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Molekulare Medizin - AG Biniossek, Massenspektrometrie - Peptidanalytik und Proteinanalytik (Proteomics) - Publikationen

Maria Silva-Garcia, Oguz Bolgi, Breyan Ross, Esther Pilla, Vijayalakshmi Kari, Markus Killisch, Nadine Stark, Christof Lenz, Melanie Spitzner, Mark D. Gorrell, Marian Grade, Henning Urlaub, Matthias Dobbelstein, Robert Huber, Ruth Geiss-Friedlander. Dipeptidyl peptidase 9 triggers BRCA2 degradation by the N-degron pathway to promote DNA-damage repair. bioRxiv August 25, 2020 https://doi.org/10.1101/2020.08.24.265033 preprint

2019 De Decker A., Vliegen G., Van Rompaey D., Peeraer A.,Bracke A., Verckist L., Jansen K., Geiss-Friedlander R., Augustyns K.,De Winter H., De Meester I, Lambeir A-M., and Van der Veken P. Novel Small Molecule-Derived, Highly Selective Substrates for Fibroblast Activation Protein (FAP). ACS Medicinal Chemistry Letters 2019.DOI: 10.1021/acsmedchemlett.9b00191 Pubmed31413802
  De Vasconcelos, N. M., Vliegen, G., Gonçalves, A., De Hert, E., Martín-Pérez, R., Van Opdenbosch, N., Jallapally A., Geiss-Friedlander R., Lambeir A-M., Augustyns K.,Van Der Veken P., De Meester I. and Lamkanfi M. DPP8/DPP9 inhibition elicits canonical Nlrp1b inflammasome hallmarks in murine macrophages. Life Science Alliance, 2(1), e201900313. 2019. DOI10.26508/lsa201900313 Pubmed30718379
2018 Ross B., Krapp S., Augustin M., Kierfersauer R., Arciniega m., Geiss-Friedlander R. and Huber R. Structures and mechanism of dipeptidyl peptidases 8 and 9, important players in cellular homeostasis and cancer. PNAS 2018. DOI: /10.1073/pnas.1717565115 Pubmed29382749
2016 Strenzke N., Chakrabarti R., Al-Moyed H., Müller A., Hoch G., Pangrsic T., Yamanbaeva G., Lenz C., Pan KT., Auge E., Geiss-Friedlander R., Urlaub H., Brose N., Wichmann C. and Reisinger E. Hair cell synaptic dysfunction, auditory fatigue and thermal sensitivity in otoferlin Ile515Thr mutants. 2016 EMBO DOI: 10.15252/embj.201694564. ** this publication was honoured in the 14th round of GöVIP by the Research Commission of the UMG27729456 DOI:10.15252/embj.201694564 Pubmed27729456
  Justa-Schuch, D., Silva-Garcia, M., Pilla, E., Engelke, M., Kilisch, M., Lenz, C., Möller, U., Nakamura, F., Urlaub, H. and Geiss-Friedlander, R. DPP9 is a novel component of the N-end rule pathway targeting the Tyrosine Kinase Syk. eLife 2016. DOI: 10.7554/eLife.16370. ** this publication was honoured in the 13th round of GöVIP by the Research Commission of the UMG DOI:10.7554/eLife.16370 Pubmed27614019
2015 Zhang, H; Maqsudi, S., Rainczuk, A., Duffield, N; Lawrence, J., Keane, FM., Justa-Schuch, D., Geiss-Friedlander, R., Gorrell, MD., Stephens, AN. Identification of Novel Dipeptidyl Peptidase 9 Substrates by 2D DIGE. 2015 FEBS Pubmed326175140 doi: 10.1111/febs.13371.

Kunadt, M., Eckermann, K., Stuendl, A., Gong, J., Russo, B., Strauss, K., Rai, S., Kügler, S., Lockhart, L.F., Schwalbe, M., Krumova, P., Oliveira, L.M.A., Bähr, M., Möbius, W., Levin, J., Giese, A., Kruse, N., Mollenhauer, B., Geiss-Friedlander, R., Ludolph, A.C., Freischmidt, A., Feiler, M.S., Danzer, K.M., Zweckstetter, M., Jovin, T.M., Simons, M., Weishaupt, J.H. and Schneider A. Extracellular vesicle sorting of α-Synuclein is regulated by sumoylation. 2015 Acta Neuropathol Pubmed25778619 doi:10.1007/s00401-015-1408-1.

2014 Justa-Schuch, D., Möller, U., and Geiss-Friedlander, R. The amino terminus extension in the long dipeptidyl peptidase 9 isoform contains a nuclear localization signal targeting the active peptidase to the nucleus. Cell. Mol. Life Sci. 71(18): 3611-3626. 2014 DOI: 10.1007/s00018-014-1591-6 Pubmed24562348

Pilla, E., Kilisch, M., Lenz, C., Urlaub, H., and Geiss-Friedlander, R. The SUMO1-E67 interacting loop peptide is an allosteric inhibitor of the dipeptidyl peptidases 8 and 9. J Biol Chem 288: 32787–32796. 2013 DOI:10.1074/jbc.M113.489179 Pubmed24072711


Pilla, E., Moller, U., Sauer, G., Mattiroli, F., Melchior, F., and Geiss Friedlander, R. A novel SUMO1-specific interacting motif in Dipeptidyl peptidase 9 (DPP9) that is important for enzymatic regulation. J Biol Chem 287: 44320–44329. 2012DOI:10.1074/jbc.M112.397224 Pubmed23152501

2009 Geiss-Friedlander R*, Parmentier N, Moller U, Urlaub H, Van den Eynde BJ, Melchior F* (2009) The cytoplasmic peptidase DPP9 is rate-limiting for degradation of proline-containing peptides. J Biol Chem 284: 27211-27219. 2009  * corresponding authors. DOI:10.1074/jbc.M109.041871 Pubmed19667070

Geiss-Friedlander R, Melchior F. SUMOylation. In Offermanns SR, Walter (ed.), Encyclopedia of Molecular Pharmacology. Springer, Vol. 2, pp. 1163-1167. 2008

2007 Geiss-Friedlander R, Melchior F. Concepts in sumoylation: a decade on. Nat Rev Mol Cell Biol 8: 947-956. 2007 Pubmed18000527
2003 Granot Z, Geiss-Friedlander R, Melamed-Book N, Eimerl S, Timberg R, Weiss AM, Hales KH, Hales DB, Stocco DM, Orly J. Proteolysis of normal and mutated steroidogenic acute regulatory proteins in the mitochondria: the fate of unwanted proteins. Mol Endocrinol 17: 2461-2476. 2003 Pubmed12958217

Jarosch E, Geiss-Friedlander R, Meusser B, Walter J, Sommer T. Protein dislocation from the endoplasmic reticulum--pulling out the suspect. Traffic 3: 530-536. 2002 Pubmed12121416


Granot Z, Silverman E, Friedlander R, Melamed-Book N, Eimerl S, Timberg R, Hales KH, Hales DB, Stocco DM, Orly J. The life cycle of the steroidogenic acute regulatory (StAR) protein: from transcription through proteolysis. Endocr Res 28: 375-386. 2002 Pubmed12530639

2000 Friedlander R, Jarosch E, Urban J, Volkwein C, Sommer T. A regulatory link between ER-associated protein degradation and the unfolded-protein response. Nat Cell Biol 2: 379-384. 2000 Pubmed10878801

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