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Medizinische Zellforschung - Publications
2017 Peintner L, Borner C. Role of apoptosis in the development of autosomal dominant polycystic kidney disease (ADPKD). Cell Tissue Res. 2017 Jul;369(1):27-39. doi: 10.1007/s00441-017-2628-6. Epub 2017 May 30 Pubmed28560694 Review.
2016 Schlicher L, Wissler M, Preiss F, Brauns-Schubert P, Jakob C, Dumit V, Borner C, Dengjel J, Maurer U. SPATA2 promotes CYLD activity and regulates TNF-induced NF-κB signaling and cell death. EMBO Rep. 2016 Oct;17(10):1485-1497. Epub 2016 Jul 25. Pubmed27458237
  Marino-Merlo F, Papaianni E, Medici MA, Macchi B, Grelli S, Mosca C, Borner C, Mastino A. HSV-1-induced activation of NF-κB protects U937 monocytic cells against both virus replication and apoptosis. Cell Death Dis. 2016 Sep 1;7(9):e2354. doi: 10.1038/cddis.2016.250. Pubmed 27584793
De Ford C, Heidersdorf B, Haun F, Murillo R, Friedrich T, Borner C, Merfort I. The clerodane diterpene casearin J induces apoptosis of T-ALL cells through SERCA inhibition, oxidative stress, and interference with Notch1 signaling.Cell Death Dis. 2016 Jan 28;7:e2070. doi: 10.1038/cddis.2015.413. Pubmed26821066
Peintner L, Novelli F, Smirnov A, Maurer U, Borner C, von Karstedt S. 9th Tuscany Retreat on Cancer Research: genetic profiling, resistance mechanisms and novel treatment concepts in cancer. Cell Death Differ. 2016 Jan;23(1):183-4. doi: 10.1038/cdd.2015.148. Epub 2015 Nov 13. Pubmed26564399
2015 Neumann S, Maadidi SE, Faletti L, Haun F, Labib S, Schejtman A, Maurer U, Borner C. How do viruses control mitochondria-mediated apoptosis? Virus Res. 2015 Nov 2;209:45-55. doi: 10.1016/j.virusres.2015.02.026. Epub 2015 Mar 1.Pubmed25736565
  Papaianni E, El Maadidi S, Schejtman A, Neumann S, Maurer U, Marino-Merlo F, Mastino A, Borner C. Phylogenetically Distant Viruses Use the Same BH3-Only Protein Puma to Trigger Bax/Bak-Dependent Apoptosis of Infected Mouse and Human Cells. PLoS One. 2015 Jun 1;10(6):e0126645. doi: 10.1371/journal.pone.0126645. eCollection 2015. Pubmed26030884
Galluzzi L, Bravo-San Pedro JM, Vitale I, Aaronson SA, Abrams JM, Adam D, Alnemri ES, Altucci L, Andrews D, Annicchiarico-Petruzzelli M, Baehrecke EH, Bazan NG, Bertrand MJ, Bianchi K, Blagosklonny MV, Blomgren K, Borner C, Bredesen DE, Brenner C, Campanella M, Candi E, Cecconi F, Chan FK, Chandel NS, Cheng EH, Chipuk JE, Cidlowski JA, Ciechanover A, Dawson TM, Dawson VL, De Laurenzi V, De Maria R, Debatin KM, Di Daniele N, Dixit VM, Dynlacht BD, El-Deiry WS, Fimia GM, Flavell RA, Fulda S, Garrido C, Gougeon ML, Green DR, Gronemeyer H, Hajnoczky G, Hardwick JM, Hengartner MO, Ichijo H, Joseph B, Jost PJ, Kaufmann T, Kepp O, Klionsky DJ, Knight RA, Kumar S, Lemasters JJ, Levine B, Linkermann A, Lipton SA, Lockshin RA, López-Otín C, Lugli E, Madeo F, Malorni W, Marine JC, Martin SJ, Martinou JC, Medema JP, Meier P, Melino S, Mizushima N, Moll U, Muñoz-Pinedo C, Nuñez G, Oberst