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Veröffentlichungen Prof. Peters

Molekulare Medizin - AG Biniossek, Massenspektrometrie - Peptidanalytik und Proteinanalytik (Proteomics) - Publikationen
2017 Hettmer S, Andrieux G, Hochrein J, Kurz P, Rössler J, Lassmann S, Werner M, von Bubnoff N, Peters C, Koscielniak E, Sparber-Sauer M, Niemeyer C, Mentzel T, Busch H, Boerries M. Epithelioid hemangioendotheliomas of the liver and lung in children and adolescents. Pediatr Blood Cancer. 2017 Jun 9. doi: 10.1002/pbc.26675. Pubmed28598585 [Epub ahead of print]
2016 Gomez-Auli A, Hillebrand LE, Biniossek ML, Peters C, Reinheckel T, Schilling O. Impact of cathepsin B on the interstitial fluid proteome of murine breast cancers. Biochimie. 2016 Mar;122:88-98. doi: 10.1016/j.biochi.2015.10.009. Epub 2015 Oct 8. Pubmed26455267
2015 Okada R, Wu Z, Zhu A, Ni J, Zhang J, Yoshimine Y, Peters C, Saftig P, Nakanishi H. Cathepsin D deficiency induces oxidative damage in brain pericytes and impairs the blood-brain barrier. Mol Cell Neurosci.2015 Jan;64:51-60. doi: 10.1016/j.mcn.2014.12.002. Epub 2014 Dec 10. PMID: 25496868
2014 Akkari L, Gocheva V, Kester JC, Hunter KE, Quick ML, Sevenich L, Wang HW, Peters C, Tang LH, Klimstra DS, Reinheckel T, Joyce JA. Distinct functions of macrophage-derived and cancer cell-derived cathepsin Z combine to promote tumor malignancy via interactions with the extracellular matrix. Genes Dev. 2014 Oct 1;28(19):2134-50. doi: 10.1101/gad.249599.114. Pubmed25274726
  Tamhane T, Arampatzidou M, Gerganova V, Tacke M, Illukkumbura R, Dauth S, Schaschke N, Peters C, Reinheckel T, Brix K. The activity and localization patterns of cathepsins B and X in cells of the mouse gastrointestinal tract differ along its length. Biol Chem. 2014 Oct 1;395(10):1201-19. doi: 10.1515/hsz-2014-0151. PMID: 25205730
  Bengsch F, Buck A, Günther SC, Seiz JR, Tacke M, Pfeifer D, von Elverfeldt D, Sevenich L, Hillebrand LE, Kern U, Sameni M, Peters C, Sloane BF, Reinheckel T. Cell type-dependent pathogenic functions of overexpressed human cathepsin B in murine breast cancer progression. Oncogene. 2014 Sep 4;33(36):4474-84. doi: 10.1038/onc.2013.395. Epub 2013 Sep 30. Pubmed24077280
  Hayashi Y, Koga Y, Zhang X, Peters C, Yanagawa Y, Wu Z, Yokoyama T, Nakanishi H. Autophagy in superficial spinal dorsal horn accelerates the cathepsin B-dependent morphine antinociceptive tolerance. Neuroscience. 2014 Sep 5;275:384-94. doi: 10.1016/j.neuroscience.2014.06.037. Epub 2014 Jun 26. Pubmed24973657
  Butinar M, Prebanda MT, Rajković J, Jerič B, Stoka V, Peters C, Reinheckel T, Krüger A, Turk V, Turk B, Vasiljeva O. Stefin B deficiency reduces tumor growth via sensitization of tumor cells to oxidative stress in a breast cancer model.Oncogene. 2014 Jun 26;33(26):3392-400. doi: 10.1038/onc.2013.314. Epub 2013 Aug 19. Pubmed23955077
  Müller S, Faulhaber A, Sieber C, Pfeifer D, Hochberg T, Gansz M, Deshmukh SD, Dauth S, Brix K, Saftig P, Peters C, Henneke P, Reinheckel T. The endolysosomal cysteine cathepsins L and K are involved in macrophage-mediated clearance of Staphylococcus aureus and the concomitant cytokine induction. FASEB J. 2014 Jan;28(1):162-75. doi: 10.1096/fj.13-232272. Pubmed24036885
2013 Ohkouchi S, Shibata M, Sasaki M, Koike M, Safig P, Peters C, Nagata S, Uchiyama Y. Biogenesis and Proteolytic Processing of Lysosomal DNase II. PLoS One. 2013;8(3):e59148. doi: 10.1371/journal.pone.0059148. Epub 2013 Mar 13. Pubmed 23516607
  Koike M, Shibata M, Ezaki J, Peters C, Saftig P, Kominami E, Uchiyama Y. Differences in expression patterns of cathepsin C/dipeptidyl peptidase I in normal, pathological and aged mouse central nervous system. Eur J Neurosci. 2013 Mar;37(5):816-30. doi: 10.1111/ejn.12096. Epub 2012 Dec 20. Pubmed23279039
2012 Unno T, Wakamori M, Koike M, Uchiyama Y, Ishikawa K, Kubota H, Yoshida T, Sasakawa H, Peters C, Mizusawa H, Watase K. Development of Purkinje cell degeneration in a knockin mouse model reveals lysosomal involvement in the pathogenesis of SCA6. Proc Natl Acad Sci U S A. 2012 Oct 23;109(43):17693-8. doi: 10.1073/pnas.1212786109. Pubmed23054835
Schurigt U, Eilenstein R, Gajda M, Leipner C, Sevenich L, Reinheckel T, Peters C, Wiederanders B, Bräuer R. Decreased arthritis severity in cathepsin L-deficient mice is attributed to an impaired T helper cell compartment. Inflamm Res. Sep;61(9):1021-9. Pubmed22674323
  Sun L, Wu Z, Hayashi Y, Peters C, Tsuda M, Inoue K, Nakanishi H. Microglial cathepsin B contributes to the initiation of peripheral inflammation-induced chronic pain. J Neurosci. 2012 Aug 15;32(33):11330-42. Pubmed22895716
