Medical Cell Research - C. Borner
Publications
2012 | Vogel S, Raulf N, Bregenhorn S, Biniossek ML, Maurer U, Czabotar P, Borner C. Cytosolic Bax: Does it require binding proteins to keep its pro-apoptotic activity in check? J Biol Chem. 2012 Jan 25. [Epub ahead of print] Pubmed22277657 |
Ferreira KS, Kreutz C, Macnelly S, Neubert K, Haber A, Bogyo M, Timmer J, Borner C. Caspase-3 feeds back on caspase-8, Bid and XIAP in type I Fas signaling in primary mouse hepatocytes. Apoptosis. 2012 Jan 13. [Epub ahead of print] Pubmed22246639 | |
2011 | Leprivier G, Rufini A, García-Sáez AJ, Borner C, Rotblat B. 7th Tuscany Retreat on Cancer Research: Genetic profiling, resistance mechanism and novel treatment concepts in cancer. Cell Death Differ. 2011 Dec 16. doi: 10.1038/cdd.2011.186. [Epub ahead of print] No abstract available. Pubmed22179574 |
Schlatter R, Philippi N, Wangorsch G, Pick R, Sawodny O, Borner C, Timmer J, Ederer M, Dandekar T. Integration of Boolean models exemplified on hepatocyte signal transduction. Brief Bioinform. 2011 Oct 20. [Epub ahead of print] Pubmed22016404 | |
Charvet C, Maurer U.GSK-3 turns p53 deadly. Cell Cycle. 2011 Nov 1;10(21):3621-2. Pubmed22033176 | |
Charvet C, Wissler M, Brauns-Schubert P, Wang SJ, Tang Y, Sigloch FC, Mellert H, Brandenburg M, Lindner SE, Breit B, Green DR, McMahon SB, Borner C, Gu W, Maurer U.Phosphorylation of Tip60 by GSK-3 Determines the Induction of PUMA and Apoptosis by p53. Mol Cell. 2011 Jun 10;42(5):584-96. Pubmed21658600 | |
Lindenboim L, Borner C, Stein R. Nuclear proteins acting on mitochondria. Biochim Biophys Acta. 2011 Apr;1813(4):584-96 Pubmed21130123 | |
Häcker G, Borner C. Preface to Mitochondria: the deadly organelle.Biochim Biophys Acta. 2011 Apr;1813(4):507. Pubmed21419936 | |
Joeckel LT, Wallich R, Martin P, Sanchez-Martinez D, Weber FC, Martin SF, Borner C, Pardo J, Froelich C, Simon MM. Mouse granzyme K has pro-inflammatory potential. Cell Death Differ. 2011 Jul;18(7):1112-9. doi: 10.1038/cdd.2011.5. Epub 2011 Feb 11. Pubmed21311565 | |
Schmich K, Schlatter R, Corazza N, Ferreira KS, Ederer M, Brunner T, Borner C, Merfort I. Tumor necrosis factor α sensitizes primary murine hepatocytes to Fas/CD95-induced apoptosis in a Bim- and Bid-dependent manner.Hepatology. 2011 Jan; 53(1):282-92. Pubmed20872776 | |
2010 | Oberle C, Huai J, Reinheckel T, Tacke M, Rassner M, Ekert PG, Buellesbach J, Borner C. Lysosomal membrane permeabilization and cathepsin release is a Bax/Bak-dependent, amplifying event of apoptosis in fibroblasts and monocytes. Cell Death Differ. 2010 Jul;17(7):1167-78. Pubmed20094062 |
Huai J, Jöckel L, Schrader K, Borner C. Role of caspases and non-caspase proteases in cell death. F1000 Biol Rep. 2010 Jun 23;2. pii: 48. Pubmed20948786 | |
Schrader K, Huai J, Jöckel L, Oberle C, Borner C. Non-caspase proteases: triggers or amplifiers of apoptosis? Cell Mol Life Sci. 2010 May;67(10):1607-18. Review. Pubmed20169397 | |
Lindenboim L, Blacher E, Borner C, Stein R. Regulation of stress-induced nuclear protein redistribution: a new function of Bax and Bak uncoupled from Bcl-x(L). Cell Death Differ. 2010 Feb;17(2):346-59. Pubmed19816507 | |
Jabbour AM, Daunt CP, Green BD, Vogel S, Gordon L, Lee RS, Silke N, Pearson RB, Vandenberg CJ, Kelly PN, Nutt SL, Strasser A, Borner C, Ekert PG. Myeloid progenitor cells lacking p53 exhibit delayed up-regulation of Puma and prolonged survival after cytokine deprivation. Blood. 2010 Jan 14;115(2):344-52. Pubmed19965665 | |
2009 | Schlatter R, Schmich K, Avalos Vizcarra I, Scheurich P, Sauter T, Borner C, Ederer M, Merfort I, Sawodny O. ON/OFF and beyond--a boolean model of apoptosis. PLoS Comput Biol. 2009 Dec;5(12):e1000595. Pubmed20011108 |
Vogel, S., Kiefer, T., Raulf, N., Sterz, K., Manoharan, A. & Borner, C. Mechanisms of Bax/Bak activation: is there any light at the end of the tunnel? Gastroenterology and Hepatology from Bed to Bench 2, S11-S18.(2009). | |
Lindenboim L, Blacher E, Borner C, Stein R. Regulation of stress-induced nuclear protein redistribution: a new function of Bax and Bak uncoupled from Bcl-x(L). Cell Death Differ. 2009 Oct 9. Pubmed19816507 | |
Philippi N, Walter D, Schlatter R, Ferreira KS, Ederer M, Sawodny O, Timmer J, Borner C, Dandekar T. Modeling system states in liver cells: Survival, apoptosis and their modifications in response to viral infection. BMC Syst Biol. 2009 Sep 22;3(1):97. Pubmed19772631 | |
Baudot AD, Jeandel PY, Mouska X, Maurer U, Tartare-Deckert S, Raynaud SD, Cassuto JP, Ticchioni M, Deckert M. The tyrosine kinase Syk regulates the survival of chronic lymphocytic leukemia B cells through PKCdelta and proteasome-dependent regulation of Mcl-1 expression. Oncogene. 2009 Sep 17;28(37):3261-73. Pubmed19581935 | |
Jost PJ, Grabow S, Gray D, McKenzie MD, Nachbur U, Huang DC, Bouillet P, Thomas HE, Borner C, Silke J, Strasser A, Kaufmann T. XIAP discriminates between type I and type II FAS-induced apoptosis. Nature. 2009 Aug 20;460(7258):1035-9. Pubmed19626005 | |
