Molekulare Medizin - AG Reinheckel
Veröffentlichungen
| 2024 | Ruiz-Blázquez P, Fernández-Fernández M, Pistorio V, Martinez-Sanchez C, Costanzo M, Iruzubieta P, Zhuravleva E, Cacho-Pujol J, Ariño S, Del Castillo-Cruz A, Núñez S, Andersen JB, Ruoppolo M, Crespo J, García-Ruiz C, Pavone LM, Reinheckel T, Sancho-Bru P, Coll M, Fernández-Checa JC, Moles A. Cathepsin D is essential for the degradomic shift of macrophages required to resolve liver fibrosis. Mol Metab. 2024 Sep;87:101989. doi: 10.1016/j.molmet.2024.101989. Epub 2024 Jul 15. PMID: 39019115. |
| Kim MJ, Kim S, Reinheckel T, Krainc D. Inhibition of cysteine protease cathepsin L increases the level and activity of lysosomal glucocerebrosidase. JCI Insight. 2024 Feb 8;9(3):e169594. doi: 10.1172/jci.insight.169594. PMID: 38329128; PMCID: PMC10967467. | |
| Schneider J, Mitschke J, Bhat M, Vogele D, Schilling O, Reinheckel T, Heß L. Cathepsin D inhibition during neuronal differentiation selectively affects individual proteins instead of overall protein turnover. Biochimie. 2024 Mar 28:S0300-9084(24)00071-3. doi: 10.1016/j.biochi.2024.03.013. Epub ahead of print. PMID: 38552867. | |
| Heß L, Aliar K, Grünwald BT, Griffin R, Lozan A, Knöller M, Khokha R, Brummer T, Reinheckel T. Dipeptidyl-peptidase 9 regulates the dynamics of tumorigenesis and metastasis in breast cancer. Biochim Biophys Acta Mol Basis Dis. 2024 Mar 25;1870(5):167133. doi: 10.1016/j.bbadis.2024.167133. Epub ahead of print. PMID: 38531482 | |
| 2023 | Neuwirt E, Magnani G, Ćiković T, Wöhrle S, Fischer L, Kostina A, Flemming S, Fischenich NJ, Saller BS, Gorka O, Renner S, Agarinis C, Parker CN, Boettcher A, Farady CJ, Kesselring R, Berlin C, Backofen R, Rodriguez-Franco M, Kreutz C, Prinz M, Tholen M, Reinheckel T, Ott T, Groß CJ, Jost PJ, Groß O. Tyrosine kinase inhibitors can activate the NLRP3 inflammasome in myeloid cells through lysosomal damage and cell lysis. Sci Signal. 2023 Jan 17;16(768):eabh1083. doi: 10.1126/scisignal.abh1083. Epub 2023 Jan 17. PMID: 36649377. |
| de Maissin H, Groß PR, Mohiuddin O, Weigt M, Nagel L, Herzog M, Wang Z, Willing R, Reichardt W, Pichotka M, Heß L, Reinheckel T, Jessen HJ, Zeiser R, Bock M, von Elverfeldt D, Zaitsev M, Korchak S, Glöggler S, Hövener JB, Chekmenev EY, Schilling F, Knecht S, Schmidt AB. In Vivo Metabolic Imaging of [1-13 C]Pyruvate-d3 Hyperpolarized By Reversible Exchange With Parahydrogen. Angew Chem Int Ed Engl. 2023 Sep 4;62(36):e202306654. doi: 10.1002/anie.202306654. Epub 2023 Jul 25. PMID: 37439488. | |
| Bettecken A*, Heß L*, Hölzen L, Reinheckel T. Dipeptidyl-Aminopeptidases 8 and 9 Regulate Autophagy and Tamoxifen Response in Breast Cancer Cells. Cells. 2023; 12(16):2031. https://doi.org/10.3390/cells12162031 | |
| 2022 | Bussi C, Heunis T, Pellegrino E, Bernard EM, Bah N, Dos Santos MS, Santucci P, Aylan B, Rodgers A, Fearns A, Mitschke J, Moore C, MacRae JI, Greco M, Reinheckel T, Trost M, Gutierrez MG. Lysosomal damage drives mitochondrial proteome remodelling and reprograms macrophage immunometabolism. Nat Commun. 2022 Nov 28;13(1):7338. doi: 10.1038/s41467-022-34632-8. PMID: 36443305; PMCID: PMC9705561. |
| Hölzen L, Syré K, Mitschke J, Brummer T, Miething C, Reinheckel T. Degradome-focused RNA interference screens to identify proteases important for breast cancer cell growth. Front Oncol. 2022 Oct 12;12:960109. doi: 10.3389/fonc.2022.960109. PMID: 36313646; PMCID: PMC9598039. | |
Hook G, Reinheckel T, Ni J, Wu Z, Kindy M, Peters C, Hook V. Cathepsin B Gene Knockout Improves Behavioral Deficits and Reduces Pathology in Models of Neurologic Disorders. Pharmacol Rev. 2022 Jul;74(3):600-629. doi: 10.1124/pharmrev.121.000527. PMID: 35710131 Review. Hölzen L, Mitschke J, Schönichen C, Hess ME, Ehrenfeld S, Boerries M, Miething C, Brummer T, Reinheckel T. RNA interference screens discover proteases as synthetic lethal partners of PI3K inhibition in breast cancer cells. Theranostics. 2022 May 16;12(9):4348-4373. doi: 10.7150/thno.68299. eCollection 2022. PMID: 35673573 Reinheckel T, Tholen M. Low-level lysosomal membrane permeabilization for limited release and sublethal functions of cathepsin proteases in the cytosol and nucleus. FEBS Open Bio. 2022 Apr;12(4):694-707. doi: 10.1002/2211-5463.13385. Epub 2022 Mar 9. PMID: 35203107 Review. Zhang T, Du H, Santos MN, Wu X, Pagan MD, Trigiani LJ, Nishimura N, Reinheckel T, Hu F. Differential regulation of progranulin derived granulin peptides. | |
| 2021 | Ni J, Zhao J, Zhang X, Reinheckel T, Turk V, Nakanishi H. Cathepsin H deficiency decreases hypoxia-ischemia-induced hippocampal atrophy in neonatal mice through attenuated TLR3/IFN-β signaling. J Neuroinflammation. 2021 Aug 10;18(1):176. doi: 10.1186/s12974-021-02227-7. PMID: 34376208; PMCID: PMC8353845. |
| Alcaraz LB, Mallavialle A, David T, Derocq D, Delolme F, Dieryckx C, Mollevi C, Boissière-Michot F, Simony-Lafontaine J, Du Manoir S, Huesgen PF, Overall CM, Tartare-Deckert S, Jacot W, Chardès T, Guiu S, Roger P, Reinheckel T, Moali C, Liaudet-Coopman E. A 9-kDa matricellular SPARC fragment released by cathepsin D exhibits pro-tumor activity in the triple-negative breast cancer microenvironment. Theranostics. 2021 Apr 15;11(13):6173-6192. doi: 10.7150/thno.58254. PMID: 33995652; PMCID: PMC8120228. | |
| Vasiljeva O, Sevenich L, Reinheckel T. Analyzing the Role of Proteases in Breast Cancer Progression and Metastasis Using Primary Cells from Transgenic Oncomice. Methods Mol Biol. 2021;2294:275-293. doi: 10.1007/978-1-0716-1350-4_20. PMID: 33742409. | |
| Gomez-Auli A, Hillebrand LE, Christen D, Günther SC, Biniossek ML, Peters C, Schilling O, Reinheckel T. The secreted inhibitor of invasive cell growth CREG1 is negatively regulated by cathepsin proteases. Cell Mol Life Sci. 2021 Jan;78(2):733-755. doi: 10.1007/s00018-020-03528-5. Epub 2020 May 8. PMID: 32385587; PMCID: PMC7873128. | |
| 2020 | Ketterer S, Mitschke J, Ketscher A, Schlimpert M, Reichardt W, Baeuerle N, Hess ME, Metzger P, Boerries M, Peters C, Kammerer B, Brummer T, Steinberg F, Reinheckel T. Cathepsin D deficiency in mammary epithelium transiently stalls breast cancer by interference with mTORC1 signaling. Nat Commun. 2020 Oct 12;11(1):5133. doi: 10.1038/s41467-020-18935-2. Pubmed33046706 |
| Parigiani MA, Ketscher A, Timme S, Bronsert P, Schlimpert M, Kammerer B, Jacquel A, Chaintreuil P, Reinheckel T. Conditional Gene Targeting Reveals Cell Type-Specific Roles of the Lysosomal Protease Cathepsin L in Mammary Tumor Progression. Cancers (Basel). 2020 Jul 22;12(8):E2004. doi: 10.3390/cancers12082004. Pubmed32707827 | |
| Hölzen L, Parigiani MA, Reinheckel T. Tumor cell- and microenvironment-specific roles of cysteine cathepsins in mouse models of human cancers. Biochim Biophys Acta Proteins Proteom. 2020 Jul;1868(7):140423. doi: 10.1016/j.bbapap.2020.140423. Epub 2020 Apr 2. Pubmed32247787 Review. | |
| Gomez-Auli A, Hillebrand LE, Christen D, Günther SC, Biniossek ML, Peters C, Schilling O, Reinheckel T. The secreted inhibitor of invasive cell growth CREG1 is negatively regulated by cathepsin proteases. Cell Mol Life Sci. 2020 May 8. doi: 10.1007/s00018-020-03528-5. Pubmed32385587 [Epub ahead of print] | |
