Publications
2024 | Kocher D, Cao L, Guiho R, Langhammer M, Lai YL, Becker P, Hamdi H, Friedel D, Selt F, Vonhören D, Zaman J, Valinciute G, Herter S, Picard D, Rettenmeier J, Maass KK, Pajtler KW, Remke M, von Deimling A, Pusch S, Pfister SM, Oehme I, Jones DTW, Halbach S, Brummer T, Martinez-Barbera JP, Witt O, Milde T, Sigaud R. Rebound growth of BRAF mutant pediatric glioma cells after MAPKi withdrawal is associated with MAPK reactivation and secretion of microglia-recruiting cytokines. J Neurooncol. 2024 Apr 17. doi: 10.1007/s11060-024-04672-9. Epub ahead of print. PMID: 38630384. |
Maas-Bauer K, Stell AV, Yan KL, de Vega E, Vinnakota JM, Unger S, Núñez N, Norona J, Talvard-Balland N, Koßmann S, Schwan C, Miething C, Martens US, Shoumariyeh K, Nestor RP, Duquesne S, Hanke K, Rackiewicz M, Hu Z, El Khawanky N, Taromi S, Andrlova H, Faraidun H, Walter S, Pfeifer D, Follo M, Waldschmidt J, Melchinger W, Rassner M, Wehr C, Schmitt-Graeff A, Halbach S, Liao J, Häcker G, Brummer T, Dengjel J, Andrieux G, Grosse R, Tugues S, Blazar BR, Becher B, Boerries M, Zeiser R. ROCK1/2 signaling contributes to corticosteroid-refractory acute graft-versus-host disease. Nat Commun. 2024 Jan 10;15(1):446. doi: 10.1038/s41467-024-44703-7. PMID: 38199985. | |
2023 | Rohrer L, Spohr C, Beha C, Griffin R, Braun S, Halbach S, Brummer T. Analysis of RAS and drug induced homo- and heterodimerization of RAF and KSR1 proteins in living cells using split Nanoluc luciferase. Cell Commun Signal. 2023 Jun 14;21(1):136. doi: 10.1186/s12964-023-01146-9. PMID: 37316874; PMCID: PMC10265822. |
Langhammer M, Schöpf J, Jaquet T, Horn K, Angel M, Spohr C, Christen D, Uhl FM, Maié T, Jacobi H, Feyerabend TB, Huber J, Panning M, Sitaru C, Costa I, Zeiser R, Aumann K, Becker H, Braunschweig T, Koschmieder S, Shoumariyeh K, Huber M, Schemionek-Reinders M, Brummer T, Halbach S. Mast cell deficiency prevents BCR::ABL1 induced splenomegaly and cytokine elevation in a CML mouse model. Leukemia. 2023 May 9. doi: 10.1038/s41375-023-01916-x. Epub ahead of print. PMID: 37161070. | |
2021 | Spohr C, Poggio T, Andrieux G, Schönberger K, Cabezas-Wallscheid N, Boerries M, Halbach S, Illert AL, Brummer T. Gab2 deficiency prevents Flt3-ITD driven acute myeloid leukemia in vivo. Leukemia. 2021 Dec 13. doi: 10.1038/s41375-021-01490-0. Epub ahead of print. PMID: 34903841. |
2020 | Uhl FM, Chen S, O'Sullivan D, Edwards-Hicks J, Richter G, Haring E, Andrieux G, Halbach S, Apostolova P, Buscher J, Duquesne S, Melchinger W, Sauer B, Shoumariyeh K, Schmitt-Graeff A, Kreutz M, Lubbert M, Duyster J, Brummer T, Boerries M, Madl T, Blazar BR, Gross O, Pearce EL, Zeiser R Metabolic reprogramming of donor T cells enhances graft-versus-leukemia effects in mice and humans. Sci Transl Med 2020 Oct 28 12doi: 10.1126/scitranslmed.abb8969 Pubmed/33115954 |
2019 | Kohler M, Ehrenfeld S, Halbach S, Lauinger M, Burk U, Reischmann N, Cheng S, Spohr C, Uhl FM, Kohler N, Ringwald K, Braun S, Peters C, Zeiser R, Reinheckel T, Brummer T B-Raf deficiency impairs tumor initiation and progression in a murine breast cancer model. Oncogene 2019 Feb 38:1324-1339 doi: 10.1038/s41388-018-0663-8 https://www.ncbi.nlm.nih.gov/pubmed/30659267 |
2018 | Herr R, Halbach S, Heizmann M, Busch H, Boerries M, Brummer T BRAF inhibition upregulates a variety of receptor tyrosine kinases and their downstream effector Gab2 in colorectal cancer cell lines. Oncogene 2018 Mar 37:1576-1593 doi: 10.1038/s41388-017-0063-5 https://www.ncbi.nlm.nih.gov/pubmed/29326440 |
Prestipino A, Emhardt AJ, Aumann K, O'Sullivan D, Gorantla SP, Duquesne S, Melchinger W, Braun L, Vuckovic S, Boerries M, Busch H, Halbach S, Pennisi S, Poggio T, Apostolova P, Veratti P, Hettich M, Niedermann G, Bartholoma M, Shoumariyeh K, Jutzi JS, Wehrle J, Dierks C, Becker H, Schmitt-Graeff A, Follo M, Pfeifer D, Rohr J, Fuchs S, Ehl S, Hartl FA, Minguet S, Miething C, Heidel FH, Kroger N, Triviai I, Brummer T, Finke J, Illert AL, Ruggiero E, Bonini C, Duyster J, Pahl HL, Lane SW, Hill GR, Blazar BR, von Bubnoff N, Pearce EL, Zeiser R Oncogenic JAK2(V617F) causes PD-L1 expression, mediating immune escape in myeloproliferative neoplasms. Sci Transl Med 2018 Feb 21 10doi: 10.1126/scitranslmed.aam7729, Pubmed/29467301 | |