Galluzzi L, Aaronson SA, Abrams J, Alnemri ES, Andrews DW, Baehrecke EH, Bazan NG, Blagosklonny MV, Blomgren K, Borner C, Bredesen DE, Brenner C, Castedo M, Cidlowski JA, Ciechanover A, Cohen GM, De Laurenzi V, De Maria R, Deshmukh M, Dynlacht BD, El-Deiry WS, Flavell RA, Fulda S, Garrido C, Golstein P, Gougeon ML, Green DR, Gronemeyer H, Hajnóczky G, Hardwick JM, Hengartner MO, Ichijo H, Jäättelä M, Kepp O, Kimchi A, Klionsky DJ, Knight RA, Kornbluth S, Kumar S, Levine B, Lipton SA, Lugli E, Madeo F, Malomi W, Marine JC, Martin SJ, Medema JP, Mehlen P, Melino G, Moll UM, Morselli E, Nagata S, Nicholson DW, Nicotera P, Nuñez G, Oren M, Penninger J, Pervaiz S, Peter ME, Piacentini M, Prehn JH, Puthalakath H, Rabinovich GA, Rizzuto R, Rodrigues CM, Rubinsztein DC, Rudel T, Scorrano L, Simon HU, Steller H, Tschopp J, Tsujimoto Y, Vandenabeele P, Vitale I, Vousden KH, Youle RJ, Yuan J, Zhivotovsky B, Kroemer G. Guidelines for the use and interpretation of assays for monitoring cell death in higher eukaryotes. Cell Death Differ. 2009 Aug;16(8):1093-107. Review. Pubmed19373242 | |
Anel A, Bleackley C, Borner C, Golstein P, Krammer PH, Müllbacher A, Pardo J, Simon MM, Trapani JA. EMBO workshop on cytotoxicity, cell death and the immune system. Cell Death Differ. 2009 May;16(5):790-3. No abstract available. Pubmed19369941 | |
Pardo J, Aguilo JI, Anel A, Martin P, Joeckel L, Borner C, Wallich R, Müllbacher A, Froelich CJ, Simon MM. The biology of cytotoxic cell granule exocytosis pathway: granzymes have evolved to induce cell death and inflammation. Microbes Infect. 2009 Apr;11(4):452-9. Review. Pubmed19249384 | |
Shen ZJ, Esnault S, Schinzel A, Borner C, Malter JS. The peptidyl-prolyl isomerase Pin1 facilitates cytokine-induced survival of eosinophils by suppressing Bax activation. Nat Immunol. 2009 Mar;10(3):257-65. Pubmed19182807 | |
2008 | Walter D, Schmich K, Vogel S, Pick R, Kaufmann T, Hochmuth FC, Haber A, Neubert K, McNelly S, von Weizsäcker F, Merfort I, Maurer U, Strasser A, Borner C. Switch from type II to I Fas/CD95 death signaling on in vitro culturing of primary hepatocytes. Hepatology. 2008 Dec;48(6):1942-53. Pubmed19003879 |
Urban C, Rhême C, Maerz S, Berg B, Pick R, Nitschke R, Borner C. Apoptosis induced by Semliki Forest virus is RNA replication dependent and mediated via Bak. Cell Death Differ. 2008 Sep;15(9):1396-407. Pubmed18437160 | |
Pardo J, Wallich R, Martin P, Urban C, Rongvaux A, Flavell RA, Müllbacher A, Borner C, Simon MM. Granzyme B-induced cell death exerted by ex vivo CTL: discriminating requirements for cell death and some of its signs. Cell Death Differ. 2008 Mar;15(3):567-79. Pubmed18064039 | |
Pardo J, Wallich R, Martin P, Urban C, Rongvaux A, Flavell RA, Muellbacher A, Borner C, Simon MM. Granzyme B-induced cell death exerted by ex vivo CTL: discriminating requirements for cell death and some of its signs. Cell Death Differ. 2008 Mar;15(3):567-79. Epub 2007 Dec 7.Pubmed18064039 | |
2007 | Colell A, Ricci JE, Tait S, Milasta S, Maurer U, Bouchier-Hayes L, Fitzgerald P, Guio-Carrion A, Waterhouse NJ, Li CW, Mari B, Barbry P, Newmeyer DD, Beere HM, Green DR. GAPDH and autophagy preserve survival after apoptotic cytochrome c release in the absence of caspase activation. Cell. 2007 Jun 1;129(5):983-97. Pubmed17540177 |
Sanjuán Szklarz LK, Kozjak-Pavlovic V, Voegtle FN, Chacinska A, Milenkovic D, Vogel S, Dürr M, Westermann B, Guiard B, Martinou JC, Borner C, Pfanner N, Meisinger C. Preprotein transport machineries of yeast mitochondrial outer membrane are not required for Bax-induced release of intermembrane space proteins. J Mol Biol. 2007 Apr 20;368(1):44-54. Pubmed17335847 | |
2006 | Sciortino MT, Perri D, Medici MA, Grelli S, Serafino A, Borner C, Mastino A. Role of Bcl-2 expression for productive herpes simplex virus 2 replication. Virology. 2006 Dec 5-20;356(1-2):136-46. Pubmed16950491 |
Charvet C, Canonigo AJ, Becart S, Maurer U, Miletic AV, Swat W, Deckert M, Altman A. Vav1 promotes T cell cycle progression by linking TCR/CD28 costimulation to FOXO1 and p27kip1 expression. J Immunol. 2006 Oct 15;177(8):5024-31. Pubmed17015685 | |
Ekert PG, Jabbour AM, Manoharan A, Heraud JE, Yu J, Pakusch M, Michalak EM, Kelly PN, Callus B, Kiefer T, Verhagen A, Silke J, Strasser A, Borner C, Vaux DL. Cell death provoked by loss of Interleukin-3 signalling is independent of Bad, Bim, and PI3 Kinase, but depends in part on Puma. Blood. 2006 Sep 1;108(5):1461-8. Pubmed16705087 | |
Borner C. In memoriam of a prominent composer of the Bcl-2 family symphony. Cell Death Differ. 2006 Aug;13(8):1248-9. Pubmed16838034 | |
Klingmüller, U. Bauer, A., Breitkopf, K., Bohl, S., Dooley, S., Zellmer, S., Kern, C., Merfort, I., Sparna, T., Donauer, J., Walz, G., Geyer, M., Kreutz, C., Hermes, M., Walter, D., Egger, L., Neubert, K., Borner, C., Götschel, F., Hecht, A., Brulport, M., Schormann, W., Sauer, C., Baumann, F., Preiss, R., Illes, P., Nickel, P. J., MacNelly, S., Godoy, P., Wiercinska, E., Ciuclan, L., Zeilinger, K., Heinrich, M., Zanger, U. M., Reuss, M., Bader, A., Gebhardt, R., Maiwald, T., Timmer, J., von Weizsäcker, F., und Hengstler, J. G. “Primary mouse hepatocytes for systems biology approaches: a standardized in vitro system for modelling of signal transduction pathways”. IEE Proc. Systems Biology, 153, 433-447. Pubmed17186705 | |
Manoharan A, Kiefer T, Leist S, Schrader K, Urban C, Walter D, Maurer U, Borner C. Identification of a 'genuine' mammalian homolog of nematodal CED-4: is the hunt over or do we need better guns? Cell Death Differ. 2006 Aug;13(8):1310-7. Pubmed16691212 | |