  Lu WD, Funkelstein L, Toneff T, Reinheckel T, Peters C, Hook V. Cathepsin H Functions as an Aminopeptidase in Secretory Vesicles for Production of Enkephalin and Galanin Peptide Neurotransmitters. J Neurochem. 2012 Aug;122(3):512-22. doi: 10.1111/j.1471-4159.2012.07788.x. Pubmed22582844
  Reinheckel T, Peters C, Krüger A, Turk B, Vasiljeva O. Differential Impact of Cysteine Cathepsins on Genetic Mouse Models of De novo Carcinogenesis: Cathepsin B as Emerging Therapeutic Target. Front Pharmacol. 2012;3:133. Epub 2012 Jul 11. Pubmed22798952
  Funkelstein L, Lu WD, Koch B, Mosier C, Toneff T, Taupenot L, O'Connor DT, Reinheckel T, Peters C, Hook V. Human cathepsin V protease participates in the production of enkephalin and NPY neurotransmitters. J Biol Chem. 2012May 4;287(19):15232-41. Pubmed22393040
2011 Sun J, Sukhova GK, Zhang J, Chen H, Sjöberg S, Libby P, Xiang M, Wang J, Peters C, Reinheckel T, Shi GP. Cathepsin L activity is essential to elastase perfusion-induced abdominal aortic aneurysms in mice. Arterioscler Thromb Vasc Biol. 2011 Nov;31(11):2500-8. PubMed21868704
  Bühling F, Kouadio M, Chwieralski CE, Kern U, Hohlfeld JM, Klemm N, Friedrichs N, Roth W, Deussing JM, Peters C, Reinheckel T. Gene targeting of the cysteine peptidase cathepsin h impairs lung surfactant in mice. PLoS One. 2011;6(10):e26247. Epub 2011 Oct 12. PubMed22022579
  Czibere L, Baur LA, Wittmann A, Gemmeke K, Steiner A, Weber P, Pütz B, Ahmad N, Bunck M, Graf C, Widner R, Kühne C, Panhuysen M, Hambsch B, Rieder G, Reinheckel T, Peters C, Holsboer F, Landgraf R, Deussing JM. Profiling trait anxiety: transcriptome analysis reveals cathepsin B (Ctsb) as a novel candidate gene for emotionality in mice. PLoS One. 2011;6(8):e23604. Epub 2011 Aug 29. PubMed21897848
  Mikhaylov G, Mikac U, Magaeva AA, Itin VI, Naiden EP, Psakhye I, Babes L, Reinheckel T, Peters C, Zeiser R, Bogyo M, Turk V, Psakhye SG, Turk B, Vasiljeva O. Ferri-liposomes as an MRI-visible drug-delivery system for targeting tumours and their microenvironment. Nat Nanotechnol. 2011 Aug 7;6(9):594-602.doi:10.1038/nnano. 2011.112. PubMed21822252
  Sevenich L, Werner F, Gajda M, Schurigt U, Sieber C, Müller S, Follo M, Peters C, Reinheckel T. Transgenic expression of human cathepsin B promotes progression and metastasis of polyoma-middle-T-induced breast cancer in mice. Oncogene. 2011 Jan 6;30(1):54-64. PubMed20818432.
2010 Konjar S, Sutton VR, Hoves S, Repnik U, Yagita H, Reinheckel T, Peters C, Turk V, Turk B, Trapani JA, Kopitar-Jerala N. Human and mouse perforin are processed in part through cleavage by the lysosomal cysteine proteinase cathepsin L. Immunology. 2010 Oct;131(2):257-67. Pubmed20497254
  Sun L, Wu Z, Baba M, Peters C, Uchiyama Y, Nakanishi H. Cathepsin B-dependent motor neuron death after nerve injury in the adult mouse. Biochem Biophys Res Commun. 2010 Aug 27;399(3):391-5. Pubmed20673755
  Dennemärker J, Lohmüller T, Müller S, Aguilar SV, Tobin DJ, Peters C, Reinheckel T. Impaired turnover of autophagolysosomes in cathepsin L deficiency. Biol Chem. 2010 Aug;391(8):913-22. Pubmed20536383
  Gocheva V, Chen X, Peters C, Reinheckel T, Joyce JA. Deletion of cathepsin H perturbs angiogenic switching, vascularization and growth of tumors in a mouse model of pancreatic islet cell cancer. Biol Chem. 2010 Aug;391(8):937-45. Pubmed2031543
  D'Angelo ME, Bird PI, Peters C, Reinheckel T, Trapani JA, Sutton VR. Cathepsin H is an additional convertase of pro-granzyme B. J Biol Chem. 2010 Jul 2;285(27):20514-9. Pubmed20435891
  Sevenich L, Hagemann S, Stoeckle C, Tolosa E, Peters C, Reinheckel T. Expression of human cathepsin L or human cathepsin V in mouse thymus mediates positive selection of T helper cells in cathepsin L knock-out mice. Biochimie. 2010 Nov;92(11):1674-80. Pubmed20347002
  Shimada N, Ohno-Matsui K, Iseki S, Koike M, Uchiyama Y, Wang J, Yoshida T, Sato T, Peters C, Mochizuki M, Morita I. Cathepsin L in bone marrow-derived cells is required for retinal and choroidal neovascularization. Am J Pathol. 2010 May;176(5):2571-80. Epub 2010 Mar 19. Pubmed20304958
  Matthews SP, Werber I, Deussing J, Peters C, Reinheckel T, Watts C. Distinct protease requirements for antigen presentation in vitro and in vivo. J Immunol. 2010 Mar 1;184(5):2423-31. Pubmed20164435
  Wartmann T, Mayerle J, Kähne T, Sahin-Tóth M, Ruthenbürger M, Matthias R, Kruse A, Reinheckel T, Peters C, Weiss FU, Sendler M, Lippert H, Schulz HU, Aghdassi A, Dummer A, Teller S, Halangk W, Lerch MM. Cathepsin L inactivates human trypsinogen, whereas cathepsin L-deletion reduces the severity of pancreatitis in mice. Gastroenterology. 2010 Feb;138(2):726-37. Pubmed19900452