| Reischmann N, Andrieux G, Griffin R, Reinheckel T, Boerries M, Brummer T. BRAFV600E drives dedifferentiation in small intestinal and colonic organoids and cooperates with mutant p53 and Apc loss in transformation. Oncogene. 2020 Sep;39(38):6053-6070. doi: 10.1038/s41388-020-01414-9. Pubmed32792685 | |
| Kavčič N, Butinar M, Sobotič B, Hafner Česen M, Petelin A, Bojić L, Zavašnik Bergant T, Bratovš A, Reinheckel T, Turk B. Intracellular cathepsin C levels determine sensitivity of cells to leucyl-leucine methyl ester-triggered apoptosis. FEBS J. 2020 Dec;287(23):5148-5166. doi: 10.1111/febs.15326. Pubmed32319717 | |
| Malla SR, Krueger B, Wartmann T, Sendler M, Mahajan UM, Weiss FU, Thiel FG, De Boni C, Gorelick FS, Halangk W, Aghdassi AA, Reinheckel T, Gukovskaya AS, Lerch MM, Mayerle J. Early trypsin activation develops independently of autophagy in caerulein-induced pancreatitis in mice. Cell Mol Life Sci. 2020 May;77(9):1811-1825. doi: 10.1007/s00018-019-03254-7. Epub 2019 Jul 30. Pubmed31363815 | |
| Hämälistö S, Stahl JL, Favaro E, Yang Q, Liu B, Christoffersen L, Loos B, Guasch Boldú C, Joyce JA, Reinheckel T, Barisic M, Jäättelä M. Spatially and temporally defined lysosomal leakage facilitates mitotic chromosome segregation. Nat Commun. 2020 Jan 13;11(1):229. doi: 10.1038/s41467-019-14009-0. Pubmed31932607 | |
| Capponi S, Stöffler N, Irimia M, Van Schaik FMA, Ondik MM, Biniossek ML, Lehmann L, Mitschke J, Vermunt MW, Creyghton MP, Graybiel AM, Reinheckel T, Schilling O, Blencowe BJ, Crittenden JR, Timmers HTM. Neuronal-specific microexon splicing of TAF1 mRNA is directly regulated by SRRM4/nSR100. RNA Biol. 2020 Jan;17(1):62-74. doi: 10.1080/15476286.2019.1667214. Pubmed31559909 | |
| 2019 | Mitschke J, Burk UC, Reinheckel T. The role of proteases in epithelial-to-mesenchymal cell transitions in cancer. Cancer Metastasis Rev. 2019 Sep;38(3):431-444. doi: 10.1007/s10555-019-09808-2. Pubmed31482486 Review |
| Hillebrand LE, Reinheckel T. Impact of proteolysis on cancer stem cell functions. Biochimie. 2019 Nov;166:214-222. doi: 10.1016/j.biochi.2019.03.002. Epub 2019 Mar 12. Pubmed30876968 Review | |
| Hillebrand LE, Wickberg SM, Gomez-Auli A, Follo M, Maurer J, Busch H, Boerries M, Reinheckel T. MMP14 empowers tumor-initiating breast cancer cells under hypoxic nutrient-depleted conditions. FASEB J. 2019 Mar;33(3):4124-4140. doi: 10.1096/fj.201801127R. Epub 2018 Dec 6. Pubmed30521382 | |
| Schwenck J, Maurer A, Fehrenbacher B, Mehling R, Knopf P, Mucha N, Haupt D, Fuchs K, Griessinger CM, Bukala D, Holstein J, Schaller M, Menendez IG, Ghoreschi K, Quintanilla-Martinez L, Gütschow M, Laufer S, Reinheckel T, Röcken M, Kalbacher H, Pichler BJ, Kneilling M. Cysteine-type cathepsins promote the effector phase of acute cutaneous delayed-type hypersensitivity reactions.Theranostics. 2019 May 31;9(13):3903-3917. doi: 10.7150/thno.31037. eCollection 2019. Pubmed31281521 | |
| Köhler M, Ehrenfeld S, Halbach S, Lauinger M, Burk U, Reischmann N, Cheng S, Spohr C, Uhl FM, Köhler N, Ringwald K, Braun S, Peters C, Zeiser R, Reinheckel T, Brummer T. B-Raf deficiency impairs tumor initiation and progression in a murine breast cancer model. Oncogene. 2019 Feb;38(8):1324-1339. doi: 10.1038/s41388-018-0663-8. Epub 2019 Jan 18. Pubmed30659267 | |
| 2018 | Martínez-Fábregas J, Prescott A, van Kasteren S, Pedrioli DL, McLean I, Moles A, Reinheckel T, Poli V, Watts C. Lysosomal protease deficiency or substrate overload induces an oxidative-stress mediated STAT3-dependent pathway of lysosomal homeostasis. Nat Commun. 2018 Dec 17;9(1):5343. doi: 10.1038/s41467-018-07741-6. Pubmed30559339 |
| Freeley S, Cardone J, Günther SC, West EE, Reinheckel T, Watts C, Kemper C, Kolev MV. Asparaginyl Endopeptidase (Legumain) Supports Human Th1 Induction via Cathepsin L-Mediated Intracellular C3 Activation. Front Immunol. 2018 Oct 24;9:2449. doi: 10.3389/fimmu.2018.02449. eCollection 2018. Pubmed30405635 | |
| Ziegler PK, Bollrath J, Pallangyo CK, Matsutani T, Canli Ö, De Oliveira T, Diamanti MA, Müller N, Gamrekelashvili J, Putoczki T, Horst D, Mankan AK, Öner MG, Müller S, Müller-Höcker J, Kirchner T, Slotta-Huspenina J, Taketo MM, Reinheckel T, Dröse S, Larner AC, Wels WS, Ernst M, Greten TF, Arkan MC, Korn T, Wirth D, Greten FR. Mitophagy in Intestinal Epithelial Cells Triggers Adaptive Immunity during Tumorigenesis. Cell. 2018 Jun 28;174(1):88-101.e16. doi: 10.1016/j.cell.2018.05.028. Epub 2018 Jun 14.. Pubmed29909986 | |
| Höhne M, Frese CK, Grahammer F, Dafinger C, Ciarimboli G, Butt L, Binz J, Hackl MJ, Rahmatollahi M, Kann M, Schneider S, Altintas MM, Schermer B, Reinheckel T, Göbel H, Reiser J, Huber TB, Kramann R, Seeger-Nukpezah T, Liebau MC, Beck BB, Benzing T, Beyer A, Rinschen MM. Single nephron proteomes connect morphology and function in proteinuric kidney disease. Kidney Int. 2018 Jun;93(6):1308-1319. doi: 10.1016/j.kint.2017.12.012. Pubmed29530281 | |
| Thriene K, Grüning BA, Bornert O, Erxleben A, Leppert J, Athanasiou I, Weber E, Kiritsi D, Nyström A, Reinheckel T, Backofen R, Has C, Bruckner-Tuderman L, Dengjel J. Combinatorial omics analysis reveals perturbed lysosomal homeostasis in collagen VII-deficient keratinocytes. Mol Cell Proteomics. 2018 Jan 11. pii: mcp.RA117.000437. doi: 10.1074/mcp.RA117.000437. Pubmed29326176 | |
| Gonzalez AC, Schweizer M, Jagdmann S, Bernreuther C, Reinheckel T, Saftig P, Damme M. Unconventional Trafficking of Mammalian Phospholipase D3 to Lysosomes. Cell Rep. 2018 Jan 23;22(4):1040-1053. doi: 10.1016/j.celrep.2017.12.100. Epub 2018 Jan 28. Pubmed29386126 | |
| Aghdassi AA, John DS, Sendler M, Weiss FU, Reinheckel T, Mayerle J, Lerch MM. Cathepsin D regulates cathepsin B activation and disease severity predominantly in inflammatory cells during experimental pancreatitis. J Biol Chem. 2018 Jan 19;293(3):1018-1029. doi: 10.1074/jbc.M117.814772. Epub 2017 Dec 11. Pubmed29229780 | |
| 2017 | Reinheckel T. New Kid on the Block. Theranostics. 2017 Jul 30;7(11):2965-2967. doi: 10.7150/thno.21603. eCollection 2017. Pubmed28824729 |
| Ketterer S, Gomez-Auli A, Hillebrand LE, Petrera A, Ketscher A, Reinheckel T. Inherited diseases caused by mutations in cathepsin protease genes. FEBS J. 2017 May;284(10):1437-1454. doi: 10.1111/febs.13980. Epub 2017 Jan 12. Pubmed27926992 | |
| Fichter CD, Przypadlo CM, Buck A, Herbener N, Riedel B, Schäfer L, Nakagawa H, Walch A, Reinheckel T, Werner M, Lassmann S. A new model system identifies EGFR/HER2 and HER2/HER3 heterodimers as potent inducers of oesophageal epithelial cell invasion. J Pathol. 2017 Dec;243(4):481-495. doi: 10.1002/path.4987. Epub 2017 Nov 5. Pubmed28940194 | |
| Sigloch FC, Tholen M, Gomez-Auli A, Biniossek ML, Reinheckel T, Schilling O. Proteomic analysis of lung metastases in a murine breast cancer model reveals divergent influence of CTSB and CTSL overexpression. J Cancer. 2017 Oct 23;8(19):4065-4074. doi: 10.7150/jca.21401. eCollection 2017. Pubmed29187882 | |
| Oortveld MAW, van Vlijmen-Willems IMJJ, Kersten FFJ, Cheng T, Verdoes M, van Erp PEJ, Verbeek S, Reinheckel T, Hendriks WJAJ, Schalkwijk J, Zeeuwen PLJM. Cathepsin B as a potential cystatin M/E target in the mouse hair follicle. FASEB J. 2017 Oct;31(10):4286-4294. doi: 10.1096/fj.201700267R. Pubmed28596234 | |
| Zhou X, Paushter DH, Feng T, Sun L, Reinheckel T, Hu F. Lysosomal processing of progranulin. Mol Neurodegener. 2017 Aug 23;12(1):62. doi: 10.1186/s13024-017-0205-9. Pubmed28835281 | |