Pardo, J., Urban, C., Galvez, E. M., Müller U., Kwon-Chung, J., Lobigs, M., Müllbacher, A. Wallich, R., Borner, C. & Simon, M. Bak is key in gliotoxin-induced apoptosis and a critical host factor of A. fumigatus virulence in mice. J. Cell Biology, Pubmed16893972 | |
Thakar J, Schleinkofer K, Borner C, Dandekar T. RIP death domain structural interactions implicated in TNF-mediated proliferation and survival. Proteins. 2006 May 15;63(3):413-23. Pubmed16470584 | |
Maurer U, Charvet C, Wagman AS, Dejardin E, Green DR. Glycogen synthase kinase-3 regulates mitochondrial outer membrane permeabilization and apoptosis by destabilization of MCL-1. Mol Cell. 2006 Mar 17;21(6):749-60.Pubmed16543145 | |
2005 | Lindenboim L, Kringel S, Braun T, Borner C, Stein R. Bak but not Bax is essential for Bcl-xS-induced apoptosis. Cell Death Differ. 2005 Jul;12(7):713-23. Pubmed15861188 |
Loop T, Dovi-Akue D, Frick M, Roesslein M, Egger L, Humar
M, Hoetzel A, Schmidt R, Borner C, Pahl HL, Geiger KK, Pannen BH. Volatile anesthetics induce caspase-dependent, mitochondria-mediated apoptosis in human T lymphocytes in vitro. Anesthesiology. 2005 Jun;102(6):1147-57. Pubmed15915027 |
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2004 |
Lindenboim L, Schlipf S, Kaufmann T, Borner C, Stein R. Bcl-x(S) induces an NGF-inhibitable cytochrome c release. Exp Cell Res. 2004 Jul 15;297(2):392-403. Pubmed15212942 |
Schinzel A, Kaufmann T, Borner C. Bcl-2 family members: intracellular targeting, membrane-insertion, and changes in subcellular localization. Biochim Biophys Acta. 2004 Mar 1;1644(2-3):95-105. Pubmed14996494 |
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Schinzel A, Kaufmann T, Schuler M, Martinalbo J, Grubb D, Borner C. Conformational control of Bax localization and apoptotic activity by Pro168. J Cell Biol. 2004 Mar 29;164(7):1021-32. Pubmed15037603 |
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Kaufmann T, Schinzel A, Borner C. Bcl-w(edding) with mitochondria. Trends Cell Biol. 2004 Jan;14(1):8-12. Pubmed14729175 |
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2003 |
Egger L, Schneider J, Rheme C, Tapernoux M, Hacki J, Borner C. Serine proteases mediate apoptosis-like cell death and phagocytosis under caspase-inhibiting conditions. Cell Death Differ. 2003 Oct;10(10):1188-1203. Pubmed14502242 |
McCaw SE, Schneider J, Liao EH, Zimmermann W, Gray-Owen SD. Immunoreceptor tyrosine-based activation motif phosphorylation during engulfment of Neisseria gonorrhoeae by the neutrophil-restricted CEACAM3 (CD66d) receptor. Mol Microbiol. 2003 Aug;49(3):623-37. Pubmed12864848 |
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Huber TB, Hartleben B, Kim J, Schmidts M, Schermer B, Keil A, Egger L, Lecha RL, Borner C, Pavenstädt H, Shaw A, Walz G, Benzing T. Nephrin and CD2AP associate with phosphoinositide 3-OH kinase and stimulate AKT-dependent signaling. Mol Cell Biol. 2003 Jul;23(14):4917-28. Pubmed12832477 |
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Gianinazzi C, Grandgirard D, Imboden H, Egger L, Meli DN, Bifrare YD, Joss PC, Tauber MG, Borner C, Leib SL. Caspase-3 mediates hippocampal apoptosis in pneumococcal meningitis. Acta Neuropathol (Berl) 2003 May;105(5):499-507. Pubmed12677451 |
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Kaufmann T, Schlipf S, Sanz J, Neubert K, Stein R, Borner C. Characterization of the signal that directs Bcl-x(L), but not Bcl-2, to the mitochondrial outer membrane. J Cell Biol 2003 Jan 6;160(1):53-64. Pubmed12515824 |
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Borner C. The Bcl-2 protein family: sensors and checkpoints for life-or-death decisions. Mol Immunol 2003 Jan;39(11):615-47, Pubmed12493639 |
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2002 |
Schempp CM, Kirkin V, Simon-Haarhaus B, Kersten A, Kiss J, Termeer CC, Gilb B, Kaufmann T, Borner C, Sleeman JP, Simon JC. Inhibition of tumour cell growth by hyperforin, a novel anticancer drug from St. John's wort that acts by induction of apoptosis. Oncogene 2002 Feb 14;21(8):1242-50. Pubmed11850844 |
Billker O, Popp A, Brinkmann V, Wenig G, Schneider J, Caron E, Meyer TF. Distinct mechanisms of internalization of Neisseria gonorrhoeae by members of the CEACAM receptor family involving Rac1- and Cdc42-dependent and -independent pathways. EMBO J 2002 Feb 15;21(4):560-571. Pubmed11847104 http://emboj.oupjournals.org/cgi/reprint/21/4/560.pdf |
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2001 |
Lindenboim L, Borner C, Stein R. Bcl-x(S) can form homodimers and heterodimers and its apoptotic activity requires localization of Bcl-x(S) to the mitochondria and its BH3 and loop domains. Cell Death Differ 2001 Sep;8(9):933-942. Pubmed11526448 |
2000 |
Conus S, Rossé T, Borner C. Failure of Bcl-2 family members to interact with Apaf-1 in normal and apoptotic cells. Cell Death Differ 2000 Oct;7(10):947-954. Pubmed11279541 |
Foyouzi-Youssefi R, Arnaudeau S, Borner C, Kelley WL, Tschopp J, Lew DP, Demaurex N, Krause KH. Bcl-2 decreases the free Ca2+ concentration within the endoplasmic reticulum. Proc Natl Acad Sci U S A 2000 May 23;97(11):5723-8 http://www.pnas.org/cgi/content/full/97/11/5723 |