  Sevenich L, Schurigt U, Sachse K, Gajda M, Werner F, Müller S, Vasiljeva O, Schwinde A, Klemm N, Deussing J, Peters C, Reinheckel T. Synergistic antitumor effects of combined cathepsin B and cathepsin Z deficiencies on breast cancer progression and metastasis in mice. Proc Natl Acad Sci U S A. 2010 Feb 9;107(6):2497-502. Pubmed20133781
  Minokadeh A, Funkelstein L, Toneff T, Hwang SR, Beinfeld M, Reinheckel T, Peters C, Zadina J, Hook V. Cathepsin L participates in dynorphin production in brain cortex, illustrated by protease gene knockout and expression. Mol Cell Neurosci. 2010 Jan;43(1):98-107. Pubmed19837164
  Terada K, Yamada J, Hayashi Y, Wu Z, Uchiyama Y, Peters C, Nakanishi H. Involvement of cathepsin B in the processing and secretion of interleukin-1beta in chromogranin A-stimulated microglia. Glia. 2010 Jan 1;58(1):114-24. Pubmed19544382
  Dennemärker J, Lohmüller T, Mayerle J, Tacke M, Lerch MM, Coussens LM, Peters C, Reinheckel T. Deficiency for the cysteine protease cathepsin L promotes tumor progression in mouse epidermis.Oncogene. 2010 Mar 18;29(11):1611-21. Pubmed20023699
2009 Xiao K, Jehle F, Peters C, Reinheckel T, Schirmer RH, Dandekar T. CA/C1 peptidases of the malaria parasites Plasmodium falciparum and P. berghei and their mammalian hosts--a bioinformatical analysis. Biol Chem. 2009 Nov;390(11):1185-97. Pubmed19663681
  Sugita S, Horie S, Nakamura O, Maruyama K, Takase H, Usui Y, Takeuchi M, Ishidoh K, Koike M, Uchiyama Y, Peters C, Yamamoto Y, Mochizuki M. Acquisition of T regulatory function in cathepsin L-inhibited T cells by eye-derived CTLA-2alpha during inflammatory conditions. J Immunol. 2009 Oct 15;183(8):5013-22. Pubmed19801522
  Beinfeld MC, Funkelstein L, Foulon T, Cadel S, Kitagawa K, Toneff T, Reinheckel T, Peters C, Hook V. Cathepsin L plays a major role in cholecystokinin production in mouse brain cortex and in pituitary AtT-20 cells: protease gene knockout and inhibitor studies. Peptides. 2009 Oct;30(10):1882-91. Pubmed19589362
  Hook VY, Kindy M, Reinheckel T, Peters C, Hook G. Genetic cathepsin B deficiency reduces beta-amyloid in transgenic mice expressing human wild-type amyloid precursor protein. Biochem Biophys Res Commun. 2009 Aug 21;386(2):284-8. Pubmed19501042
  Vreemann A, Qu H, Mayer K, Andersen LB, Stefana MI, Wehner S, Lysson M, Farcas AM, Peters C, Reinheckel T, Kalff J, Brix K. Cathepsin B release from rodent intestine mucosa due to mechanical injury results in extracellular matrix damage in early post-traumatic phases.Biol Chem. 2009 May-Jun;390(5-6):481-92. Pubmed19335208
  Wilson SR, Peters C, Saftig P, Brömme D. Cathepsin K activity-dependent regulation of osteoclast actin ring formation and bone resorption. J Biol Chem. 2009 Jan 23;284(4):2584-92. Pubmed19028686
2008 Funkelstein L, Toneff T, Mosier C, Hwang SR, Beuschlein F, Lichtenauer UD, Reinheckel T, Peters C, Hook V. Major Role of Cathepsin L for Producing the Peptide Hormones ACTH, {beta}-Endorphin, and {alpha}-MSH, Illustrated by Protease Gene Knockout and Expression. J BiolChem. 2008 Dec19; 283(51):356529. Pubmed18849346
  Funkelstein L, Toneff T, Hwang SR, Reinheckel T, Peters C, Hook V. Cathepsin L participates in the production of neuropeptide Y in secretory vesicles, demonstrated by protease gene knockout and expression. J Neurochem. 2008 Jul;106(1):384-91. Pubmed18410501
  Vasiljeva O, Korovin M, Gajda M, Brodoefel H, Bojic L, Krüger A, Schurigt U, Sevenich L, Turk B, Peters C, Reinheckel T. Reduced tumour cell proliferation and delayed development of high-grade mammary carcinomas in cathepsin B-deficient mice. Oncogene. 2008 Jul 10;27(30):4191-9. Pubmed18345026
  Reinheckel, T., Gocheva, V., Peters, C., Joyce, J.A.: Roles of Cysteine Proteases in Tumor Progression: Analysis of Cysteine Cathepsin Knockout Mice in Cancer Models. In: D. Edwards et al. (eds.): The Cancer Degradome, Springer Science, cap. 15. 2008 / Buchbeitrag
2007 Bojic L, Petelin A, Stoka V, Reinheckel T, Peters C, Turk V, Turk B. Cysteine cathepsins are not involved in Fas/CD95 signalling in primary skin fibroblasts. FEBS Lett. 2007 Nov 13;581(27):5185-90. Pubmed1950288
  Spira D, Stypmann J, Tobin DJ, Petermann I, Mayer C, Haggemann S, Vasiljeva O, Günther T, Schüle R, Peters C, Reinheckel T. Cell type-specific functions of the lysosomal protease cathepsin L in the heart. J Biol Chem. 2007 Oct 17. Pubmed17942402