A, Panaretakis T, Penninger JM, Peter ME, Piacentini M, Pinton P, Prehn JH, Puthalakath H, Rabinovich GA, Ravichandran KS, Rizzuto R, Rodrigues CM, Rubinsztein DC, Rudel T, Shi Y, Simon HU, Stockwell BR, Szabadkai G, Tait SW, Tang HL, Tavernarakis N, Tsujimoto Y, Vanden Berghe T, Vandenabeele P, Villunger A, Wagner EF, Walczak H, White E, Wood WG, Yuan J, Zakeri Z, Zhivotovsky B, Melino G, Kroemer G. Essential versus accessory aspects of cell death: recommendations of the NCCD 2015. Cell Death Differ. 2015 Jan;22(1):58-73. doi: 10.1038/cdd.2014.137. Epub 2014 Sep 19. Pubmed25236395 Review
2014 Lutz A, Sanwald J, Thomas M, Feuer R, Sawodny O, Ederer M, Borner C, Humar M, Merfort I. Interleukin-1β Enhances FasL-Induced Caspase-3/-7 Activity without Increasing Apoptosis in Primary Mouse Hepatocytes. PLoS One. 2014 Dec 31;9(12):e115603. doi: 10.1371/journal.pone.0115603. eCollection 2014. Pubmed25551609
  Lindenboim L, Sasson T, Worman HJ, Borner C, Stein R. Cellular stress induces Bax-regulated nuclear bubble budding and rupture followed by nuclear protein release. Nucleus. 2014 Nov 2;5(6):527-41. doi: 10.4161/19491034.2014.970105. Pubmed25482068
Lindner SE, Wissler M, Gründer A, Aumann K, Ottina E, Peintner L, Brauns-Schubert P, Preiss F, Herzog S, Borner C, Charvet C, Villunger A, Pahl HL, Maurer U. Increased leukocyte survival and accelerated onset of lymphoma in the absence of MCL-1 S159-phosphorylation.
Oncogene. 2014 Oct 30;33(44):5221-4. doi: 10.1038/onc.2013.469. Epub 2013 Nov 11. Pubmed24213575
Borner C, Andrews DW. The apoptotic pore on mitochondria: are we breaking through or still stuck? Cell Death Differ. 2014 Feb;21(2):187-91. doi: 10.1038/cdd.2013.169. Pubmed24413197 Editorial
El Maadidi S, Faletti L, Berg B, Wenzl C, Wieland K, Chen ZJ, Maurer U, Borner C. A novel mitochondrial MAVS/Caspase-8 platform links RNA virus-induced innate antiviral signaling to Bax/Bak-independent apoptosis. J Immunol. 2014 Feb 1;192(3):1171-83. doi: 10.4049/jimmunol.1300842. Epub 2014 Jan 3. Pubmed24391214
2013 Geissler A, Haun F, Frank DO, Wieland K, Simon MM, Idzko M, Davis RJ, Maurer U, Borner C. Apoptosis induced by the fungal pathogen gliotoxin requires a triple phosphorylation of Bim by JNK. Cell Death Differ. 2013 Oct;20(10):1317-29. doi: 10.1038/cdd.2013.78. Epub 2013 Jul 5.. Pubmed23832115
  Huai J, Vögtle FN, Jöckel L, Li Y, Kiefer T, Ricci JE, Borner C. TNFα-induced lysosomal membrane permeability (LMP) is downstream of MOMP and triggered by caspase-mediated p75 cleavage and ROS formation. J Cell Sci. 2013 Sep 1;126(Pt 17):4015-25. doi: 10.1242/jcs.129999. Epub 2013 Jun 20. Pubmed23788428
Lindenboim L, Ferrando-May E, Borner C, Stein R. Non-canonical function of Bax in stress-induced nuclear protein redistribution. Cell Mol Life Sci. 2013 Aug;70(16):3013-27. doi: 10.1007/s00018-013-1306-4. Epub 2013 Mar 9. Pubmed23475110