| Silva-Vilches C, Pletinckx K, Lohnert M, Pavlovic V, Ashour D, John V, Vendelova E, Kneitz S, Zhou J, Chen R, Reinheckel T, Mueller TD, Bodem J, Lutz MB. Low doses of cholera toxin and its mediator cAMP induce CTLA-2 secretion by dendritic cells to enhance regulatory T cell conversion. PLoS One. 2017 Jul 31;12(7):e0178114. doi: 10.1371/journal.pone.0178114. eCollection 2017. Pubmed28759565 | |
| Allan ERO, Campden RI, Ewanchuk BW, Tailor P, Balce DR, McKenna NT, Greene CJ, Warren AL, Reinheckel T, Yates RM.A role for cathepsin Z in neuroinflammation provides mechanistic support for an epigenetic risk factor in multiple sclerosis. J Neuroinflammation. 2017 May 10;14(1):103. doi: 10.1186/s12974-017-0874-x. Pubmed28486971 | |
| Naeem AS, Tommasi C, Cole C, Brown SJ, Zhu Y, Way B, Willis Owen SA, Moffatt M, Cookson WO, Harper JI, Di WL, Brown SJ, Reinheckel T, O'Shaughnessy RF. A mechanistic target of rapamycin complex 1/2 (mTORC1)/V-Akt murine thymoma viral oncogene homolog 1 (AKT1)/cathepsin H axis controls filaggrin expression and processing in skin, a novel mechanism for skin barrier disruption in patients with atopic dermatitis. J Allergy Clin Immunol. 2017 Apr;139(4):1228-1241. doi: 10.1016/j.jaci.2016.09.052. Epub 2016 Nov 29. Pubmed27913303 | |
| Mengwasser J, Babes L, Cordes S, Mertlitz S, Riesner K, Shi Y, McGearey A, Kalupa M, Reinheckel T, Penack O. Cathepsin E Deficiency Ameliorates Graft-versus-Host Disease and Modifies Dendritic Cell Motility. Front Immunol. 2017 Mar 1;8:203. doi: 10.3389/fimmu.2017.00203. Pubmed28298913 | |
| van der Meer LT, Terry SY, van Ingen Schenau D, Andree KC, Franssen GM, Roeleveld DM, Metselaar BM, Reinheckel T, Hoogerbrugge PM, Boerman OC, van Leeuwen FN. In vivo imaging of antileukemic drug asparaginase reveals a rapid macrophage mediated clearance from the bone marrow. J Nucl Med. 2017 Feb;58(2):214-220. doi: 10.2967/jnumed.116.177741. Pubmed27493268 | |
| Welsby I, Detienne S, N'Kuli F, Thomas S, Wouters S, Bechtold V, De Wit D, Gineste R, Reinheckel T, Elouahabi A, Courtoy PJ, Didierlaurent AM, Goriely S. Lysosome-Dependent Activation of Human Dendritic Cells by the Vaccine Adjuvant QS-21. Front Immunol. 2017 Jan 5;7:663. doi: 10.3389/fimmu.2016.00663. Pubmed28105029 | |
| 2016 | Hillebrand LE, Bengsch F, Hochrein J, Hülsdünker J, Bender J, Follo M, Busch H, Boerries M, Reinheckel T. Proteolysis-a characteristic of tumor-initiating cells in murine metastatic breast cancer. Oncotarget. 2016 Sep 6;7(36):58244-58260. doi: 10.18632/oncotarget.11309. Pubmed27542270 |
| Gomez-Auli A, Hillebrand LE, Biniossek ML, Peters C, Reinheckel T, Schilling O. Impact of cathepsin B on the interstitial fluid proteome of murine breast cancers. Biochimie. 2016 Mar;122:88-98. doi: 10.1016/j.biochi.2015.10.009. Epub 2015 Oct 8. Pubmed26455267 | |
| Ketscher A, Ketterer S, Dollwet-Mack S, Reif U, Reinheckel T. Neuroectoderm-specific deletion of cathepsin D in mice models human inherited neuronal ceroid lipofuscinosis type 10. Biochimie. 2016 Mar;122:219-26. doi: 10.1016/j.biochi.2015.07.020. Epub 2015 Jul 29. Pubmed26232697 | |
| Garsen M, Rops AL, Dijkman H, Willemsen B, van Kuppevelt TH, Russel FG, Rabelink TJ, Berden JH, Reinheckel T, van der Vlag J. Cathepsin L is crucial for the development of early experimental diabetic nephropathy. Kidney Int. 2016 Nov;90(5):1012-1022. doi: 10.1016/j.kint.2016.06.035. Pubmed27575559 | |
| Kasabova M, Villeret B, Gombault A, Lecaille F, Reinheckel T, Marchand-Adam S, Couillin I, Lalmanach G. Discordance in cathepsin B and cystatin C expressions in bronchoalveolar fluids between murine bleomycin-induced fibrosis and human idiopathic fibrosis. Respir Res. 2016 Sep 22;17(1):118. Pubmed27658724 | |
| Edgington-Mitchell LE, Wartmann T, Fleming AK, Gocheva V, van der Linden WA, Withana NP, Verdoes M, Aurelio L, Edgington-Mitchell D, Lieu T, Parker BS, Graham B, Reinheckel T, Furness JB, Joyce JA, Storz P, Halangk W, Bogyo M, Bunnett NW. Legumain is Activated in Macrophages during Pancreatitis. Am J Physiol Gastrointest Liver Physiol. 2016 Sep 1;311(3):G548-G560. doi: 10.1152/ajpgi.00047.2016. Epub 2016 Aug 11. Pubmed27514475 | |
| Ohrvik H, Logeman B, Turk B, Reinheckel T, Thiele DJ. Cathepsin Protease Controls Copper and Cisplatin Accumulation via Cleavage of the Ctr1 Metal-binding Ecto-domain. J Biol Chem. 2016 Jul 1;291(27):13905-16. doi: 10.1074/jbc.M116.731281. Epub 2016 May 3. Pubmed27143361 | |
| Ziltener P, Reinheckel T, Oxenius A. Neutrophil and Alveolar Macrophage-Mediated Innate Immune Control of Legionella pneumophila Lung Infection via TNF and ROS. PLoS Pathog. 2016 Apr 22;12(4):e1005591. doi: 10.1371/journal.ppat.1005591. eCollection 2016 Apr. Pubmed27105352 | |
| 2015 | Tholen M, Wolanski J, Stolze B, Chiabudini M, Gajda M, Bronsert P, Stickeler E, Rospert S, Reinheckel T. Stress-resistant Translation of Cathepsin L mRNA in Breast Cancer Progression. J Biol Chem. 2015 Jun 19;290(25):15758-69. doi: 10.1074/jbc.M114.624353. Pubmed25957406 |
| Kern U, Wischnewski V, Biniossek ML, Schilling O, Reinheckel T. Lysosomal protein turnover contributes to the acquisition of TGFβ-1 induced invasive properties of mammary cancer cells. Mol Cancer. 2015 Feb 15;14(1):39. doi: 10.1186/s12943-015-0313-5. Pubmed25744631 | |
| Walter K, Steinwede K, Aly S, Reinheckel T, Bohling J, Maus UA, Ehlers S. Cathepsin G in Experimental Tuberculosis: Relevance for Antibacterial Protection and Potential for Immunotherapy. J Immunol. 2015 Oct 1;195(7):3325-33. doi: 10.4049/jimmunol.1501012. Epub 2015 Aug 28. Pubmed26320257 | |
| Bach AS, Derocq D, Laurent-Matha V, Montcourrier P, Sebti S, Orsetti B, Theillet C, Gongora C, Pattingre S, Ibing E, Roger P, Linares LK, Reinheckel T, Meurice G, Kaiser FJ, Gespach C, Liaudet-Coopman E. Nuclear cathepsin D enhances TRPS1 transcriptional repressor function to regulate cell cycle progression and transformation in human breast cancer cells. Oncotarget. 2015 Sep 29;6(29):28084-103. doi: 10.18632/oncotarget.4394. Pubmed26183398 | |
| Weber E, Barbulescu E, Medek R, Reinheckel T, Sameni M, Anbalagan A, Moin K, Sloane BF. Cathepsin B-deficient mice as source of monoclonal anti-cathepsin B antibodies. Biol Chem. 2015 Mar 1;396(3):277-81. doi: 10.1515/hsz-2014-0191. Pubmed25205719 | |
| Seubert B, Grünwald B, Kobuch J, Cui H, Schelter F, Schaten S, Siveke JT, Lim NH, Nagase H, Simonavicius N, Heikenwälder M, Reinheckel T, Sleeman JP, Janssen KP, Knolle PA, Krüger A. TIMP-1 creates a pre-metastatic niche in the liver through SDF-1/CXCR4-dependent neutrophil recruitment in mice. Hepatology. 2015 Jan;61(1):238-48. doi: 10.1002/hep.27378. Epub 2014 Nov 24.. Pubmed25131778 | |
| 2014 | Tholen M, Hillebrand LE, Tholen S, Sedelmeier O, Arnold SJ, Reinheckel T. Out-of-frame start codons prevent translation of truncated nucleo-cytosolic cathepsin L in vivo. Nat Commun. 2014 Sep 15;5:4931. doi: 10.1038/ncomms5931. Pubmed25222295 |
| Bengsch F, Buck A, Günther SC, Seiz JR, Tacke M, Pfeifer D, von Elverfeldt D, Sevenich L, Hillebrand LE, Kern U, Sameni M, Peters C, Sloane BF, Reinheckel T. Cell type-dependent pathogenic functions of overexpressed human cathepsin B in murine breast cancer progression. Oncogene. 2014 Sep 4;33(36):4474-84. doi: 10.1038/onc.2013.395. Epub 2013 Sep 30. Pubmed24077280 | |