  Yamasaki R, Zhang J, Koshiishi I, Sastradipura Suniarti DF, Wu Z, Peters C, Schwake M, Uchiyama Y, Kira J, Saftig P, Utsumi H, Nakanishi H. Involvement of lysosomal storage-induced p38 MAP kinase activation in the overproduction of nitric oxide by microglia in cathepsin D-deficient mice.Mol Cell Neurosci. 2007 Aug;35(4):573-84. Pubmed17570679
  Kitamoto S, Sukhova GK, Sun J, Yang M, Libby P, Love V, Duramad P, Sun C, Zhang Y, Yang X, Peters C, Shi GP. Cathepsin L deficiency reduces diet-induced atherosclerosis in low-density lipoprotein receptor-knockout mice. Circulation. 2007 Apr 17;115(15):2065-75. Epub 2007 Apr 2. Pubmed17404153
  Vasiljeva O, Reinheckel T, Peters C, Turk D, Turk V, Turk B. Emerging roles of cysteine cathepsins in disease and their potential as drug targets. Curr Pharm Des. 2007;13(4):387-403. Pubmed17311556
2006 Baran K, Ciccone A, Peters C, Yagita H, Bird PI, Villadangos JA, Trapani JA. Cytotoxic T lymphocytes from cathepsin B-deficient mice survive normally in vitro and in vivo after encountering and killing target cells. J Biol Chem. 2006 Oct 13;281(41):30485-91. Pubmed16914553
  Everts V, Korper W, Hoeben KA, Jansen ID, Bromme D, Cleutjens KB, Heeneman S, Peters C, Reinheckel T, Saftig P, Beertsen W. Osteoclastic bone degradation and the role of different cysteine proteinases and matrix metalloproteinases: differences between calvaria and long bone. J Bone Miner Res. 2006 Sep;21(9):1399-408. Pubmed16939398
  Sevenich L, Pennacchio LA, Peters C, Reinheckel T. Human cathepsin L rescues the neurodegeneration and lethality in cathepsin B/L double-deficient mice. Biol Chem. 2006 Jul;387(7):885-91. Pubmed16913838
  Petermann I, Mayer C, Stypmann J, Biniossek ML, Tobin DJ, Engelen MA, Dandekar T, Grune T, Schild L, Peters C, Reinheckel T. Lysosomal, cytoskeletal, and metabolic alterations in cardiomyopathy of cathepsin L knockout mice. FASEB J. 2006 Jun;20(8):1266-8. Pubmed16636100
  Vasiljeva O, Papazoglou A, Kruger A, Brodoefel H, Korovin M, Deussing J, Augustin N, Nielsen BS, Almholt K, Bogyo M, Peters C, Reinheckel T. Tumor cell-derived and macrophage-derived cathepsin B promotes progression and lung metastasis of mammary cancer. Cancer Res. 2006 May 15;66(10):5242-50. Pubmed16707449
  Gocheva V, Zeng W, Ke D, Klimstra D, Reinheckel T, Peters C, Hanahan D, Joyce JA. Distinct roles for cysteine cathepsin genes in multistage tumorigenesis. Genes Dev. 2006 Mar 1;20(5):543-56. Pubmed16481467
2005 Reinheckel T, Hagemann S, Dollwet-Mack S, Martinez E, Lohmuller T, Zlatkovic G, Tobin DJ, Maas-Szabowski N, Peters C. The lysosomal cysteine protease cathepsin L regulates keratinocyte proliferation by control of growth factor recycling. J Cell Sci. 2005 Aug 1;118(Pt 15):3387-95. Pubmed16079282
  Henningsson F, Yamamoto K, Saftig P, Reinheckel T, Peters C, Knight SD, Pejler G. A role for cathepsin E in the processing of mast-cell carboxypeptidase A. J Cell Sci. 2005 May 1;118(Pt 9):2035-42. Pubmed15860733
  Urbich C, Heeschen C, Aicher A, Sasaki KI, Bruhl T, Farhadi MR, Vajkoczy P, Hofmann WK, Peters C, Pennacchio LA, Abolmaali ND, Chavakis E, Reinheckel T, Zeiher AM, Dimmeler S. Cathepsin L is required for endothelial progenitor cell-induced neovascularization. Nat Med. 2005 Feb;11(2):206-13. Pubmed15665831
2004 Hagemann S, Gunther T, Dennemarker J, Lohmuller T, Bromme D, Schule R, Peters C, Reinheckel T. The human cysteine protease cathepsin V can compensate for murine cathepsin L in mouse epidermis and hair follicles. Eur J Cell Biol. 2004 Dec;83(11-12):775-80. Pubmed15679121
  Wille A, Gerber A, Heimburg A, Reisenauer A, Peters C, Saftig P, Reinheckel T, Welte T, Buhling F. Cathepsin L is involved in cathepsin D processing and regulation of apoptosis in A549 human lung epithelial cells. Biol Chem. 2004 Jul;385(7):665-70. Pubmed15318816
  Hook V, Yasothornsrikul S, Greenbaum D, Medzihradszky KF, Troutner K, Toneff T, Bundey R, Logrinova A, Reinheckel T, Peters C, Bogyo M. Cathepsin L and Arg/Lys aminopeptidase: a distinct prohormone processing pathway for the biosynthesis of peptide neurotransmitters and hormones. Biol Chem. 2004 Jun;385(6):473-80. Pubmed15255178
  Faller D, Reinheckel T, Wenzler D, Hagemann S, Xiao K, Honerkamp J, Peters C, Dandekar T, Timmer J. An open source protein gel documentation system for proteome analyses. J Chem Inf Comput Sci. 2004 Jan-Feb;44(1):168-9. Pubmed14741024
2003 Houseweart MK, Pennacchio LA, Vilaythong A, Peters C, Noebels JL, Myers RM. Cathepsin B but not cathepsins L or S contributes to the pathogenesis of Unverricht-Lundborg progressive myoclonus epilepsy (EPM1). J Neurobiol. 2003 Sep 15;56(4):315-27.