  Godoy P, Hewitt NJ, Albrecht U, Andersen ME, Ansari N, Bhattacharya S, Bode JG, Bolleyn J, Borner C, Böttger J, Braeuning A, Budinsky RA, Burkhardt B, Cameron NR, Camussi G, Cho CS, Choi YJ, Craig Rowlands J, Dahmen U, Damm G, Dirsch O, Donato MT, Dong J, Dooley S, Drasdo D, Eakins R, Ferreira KS, Fonsato V, Fraczek J, Gebhardt R, Gibson A, Glanemann M, Goldring CE, Gómez-Lechón MJ, Groothuis GM, Gustavsson L, Guyot C, Hallifax D, Hammad S, Hayward A, Häussinger D, Hellerbrand C, Hewitt P, Hoehme S, Holzhütter HG, Houston JB, Hrach J, Ito K, Jaeschke H, Keitel V, Kelm JM, Kevin Park B, Kordes C, Kullak-Ublick GA, LeCluyse EL, Lu P, Luebke-Wheeler J, Lutz A, Maltman DJ, Matz-Soja M, McMullen P, Merfort I, Messner S, Meyer C, Mwinyi J, Naisbitt DJ, Nussler AK, Olinga P, Pampaloni F, Pi J, Pluta L, Przyborski SA, Ramachandran A, Rogiers V, Rowe C, Schelcher C, Schmich K, Schwarz M, Singh B, Stelzer EH, Stieger B, Stöber R, Sugiyama Y, Tetta C, Thasler WE, Vanhaecke T, Vinken M, Weiss TS, Widera A, Woods CG, Xu JJ, Yarborough KM, Hengstler JG. Recent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in investigating mechanisms of hepatotoxicity, cell signaling and ADME. Arch Toxicol. 2013 Aug;87(8):1315-530. doi: 10.1007/s00204-013-1078-5. Epub 2013 Aug 23. Pubmed23974980
Weber M, Gawanbacht A, Habjan M, Rang A, Borner C, Schmidt AM, Veitinger S, Jacob R, Devignot S, Kochs G, García-Sastre A, Weber F. Incoming RNA Virus Nucleocapsids Containing a 5'-Triphosphorylated Genome Activate RIG-I and Antiviral Signaling. Cell Host Microbe. 2013 Mar 13;13(3):336-46. doi: 10.1016/j.chom.2013.01.012. PMID: 23498958
2012 Joeckel LT, Wallich R, Metkar SS, Froelich CJ, Simon MM, Borner C. IL-1R signaling is essential for induction of pro-apoptotic CD8 T cells, viral clearance and pathology during LCMV infection in mice.J Virol. 2012 Aug;86(16):8713-9.Pubmed22674984
Jo J, Bengsch B, Seigel B, Rau SJ, Schmidt J, Bisse E, Aichele P, Aichele U, Joeckel L, Royer C, Ferreira KS, Borner C, Baumert TF, Blum HE, Lohmann V, Fischer R, Thimme R.Low perforin expression of early differentiated HCV-specific CD8+ T cells limits their hepatotoxic potential. J Hepatol. 2012 Jul;57(1):9-16. Pubmed22425625
Ferreira KS, Kreutz C, Macnelly S, Neubert K, Haber A, Bogyo M, Timmer J, Borner C. Caspase-3 feeds back on caspase-8, Bid and XIAP in type I Fas signaling in primary mouse hepatocytes. Apoptosis. 2012 May;17(5):503-15. doi: 10.1007/s10495-011-0691-0. Pubmed22246639
  Schlatter R, Philippi N, Wangorsch G, Pick R, Sawodny O, Borner C, Timmer J, Ederer M, Dandekar T. Integration of Boolean models exemplified on hepatocyte signal transduction. Brief Bioinform. 2012 May;13(3):365-76. Epub 2011 Oct 20 Pubmed22016404
Vogel S, Raulf N, Bregenhorn S, Biniossek ML, Maurer U, Czabotar P, Borner C. Cytosolic Bax: Does it require binding proteins to keep its pro-apoptotic activity in check? J Biol Chem. 2012Mar 16;287(12):9112-27. Pubmed22277657
