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Molekulare Medizin - AG Biniossek, Massenspektrometrie - Peptidanalytik und Proteinanalytik (Proteomics) - Publikationen
2021 Klionsky DJ, Abdel-Aziz AK, Abdelfatah S, Geiss-Friedlander R, et al. Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition) [published online ahead of print, 2021 Feb 8]. Autophagy. 2021;1-382. doi:10.1080/15548627.2020.1797280, Pubmed33634751

 

Kas Steuten, Heeyoung Kim, John C. Widen, Brett M. Babin, Ouma Onguka, Scott Lovell, Oguz Bolgi, Berati Cerikan, Christopher J. Neufeldt, Mirko Cortese, Ryan K. Muir, John M. Bennett, Ruth Geiss-Friedlander, Christoph Peters, Ralf Bartenschlager, and Matthew Bogyo.
Challenges for Targeting SARS-CoV-2 Proteases as a Therapeutic Strategy for COVID-19. ACS Infect. Dis., February 11, 2021. DOI: 10.1021/acsinfecdis.0c00815
2020

Maria Silva-Garcia, Oguz Bolgi, Breyan Ross, Esther Pilla, Vijayalakshmi Kari, Markus Killisch, Nadine Stark, Christof Lenz, Melanie Spitzner, Mark D. Gorrell, Marian Grade, Henning Urlaub, Matthias Dobbelstein, Robert Huber, Ruth Geiss-Friedlander. Dipeptidyl peptidase 9 triggers BRCA2 degradation by the N-degron pathway to promote DNA-damage repair. bioRxiv August 25, 2020 https://doi.org/10.1101/2020.08.24.265033 preprint

2019 De Decker A., Vliegen G., Van Rompaey D., Peeraer A.,Bracke A., Verckist L., Jansen K., Geiss-Friedlander R., Augustyns K.,De Winter H., De Meester I, Lambeir A-M., and Van der Veken P. Novel Small Molecule-Derived, Highly Selective Substrates for Fibroblast Activation Protein (FAP). ACS Medicinal Chemistry Letters 2019.DOI: 10.1021/acsmedchemlett.9b00191 Pubmed31413802
  De Vasconcelos, N. M., Vliegen, G., Gonçalves, A., De Hert, E., Martín-Pérez, R., Van Opdenbosch, N., Jallapally A., Geiss-Friedlander R., Lambeir A-M., Augustyns K.,Van Der Veken P., De Meester I. and Lamkanfi M. DPP8/DPP9 inhibition elicits canonical Nlrp1b inflammasome hallmarks in murine macrophages. Life Science Alliance, 2(1), e201900313. 2019. DOI10.26508/lsa201900313 Pubmed30718379
2018 Ross B., Krapp S., Augustin M., Kierfersauer R., Arciniega m., Geiss-Friedlander R. and Huber R. Structures and mechanism of dipeptidyl peptidases 8 and 9, important players in cellular homeostasis and cancer. PNAS 2018. DOI: /10.1073/pnas.1717565115 Pubmed29382749
2016 Strenzke N., Chakrabarti R., Al-Moyed H., Müller A., Hoch G., Pangrsic T., Yamanbaeva G., Lenz C., Pan KT., Auge E., Geiss-Friedlander R., Urlaub H., Brose N., Wichmann C. and Reisinger E. Hair cell synaptic dysfunction, auditory fatigue and thermal sensitivity in otoferlin Ile515Thr mutants. 2016 EMBO DOI: 10.15252/embj.201694564. ** this publication was honoured in the 14th round of GöVIP by the Research Commission of the UMG27729456 DOI:10.15252/embj.201694564 Pubmed27729456
  Justa-Schuch, D., Silva-Garcia, M., Pilla, E., Engelke, M., Kilisch, M., Lenz, C., Möller, U., Nakamura, F., Urlaub, H. and Geiss-Friedlander, R. DPP9 is a novel component of the N-end rule pathway targeting the Tyrosine Kinase Syk. eLife 2016. DOI: 10.7554/eLife.16370. ** this publication was honoured in the 13th round of GöVIP by the Research Commission of the UMG DOI:10.7554/eLife.16370 Pubmed27614019
2015 Zhang, H; Maqsudi, S., Rainczuk, A., Duffield, N; Lawrence, J., Keane, FM., Justa-Schuch, D., Geiss-Friedlander, R., Gorrell, MD., Stephens, AN. Identification of Novel Dipeptidyl Peptidase 9 Substrates by 2D DIGE. 2015 FEBS Pubmed326175140 doi: 10.1111/febs.13371.
 