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Häcki J, Egger L, Monney L, Conus S, Rossé T, Fellay I, Borner C. Apoptotic crosstalk between the endoplasmic reticulum and mitochondria controlled by Bcl-2. Oncogene 2000 May 4;19(19):2286-95. Pubmed10822379 |
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Conus S, Kaufmann T, Fellay I, Otter I, Rossé T, Borner C. Bcl-2 is a monomeric protein: prevention of homodimerization by structural constraints. EMBO J 2000 Apr 3;19(7):1534-44. Pubmed10747022 |
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Vieira O, Escargueil-Blanc I, Jürgens G, Borner C, Almeida L, Salvayre R, Negre-Salvayre A. Oxidized LDLs alter the activity of the ubiquitin-proteasome pathway: potential role in oxidized LDL-induced apoptosis. FASEB J 2000 Mar;14(3):532-42 http://www.fasebj.org/cgi/content/abstract/14/3/532 |
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1999 |
Sugimoto C, Fujieda S, Seki M, Sunaga H, Fan GK, Tsuzuki H, Borner C, Saito H, Matsukawa S. Apoptosis-promoting gene (bax) transfer potentiates sensitivity of squamous cell carcinoma to cisplatin in vitro and in vivo. Int J Cancer 1999 Sep 9;82(6):860-7. Pubmed10446454 |
Borner C, Schlagbauer Wadl H, Fellay I, Selzer E, Polterauer P, Jansen B. Mutated N-ras upregulates Bcl-2 in human melanoma in vitro and in SCID mice. Melanoma Res 1999 Aug;9(4):347-50. Pubmed10504052 |
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Borner C, Monney L. Apoptosis without caspases: an inefficient molecular guillotine? Cell Death Differ 1999 Jun;6(6):497-507. Pubmed10381652 |
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Borner C, Monney L, Olivier R, Rossé T, Häcki J, Conus S. Life and death in a medieval atmosphere. Cell Death Differ 1999 Feb;6(2):201-6. Pubmed10200567 |
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1998 |
Grandgirard D, Studer E, Monney L, Belser T, Fellay I, Borner C, Michel MR. Alphaviruses induce apoptosis in Bcl-2-overexpressing cells: evidence for a caspase-mediated, proteolytic inactivation of Bcl-2. EMBO J 1998 Aug 10;17(5):1268-78 http://www.emboj.org/cgi/content/full/17/5/1268 |
Monney L, Otter I, Olivier R, Ozer HL, Haas AL, Omura S, Borner C. Defects in the ubiquitin pathway induce caspase-independent apoptosis blocked by Bcl-2. J Biol Chem 1998 Mar 13;273(11):6121-31 http://www.jbc.org/cgi/content/full/273/11/6121 |
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Otter I, Conus S, Ravn U, Rager M, Olivier R, Monney L, Fabbro D, Borner C. The binding properties and biological activities of Bcl-2 and Bax in cells exposed to apoptotic stimuli. J Biol Chem 1998 Mar 13;273(11):6110-20 http://www.jbc.org/cgi/content/full/273/11/6110 |
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Monney L, Olivier R, Otter I, Jansen B, Poirier GG, Borner C. Role of an acidic compartment in tumor-necrosis-factor-alpha-induced production of ceramide, activation of caspase-3 and apoptosis. Eur J Biochem 1998 Jan 15;251(1-2):295-303 http://www.blackwell-synergy.com/Journals/member/institutions/processfree2.asp? contentid=ejb.1998.23&filetype=abstracts&article=25391 |
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Rossé T, Olivier R, Monney L, Rager M, Conus S, Fellay I, Jansen B, Borner C. Bcl-2 prolongs cell survival after Bax-induced release of cytochrome c. Nature 1998 Jan 29;391(6666):496-9. Pubmed9461218 |
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1997 |
Weinstein IB, Kahn SM, O'Driscoll K, Borner C, Bang D, Jiang W, Blackwood A, Nomoto K. The role of protein kinase C in signal transduction, growth control and lipid metabolism. Adv Exp Med Biol 1997;400A:313-21. Pubmed9547573 |
Ye Q, Wei Y, Fischer R, Borner C, Berchtold MW. Expression of calmodulin and calmodulin binding proteins in rat fibroblasts stably transfected with protein kinase C and oncogenes. Biochim Biophys Acta 1997 Oct 30;1359(1):89-96. Pubmed9398089 |
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Olivier R, Otter I, Monney L, Wartmann M, Borner C. Bcl-2 does not require Raf kinase activity for its death-protective function. Biochem J 1997 May 15;324 ( Pt 1):75-83 http://www.biochemj.org/bj//324/0075/bj3240075.htm |
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Pourzand C, Rossier G, Reelfs O, Borner C, Tyrrell RM. Overxpression of Bcl-2 inhibits UVA-mediated immediate apoptosiinrat 6 fibroblasts: evidence for the involvement of Bcl-2 as an antioxidant. Cancer Res 1997 Apr 15;57(8):1405-11. Pubmed9108435 |
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1996 |
Borner C. Diminished cell proliferation associated with the death-protective activity of Bcl-2. J Biol Chem 1996 May 31;271(22):12695-8 http://www.jbc.org/cgi/content/full/271/22/12695 |
Zhang J, Alter N, Reed JC, Borner C, Obeid LM, Hannun YA. Bcl-2 interrupts the ceramide-mediated pathway of cell death. Proc Natl Acad Sci U S A 1996 May 28;93(11):5325-8 http://www.pnas.org/cgi/reprint/93/11/5325 |
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Monney L, Otter I, Olivier R, Ravn U, Mirzasaleh H, Fellay I, Poirier GG, Borner C. Bcl-2 overexpression blocks activation of the death protease CPP32/Yama/apopain. Biochem Biophys Res Commun 1996 Apr 16;221(2):340-5. Pubmed8619857 |