| Tholen S, Biniossek ML, Gansz M, Ahrens TD, Schlimpert M, Kizhakkedathu JN, Reinheckel T, Schilling O. Double deficiency of cathepsins B and L results in massive secretome alterations and suggests a degradative cathepsin-MMP axis. Cell Mol Life Sci. 2014 Mar;71(5):899-916. doi: 10.1007/s00018-013-1406-1. Epub 2013 Jun 29. Pubmed23811845 | |
| Müller S, Faulhaber A, Sieber C, Pfeifer D, Hochberg T, Gansz M, Deshmukh SD, Dauth S, Brix K, Saftig P, Peters C, Henneke P, Reinheckel T. The endolysosomal cysteine cathepsins L and K are involved in macrophage-mediated clearance of Staphylococcus aureus and the concomitant cytokine induction. FASEB J. 2014 Jan;28(1):162-75. doi: 10.1096/fj.13-232272. Pubmed24036885 | |
| Kowalewski B, Lübke T, Kollmann K, Braulke T, Reinheckel T, Dierks T, Damme M. Molecular characterization of arylsulfatase G - Molecular characterization of arylsulfatase G - expression, processing, glycosylation, transport and activity. J Biol Chem. 2014 Oct 3;289(40):27992-8005. doi: 10.1074/jbc.M114.584144. Pubmed25135642 | |
| Akkari L, Gocheva V, Kester JC, Hunter KE, Quick ML, Sevenich L, Wang HW, Peters C, Tang LH, Klimstra DS, Reinheckel T, Joyce JA. Distinct functions of macrophage-derived and cancer cell-derived cathepsin Z combine to promote tumor malignancy via interactions with the extracellular matrix. Genes Dev. 2014 Oct 1;28(19):2134-50. doi: 10.1101/gad.249599.114. Pubmed25274726 | |
| Tamhane T, Arampatzidou M, Gerganova V, Tacke M, Illukkumbura R, Dauth S, Schaschke N, Peters C, Reinheckel T, Brix K. The activity and localization patterns of cathepsins B and X in cells of the mouse gastrointestinal tract differ along its length. Biol Chem. 2014 Oct 1;395(10):1201-19. doi: 10.1515/hsz-2014-0151. Pubmed25205730 | |
| Gonzalez-Leal IJ, Röger B, Schwarz A, Schirmeister T, Reinheckel T, Lutz MB, Moll H. Cathepsin B in Antigen-Presenting Cells Controls Mediators of the Th1 Immune Response during Leishmania major Infection. PLoS Negl Trop Dis. 2014 Sep 25;8(9):e3194. doi: 10.1371/journal.pntd.0003194. eCollection 2014 Sep. Pubmed25255101 | |
| Fløyel T, Brorsson C, Nielsen LB, Miani M, Bang-Berthelsen CH, Friedrichsen M, Overgaard AJ, Berchtold LA, Wiberg A, Poulsen P, Hansen L, Rosinger S, Boehm BO, Ram R, Nguyen Q, Mehta M, Morahan G, Concannon P, Bergholdt R, Nielsen JH, Reinheckel T, von Herrath M, Vaag A, Eizirik DL, Mortensen HB, Størling J, Pociot F. CTSH regulates β-cell function and disease progression in newly diagnosed type 1 diabetes patients. Proc Natl Acad Sci U S A. 2014 Jul 15;111(28):10305-10. doi: 10.1073/pnas.1402571111. Epub 2014 Jun 30. Pubmed24982147 | |
| Pensa S, Neoh K, Resemann HK, Kreuzaler PA, Abell K, Clarke NJ, Reinheckel T, Kahn CR, Watson CJ. The PI3K regulatory subunits p55α and p50α regulate cell death in vivo. Cell Death Differ.2014 Sep;21(9):1442-50. doi: 10.1038/cdd.2014.59. Epub 2014 Jun 6. Pubmed24902901 | |
| Butinar M, Prebanda MT, Rajković J, Jerič B, Stoka V, Peters C, Reinheckel T, Krüger A, Turk V, Turk B, Vasiljeva O. Stefin B deficiency reduces tumor growth via sensitization of tumor cells to oxidative stress in a breast cancer model.Oncogene. 2014 Jun 26;33(26):3392-400. doi: 10.1038/onc.2013.314. Epub 2013 Aug 19. Pubmed23955077 | |
| Timme S, Ihde S, Fichter CD, Waehle V, Bogatyreva L, Atanasov K, Kohler I, Schöpflin A, Geddert H, Faller G, Klimstra D, Tang L, Reinheckel T, Hauschke D, Busch H, Boerries M, Werner M, Lassmann S. STAT3 expression, activity and functional consequences of STAT3 inhibition in esophageal squamous cell carcinomas and Barrett's adenocarcinomas.Oncogene. 2014 Jun 19;33(25):3256-66. doi: 10.1038/onc.2013.298. Epub 2013 Aug 5. Pubmed23912451 | |
| 2013 | Reinheckel T. On the road to inflammation: Linking lysosome disruption, lysosomal protease release and necrotic death of immune cells. Cell Cycle. 2013 Jul 1;12(13):1994. doi: 10.4161/cc.25316. Epub 2013 Jun 11. Pubmed23759575 |
| Tholen S, Biniossek ML, Gansz M, Gomez-Auli A, Werner F, Noel A, Kizhakkedathu JN, Boerries M, Busch H, Reinheckel T, Schilling O. Deletion of cysteine cathepsins B or L yields differential impacts on murine skin proteome and degradome. Mol Cell Proteomics. 2013 Mar;12(3):611-25. doi: 10.1074/mcp.M112.017962. Epub 2012 Dec 10. Pubmed23233448 | |
| Liszewski MK, Kolev M, Le Friec G, Leung M, Bertram PG, Fara AF, Subias M, Pickering MC, Drouet C, Meri S, Arstila TP, Pekkarinen PT, Ma M, Cope A, Reinheckel T, Rodriguez de Cordoba S, Afzali B, Atkinson JP, Kemper C. Intracellular Complement Activation Sustains T Cell Homeostasis and Mediates Effector Differentiation.Immunity. 2013 Dec 3. pii: S1074-7613(13)00509-8. doi: 10.1016/j.immuni.2013.10.018. Pubmed24315997 | |
| Ruffell B, Affara NI, Cottone L, Junankar S, Johansson M, Denardo DG, Korets L, Reinheckel T, Sloane BF, Bogyo M, Coussens LM. Cathepsin C is a tissue-specific regulator of squamous carcinogenesis. Genes Dev. 2013 Oct 1;27(19):2086-98. doi: 10.1101/gad.224899.113. Epub 2013 Sep 24. Pubmed24065739 | |
| Bühler A, Berger S, Werner F, Martin G, Han H, Vierkotten S, Pielen A, Boehringer D, Schlunck G, Fauser S, Agostini HT, Reinheckel T, Stahl A. Cathepsin proteases promote angiogenic sprouting and laser-induced choroidal neovascularisation in mice. Exp Eye Res. 2013 Oct;115:73-8. doi: 10.1016/j.exer.2013.06.014. Epub 2013 Jun 22. Pubmed23800510 | |
| Aldahmesh MA, Khan AO, Alkuraya H, Adly N, Anazi S, Al-Saleh AA, Mohamed JY, Hijazi H, Prabakaran S, Tacke M, Al-Khrashi A, Hashem M, Reinheckel T, Assiri A, Alkuraya FS. Mutations in LRPAP1 Are Associated with Severe Myopia in Humans. Am J Hum Genet. 2013 Aug 8;93(2):313-20. doi: 10.1016/j.ajhg.2013.06.002. Epub 2013 Jul 3.. Pubmed23830514 | |
| Krueger S, Bernhardt A, Kalinski T, Baldensperger M, Zeh M, Teller A, Adolf D, Reinheckel T, Roessner A, Kuester D. Induction of premalignant host responses by cathepsin x/z-deficiency in helicobacter pylori-infected mice. PLoS One. 2013 Jul 30;8(7):e70242. doi: 10.1371/journal.pone.0070242. Print 2013. Pubmed23936173 | |
| Gansz M., Kern U., Peters C. and Reinheckel T. : Exploring Systemic Functions of Lysomal Proteases: The Perspective of Genetically Modified Mouse Models. In: K. Brix and W. Stöcker (eds.): Proteases: Structure and Function, Springer Science, cap. 6. 2013 / Buchbeitrag | |
| 2012 | Reinheckel T, Peters C, Krüger A, Turk B, Vasiljeva O. Differential Impact of Cysteine Cathepsins on Genetic Mouse Models of De novo Carcinogenesis: Cathepsin B as Emerging Therapeutic Target. Front Pharmacol. 2012;3:133. Epub 2012 Jul 11. Pubmed22798952 |
| Müller S, Dennemärker J, Reinheckel T. Specific functions of lysosomal proteases in endocytic and autophagic pathways. Biochim Biophys Acta. 2012 Jan;1824(1):34-43.Epub 2011 Jul 13. Pubmed21767668 | |
| Andrea Marzi, Thomas Reinheckel, Heinz Feldmann. Cathepsin B & L Are Not Required for Ebola Virus Replication. PLoS Negl Trop Dis. 2012 December; 6(12): e1923. Published online 2012 December 6. doi: 10.1371/journal.pntd.0001923 PMCID: Pubmed3516577 | |
| Steenhuis P, Froemming J, Reinheckel T, Storch S. Proteolytic cleavage of the disease-related lysosomal membrane glycoprotein CLN7. Biochim Biophys Acta. 2012 Oct;1822(10):1617-28. Pubmed22668694 | |