  Yasothornsrikul S, Greenbaum D, Medzihradszky KF, Toneff T, Bundey R, Miller R, Schilling B, Petermann I, Dehnert J, Logvinova A, Goldsmith P, Neveu JM, Lane WS, Gibson B, Reinheckel T, Peters C, Bogyo M, Hook V. Cathepsin L in secretory vesicles functions as a prohormone-processing enzyme for production of the enkephalin peptide neurotransmitter. Proc Natl Acad Sci U S A. 2003 Aug 5;100(16):9590-5. Pubmed12869695
  Lohmuller T, Wenzler D, Hagemann S, Kiess W, Peters C, Dandekar T, Reinheckel T. Toward computer-based cleavage site prediction of cysteine endopeptidases. Biol Chem. 2003 Jun;384(6):899-909. Pubmed12887057
2002 Nishimura F, Naruishi H, Naruishi K, Yamada T, Sasaki J, Peters C, Uchiyama Y, Murayama Y. Cathepsin-L, a key molecule in the pathogenesis of drug-induced and I-cell disease-mediated gingival overgrowth: a study with cathepsin-L-deficient mice. Am J Pathol 2002 Dec;161(6):2047-52. Pubmed12466121
  Ebert DH, Deussing J, Peters C, Dermody TS. Cathepsin L and cathepsin B mediate reovirus disassembly in murine fibroblast cells. J Biol Chem 2002 Jul 5;277(27):24609-17. Pubmed11986312
  Honey K, Nakagawa T, Peters C, Rudensky A. Cathepsin L regulates CD4+ T cell selection independently of its effect on invariant chain: a role in the generation of positively selecting peptide ligands. J Exp Med 2002 May 20;195(10):1349-58. Pubmed12021314
  Tobin DJ, Foitzik K, Reinheckel T, Mecklenburg L, Botchkarev VA, Peters C, Paus R. The lysosomal protease cathepsin L is an important regulator of keratinocyte and melanocyte differentiation during hair follicle morphogenesis and cycling. Am J Pathol 2002 May;160(5):1807-21. Pubmed12000732
  Nishioku T, Hashimoto K, Yamashita K, Liou SY, Kagamiishi Y, Maegawa H, Katsube N, Peters C, von Figura K, Saftig P, Katunuma N, Yamamoto K, Nakanishi H. Involvement of cathepsin E in exogenous antigen processing in primary cultured murine microglia. J Biol Chem 2002 Feb 15;277(7):4816-22. Pubmed11719510
  Deussing J, Kouadio M, Rehman S, Werber I, Schwinde A, Peters C. Identification and characterization of a dense cluster of placenta-specific cysteine peptidase genes and related genes on mouse chromosome 13. Genomics 2002 Feb;79(2):225-40. Pubmed11829493
  Zwad O, Kubler B, Roth W, Scharf JG, Saftig P, Peters C, Braulke T. Decreased intracellular degradation of insulin-like growth factor binding protein-3 in cathepsin L-deficient fibroblasts. FEBS Lett 2002 510(3), 211-215. Pubmed11801256
2001 Nishioku T, Hashimoto K, Yamashita K, Liou SY, Kagamiishi Y, Maegawa H, Katsube N, Peters C, von Figura K, Saftig P, Katunuma N, Yamamoto K, Nakanishi H. Involvement of cathepsin E in exogenous antigen processing in primary cultured murine microglia. J Biol Chem 2001 Nov 21. Pubmed1171951
  Honey K, Duff M, Beers C, Brissette WH, Elliott EA, Peters C, Maric M, Cresswell P, Rudensky A. (2001) Cathepsin S regulates the expression of cathepsin L and the turnover of gamma-interferon-inducible lysosomal thiol reductase in B lymphocytes. J Biol Chem 276(25), 22573-8. Pubmed11306582
  Nakanishi H, Zhang J, Koike M, Nishioku T, Okamoto Y, Kominami E, von Figura K, Peters C, Yamamoto K, Saftig P, Uchiyama Y. (2001) Involvement of nitric oxide released from microglia-macrophages in pathological changes of cathepsin D-deficient mice. J Neurosci 21(19), 7526-33. Pubmed11567042
  Reinheckel T, Deussing J, Roth W, Peters C. Towards specific functions of lysosomal cysteine peptidases: phenotypes of mice deficient for cathepsin B or cathepsin L. Biol Chem 382(5), 735-41. Pubmed11517926
2000 Deussing, J., von Olshausen, I., and Peters, C. (2000). Murine and Human Cathepsin Z: cDNA-cloning, characterization of the genes and chromosomal localization. Biochim. Biophys. Acta 1491, 93-106. Pubmed10760573
  Deussing, J., Tisljar, K., Papazoglou, A., and Peters, C. (2000). Mouse Cathepsin F: cDNA cloning, genomic organization and chromosomal assignment of the gene. Gene 251(2):165-73. Pubmed10876093
  Guicciardi, M.E., Deussing, J., Miyoshi, H., Bronk, S.F., Svingen, P.A., Peters, C., Kaufmann, S.H., and Gores, G.J. (2000) Cathepsin B contributes to TNF-alpha-mediated hepatocyte apoptosis by promoting mitochondrial release of cytochrome c. J. Clin. Invest. 106, 1127-37. Pubmed11067865
  Halangk, W., Lerch, M.M., Brandt-Nedelev, B., Roth, W., Ruthenbuerger, M., Reinheckel, T., Domschke, W., Lippert, H., Peters, C., and Deussing, J. (2000). Role of cathepsin B in intracellular trypsinogen activation and the onset of acute pancreatitis. J. Clin. Invest. 106, 773-81. Pubmed10995788
  Heinrich, M., Wickel, M., Winoto-Morbach, S., Schneider-Brachert, W., Weber, T., Brunner, J., Saftig, P., Peters, C., Krönke, M., and Schütze, S. (2000). Ceramide as an activator lipid of cathepsin D (Review). Adv. Exp. Med. Biol. 477, 305-15. Pubmed10849758