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1995 |
Schröter M, Lowin B, Borner C, Tschopp J. Regulation of Fas(Apo-1/CD95)- and perforin-mediated lytic pathways of primary cytotoxic T lymphocytes by the protooncogene bcl-2. Eur J Immunol 1995 Dec;25(12):3509-13. Pubmed8566045 |
Borner C, Ueffing M, Jaken S, Parker PJ, Weinstein IB. Two closely related isoforms of protein kinase C produce reciprocal effects on the growth of rat fibroblasts. Possible molecular mechanisms. J Biol Chem 1995 Jan 6;270(1):78-86 http://www.jbc.org/cgi/content/full/270/1/78 |
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1994 |
Kahn SM, O'Driscoll KR, Jiang W, Borner C, Xu DB, Blackwood MA, Zhang YJ, Nomoto K, Weinstein IB. Suppression of mitogenic activity by stable expression of the regulatory domain of PKC beta. Carcinogenesis 1994 Dec;15(12):2919-25. Pubmed8001256 |
Borner C, Olivier R, Martinou I, Mattmann C, Tschopp J, Martinou JC. Dissection of functional domains in Bcl-2 alpha by site-directed mutagenesis. Biochem Cell Biol 1994 Nov-Dec;72(11-12):463-9. Pubmed7654319 |
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Borner C, Martinou I, Mattmann C, Irmler M, Schaerer E, Martinou JC, Tschopp J. The protein bcl-2 alpha does not require membrane attachment, but two conserved domains to suppress apoptosis. J Cell Biol 1994 Aug;126(4):1059-68. Pubmed8051205 |
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1993 |
Peitsch MC, Borner C, Tschopp J. Sequence similarity of phospholipase A2 activating protein and the G protein beta-subunits: a new concept of effector protein activation in signal transduction? Trends Biochem Sci 1993 Aug;18(8):292-3. Pubmed8236442 |
Fabbro, D. & Borner, C. (1993) Protein kinase C. Human protein data EMBL (A. Haeberli, ed.) VHC Verlags GmBH, Weinheim |
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Weinstein, I. B., Borner, C., Guadagno Nichols, S., O'Driscoll, K., Cacace, A. & Fabbro, D. (1993) The roles of specific isoforms of protein kinase C (PKC) in growth control, oncogene-induced cell transformation, and differentiation (Review) In: The pharmacology of cell differentiation. R. A. Rifkind (ed.); Elsevier Science Publishers, B. V., pp. 15-23. |
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Kahn, S. M., O'Driscoll, K., Borner, C., Bang, D., Jiang, W., Blackwood, A., Nomoto, K. & Weinstein, I. B. (1993) Inhibition of diacylglycerol production in rat 6 cells that stably express only the regulatory domain of protein kinase CbI. In: Advances in polyunsaturated fatty acid research. T. Yasugi, H. Nakamura, and M. Soma (eds.); Elsevier Science Publishers, B. V., pp. 45-50. |
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1992 |
Borner C, Guadagno Nichols S, Fabbro D, Weinstein IB. Expression of four protein kinase C isoforms in rat fibroblasts. I. Distinct subcellular distribution and regulation by calcium and phorbol esters. J Biol Chem 1992 Jun 25;267(18):12892-9. Pubmed1618787 |
Borner C, Guadagno Nichols S, Hsiao WW, Fabbro D, Barr M, Weinstein IB. Expression of four protein kinase C isoforms in rat fibroblasts. II. Differential alterations in ras-, src-, and fos-transformed cells. J Biol Chem 1992 Jun 25;267(18):12900-10. Pubmed1618788 |
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Tulchin N, Ornstein L, Harpaz N, Guillem J, Borner C, O'Toole K. c-myc protein distribution. Neoplastic tissues of the human colon. Am J Pathol 1992 Mar;140(3):719-29. Pubmed1372161 |
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Guadagno Nichols S, Borner C, Weinstein IB. Altered regulation of a major substrate of protein kinase C in rat 6 fibroblasts overproducing PKC beta I. J Biol Chem 1992 Feb 5;267(4):2697-707. Pubmed1370830 |
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Fabbro D, Küng W, Costa SD, Borner C, Regenass U, Eppenberger U. Involvement of protein kinase C in the growth regulation of human breast cancer cells. Cancer Treat Res 1992;61:229-48. Pubmed1360235 |
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Borner, C. & Fabbro, D. (1992) PKC and Cellular Transformation (Review) In: Protein kinase C: Current concepts and perspectives. R. Epand and D. Lester (eds.); Ellis Horwood Publisher, Sussex, England, pp. 296-352. |
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O'Driscoll, K. R., Kahn, S. M., Borner, C. M., Jiang, W. & Weinstein, I. B. (1992) Studies on the role of protein kinase C in multistage carcinogenesis and their relevance to risk extrapolation (Review). In: Oncogene and transgenic correlates of cancer risk assessments. C. Zervos (ed.); Plenum Press, New York, pp. 43-59. |
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1991 |
Borner C, Filipuzzi I, Weinstein IB, Imber R. Failure of wild-type or a mutant form of protein kinase C-alpha to transform fibroblasts. Nature 1991 Sep 5;353(6339):78-80. Pubmed1881450 |
Fabbro, D., Küng, W., Costa, S. D., Borner, C., Regenass, U. & Eppenberger, U. (1991) Involvement of protein kinase C in the growth regulation of human breast cancer cells. In: Genes, Oncogenes, and Hormones: Advances in Cellular and Molecular Biology of Breast Cancer. R. B. Dickson & M. E. Lippman (eds.); Kluwer Academic Publishers, Boston, pp. 229-248. |