| Schurigt U, Eilenstein R, Gajda M, Leipner C, Sevenich L, Reinheckel T, Peters C, Wiederanders B, Bräuer R. Decreased arthritis severity in cathepsin L-deficient mice is attributed to an impaired T helper cell compartment. Inflamm Res. Sep;61(9):1021-9. Pubmed22674323 | |
| Lu WD, Funkelstein L, Toneff T, Reinheckel T, Peters C, Hook V. Cathepsin H Functions as an Aminopeptidase in Secretory Vesicles for Production of Enkephalin and Galanin Peptide Neurotransmitters. J Neurochem.2012 Aug;122(3):512-22. doi: 10.1111/j.1471-4159.2012.07788.x. Epub 2012 Jun 21. Pubmed22582844 | |
| Pilzner C, Bühling F, Reinheckel T, Chwieralski C, Rathinasamy A, Lauenstein HD, Wex T, Welte T, Braun A, Groneberg DA. Allergic Airway Inflammation in Mice Deficient for the Antigen-Processing Protease Cathepsin E. Int Arch Allergy Immunol. 2012 Jul 26;159(4):367-383. Pubmed22846634 | |
| Gopinathan A, Denicola GM, Frese KK, Cook N, Karreth FA, Mayerle J, Lerch MM, Reinheckel T, Tuveson DA. Cathepsin B promotes the progression of pancreatic ductal adenocarcinoma in mice Gut. 2012 Jun;61(6):877-84. Epub 2011 Dec 9.PubMed22157328 | |
| Funkelstein L, Lu WD, Koch B, Mosier C, Toneff T, Taupenot L, O'Connor DT, Reinheckel T, Peters C, Hook V. Human cathepsin V protease participates in the production of enkephalin and NPY neurotransmitters. J Biol Chem. 2012May 4;287(19):15232-41. Pubmed22393040 | |
| Diederich S, Sauerhering L, Weis M, Altmeppen H, Schaschke N, Reinheckel T, Erbar S, Maisner A. Activation of the Nipah virus fusion protein in MDCK cells is mediated by cathepsin B within the endosomal-recycling compartment. J Virol. 2012Apr;86(7):3736-45. Epub 2012 Jan 25. Pubmed22278224 | |
| Grimm S, Horlacher M, Catalgol B, Hoehn A, Reinheckel T, Grune T. Cathepsins D and L reduce the toxicity of advanced glycation end products. Free Radic Biol Med. 2012 Mar 15;52(6):1011-23. Epub 2012 Jan 4.PubMed22245096 | |
| Werner F., Sachse K. and Reinheckel T. Secreted Cysteine Cathepsins - Versatile Players in Extracellular Proteolysis. In: Niels Behrendt (ed.): Matrix Proteases in Health and Disease, Wiley-VCH, cap. 11. 2012 / Buchbeitrag | |
| 2011 | Bühling F, Kouadio M, Chwieralski CE, Kern U, Hohlfeld JM, Klemm N, Friedrichs N, Roth W, Deussing JM, Peters C, Reinheckel T. Gene targeting of the cysteine peptidase cathepsin h impairs lung surfactant in mice. PLoS One. 2011;6(10):e26247. Epub 2011 Oct 12. PubMed22022579 |
| Sevenich L, Werner F, Gajda M, Schurigt U, Sieber C, Müller S, Follo M, Peters C, Reinheckel T. Transgenic expression of human cathepsin B promotes progression and metastasis of polyoma-middle-T-induced breast cancer in mice. Oncogene. 2011 Jan 6;30(1):54-64. Epub 2010 Sep 6. PubMed20818432. | |
| Sun J, Sukhova GK, Zhang J, Chen H, Sjöberg S, Libby P, Xiang M, Wang J, Peters C, Reinheckel T, Shi GP. Cathepsin L activity is essential to elastase perfusion-induced abdominal aortic aneurysms in mice. Arterioscler Thromb Vasc Biol. 2011 Nov;31(11):2500-8. PubMed21868704 | |
| Tholen S, Biniossek ML, Geßler AL, Müller S, Weißer J, Kizhakkedathu JN, Reinheckel T, Schilling O. Contribution of cathepsin L to secretome composition and cleavage pattern of mouse embryonic fibroblasts. Biol Chem. 2011 Nov;392(11):961-971. PubMed21972973 | |
| Arampatzidou M, Mayer K, Iolyeva ME, Asrat SG, Ravichandran M, Günther T, Schüle R, Reinheckel T, Brix K. Studies of intestinal morphology and cathepsin B expression in a transgenic mouse aiming at intestine-specific expression of Cath B-EGFP. Biol Chem. 2011 Nov;392(11):983-93. PubMed21871011 | |
| Savalas LR, Gasnier B, Damme M, Lübke T, Wrocklage C, Debacker C, Jezegou A, Reinheckel T, Hasilik A, Saftig P, Schröder BA. "Disrupted in renal carcinoma 2" (DIRC2) - a novel transporter of the lysosomal membrane - is proteolytically processed by cathepsin L. Biochem J. 2011 Oct 1;439(1):113-28. Pubmed21692750 | |
| Yaddanapudi S, Altintas MM, Kistler AD, Fernandez I, Möller CC, Wei C, Peev V, Flesche JB, Forst AL, Li J, Patrakka J, Xiao Z, Grahammer F, Schiffer M, Lohmüller T, Reinheckel T, Gu C, Huber TB, Ju W, Bitzer M, Rastaldi MP, Ruiz P, Tryggvason K, Shaw AS, Faul C, Sever S, Reiser J. CD2AP in mouse and human podocytes controls a proteolytic program that regulates cytoskeletal structure and cellular survival. J Clin Invest. 2011 Oct 3;121(10):3965-80. doi: 10.1172/JCI58552. Epub 2011 Sep 12. PubMed21911934 | |
| Czibere L, Baur LA, Wittmann A, Gemmeke K, Steiner A, Weber P, Pütz B, Ahmad N, Bunck M, Graf C, Widner R, Kühne C, Panhuysen M, Hambsch B, Rieder G, Reinheckel T, Peters C, Holsboer F, Landgraf R, Deussing JM. Profiling trait anxiety: transcriptome analysis reveals cathepsin B (Ctsb) as a novel candidate gene for emotionality in mice. PLoS One. 2011;6(8):e23604. Epub 2011 Aug 29. PubMed21897848 | |
| Mikhaylov G, Mikac U, Magaeva AA, Itin VI, Naiden EP, Psakhye I, Babes L, Reinheckel T, Peters C, Zeiser R, Bogyo M, Turk V, Psakhye SG, Turk B, Vasiljeva O. Ferri-liposomes as an MRI-visible drug-delivery system for targeting tumours and their microenvironment. Nat Nanotechnol. 2011 Aug 7;6(9):594-602. doi: 10.1038/nnano.2011.112. Pubmed21822252 | |
Kraus S, Bunsen T, Schuster S, Cichoń MA, Tacke M, Reinheckel T, Sommerhoff CP, Jochum M, Nägler DK. Cellular senescence induced by cathepsin X downregulation. Eur J Cell Biol. 2011 Aug;90(8):678-86.Pubmed21616554 | |
| Miller G, Matthews SP, Reinheckel T, Fleming S, Watts C.Asparagine endopeptidase is required for normal kidney physiology and homeostasis. FASEB J. 2011 May;25(5):1606-17. Epub 2011 Feb 3. Pubmed21292981 | |
| Carrasco-Marín E, Fernández-Prieto L, Rodriguez-Del Rio E, Madrazo-Toca F, Reinheckel T, Saftig P, Alvarez-Dominguez C. LIMP-2 Links Late Phagosomal Trafficking with the Onset of the Innate Immune Response to Listeria monocytogenes: A ROLE IN MACROPHAGE ACTIVATION. J Biol Chem. 2011 Feb 4;286(5):3332-41. Epub 2010 Dec 1.Pubmed21123180 | |
| Masset A, Maillard C, Sounni N, Jacobs N, Bruyère F, Delvenne P, Tacke M, Reinheckel T, Foidart JM, Coussens L, Noël A. Unimpeded skin carcinogenesis in K14-HPV16 transgenic mice deficient for plasminogen activator inhibitor. Int J Cancer. 2011 Jan 15;128(2):283-93. Epub 2010 Mar 15. Pubmed20232379 | |
| 2010 | Sevenich L, Hagemann S, Stoeckle C, Tolosa E, Peters C, Reinheckel T. Expression of human cathepsin L or human cathepsin V in mouse thymus mediates positive selection of T helper cells in cathepsin L knock-out mice. Biochimie. 2010 Nov;92(11):1674-80. Pubmed20347002 |
| Reiser J, Adair B, Reinheckel T. Specialized roles for cysteine cathepsins in health and disease. J Clin Invest. 2010 Oct 1;120(10):3421-31. Pubmed20921628. | |
| Dennemärker J, Lohmüller T, Müller S, Aguilar SV, Tobin DJ, Peters C, Reinheckel T. Impaired turnover of autophagolysosomes in cathepsin L deficiency. Biol Chem. 2010 Aug;391(8):913-22. Pubmed20536383 | |
| Dennemärker J, Lohmüller T, Mayerle J, Tacke M, Lerch MM, Coussens LM, Peters C, Reinheckel T. Deficiency for the cysteine protease cathepsin L promotes tumor progression in mouse epidermis.Oncogene. 2010 Mar 18;29(11):1611-21. Epub 2009 Dec 21. Pubmed20023699 | |