Kunadt, M., Eckermann, K., Stuendl, A., Gong, J., Russo, B., Strauss, K., Rai, S., Kügler, S., Lockhart, L.F., Schwalbe, M., Krumova, P., Oliveira, L.M.A., Bähr, M., Möbius, W., Levin, J., Giese, A., Kruse, N., Mollenhauer, B., Geiss-Friedlander, R., Ludolph, A.C., Freischmidt, A., Feiler, M.S., Danzer, K.M., Zweckstetter, M., Jovin, T.M., Simons, M., Weishaupt, J.H. and Schneider A. Extracellular vesicle sorting of α-Synuclein is regulated by sumoylation. 2015 Acta Neuropathol Pubmed25778619 doi:10.1007/s00401-015-1408-1.

2014 Justa-Schuch, D., Möller, U., and Geiss-Friedlander, R. The amino terminus extension in the long dipeptidyl peptidase 9 isoform contains a nuclear localization signal targeting the active peptidase to the nucleus. Cell. Mol. Life Sci. 71(18): 3611-3626. 2014 DOI: 10.1007/s00018-014-1591-6 Pubmed24562348
2013

Pilla, E., Kilisch, M., Lenz, C., Urlaub, H., and Geiss-Friedlander, R. The SUMO1-E67 interacting loop peptide is an allosteric inhibitor of the dipeptidyl peptidases 8 and 9. J Biol Chem 288: 32787–32796. 2013 DOI:10.1074/jbc.M113.489179 Pubmed24072711

2012

Pilla, E., Moller, U., Sauer, G., Mattiroli, F., Melchior, F., and Geiss Friedlander, R. A novel SUMO1-specific interacting motif in Dipeptidyl peptidase 9 (DPP9) that is important for enzymatic regulation. J Biol Chem 287: 44320–44329. 2012DOI:10.1074/jbc.M112.397224 Pubmed23152501

2009 Geiss-Friedlander R*, Parmentier N, Moller U, Urlaub H, Van den Eynde BJ, Melchior F* (2009) The cytoplasmic peptidase DPP9 is rate-limiting for degradation of proline-containing peptides. J Biol Chem 284: 27211-27219. 2009  * corresponding authors. DOI:10.1074/jbc.M109.041871 Pubmed19667070
2008

Geiss-Friedlander R, Melchior F. SUMOylation. In Offermanns SR, Walter (ed.), Encyclopedia of Molecular Pharmacology. Springer, Vol. 2, pp. 1163-1167. 2008

2007 Geiss-Friedlander R, Melchior F. Concepts in sumoylation: a decade on. Nat Rev Mol Cell Biol 8: 947-956. 2007 Pubmed18000527
2003 Granot Z, Geiss-Friedlander R, Melamed-Book N, Eimerl S, Timberg R, Weiss AM, Hales KH, Hales DB, Stocco DM, Orly J. Proteolysis of normal and mutated steroidogenic acute regulatory proteins in the mitochondria: the fate of unwanted proteins. Mol Endocrinol 17: 2461-2476. 2003 Pubmed12958217
2002

Jarosch E, Geiss-Friedlander R, Meusser B, Walter J, Sommer T. Protein dislocation from the endoplasmic reticulum--pulling out the suspect. Traffic 3: 530-536. 2002 Pubmed12121416

 

Granot Z, Silverman E, Friedlander R, Melamed-Book N, Eimerl S, Timberg R, Hales KH, Hales DB, Stocco DM, Orly J. The life cycle of the steroidogenic acute regulatory (StAR) protein: from transcription through proteolysis. Endocr Res 28: 375-386. 2002 Pubmed12530639

2000 Friedlander R, Jarosch E, Urban J, Volkwein C, Sommer T. A regulatory link between ER-associated protein degradation and the unfolded-protein response. Nat Cell Biol 2: 379-384. 2000 Pubmed10878801

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