2017 | Weinberg F, Reischmann N, Fauth L, Taromi S, Mastroianni J, Kohler M, Halbach S, Becker AC, Deng N, Schmitz T, Uhl FM, Herbener N, Riedel B, Beier F, Swarbrick A, Lassmann S, Dengjel J, Zeiser R, Brummer T The Atypical Kinase RIOK1 Promotes Tumor Growth and Invasive Behavior. EBioMedicine 2017 Jun 20:79-97 doi: 10.1016/j.ebiom.2017.04.015, Pubmed/28499923 |
2016 | Bier D, Bartel M, Sies K, Halbach S, Higuchi Y, Haranosono Y, Brummer T, Kato N, Ottmann C Small-Molecule Stabilization of the 14-3-3/Gab2 Protein-Protein Interaction (PPI) Interface. ChemMedChem 2016 Apr 19 11:911-8 doi: 10.1002/cmdc.201500484, Pubmed/26644359 |
Halbach S, Dengjel J, Brummer T Quantitative Proteomics Analysis of Leukemia Cells. Methods Mol Biol 2016 1465:139-48 doi: 10.1007/978-1-4939-4011-0_12, Pubmed/27581145 | |
Halbach S, Hu Z, Gretzmeier C, Ellermann J, Wohrle FU, Dengjel J, Brummer T Axitinib and sorafenib are potent in tyrosine kinase inhibitor resistant chronic myeloid leukemia cells. Cell Commun Signal 2016 Feb 24 14:6 doi: 10.1186/s12964-016-0129-y, Pubmed/26912052 | |
Halbach S, Kohler M, Uhl FM, Huber J, Zeiser R, Koschmieder S, Aumann K, Brummer T Gab2 is essential for Bcr-Abl-mediated leukemic transformation and hydronephrosis in a chronic myeloid leukemia mouse model. Leukemia 2016 Sep 30:1942-5 doi: 10.1038/leu.2016.92, Pubmed/27125306 | |
International Cancer Genome Consortium PedBrain Tumor P Recurrent MET fusion genes represent a drug target in pediatric glioblastoma. Nat Med 2016 Nov 22:1314-1320 doi: 10.1038/nm.4204, Pubmed/27748748 | |
2015 | Haug S, Schnerch D, Halbach S, Mastroianni J, Dumit VI, Follo M, Hasenburg A, Kohler M, Dierbach H, Herzog S, Proske A, Werner M, Dengjel J, Brummer T, Lassmann S, Wasch R, Zeiser R Metadherin exon 11 skipping variant enhances metastatic spread of ovarian cancer. Int J Cancer 2015 May 15 136:2328-40 doi: 10.1002/ijc.29289 Pubmed/25346496 |
Herr R, Kohler M, Andrlova H, Weinberg F, Moller Y, Halbach S, Lutz L, Mastroianni J, Klose M, Bittermann N, Kowar S, Zeiser R, Olayioye MA, Lassmann S, Busch H, Boerries M, Brummer T B-Raf inhibitors induce epithelial differentiation in BRAF-mutant colorectal cancer cells. Cancer Res 2015 Jan 1 75:216-29 doi: 10.1158/0008-5472.CAN-13-3686, Pubmed/25381152 | |
Willmann L, Erbes T, Halbach S, Brummer T, Jager M, Hirschfeld M, Fehm T, Neubauer H, Stickeler E, Kammerer B Exometabolom analysis of breast cancer cell lines: Metabolic signature. Scientific reports 2015 Aug 21 5:13374 doi: 10.1038/srep13374, Pubmed/26293811 | |
Willmann L, Schlimpert M, Halbach S, Erbes T, Stickeler E, Kammerer B Metabolic profiling of breast cancer: Differences in central metabolism between subtypes of breast cancer cell lines. Journal of chromatography B, Analytical technologies in the biomedical and life sciences 2015 Sep 1 1000:95-104 doi: 10.1016/j.jchromb.2015.07.021 Pubmed/26218769 | |
2013 | Halbach S, Rigbolt KT, Wohrle FU, Diedrich B, Gretzmeier C, Brummer T, Dengjel J Alterations of Gab2 signalling complexes in imatinib and dasatinib treated chronic myeloid leukaemia cells. Cell Commun Signal 2013 Apr 22 11:30 doi: 10.1186/1478-811X-11-30 Pubmed/23607741 |
Wohrle FU, Halbach S, Aumann K, Schwemmers S, Braun S, Auberger P, Schramek D, Penninger JM, Lassmann S, Werner M, Waller CF, Pahl HL, Zeiser R, Daly RJ, Brummer T Gab2 signaling in chronic myeloid leukemia cells confers resistance to multiple Bcr-Abl inhibitors. Leukemia 2013 Jan 27:118-29 doi: 10.1038/leu.2012.222 Pubmed/22858987 | |
2012 | Roring M, Herr R, Fiala GJ, Heilmann K, Braun S, Eisenhardt AE, Halbach S, Capper D, von Deimling A, Schamel WW, Saunders DN, Brummer T Distinct requirement for an intact dimer interface in wild-type, V600E and kinase-dead B-Raf signalling. EMBO J 2012 May 30 31:2629-47 doi: 10.1038/emboj.2012.100, Pubmed/22510884 |
Wohrle FU, Halbach S, Brummer T The versatile role of Gab1 in the circulatory system. Circ J 2012 76:1838-9 doi: 10.1253/circj.cj-12-Pubmed/22785000 | |