  Leprivier G, Rufini A, García-Sáez AJ, Borner C, Rotblat B. 7th Tuscany Retreat on Cancer Research: Genetic profiling, resistance mechanism and novel treatment concepts in cancer. Cell Death Differ. 2012 Mar;19(3):546-8. doi: 10.1038/cdd.2011.186. Epub 2011 Dec 16. Pubmed22179574
2011 Charvet C, Maurer U.GSK-3 turns p53 deadly. Cell Cycle. 2011 Nov 1;10(21):3621-2. Pubmed22033176
Charvet C, Wissler M, Brauns-Schubert P, Wang SJ, Tang Y, Sigloch FC, Mellert H, Brandenburg M, Lindner SE, Breit B, Green DR, McMahon SB, Borner C, Gu W, Maurer U.Phosphorylation of Tip60 by GSK-3 Determines the Induction of PUMA and Apoptosis by p53. Mol Cell. 2011 Jun 10;42(5):584-96. Pubmed21658600
  Lindenboim L, Borner C, Stein R. Nuclear proteins acting on mitochondria. Biochim Biophys Acta. 2011 Apr;1813(4):584-96 Pubmed21130123
Häcker G, Borner C. Preface to Mitochondria: the deadly organelle.Biochim Biophys Acta. 2011 Apr;1813(4):507. Pubmed21419936
  Joeckel LT, Wallich R, Martin P, Sanchez-Martinez D, Weber FC, Martin SF, Borner C, Pardo J, Froelich C, Simon MM. Mouse granzyme K has pro-inflammatory potential. Cell Death Differ. 2011 Jul;18(7):1112-9. doi: 10.1038/cdd.2011.5. Epub 2011 Feb 11. Pubmed21311565
Schmich K, Schlatter R, Corazza N, Ferreira KS, Ederer M, Brunner T, Borner C, Merfort I. Tumor necrosis factor α sensitizes primary murine hepatocytes to Fas/CD95-induced apoptosis in a Bim- and Bid-dependent manner.Hepatology. 2011 Jan; 53(1):282-92. Pubmed20872776
2010 Oberle C, Huai J, Reinheckel T, Tacke M, Rassner M, Ekert PG, Buellesbach J, Borner C. Lysosomal membrane permeabilization and cathepsin release is a Bax/Bak-dependent, amplifying event of apoptosis in fibroblasts and monocytes. Cell Death Differ. 2010 Jul;17(7):1167-78. Pubmed20094062
Huai J, Jöckel L, Schrader K, Borner C. Role of caspases and non-caspase proteases in cell death. F1000 Biol Rep. 2010 Jun 23;2. pii: 48. Pubmed20948786
Schrader K, Huai J, Jöckel L, Oberle C, Borner C. Non-caspase proteases: triggers or amplifiers of apoptosis? Cell Mol Life Sci. 2010 May;67(10):1607-18. Review. Pubmed20169397
Lindenboim L, Blacher E, Borner C, Stein R. Regulation of stress-induced nuclear protein redistribution: a new function of Bax and Bak uncoupled from Bcl-x(L). Cell Death Differ. 2010 Feb;17(2):346-59. Pubmed19816507
Jabbour AM, Daunt CP, Green BD, Vogel S, Gordon L, Lee RS, Silke N, Pearson RB, Vandenberg CJ, Kelly PN, Nutt SL, Strasser A, Borner C, Ekert PG. Myeloid progenitor cells lacking p53 exhibit delayed up-regulation of Puma and prolonged survival after cytokine deprivation. Blood. 2010 Jan 14;115(2):344-52. Pubmed19965665
2009 Schlatter R, Schmich K, Avalos Vizcarra I, Scheurich P, Sauter T, Borner C, Ederer M, Merfort I, Sawodny O. ON/OFF and beyond--a boolean model of apoptosis. PLoS Comput Biol. 2009 Dec;5(12):e1000595. Pubmed20011108
Vogel, S., Kiefer, T., Raulf, N., Sterz, K., Manoharan, A. & Borner, C. Mechanisms of Bax/Bak activation: is there any light at the end of the tunnel? Gastroenterology and Hepatology from Bed to Bench 2, S11-S18.(2009).