  Hrabe de Angelis, M.H., Flaswinkel, H., Fuchs, H., Rathkolb, B., Soewarto, D., Marschall, S., Heffner, S., Pargent, W., Wuensch, K., Jung, M., Reis, A., Richter, T., Alessandrini, F., Jakob, T., Fuchs, E., Kolb, H., Kremmer, E., Schaeble, K., Rollinski, B., Roscher, A., Peters, C., Meitinger, T., Strom, T., Steckler, T., Holsboer, F., Klopstock T. Gekeler, F., Schindewolf, C., Jung, T., Avraham, K., Behrendt, H., Ring, J., Zimmer, A., Schughart, K., Pfeffer, K., Wolf, E., and Balling, R. (2000) Genome-wide, large-scale production of mutant mice by ENU mutagenesis. Nat. Genet. 25, 444-7. Pubmed10932192
  Koike, M., Nakanishi, H., Saftig, P., Ezaki, J., Isahara, K., Ohsawa, Y., Schulz-Schaeffer, W., Watanabe, T., Waguri, S., Kametaka, S., Shibata, M., Yamamoto, K., Kominami, E., Peters, C., von Figura, K., and Uchiyama, Y. (2000). Cathepsin D deficiency induces lysosomal storage with ceroid lipofuscin in mouse CNS neurons. J. Neurosci. 20, 6898-906. Pubmed10995834
  Moin, K., Demchik, L., Mai, J., Deussing, J., Peters, C., and Sloane, B.F. (2000). Observing proteases in living cells (Review). Adv. Exp. Med. Biol. 477, 391-401. Pubmed10849765
  Roth, W., Deussing, J., Botchkarev, V.A., Pauly-Evers, M., Saftig, P., Hafner, A., Schmidt, P., Schmahl, W., Scherer, J., Anton-Lamprecht, I., von Figura, K., Paus, R., and Peters, C. (2000). Cathepsin L deficiency as molecular defect of furless: hyperproliferation of keratinocytes and pertubation of hair follicle cycling. FASEB J., 14, 2075-86. Pubmed11023992
  Tatnell, P.J., Cook, M., Peters, C., and Kay, J. (2000) Molecular organization, expression and chromosomal localization of the mouse pronapsin gene. Eur. J. Biochem. 267, 6921-30. Pubmed11082205
  Botchkareva, N.V., Botchkarev, V.A., Welker, P., Airaksinen, M., Roth, W., Suvanto, P., Müller-Röver, S., Hadshiew, I.M., Peters, C., and Paus, R. (2000). New roles for glial cell line-derived neurotrophic factor and neurturin: involvement in hair cycle control. Am. J. Pathol. 156, 1041-53. Pubmed10702420
1999 Heinrich, M., Wickel, M., Schneider-Brachert, W., Sandberg, C., Gahr, J., Schwandner, R., Weber, T., Brunner, J., Saftig, P., Peters, C., Brunner, J., Krönke, M., and Schütze, S. (1999). Cathepsin D targeted by acid sphingomyelinase-derived ceramide. EMBO J. 18, 5252-63. Pubmed10508159
  Tisljar, K., Deussing, J., and Peters, C. (1999). Cathepsin J, a novel murine cysteine protease of the papain family with a placenta-restricted expression. FEBS Lett. 459, 299-304. Pubmed10526153
  Botchkarev, V.A., Botchkareva, N.V., Roth, W., Nakamura, M., Chen, L.-H., Herzog, W., Lindner, G., McMahon, J.A., Peters, C., Lauster, R., McMahon, A.P., and Paus, R. (1999). Noggin is a mesenchymally derived stimulator of hair follicle induction. Nat. Cell Biol. 1, 158-64. Pubmed10559902
  Villadangos, J.A., Bryant, R.A., Deussing, J., Driessen, C., Lennon-Dumenil, A.M., Riese, R.J., Roth, W., Saftig, P., Shi, G.P., Chapman, H.A., Peters, C., and Ploegh, H.L. (1999). Proteases involved in MHC class II antigen presentation. (Review). Immunol. Rev. 172, 109-20. Pubmed10631941
1998 Deussing, J., Roth, W., Saftig, P., Peters, C., Ploegh, H.L., and Villadangos, J.A. (1998). Cathepsins B and D are dispensable for major histocompatibility complex class II-mediated antigen presentation. Proc. Natl. Acad. Sci. USA 95, 4516-21. Pubmed9539769
  Nakagawa, T., Roth, W., Wong, P., Nelson, A., Farr, A., Deussing, J., Villadangos, J.A., Ploegh, H., Peters, C., and Rudensky, A. (1998). Cathepsin L: critical role in Ii degradation and CD4 T cell selection in the thymus. Science 280, 450-3. Pubmed9545226
  Tatnell, P.J., Roth, W., Deussing, J., Peters, C., and Kay, J. (1998). Mouse procathepsin E gene: molecular organisation and chromosomal localisation. Biochim. Biophys. Acta 1398(1), 57-66. Pubmed9602058
  Wu, G. S., Saftig, P., Peters, C., and El-Deiry, W. S. (1998). Potential role for cathepsin D in p53-dependent tumor suppression and chemosensitivity. Oncogene 16, 2177-83. Pubmed9619826
1997 Deussing, J., Pauly-Evers, M., Roth, W., Saftig, P., and Peters, C. (1997). Manipulating the Mouse Genome (Review). Futura 12, 162-71
  Deussing, J., Roth, W., Rommerskirch, W., Wiederanders, B., von Figura, K., and Peters, C. (1997). The genes of the lysosomal cysteine proteinases cathepsin B, H, L, and S map to different mouse chromosomes. Mamm. Genome 8, 241-5. Pubmed9096102
  Saftig, P., Hartmann, D., Lüllmann-Rauch, R., Wolff, J., Evers, M., Köster, A., Hetman, M., von Figura, K., and Peters, C. (1997). Mice deficient in lysosomal acid phosphatase develop lysosomal storage in the kidney and central nervous system. J. Biol. Chem. 272, 18628-35. Pubmed9228031
  Villadangos, J.A., Riese, R.J., Peters, C., Chapman, H.A., and Ploegh, H.L. (1997). Degradation of mouse invariant chain: roles of cathepsins S and D and the influence of major histocompatibility complex polymorphism. J. Exp. Med. 186, 549-60. Pubmed9254653