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1990 |
Borner C, Guadagno Nichols S, Hsieh LL, Hsiao WL, Weinstein IB. Transformation by a ras oncogene causes increased expression of protein kinase C-alpha and decreased expression of protein kinase C-epsilon. Cell Growth Differ 1990 Dec;1(12):653-60. Pubmed2288879 |
Rotenberg SA, Krauss RS, Borner CM, Weinstein IB. Characterization of a specific form of protein kinase C overproduced by a C3H 10T1/2 cell line. Biochem J 1990 Feb 15;266(1):173-8. Pubmed2310371, Portland Press |
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Krauss RS, Housey GM, Hsiao WL, Johnson MK, Rotenberg SA, Borner CM, Weinstein IB. The role of protein kinase C in signal transduction and cellular transformation. Prog Clin Biol Res 1990;340D:175-82, Review. Pubmed2196578 |
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Weinstein IB, Borner C, Krauss R, O'Driscoll K, Choi P, Moritomi M, Hoshina S, Hsieh L-L, Tchou-Wong K-M, Guadagno Nichols S, Ueffing M, Guillem J. Pleiotropic effects of protein kinase C and the concept of carcinogenesis as a progressive disorder in signal transduction. Adv in Second Messenger and Phosphoprotein Res 1990; 26:182-96. |
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Kahn SM, Jiang W, Borner C, O'Driscoll K, Weinstein IB. Construction of defined deletion mutants by thermal cycled fusion: Applications to protein kinase C. Technique 1990; 2:27-30. |
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1989 |
Borner C, Filipuzzi I, Wartmann M, Eppenberger U, Fabbro D. Biosynthesis and posttranslational modifications of protein kinase C in human breast cancer cells. J Biol Chem 1989 Aug 15;264(23):13902-9. Pubmed2474538 |
1988 |
Borner C, Eppenberger U, Wyss R, Fabbro D. Continuous synthesis of two protein-kinase-C-related proteins after down-regulation by phorbol esters. Proc Natl Acad Sci U S A 1988 Apr;85(7):2110-4. Pubmed3353368 |
Fabbro D, Mazurek N, Borner C, Conscience JF, Erne P. Role of protein kinase C (PKC) in short- and long-term cellular responses: inhibition of agonist-mediated calcium transients and down-regulation of PKC. J Cardiovasc Pharmacol 1988;12 Suppl 5:S73-9. Pubmed2469882 |
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1987 |
Borner C, Wyss R, Regazzi R, Eppenberger U, Fabbro D. Immunological quantitation of phospholipid/Ca2+-dependent protein kinase of human mammary carcinoma cells: inverse relationship to estrogen receptors. Int J Cancer 1987 Sep 15;40(3):344-8. Pubmed3623717 |
Wyss R, Fabbro D, Regazzi R, Borner C, Takahashi A, Eppenberger U. Phorbol ester and epidermal growth factor receptors in human breast cancer. Anticancer Res 1987 Jul-Aug;7(4B):721-7. Pubmed3499860 |
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Mazurek N, Regazzi R, Borner C, Wyss R, Conscience JF, Erne P, Eppenberger U, Fabbro D. Altered protein kinase C in a mast cell variant defective in exocytosis. Proc Natl Acad Sci U S A 1987 Mar;84(5):1277-81. Pubmed3493490 |
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Erne P, Mazurek N, Borner C, Conscience JF, Eppenberger U, Fabbro D. Translocation of protein kinase C is not required to inhibit the antigen-induced increase of cytosolic calcium in a mast cell line. Biochem Biophys Res Commun 1987 Feb 27;143(1):252-9. Pubmed3103618 |
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Fabbro D, Regazzi R, Costa SD, Borner C, Eppenberger U. Protein kinase C desensitization by phorbol esters and its impact on growth of human breast cancer cells. Year Book of Cancer 1987; 545-546. |
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1986 |
Regazzi R, Fabbro D, Costa SD, Borner C, Eppenberger U. Effects of tumor promoters on growth and on cellular redistribution of phospholipid/Ca2+-dependent protein kinase in human breast cancer cells. Int J Cancer 1986 May 15;37(5):731-7. Pubmed3084390 |
Fabbro D, Regazzi R, Costa SD, Borner C, Eppenberger U. Protein kinase C desensitization by phorbol esters and its impact on growth of human breast cancer cells. Biochem Biophys Res Commun 1986 Feb 26;135(1):65-73. Pubmed3513765 |
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Fabbro, D., Wyss, R., Borner, C. & Regazzi, R. (1986) Epidermal growth factor receptor and calcium/phospholipid-dependent protein kinase activities in human mammary tumor cells. In: S. Eckhardt, J. H. Holzner, G. A. Nagel (eds.); Contributions to Oncology: Endocrine Therapy of Breast Cancer 23, 33-44, Karger, Basel. |
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1998 |
Borner, C., Monney, L., Olivier, R., Rossé, T., Conus, S. and Fellay, I. (1998) Bcl-2 and Bax: the "good" and the "bad" for cell survival. On behalf of the international STCS meeting on "Life and Death of a Cell", Sept 17-18, 1998, Fribourg, Switzerland Anticancer Res 18, 4521. |
Borner, C., Olivier, R., Otter, I., Jansen, B., Poirier, G. G., and Monney, L. (1998) Role of an acidic compartment in TNF-a-induced production of ceramide, activation of caspase-3 (CPP32) and apoptosis. On behalf of the Annual Swiss Cancer Meeting, 28.8.97, St. Gallen, Switzerland, in"Recent Results in Cancer Research", Springer Publisher. |
