast cancer cells.
Biochem Biophys Res Commun 1986 Feb 26;135(1):65-73. Pubmed3513765
  Fabbro, D., Wyss, R., Borner, C. & Regazzi, R. (1986) Epidermal growth factor receptor and calcium/phospholipid-dependent protein kinase activities in human mammary tumor cells.
In: S. Eckhardt, J. H. Holzner, G. A. Nagel (eds.); Contributions to Oncology: Endocrine Therapy of Breast Cancer 23, 33-44, Karger, Basel.
1981 Peters, C., Schwermann, J., Schmidt, A., and Buddecke, E. (1981). 
Phosphate ester groups in proteoglycans from bovine nasal cartilage.
Biochim. Biophys. Acta 673, 270-8 Pubmed7225419
 
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