1996 Braulke, T., Claussen, M., Saftig, P., Wendland, M., Neifer, K., Schmidt, B., Zapf, J., von Figura, K., and Peters, C. (1996). Proteolysis of IGFBPs by cathepsin D in vitro and in cathepsin D-deficient mice (Review). Prog. Growth Factor Res. 6, 265-71. Pubmed8817669
  Evers, M., Saftig, P., Schmidt, P., Hafner, A., McLoghlin, D.B., Schmahl, W., Hess, B., von Figura, K., and Peters, C. (1996). Targeted disruption of the arylsulfatase B gene results in mice resembling the phenotype of mucopolysaccharidosis VI. Proc. Natl. Acad. Sci. USA 93, 8214-9. Pubmed8710849
  Hess, B., Saftig, P., Hartmann, D., Coenen, R., Lüllmann-Rauch, R., Goebel, H. H., Evers, M., von Figura, K., D´Hooge, R., Nagels, G., DeDeyn, P., Peters, C., and Gieselmann, V. (1996). Phenotype of arylsulfatase A-deficient mice: relationship to human metachromatic leukodystrophy. Proc. Natl. Acad. Sci. USA 93, 14821-6. Pubmed8962139
  Isbrandt, D., Hopwood, J.J., von Figura, K., and Peters, C. (1996). Two novel frameshift mutations causing premature stop codons in a patient with the severe form of Maroteaux-Lamy syndrome. Hum. Mutat. 7, 361-3. Pubmed8723688
  Litjens, T., Brooks, D.A., Peters, C., Gibson, G.J., and Hopwood, J.J. (1996). Identification, expression, and biochemical characterization of N-acetylgalactosamine-4-sulfatase mutations and relationship with clinical phenotype in MPS-VI patients. Am. J. Hum. Genet. 58, 1127-34. Pubmed8651289
  Saftig, P., Peters, C., von Figura, K., Craessaerts, K., van Leuven, F., and De Strooper, B. (1996). Amyloidogenic processing of human amyloid precursor protein in hippocampal neurons devoid of cathepsin D. J. Biol. Chem. 271, 27241-4. Pubmed8910296
1995 Brooks, D.A., Robertson, D.A., Bindloss, C., Litjens, T., Anson, D.S., Peters, C., Morris, C.P., and Hopwood, J.J. (1995). Two site-directed mutations abrogate enzyme activity but have different effects on the conformation and cellular content of the N-acetylgalactosamine 4-sulphatase protein. Biochem. J. 307, 457-463. Pubmed7733883
  Saftig, P., Hetman, M., Schmahl, W., Weber, K., Heine, L., Mossmann, H., Köster, A., Hess, B., Evers, M., von Figura, K., and Peters, C. (1995). Mice deficient for the lysosomal proteinase cathepsin D exhibit progressive atrophy of the intestinal mucosa and profound destruction of lymphoid cells. EMBO J. 14, 3599-608. Pubmed7641679
1994 Arlt, G., Brooks, D.A., Isbrandt, D., Hopwood, J.J., Bielicki, J., Bradford, T.M., Bindloss-Petherbridge, C.A., von Figura, K., and Peters, C. (1994). Juvenile form of mucopolysaccharidosis VI (Maroteaux-Lamy syndrome). A C-terminal extension causes instability but increases catalytic efficiency of arylsulfatase B. J. Biol. Chem. 269, 9638-43. Pubmed8144552
  von Figura, K., Hille-Rehfeld, A., Lehmann, L., Peters, C., and Prill, V. Signal-Mediated Targeting of Lysosomal Membrane Glycoproteins (Review). 44. Colloquium Mosbach 1993, DNA Replication and the Cell Cycle, Springer-Verlag Berlin Heidelberg pp. 33-44
  Hetman, M., Perschl, A., Saftig, P., von Figura, K., and Peters, C. (1994). Mouse cathepsin D gene: molecular organization, characterization of the promoter, and chromosomal localization. DNA Cell Biol. 13, 419-27. Pubmed8011168
  Isbrandt, D., Arlt, G., Brooks, D.A., Hopwood, J.J., von Figura, K., and Peters, C. (1994). Mucopolysaccharidosis VI (Maroteaux-Lamy syndrome): six unique arylsulfatase B gene alleles causing variable disease phenotypes. Am. J. Hum. Genet. 54, 454-63. Pubmed8116615
  Peters, C., and von Figura, K. (1994). Biogenesis of lysosomal membranes (Review). FEBS Lett. 346, 108-14. Pubmed8206148
  Voskoboeva, E., Isbrandt, D., von Figura, K., Krasnopolskaya, X., and Peters, C. (1994). Four novel mutant alleles of the arylsulfatase B gene in two patients with intermediate form of mucopolysaccharidosis VI (Maroteaux-Lamy Syndrome). Hum. Genet. 93, 259-64. Pubmed8125475
1993 Brömme, D., Bonneau, P.R., Lachance, P., Wiederanders, B., Kirschke, H., Peters, C., Thomas, D.Y., Storer, A.C., and Vernet, T. (1993). Functional expression of human cathepsin S in Saccharomyces cerevisiae: purification and characterization of the recombinant enzyme. J. Biol. Chem. 268, 4832-8.. Pubmed8444861
  Köster, A., Saftig, P., Matzner, U., von Figura, K., Peters, C., and Pohlmann, R. (1993). Targeted disruption of the M(r) 46,000 mannose 6-phosphate receptor gene in mice results in misrouting of lysosomal proteins. EMBO J. 12, 5219-23. Pubmed8262064
  Modaressi, S., Rupp, K., von Figura, K., and Peters, C. (1993). Structure of the human arylsulfatase B gene. Biol. Chem. Hoppe Seyler 374, 327-35. Pubmed7687847
  Prill, V., Lehmann, L., von Figura, K., and Peters, C. (1993). The cytoplasmic tail of lysosomal acid phosphatase contains overlapping but distinct signals for basolateral sorting and rapid internalization in polarized MDCK cells. EMBO J. 12, 2181-93. Pubmed8491206