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Conus, S., Fellay, I., Otter, I., Rossé, T., Wartmann, M. & Borner, C. (1998) Bcl-2 does not readily form homodimers. On behalf of the international STCS meeting on "Life and Death of a Cell", Sept 17-18, 1998, Fribourg, Switzerland Anticancer Res 18, 4524. |
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Häcki, J., Monney, L., Conus, S., Rossé, T., Olivier, R., Baggiolini, M. & Borner, C. (1998) Loss of procaspase-3 in response to the caspase inhibitor z-VAD-fmk. On behalf of the international STCS meeting on "Life and Death of a Cell", Sept 17-18, 1998, Fribourg, Switzerland Anticancer Res 18, 4533. |
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Pourzand, C., Borner, C. & Tyrell, R. M. (1998) Iron does not play a role in UVA-mediated immediate apoptosis in rat R6 fibroblasts. On behalf of the international STCS meeting on "Life and Death of a Cell", Sept 17-18, 1998, Fribourg, Switzerland Anticancer Res 18, 4548. |
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Schlagbauer-Wadl, H., Wacheck, V., Borner, C., Fink, D., Mensik, C., Eichler, H.-G.,Wolff, K., Pehamberger, H. & Jansen, B. (1998) Bcl-2 mediates chemoresistance in human melanoma. On behalf of the international STCS meeting on "Life and Death of a Cell", Sept 17-18, 1998, Fribourg, Switzerland Anticancer Res 18, 4552-4553. |
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Schlagbauer-Wadl, H., Wacheck, V., Borner, C., Fink, D., Mensik, C., Eichler, H.-G.,Wolff, K., Pehamberger, H. & Jansen, B. (1998) Bcl-2 mediates chemoresistance in human melanoma. On behalf of the international STCS meeting on "Life and Death of a Cell", Sept 17-18, 1998, Fribourg, Switzerland Anticancer Res 18, 4552-4553. |
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Wacheck, V., Selzer, E., Mayer, B., Schlagbauer-Wadl, H., Borner, C., Wolff, K., Pehamberger, D., Eichler, H.-G. & Jansen, B. (1998) Selective blockage of apoptosis pathways by Bcl-2. On behalf of the international STCS meeting on "Life and Death of a Cell", Sept 17-18, 1998, Fribourg, Switzerland Anticancer Res 18, 4561-4562. |
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Grandgirard, D., Studer, E., Monney, L., Fellay, I., Belser, T., Borner, C. & Michel, M. R. (1998) Regulation of alphavirus-induced death by Bcl-2. On behalf of the international STCS meeting on "Life and Death of a Cell", Sept 17-18, 1998, Fribourg, Switzerland Anticancer Res 18, 4531. |
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1996 |
Borner, C. (1996) A lysosomal component required for cell death induced by tumor necrosis factor a. 28th Annual Meeting of the Swiss Society of Experimental Biology (USGEB), March 27-29, 1996, Zürich-Irchel Experientia 52, p. A79, Birkhäuser. |
Monney, L., and Borner, C. (1996) Bcl-2 protects from cell death induced by a toxic overload of aberrant protein. 28th Annual Meeting of the Swiss Society of Experimental Biology (USGEB), March 27-29, 1996, Zürich-Irchel Experientia 52, p. A79, Birkhäuser. |
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Olivier, R., Martinou, I., Martinou, J.-C., and Borner, C. (1996) Chimera between Bcl-2 and Bax: a tool to dissect domains for survival and death. 28th Annual Meeting of the Swiss Society of Experimental Biology (USGEB), March 27-29, 1996, Zürich-Irchel Experientia 52, p. A79, Birkhäuser. |
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Otter, I., and Borner, C. (1996) Analysis of proteins that bind to Bcl-2 during apoptotic stresses. 28th Annual Meeting of the Swiss Society of Experimental Biology (USGEB), March 27-29, 1996, Zürich-Irchel Experientia 52, p. A79, Birkhäuser. |
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Otter, I., and Borner, C. (1996) Analysis of proteins that bind to Bcl-2 during apoptotic stresses. The life and death of a cell, 4th IUBMB Conference, Edinburgh, July 14-17, 1996 Biochemical Society Transactions 24, p. 600S |
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Wartmann, M., Olivier, R., Otter, I., Monney, L., and Borner, C. (1996) Bcl-2 confers cell death protection via a R-ras- and Raf-independent pathway. The life and death of a cell, 4th IUBMB Conference, Edinburgh, July 14-17, 1996 Biochemical Society Transactions 24, p. 598S |
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1995 |
Borner, C. (1995) Bcl-2 slows down the proliferation of eukaryotic and prokaryotic cells. 27th Annual Meeting of the Swiss Society of Experimental Biology (USGEB), March 30 & 31, 1995, Fribourg Experientia 51, p. A88, Birkhäuser. |
Favre, D. & Borner, C. (1995) Impact of the survival factor Bcl-2 on protein turnover. 27th Annual Meeting of the Swiss Society of Experimental Biology (USGEB), March 30 & 31, 1995, Fribourg Experientia 51, p. A88, Birkhäuser. |
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Olivier, R., Otter, I., and Borner, C. (1995) The interaction of Bcl-2 with the raf-signalling pathway. 27th Annual Meeting of the Swiss Society of Experimental Biology (USGEB), March 30 & 31, 1995, Fribourg Experientia 51, p. A88, Birkhäuser. |
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Otter, I., and Borner, C. (1995) Identification of proteins which interact with the survival factor Bcl-2. 27th Annual Meeting of the Swiss Society of Experimental Biology (USGEB), March 30 & 31, 1995, Fribourg Experientia 51, p. A88, Birkhäuser. |