| Sevenich L, Schurigt U, Sachse K, Gajda M, Werner F, Müller S, Vasiljeva O, Schwinde A, Klemm N, Deussing J, Peters C, Reinheckel T. Synergistic antitumor effects of combined cathepsin B and cathepsin Z deficiencies on breast cancer progression and metastasis in mice. Proc Natl Acad Sci U S A. 2010 Feb 9;107(6):2497-502. Pubmed20133781 | |
| Konjar S, Sutton VR, Hoves S, Repnik U, Yagita H, Reinheckel T, Peters C, Turk V, Turk B, Trapani JA, Kopitar-Jerala N. Human and mouse perforin are processed in part through cleavage by the lysosomal cysteine proteinase cathepsin L. Immunology. 2010 Oct;131(2):257-67. Pubmed20497254 | |
| Bernhardt A, Kuester D, Roessner A, Reinheckel T, Krueger S. Cathepsin X deficient gastric epithelial cells in coculture with macrophages-characterization of cytokine response and migration capability after H. pylori infection. J Biol Chem. 2010 Oct 29;285(44):33691-700. Pubmed20736174 | |
| Konjar S, Sutton VR, Hoves S, Repnik U, Yagita H, Reinheckel T, Peters C, Turk V, Turk B, Trapani JA, Kopitar-Jerala N. Human and mouse perforin are processed in part through cleavage by the lysosomal cysteine proteinase cathepsin L. Immunology. 2010 Oct;131(2):257-67. Pubmed20497254 | |
| Zeeuwen PL, van Vlijmen-Willems IM, Cheng T, Rodijk-Olthuis D, Hitomi K, Hara-Nishimura I, John S, Smyth N, Reinheckel T, Hendriks WJ, Schalkwijk J. The cystatin M/E-cathepsin L balance is essential for tissue homeostasis in epidermis, hair follicles, and cornea..FASEB J. 2010 Oct;24(10):3744-55. Epub 2010 May 21. Pubmed20495178 | |
| Grimm S, Ernst L, Grötzinger N, Höhn A, Breusing N, Reinheckel T, Grune T. Cathepsin D is one of the major enzymes involved in intracellular degradation of AGE-modified proteins. Free Radic Res. 2010 Sep;44(9):1013-26. Pubmed20560835 | |
| Gocheva V, Chen X, Peters C, Reinheckel T, Joyce JA. Deletion of cathepsin H perturbs angiogenic switching, vascularization and growth of tumors in a mouse model of pancreatic islet cell cancer. Biol Chem. 2010 Aug;391(8):937-45.Pubmed2031543 | |
| Oberle C, Huai J, Reinheckel T, Tacke M, Rassner M, Ekert PG, Buellesbach J, Borner C. Lysosomal membrane permeabilization and cathepsin release is a Bax/Bak-dependent, amplifying event of apoptosis in fibroblasts and monocytes. Cell Death Differ. 2010 Jul;17(7):1167-78. Pubmed20094062 | |
| D'Angelo ME, Bird PI, Peters C, Reinheckel T, Trapani JA, Sutton VR. Cathepsin H is an additional convertase of pro-granzyme B. J Biol Chem. 2010 Jul 2;285(27):20514-9. Pubmed20435891 | |
| Matthews SP, Werber I, Deussing J, Peters C, Reinheckel T, Watts C. Distinct protease requirements for antigen presentation in vitro and in vivo. J Immunol. 2010 Mar 1;184(5):2423-31. Pubmed20164435 | |
| Wartmann T, Mayerle J, Kähne T, Sahin-Tóth M, Ruthenbürger M, Matthias R, Kruse A, Reinheckel T, Peters C, Weiss FU, Sendler M, Lippert H, Schulz HU, Aghdassi A, Dummer A, Teller S, Halangk W, Lerch MM. Cathepsin L inactivates human trypsinogen, whereas cathepsin L-deletion reduces the severity of pancreatitis in mice. Gastroenterology. 2010 Feb;138(2):726-37. Pubmed19900452 | |
| Minokadeh A, Funkelstein L, Toneff T, Hwang SR, Beinfeld M, Reinheckel T, Peters C, Zadina J, Hook V. Cathepsin L participates in dynorphin production in brain cortex, illustrated by protease gene knockout and expression. Mol Cell Neurosci. 2010 Jan;43(1):98-107. Epub 2009 Oct 22. Pubmed19837164 | |
| 2009 | Xiao K, Jehle F, Peters C, Reinheckel T, Schirmer RH, Dandekar T. CA/C1 peptidases of the malaria parasites Plasmodium falciparum and P. berghei and their mammalian hosts--a bioinformatical analysis. Biol Chem. 2009 Nov;390(11):1185-97. Pubmed19663681 |
| Hook VY, Kindy M, Reinheckel T, Peters C, Hook G. Genetic cathepsin B deficiency reduces beta-amyloid in transgenic mice expressing human wild-type amyloid precursor protein. Biochem Biophys Res Commun. 2009 Aug 21;386(2):284-8. Pubmed19501042 | |
| Beinfeld MC, Funkelstein L, Foulon T, Cadel S, Kitagawa K, Toneff T, Reinheckel T, Peters C, Hook V. Cathepsin L plays a major role in cholecystokinin production in mouse brain cortex and in pituitary AtT-20 cells: protease gene knockout and inhibitor studies. Peptides. 2009 Oct;30(10):1882-91. Pubmed19589362 | |
| Vreemann A, Qu H, Mayer K, Andersen LB, Stefana MI, Wehner S, Lysson M, Farcas AM, Peters C, Reinheckel T, Kalff J, Brix K. Cathepsin B release from rodent intestine mucosa due to mechanical injury results in extracellular matrix damage in early post-traumatic phases. Biol Chem. 2009 May-Jun;390(5-6):481-92. Pubmed19335208 | |
| Caglic D, Kosec G, Bojic L, Reinheckel T, Turk V, Turk B. Murine and human cathepsin B exhibit similar properties: possible implications for drug discovery. Biol Chem. 2009 Feb;390(2):175-9. Erratum in: Biol Chem. 2009 May-Jun;390(5-6):517. Pubmed19040356 | |
| 2008 | Funkelstein L, Toneff T, Mosier C, Hwang SR, Beuschlein F, Lichtenauer UD, Reinheckel T, Peters C, Hook V. Major Role of Cathepsin L for Producing the Peptide Hormones ACTH, {beta}-Endorphin, and {alpha}-MSH, Illustrated by Protease Gene Knockout and Expression. J Biol Chem. 2008 Dec 19;283(51):35652-9; Pubmed18849346 |
| Halle A, Hornung V, Petzold GC, Stewart CR, Monks BG, Reinheckel T, Fitzgerald KA, Latz E, Moore KJ, Golenbock DT. The NALP3 inflammasome is involved in the innate immune response to amyloid-beta. Nat Immunol. 2008 Aug;9(8):857-65. Pubmed18604209 | |
Schurigt U, Sevenich L, Vannier C, Gajda M, Schwinde A, Werner F, Stahl A, von Elverfeldt D, Becker AK, Bogyo M, Peters C, Reinheckel T. Trial of the cysteine cathepsin inhibitor JPM-OEt on early and advanced mammary cancer stages in the MMTV-PyMT-transgenic mouse model. Biol Chem. 2008 Aug;389(8):1067-74.Pubmed18710344 | |
| Vasiljeva O, Korovin M, Gajda M, Brodoefel H, Bojic L, Krüger A, Schurigt U, Sevenich L, Turk B, Peters C, Reinheckel T. Reduced tumour cell proliferation and delayed development of high-grade mammary carcinomas in cathepsin B-deficient mice. Oncogene. 2008 Jul 10;27(30):4191-9. Pubmed18345026 | |
Funkelstein L, Toneff T, Hwang SR, Reinheckel T, Peters C, Hook V. Cathepsin L participates in the production of neuropeptide Y in secretory vesicles, demonstrated by protease gene knockout and expression. J Neurochem. 2008 Jul;106(1):384-91. Pubmed18410501 | |
| Conus S, Perozzo R, Reinheckel T, Peters C, Scapozza L, Yousefi S, Simon HU. Caspase-8 is activated by cathepsin D initiating neutrophil apoptosis during the resolution of inflammation. J Exp Med. 2008 Mar 17;205(3):685-98. Pubmed18299403 | |
| Wolf P, Alt K, Bühler P, Katzenwadel A, Wetterauer U, Tacke M, Elsässer-Beile U. Anti-PSMA immunotoxin as novel treatment for prostate cancer? High and specific antitumor activity on human prostate xenograft tumors in SCID mice. Prostate. 2008 Feb 1;68(2):129-38. Pubmed18044731 | |
| Bühler P, Wolf P, Gierschner D, Schaber I, Katzenwadel A, Schultze-Seemann W, Wetterauer U, Tacke M, Swamy M, Schamel WW, Elsässer-Beile U. A bispecific diabody directed against prostate-specific membrane antigen and CD3 induces T-cell mediated lysis of prostate cancer cells. Cancer Immunol Immunother. 2008 Jan;57(1):43-52. Epub 2007 Jun 20. Pubmed17579857 | |