Lindenboim L, Blacher E, Borner C, Stein R. Regulation of stress-induced nuclear protein redistribution: a new function of Bax and Bak uncoupled from Bcl-x(L). Cell Death Differ. 2009 Oct 9. Pubmed19816507
  Philippi N, Walter D, Schlatter R, Ferreira KS, Ederer M, Sawodny O, Timmer J, Borner C, Dandekar T. Modeling system states in liver cells: Survival, apoptosis and their modifications in response to viral infection. BMC Syst Biol. 2009 Sep 22;3(1):97. Pubmed19772631
  Baudot AD, Jeandel PY, Mouska X, Maurer U, Tartare-Deckert S, Raynaud SD, Cassuto JP, Ticchioni M, Deckert M. The tyrosine kinase Syk regulates the survival of chronic lymphocytic leukemia B cells through PKCdelta and proteasome-dependent regulation of Mcl-1 expression. Oncogene. 2009 Sep 17;28(37):3261-73. Pubmed19581935
  Jost PJ, Grabow S, Gray D, McKenzie MD, Nachbur U, Huang DC, Bouillet P, Thomas HE, Borner C, Silke J, Strasser A, Kaufmann T. XIAP discriminates between type I and type II FAS-induced apoptosis. Nature. 2009 Aug 20;460(7258):1035-9. Pubmed19626005
Galluzzi L, Aaronson SA, Abrams J, Alnemri ES, Andrews DW, Baehrecke EH, Bazan NG, Blagosklonny MV, Blomgren K, Borner C, Bredesen DE, Brenner C, Castedo M, Cidlowski JA, Ciechanover A, Cohen GM, De Laurenzi V, De Maria R, Deshmukh M, Dynlacht BD, El-Deiry WS, Flavell RA, Fulda S, Garrido C, Golstein P, Gougeon ML, Green DR, Gronemeyer H, Hajnóczky G, Hardwick JM, Hengartner MO, Ichijo H, Jäättelä M, Kepp O, Kimchi A, Klionsky DJ, Knight RA, Kornbluth S, Kumar S, Levine B, Lipton SA, Lugli E, Madeo F, Malomi W, Marine JC, Martin SJ, Medema JP, Mehlen P, Melino G, Moll UM, Morselli E, Nagata S, Nicholson DW, Nicotera P, Nuñez G, Oren M, Penninger J, Pervaiz S, Peter ME, Piacentini M, Prehn JH, Puthalakath H, Rabinovich GA, Rizzuto R, Rodrigues CM, Rubinsztein DC, Rudel T, Scorrano L, Simon HU, Steller H, Tschopp J, Tsujimoto Y, Vandenabeele P, Vitale I, Vousden KH, Youle RJ, Yuan J, Zhivotovsky B, Kroemer G. Guidelines for the use and interpretation of assays for monitoring cell death in higher eukaryotes. Cell Death Differ. 2009 Aug;16(8):1093-107. Review. Pubmed19373242
  Anel A, Bleackley C, Borner C, Golstein P, Krammer PH, Müllbacher A, Pardo J, Simon MM, Trapani JA. EMBO workshop on cytotoxicity, cell death and the immune system. Cell Death Differ. 2009 May;16(5):790-3. No abstract available. Pubmed19369941
Pardo J, Aguilo JI, Anel A, Martin P, Joeckel L, Borner C, Wallich R, Müllbacher A, Froelich CJ, Simon MM. The biology of cytotoxic cell granule exocytosis pathway: granzymes have evolved to induce cell death and inflammation. Microbes Infect. 2009 Apr;11(4):452-9. Review. Pubmed19249384
Shen ZJ, Esnault S, Schinzel A, Borner C, Malter JS. The peptidyl-prolyl isomerase Pin1 facilitates cytokine-induced survival of eosinophils by suppressing Bax activation. Nat Immunol. 2009 Mar;10(3):257-65. Pubmed19182807
2008 Walter D, Schmich K, Vogel S, Pick R, Kaufmann T, Hochmuth FC, Haber A, Neubert K, McNelly S, von Weizsäcker F, Merfort I, Maurer U, Strasser A, Borner C. Switch from type II to I Fas/CD95 death signaling on in vitro culturing of primary hepatocytes. Hepatology. 2008 Dec;48(6):1942-53. Pubmed19003879
  Urban C, Rhême C, Maerz S, Berg B, Pick R, Nitschke R, Borner C. Apoptosis induced by Semliki Forest virus is RNA replication dependent and mediated via Bak. Cell Death Differ. 2008 Sep;15(9):1396-407. Pubmed18437160
  Pardo J, Wallich R, Martin P, Urban C, Rongvaux A, Flavell RA, Müllbacher A, Borner C, Simon MM. Granzyme B-induced cell death exerted by ex vivo CTL: discriminating requirements for cell death and some of its signs. Cell Death Differ. 2008 Mar;15(3):567-79. Pubmed18064039
Pardo J, Wallich R, Martin P, Urban C, Rongvaux A, Flavell RA, Muellbacher A, Borner C, Simon MM. Granzyme B-induced cell death exerted by ex vivo CTL: discriminating requirements for cell death and some of its signs. Cell Death Differ. 2008 Mar;15(3):567-79. Epub 2007 Dec 7.Pubmed18064039
2007 Colell A, Ricci JE, Tait S, Milasta S, Maurer U, Bouchier-Hayes L,
Fitzgerald P, Guio-Carrion A, Waterhouse NJ, Li CW, Mari B, Barbry P, Newmeyer DD, Beere HM, Green DR. GAPDH and autophagy preserve survival after apoptotic cytochrome c release in the absence of caspase activation. Cell. 2007 Jun 1;129(5):983-97. Pubmed17540177
  Sanjuán Szklarz LK, Kozjak-Pavlovic V, Voegtle FN, Chacinska A, Milenkovic D, Vogel S, Dürr M, Westermann B, Guiard B, Martinou JC, Borner C, Pfanner N, Meisinger C. Preprotein transport machineries of yeast mitochondrial outer membrane are not required for Bax-induced release of intermembrane space proteins. J Mol Biol. 2007 Apr 20;368(1):44-54. Pubmed17335847
2006 Sciortino MT, Perri D, Medici MA, Grelli S, Serafino A, Borner C, Mastino A. Role of Bcl-2 expression for productive herpes simplex virus 2 replication. Virology. 2006 Dec 5-20;356(1-2):136-46.