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1994 |
Borner, C., Martinou, I., Mattmann, C., Imber, M., Schaerer, E., Martinou,J.-C. & Tschopp, J. (1994) Bcl-2 does not require membrane attachment for its survival activity. 26th Annual Meeting of the Swiss Society of Experimental Biology (USGEB), March 17 & 18, 1994, Bern. Experientia 50, p. A3, Birkhäuser. |
1993 |
Borner, C., Ueffing, M. & Weinstein. I. B. (1993) Opposing impact of two PKC isoforms on cell growth and transformation. In: Keystone Symposia on Molecular and Cellular Biology, J. Cellular Biochemistry, Supplement 17A, p. 264. |
1992 |
Borner, C., Guadagno Nichols, S., Fabbro, D., Hsiao, W., Barr, M. & Weinstein, I. B. (1992) Expression of PKC isoforms in rat fibroblasts. 24th Annual Meeting of the Swiss Society of Experimental Biology (USGEB), March 19 & 20, 1992, Basle. Experientia 48, p. A30, Birkhäuser. |
1991 |
Borner, C., Guadagno Nichols, S., Hsiao, W.-W. L. & Weinstein, I. B. (1991) Increased expression of PKCa and decreased expression of PKCe in cells transformed by ras, fos or src oncogenes. In: UCLA Symposia on Molecular and Cellular Biology, J. Cellular Biochemistry, Supplement 15B, p. 148. |
Guadagno, S. N., Borner, C., & Weinstein. I. B. (1991) Regulation of the MARCKS protein in cell lines which overexpress PKCbI. In: UCLA Symposia on Molecular and Cellular Biology, J. Cellular Biochemistry, Supplement 15B, p. 163 |
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Gazetas, P., Borner, C., Ueffing, M., Pocsidio, J., Logerfo, P. & Weinstein, I. B. (1991) Elevated levels of PKA activity in human breast cancer. In: UCLA Symposia on Molecular and Cellular Biology, J. Cellular Biochemistry, Supplement 15B, p. 154 |
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O'Driscoll, K., Kahn, S. M., Borner, C., Jiang, W. & Weinstein, I. B. (1991) Stable expression of regulatory domain deletion mutants of PKCbI in rat fibroblasts. In: UCLA Symposia on Molecular and Cellular Biology, J. Cellular Biochemistry, Supplement 15B, p. 163 |
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Fabbro, D., Wolf, M., Filipuzzi, I., Borner, C., Imber, R., Meyer, T. & Matter, A. (1991) Effects of staurosporine and derivatives on PKC. In: UCLA Symposia on Molecular and Cellular Biology, J. Cellular Biochemistry, Supplement 15B, p. 152 |
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1990 |
Borner, C., Nichols, S., Hsieh, L. L., Hsiao, W.-L.W. & Weinstein, I. B. (1990) Differential expression of protein kinase C isoforms during multistep carcinogenesis. In: UCLA Symposia on Molecular and Cellular Biology, J. Cellular Biochemistry, Supplement 14B, p. 285. |
1988 |
Borner, C., Filipuzzi, I., Eppenberger, U. & Fabbro, D. (1988) Biosynthesis and posttranslational modifications of protein kinase C in human breast cancer cells. 20th Annual Meeting of the Swiss Society for Experimental Biology (USGEB), March 10 & 11, Interlaken. Experientia 44, p. A1-A98, Birkhäuser |
1986 |
Fabbro, D., Regazzi, R., Costa, S. D., Borner, C. & Eppenberger, U. (1986) Protein kinase C desensitization by phorbol esters and its impact on growth of human breast cancer cells. 1st International Congress on Cancer and Hormones, Endocrinology and Malignancy, Basic and Clinical Issue, April 22-27, Rome, Italy. Anticancer Res 6 (3), part A |
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1998 |
Mort cellulaire: découverte à Fribourg. Le Nouveau Quotidien, 3.2.98, text by press communication |
Mort des cellules: une découverte à Fribourg. La Gruyère, 3.2.98, text by press communication | |
Universität Freiburg: Wie sterben Zellen? Freiburger Nachrichten, 3.2.98, text by press communication | |
Université: La mort des cellules est mieux comprise. La Liberté, 3.2.98, text by press communication | |
Sterben, um leben zu koennen: Journal Universitas Friburgensis, 3/98, text by Christoph Borner | |
A l'Université, des biochimistes cernent le mystère des cellules immortelles et au péril de l'organisme, des cellules refusent de mourir. Pourquoi? La Liberté, 26.3.98, text by Jean Ammann, journalist |
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Vos lettres, Recherche contre le cancer (pour le combat de l'initiative sur le génie génétique). La Liberté, 25.4.98, text by Christoph Borner | |
Fribourg, 300 chercheurs de 21 pays vont parler de la mort de la cellule. Captivant. La Liberté, 16.9.98, text by Pierre-André Sieber, journalist | |
Universität: Kolloquium zum Zelltod. Freiburger Nachrichten, 18.9.98, text by press communication | |
Cellules: mourir pour que l'organisme puisse vivre. Le Journal du Cancer de la Ligue Suisse Contre le Cancer, Oct 1998. text by Christiane Kuhn, journalist | |
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1998 | Interview about the article "Bcl-2 prolongs cell survival after Bax-induced release of cytochrome c Nature , 391, 496-499" in the french-speaking and german-speaking local radios of Fribourg/Freiburg. January 29, 1998 |
Interview about "Est-ce que vous voulez devenir 120 ans?" in the local Fribourg radio "Radio de quartier". September 26, 1998 |
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