| Reinheckel, T., Gocheva, V., Peters, C., Joyce, J.A.:Roles of Cysteine Proteases in Tumor Progression: Analysis of Cysteine Cathepsin Knockout Mice in Cancer Models. In: D. Edwards et al. (eds.): The Cancer Degradome, Springer Science, cap. 15. 2008 / Buchbeitrag | |
| 2007 | Bojic L, Petelin A, Stoka V, Reinheckel T, Peters C, Turk V, Turk B.Cysteine cathepsins are not involved in Fas/CD95 signalling in primary skin fibroblasts. 2007 Nov 13;581(27):5185-90. Pubmed17950288 |
| Spira D, Stypmann J, Tobin DJ, Petermann I, Mayer C, Haggemann S, Vasiljeva O, Günther T, Schüle R, Peters C, Reinheckel T.Cell type-specific functions of the lysosomal protease cathepsin L in the heart. J Biol Chem. 2007 Oct 17. Pubmed17942402 | |
| Vasiljeva O, Reinheckel T, Peters C, Turk D, Turk V, Turk B. Emerging roles of cysteine cathepsins in disease and their potential as drug targets.Curr Pharm Des. 2007;13(4):387-403. Pubmed17311556 | |
| Tiwari N, Garbi N, Reinheckel T, Moldenhauer G, Hämmerling GJ, Momburg F. A transporter associated with antigen-processing independent vacuolar pathway for the MHC class I-mediated presentation of endogenous transmembrane proteins. J Immunol. 2007 Jun 15;178(12):7932-42. Pubmed17548631 | |
| 2006 | Rocken C, Fandrich M, Stix B, Tannert A, Hortschansky P, Reinheckel T, Saftig P, Kahne T, Menard R, Ancsin JB, Buhling F. Cathepsin protease activity modulates amyloid load in extracerebral amyloidosis. J Pathol. 2006 Dec;210(4):478-87. Pubmed17068745 |
| Perez-Amodio S, Jansen DC, Schoenmaker T, Vogels IM, Reinheckel T, Hayman AR, Cox TM, Saftig P, Beertsen W, Everts V. Calvarial osteoclasts express a higher level of tartrate-resistant acid phosphatase than long bone osteoclasts and activation does not depend on cathepsin K or L activity. Calcif Tissue Int. 2006 Oct;79(4):245-54. Epub 2006 Oct 10. Pubmed17033726 | |
| Cheng T, Hitomi K, van Vlijmen-Willems IM, de Jongh GJ, Yamamoto K, Nishi K, Watts C, Reinheckel T, Schalkwijk J, Zeeuwen PL: Cystatin M/E is a high affinity inhibitor of cathepsin V and cathepsin L by a reactive site that is distinct from the legumain-binding site. A novel clue for the role of cystatin M/E in epidermal cornification. J Biol Chem, 2006; 281 (23) : 15893-15899, Pubmed16565075 | |
| Everts V, Korper W, Hoeben KA, Jansen ID, Bromme D, Cleutjens KB, Heeneman S, Peters C, Reinheckel T, Saftig P, Beertsen W: Osteoclastic bone degradation and the role of different cysteine proteinases and matrix metalloproteinases: differences between calvaria and long bone. J Bone Miner Res, 2006; 21 (9) : 1399-1408, Pubmed16939398 | |
| Gocheva V, Zeng W, Ke D, Klimstra D, Reinheckel T, Peters C, Hanahan D, Joyce JA: Distinct roles for cysteine cathepsin genes in multistage tumorigenesis. Gene Dev, 2006; 20 (5) : 543-556, Pubmed16481467 | |
| Petermann I, Mayer C, Stypmann J, Biniossek ML, Tobin DJ, Engelen MA, Dandekar T, Grune T, Schild L, Peters C, Reinheckel T: Lysosomal, cytoskeletal, and metabolic alterations in cardiomyopathy of cathepsin L knockout mice. FASEB J, 2006; 20 (8) : 1266-1268, Pubmed16636100 | |
| Sevenich L, Pennacchio LA, Peters C, Reinheckel T: Human cathepsin L rescues the neurodegeneration and lethality in cathepsin B/L double-deficient mice. Biol Chem, 2006; 387 (7) : 885-891, Pubmed16913838 | |
| Vasiljeva O, Papazoglou A, Kruger A, Brodoefel H, Korovin M, Deussing J, Augustin N, Nielsen BS, Almholt K, Bogyo M, Peters C, Reinheckel T: Tumor cell-derived and macrophage-derived cathepsin B promotes progression and lung metastasis of mammary cancer. Cancer Res, 2006; 66 (10) : 5242-5250, Pubmed16707449 | |
| 2005 | Reinheckel T, Hagemann S, Dollwet-Mack S, Martinez E, Lohmuller T, Zlatkovic G, Tobin DJ, Maas-Szabowski N, Peters C. The lysosomal cysteine protease cathepsin L regulates keratinocyte proliferation by control of growth factor recycling. J Cell Sci. 2005 Aug 1;118(Pt 15):3387-95. Pubmed16079282 |
| Henningsson F, Yamamoto K, Saftig P, Reinheckel T, Peters C, Knight SD, Pejler G. A role for cathepsin E in the processing of mast-cell carboxypeptidase A. J Cell Sci. 2005 May 1;118(Pt 9):2035-42. Pubmed15860733 | |
| Urbich C, Heeschen C, Aicher A, Sasaki KI, Bruhl T, Farhadi MR, Vajkoczy P, Hofmann WK, Peters C, Pennacchio LA, Abolmaali ND, Chavakis E, Reinheckel T, Zeiher AM, Dimmeler S. Cathepsin L is required for endothelial progenitor cell-induced neovascularization. Nat Med. 2005 Feb;11(2):206-13. Epub 2005 Jan 23. Pubmed15665831 | |
| 2004 | Hagemann S, Gunther T, Dennemarker J, Lohmuller T, Bromme D, Schule R, Peters C, Reinheckel T. The human cysteine protease cathepsin V can compensate for murine cathepsin L in mouse epidermis and hair follicles. Eur J Cell Biol. 2004 Dec;83(11-12):775-80. Pubmed15679121 |
| Wille A, Gerber A, Heimburg A, Reisenauer A, Peters C, Saftig P, Reinheckel T, Welte T, Buhling F. Cathepsin L is involved in cathepsin D processing and regulation of apoptosis in A549 human lung epithelial cells. Biol Chem. 2004 Jul;385(7):665-70. Pubmed15318816 | |
| Hook V, Yasothornsrikul S, Greenbaum D, Medzihradszky KF, Troutner K, Toneff T, Bundey R, Logrinova A, Reinheckel T, Peters C, Bogyo M. Cathepsin L and Arg/Lys aminopeptidase: a distinct prohormone processing pathway for the biosynthesis of peptide neurotransmitters and hormones. Biol Chem. 2004 Jun;385(6):473-80. Pubmed15255178 | |
| Faller D, Reinheckel T, Wenzler D, Hagemann S, Xiao K, Honerkamp J, Peters C, Dandekar T, Timmer J. An open source protein gel documentation system for proteome analyses. J Chem Inf Comput Sci. 2004 Jan-Feb;44(1):168-9. Pubmed14741024 | |
| 2003 | Schild L, Reinheckel T, Reiser M, Horn TF, Wolf G, Augustin W. Nitric oxide produced in rat liver mitochondria causes oxidative stress and impairment of respiration after transient hypoxia. FASEB J. 2003 Dec;17(15):2194-201. Pubmed14656981 |
| Strauch OF, Stypmann J, Reinheckel T, Martinez E, Haverkamp W, Peters C. Cardiac and ocular pathologies in a mouse model of mucopolysaccharidosis type VI. Pediatr Res. 2003 Nov;54(5):701-8. Epub 2003 Aug 06. Pubmed12904606 | |
| Yasothornsrikul S, Greenbaum D, Medzihradszky KF, Toneff T, Bundey R, Miller R, Schilling B, Petermann I, Dehnert J, Logvinova A, Goldsmith P, Neveu JM, Lane WS, Gibson B, Reinheckel T, Peters C, Bogyo M, Hook V. Cathepsin L in secretory vesicles functions as a prohormone-processing enzyme for production of the enkephalin peptide neurotransmitter. Proc Natl Acad Sci U S A. 2003 Aug 5;100(16):9590-5. Epub 2003 Jul 17. Pubmed12869695, http://www.pnas.org/cgi/reprint/100/16/9590.pdf | |
| Friedrichs B, Tepel C, Reinheckel T, Deussing J, von Figura K, Herzog V, Peters C, Saftig P, Brix K. Thyroid functions of mouse cathepsins B, K, and L. J Clin Invest. 2003 Jun;111(11):1733-45. Pubmed12782676 | |
| Lohmuller T, Wenzler D, Hagemann S, Kiess W, Peters C, Dandekar T, Reinheckel T. Toward computer-based cleavage site prediction of cysteine endopeptidases. Biol Chem. 2003 Jun;384(6):899-909. Pubmed12887057 | |
| 2002 | Grune T, Reinheckel T, North JA, Li R, Bescos PB, Shringarpure R, Davies KJ. Ezrin turnover and cell shape changes catalyzed by proteasome in oxidatively stressed cells. FASEB J 2002 Oct;16(12):1602-10. Pubmed12374783, PDF |