1992 Anson, D.S., Taylor, J.A., Bielicki, J., Harper, G.S., Peters, C., Gibson, G.J., and Hopwood, J.J. (1992). Correction of human mucopolysaccharidosis type VI fibroblasts with recombinant N-acetylgalactosamine- 4-sulphatase. Biochem. J. 284, 789-94. Pubmed1320379
  Bresciani, R., Peters, C., and von Figura, K. (1992). Lysosomal acid phosphatase is not involved in the dephosphorylation of mannose 6-phosphate containing lysosomal proteins. Eur. J. Cell Biol. 58, 57-61. Pubmed1353723
  Hille, A., Klumperman, J., Geuze, H.J., Peters, C., Brodsky, F.M., and von Figura, K. (1992). Lysosomal acid phosphatase is internalized via clathrin-coated pits. Eur. J. Cell Biol. 59, 106-15. Pubmed1468434
  Lehmann, L.E., Eberle, W., Krull, S., Prill, V., Schmidt, B., Sander, C., von Figura, K., and Peters, C. (1992). The internalization signal in the cytoplasmic tail of lysosomal acid phosphatase consists of the hexapeptide PGYRHV. EMBO J. 11, 4391-4399. Pubmed1425575
  Litjens, T., Morris, C.P., Robertson, E.F., Peters, C., von Figura, K., and Hopwood, J.J. (1992). An N-acetylgalactosamine- 4-sulfatase mutation (delta G238) results in a severe Maroteaux-Lamy phenotype. Hum. Mutat. 1, 397-402. Pubmed1301949
  Peters, C., Braun, M., Weber, B., Wendland, M., Schmidt, B., Pohlmann, R., Waheed, A. and von Figura, K. (1992). The nineteen amino acid cytoplasmic tail of lysosomal acid phosphatase contains an endocytosis signal necessary and sufficient for targeting to lysosomes (Review). in: Endocytosis. Ed.: P.J. Courtoy. NATO ASI Series, Vol. H 62, Springer-Verlag Berlin Heidelberg.
  Wiederanders, B., Brömme, D., Kirschke, H., von Figura, K., Schmidt, B., and Peters, C. (1992). Phylogenetic conservation of cysteine proteinases. Cloning and expression of a cDNA coding for human cathepsin S. J. Biol. Chem. 267, 13708-13. Pubmed1377692
1991 Eberle, W., Sander, C., Klaus, W., Schmidt, B., von Figura, K., and Peters, C. (1991). The essential tyrosine of the internalization signal in lysosomal acid phosphatase is part of a beta turn. Cell 67, 1203-9. Pubmed1760845
  Peters, C., Rommerskirch, W., Modaressi, S., and von Figura, K. (1991). Restoration of arylsulfatase B activity in human mucopolysaccharidosis- type-VI fibroblasts by retroviral-vector-mediated gene transfer. Biochem. J. 276, 499-504. Pubmed1904721
  Rommerskirch, W., Fluharty, A.L., Peters, C., von Figura, K., and Gieselmann, V. (1991). Restoration of arylsulfatase A activity in human-metachromatic- leukodystrophy fibroblasts via retroviral-vector-mediated gene transfer. Biochem. J. 280, 459-61. Pubmed1684103
  Wicker, G., Prill, V., Brooks, D., Gibson, G., Hopwood, J., von Figura, K., and Peters, C. (1991). Mucopolysaccharidosis VI (Maroteaux-Lamy Syndrome): An intermediate clinical phenotype caused by substitution of valine for glycine at position 137 of arylsulfatase B. J. Biol. Chem. 266, 21386-91. Pubmed1718978 
1990 Peters, C., Braun, M., Weber, B., Wendland, M., Schmidt, B., Pohlmann, R., Waheed, A., and von Figura, K. (1990). Targeting of a lysosomal membrane protein: a tyrosine-containing endocytosis signal in the cytoplasmic tail of lysosomal acid phosphatase is necessary and sufficient for targeting to lysosomes. EMBO J. 9, 3497-506. Pubmed2209556
  Peters, C., Schmidt, B., Rommerskirch, W., Rupp, K., Zühlsdorf, M., Vingron, M., Meyer, H.E., Pohlmann, R., and von Figura, K. (1990). Phylogenetic conservation of arylsulfatases. cDNA cloning and expression of human arylsulfatase B. J. Biol. Chem. 265, 3374-81. Pubmed2303452
1989 Peters, C., Geier, C., Pohlmann, R., Waheed, A., von Figura, K., Roiko, K., Virkkunen, P., Henttu, P., and Vihko, P. (1989). High degree of homology between primary structure of human lysosomal acid phosphatase and human prostatic acid phosphatase. Biol. Chem. Hoppe Seyler 370, 177-81. Pubmed2706086
  Peters, C., Kruse, U., Pollwein, R., Grzeschik, K.H., and Sippel, A.E. (1989). The human lysozyme gene. Sequence organization and chromosomal localization. Eur. J. Biochem. 182, 507-16. Pubmed2546758
1988 Bonifer, C., Hecht, A., Peters, C., and Sippel. A.E. (1988). Rat antibodies as probes for the characterization of progesterone receptor A and B proteins from laying hen oviduct cytosol. Biochim. Biophys. Acta 968, 96-108. Pubmed3337848
1987 Peters, C., Sippel, A.E., Vingron, M., and Klempnauer K.H. (1987). Drosophila and vertebrate myb proteins share two conserved regions, one of which functions as a DNA-binding domain. EMBO J. 6, 3085-90. Pubmed3121304
1981 Peters, C., Schwermann, J., Schmidt, A., and Buddecke, E. (1981). Phosphate ester groups in proteoglycans from bovine nasal cartilage. Biochim. Biophys. Acta 673, 270-8. Pubmed7225419

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