| Tobin DJ, Foitzik K, Reinheckel T, Mecklenburg L, Botchkarev VA, Peters C, Paus R. The lysosomal protease cathepsin L is an important regulator of keratinocyte and melanocyte differentiation during hair follicle morphogenesis and cycling. Am J Pathol 2002 May;160(5):1807-21. Pubmed12000732, http://ajp.amjpathol.org/cgi/content/full/160/5/1807, PDF | |
| Stypmann J, Glaser K, Roth W, Tobin DJ, Petermann I, Matthias R, Monnig G, Haverkamp W, Breithardt G, Schmahl W, Peters C, Reinheckel T. Dilated cardiomyopathy in mice deficient for the lysosomal cysteine peptidase cathepsin L. Proc Natl Acad Sci U S A 2002 Apr 30;99(9):6234-9. Pubmed11972068, http://www.pnas.org/cgi/content/full/99/9/6234, PDF | |
| Pross M, Mantke R, Kunz D, Reinheckel T, Halangk W, Lippert H, Schulz HU. Reduced neutrophil sequestration in lung tissue after laparoscopic lavage in a rat peritonitis model. World J Surg 2002 Jan;26(1):49-53. Pubmed11898033 | |
| Grune T, Reinheckel T, Li R, North JA, Davies KJ. Proteasome-dependent turnover of protein disulfide isomerase in oxidatively stressed cells. Arch Biochem Biophys 2002 Jan 15;397(2):407-13. Pubmed11795901 | |
| 2001 | Reinheckel T, Deussing J, Roth W, Peters C. Towards specific functions of lysosomal cysteine peptidases: phenotypes of mice deficient for cathepsin B or cathepsin L. Biol Chem 2001 382(5): 735-41. Pubmed11517926 |
| Reinheckel T, Grune T. Regulation of the degradation of oxidized proteins. In: Nesaretnam K., Packer L. (Hrsg): Micronutrients and Health: Molecular Biological Mechanisms. AOCS Press, 2001; chap 17. | |
| Schulz HU, Böhm AK, Halangk W, Lippert H, Reinheckel T. Insertions-Deletions-Polymorphismus im humanen T6 Trypsinogen-Gen: Bedeutung für die Entwicklung einer chronischen Pankreatitis. Chirurgisches Forum 2001; 30:, 2001; 219-221. | |
| Gilgenast O, Brandt-Nedelev B, Wiswedel I, Lippert H, Halangk W, Reinheckel T. Differential oxidative injury in extrapancreatic tissues during experimental pancreatitis: modification of lung proteins by 4- hydroxynonenal. Dig Dis Sci 2001 Apr;46(4):932-937. Pubmed11330437 | |
| 2000 | Pross M, Schulz HU, Flechsig A, Manger T, Halangk W, Augustin W, Lippert H, Reinheckel T. Oxidative stress in lung tissue induced by CO(2) pneumoperitoneum in the rat. Surg Endosc 2000 Dec;14(12):1180-4. Pubmed11148794 |
| Halangk W, Lerch MM, Brandt-Nedelev B, Roth W, Ruthenbuerger M, Reinheckel T, Domschke W, Lippert H, Peters C, Deussing J. Role of cathepsin B in intracellular trypsinogen activation and the onset of acute pancreatitis. J Clin Invest 2000 Sep;106(6):773-81. Pubmed10995788, http://www.jci.org/cgi/content/full/106/6/773?view=full&pmid=10995788 | |
| Reinheckel T, Grune T, Davies KJ. The measurement of protein degradation in response to oxidative stress. Methods Mol Biol 2000;99:49-60. Pubmed10909076 | |
| Reinheckel T, Ullrich O, Sitte N, Grune T. Differential impairment of 20S and 26S proteasome activities in human hematopoietic K562 cells during oxidative stress. Arch Biochem Biophys 2000 May 1;377(1):65-8. Pubmed10775442 | |
| Reinheckel T, Körn S, Möhring S, Augustin W, Halangk W, Schild L. Adaptation of protein carbonyl detection to the requirements of proteome analysis demonstrated for hypoxia/reoxygenation in isolated rat liver mitochondria. Arch Biochem Biophys 2000 Apr 1;376(1):59-65. Pubmed10729190 | |
| Pross M, Manger T, Reinheckel T, Mirow L, Kunz D, Lippert H. Endoscopic treatment of clinically symptomatic leaks of thoracic esophageal anastomoses. Gastrointest Endosc 2000 Jan;51(1):73-6. Pubmed10625803 | |
| 1999 | Ullrich O, Reinheckel T, Sitte N, Grune T. Degradation of hypochlorite-damaged glucose-6-phosphate dehydrogenase by the 20S proteasome. Free Radic Biol Med 1999 Sep;27(5-6):487-92. Pubmed10490267 |
| Ullrich O, Reinheckel T, Sitte N, Hass R, Grune T, Davies KJ. Poly-ADP ribose polymerase activates nuclear proteasome to degrade oxidatively damaged histones. Proc Natl Acad Sci U S A 1999 May 25;96(11):6223-8. Pubmed10339569, http://www.pnas.org/cgi/content/full/96/11/6223 | |
| Reinheckel T, Bohne M, Halangk W, Augustin W, Gollnick H. Evaluation of UVA-mediated oxidative damage to proteins and lipids in extracorporeal photoimmunotherapy. Photochem Photobiol 1999 May;69(5):566-70. Pubmed10333762 | |
| Reinheckel T, Prause J, Nedelev B, Augustin W, Schulz HU, Lippert H, Halangk W. Oxidative stress affects pancreatic proteins during the early pathogenesis of rat caerulein pancreatitis. Digestion 1999 Jan-Feb;60(1):56-62. Pubmed9892799 | |
| 1998 | Pross M, Manger T, Reinheckel T, Mantke R, Lippert H. Cylinder implantation--a new method for endoscopic treatment of anastomotic dehiscence. Endoscopy 1998 Nov;30(9):S102-3. Pubmed9932769 |
| Reinheckel T, Sitte N, Ullrich O, Kuckelkorn U, Davies KJ, Grune T. Comparative resistance of the 20S and 26S proteasome to oxidative stress. Biochem J 1998 Nov 1;335 ( Pt 3):637-42. Pubmed9794805, http://www.biochemj.org/bj/335/0637/bj3350637.htm | |
| Reinheckel T, Noack H, Lorenz S, Wiswedel I, Augustin W. Comparison of protein oxidation and aldehyde formation during oxidative stress in isolated mitochondria. Free Radic Res 1998 Oct;29(4):297-305. Pubmed9860044 | |
| Seidel B, Keilhoff G, Reinheckel T, Wolf G. Differentially expressed genes in hippocampal cell cultures in response to an excitotoxic insult by quinolinic acid. Brain Res Mol Brain Res 1998 Oct 1;60(2):296-300. Pubmed9757068 | |
| Reinheckel T, Nedelev B, Prause J, Augustin W, Schulz HU, Lippert H, Halangk W. Occurrence of oxidatively modified proteins: an early event in experimental acute pancreatitis. Free Radic Biol Med 1998 Feb;24(3):393-400. Pubmed9438551 | |
| 1997 | Schild L, Reinheckel T, Wiswedel I, Augustin W. Short-term impairment of energy production in isolated rat liver mitochondria by hypoxia/reoxygenation: involvement of oxidative protein modification. Biochem J 1997 Nov 15;328 ( Pt 1):205-10. Pubmed9359854, http://www.biochemj.org/bj//328/0205/bj3280205.htm |
| Schild L, Plumeyer F, Reinheckel T, Augustin W. Micromolar calcium prevents isolated rat liver mitochondria from anoxia-reoxygenation injury. Biochem Mol Biol Int 1997 Sep;43(1):35-45. Pubmed9315280 | |
| Augustin W, Wiswedel I, Noack H, Reinheckel T, Reichelt O. Role of endogenous and exogenous antioxidants in the defence against functional damage and lipid peroxidation in rat liver mitochondria. Mol Cell Biochem 1997 Sep;174(1-2):199-205. Pubmed9309688 | |
| Grune T, Reinheckel T, Davies KJ. Degradation of oxidized proteins in mammalian cells. FASEB J 1997 Jun;11(7):526-34. Pubmed9212076 | |
| 1996 | Grune T, Reinheckel T, Davies KJ. Degradation of oxidized proteins in K562 human hematopoietic cells by proteasome. J Biol Chem 1996 Jun 28;271(26):15504-9. Pubmed8663134, http://www.jbc.org/cgi/content/full/271/26/15504 |
| 1995 | Reinheckel T, Wiswedel I, Noack H, Augustin W. Electrophoretic evidence for the impairment of complexes of the respiratory chain during iron/ascorbate induced peroxidation in isolated rat liver mitochondria. Biochim Biophys Acta 1995 Oct 4;1239(1):45-50. Pubmed7548143 |
| Grune T, Reinheckel T, Joshi M, Davies KJ. Proteolysis in cultured liver epithelial cells during oxidative stress. Role of the multicatalytic proteinase complex, proteasome. J Biol Chem 1995 Feb 3;270(5):2344-51. Pubmed7836468, http://www.jbc.org/cgi/content/full/270/5/2344 | |
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