Pubmed16950491
  Charvet C, Canonigo AJ, Becart S, Maurer U, Miletic AV, Swat W, Deckert M, Altman A. Vav1 promotes T cell cycle progression by linking TCR/CD28 costimulation to FOXO1 and p27kip1 expression. J Immunol. 2006 Oct 15;177(8):5024-31. Pubmed17015685
  Ekert PG, Jabbour AM, Manoharan A, Heraud JE, Yu J, Pakusch M, Michalak EM, Kelly PN, Callus B, Kiefer T, Verhagen A, Silke J, Strasser A, Borner C, Vaux DL. Cell death provoked by loss of Interleukin-3 signalling is independent of Bad, Bim, and PI3 Kinase, but depends in part on Puma. Blood. 2006 Sep 1;108(5):1461-8. Pubmed16705087
  Borner C. In memoriam of a prominent composer of the Bcl-2 family symphony. Cell Death Differ. 2006 Aug;13(8):1248-9. Pubmed16838034
  Klingmüller, U. Bauer, A., Breitkopf, K., Bohl, S., Dooley, S., Zellmer, S., Kern, C., Merfort, I., Sparna, T., Donauer, J., Walz, G., Geyer, M., Kreutz, C., Hermes, M., Walter, D., Egger, L., Neubert, K., Borner, C., Götschel, F., Hecht, A., Brulport, M., Schormann, W., Sauer, C., Baumann, F., Preiss, R., Illes, P., Nickel, P. J., MacNelly, S., Godoy, P., Wiercinska, E., Ciuclan, L., Zeilinger, K., Heinrich, M., Zanger, U. M., Reuss, M., Bader, A., Gebhardt, R., Maiwald, T., Timmer, J., von Weizsäcker, F., und Hengstler, J. G. “Primary mouse hepatocytes for systems biology approaches: a standardized in vitro system for modelling of signal transduction pathways”. IEE Proc. Systems Biology, 153, 433-447. Pubmed17186705
  Manoharan A, Kiefer T, Leist S, Schrader K, Urban C, Walter D, Maurer U, Borner C. Identification of a 'genuine' mammalian homolog of nematodal CED-4: is the hunt over or do we need better guns? Cell Death Differ. 2006 Aug;13(8):1310-7. Pubmed16691212
  Pardo, J., Urban, C., Galvez, E. M., Müller U., Kwon-Chung, J., Lobigs, M., Müllbacher, A. Wallich, R., Borner, C. & Simon, M. Bak is key in gliotoxin-induced apoptosis and a critical host factor of A. fumigatus virulence in mice. J. Cell Biology, Pubmed16893972
  Thakar J, Schleinkofer K, Borner C, Dandekar T. RIP death domain structural interactions implicated in TNF-mediated proliferation and survival. Proteins. 2006 May 15;63(3):413-23. Pubmed16470584
  Maurer U, Charvet C, Wagman AS, Dejardin E, Green DR. Glycogen synthase kinase-3 regulates mitochondrial outer membrane permeabilization and apoptosis by destabilization of MCL-1. Mol Cell. 2006 Mar 17;21(6):749-60.Pubmed16543145
2005 Lindenboim L, Kringel S, Braun T, Borner C, Stein R.
Bak but not Bax is essential for Bcl-xS-induced apoptosis.
Cell Death Differ. 2005 Jul;12(7):713-23. Pubmed15861188
  Loop T, Dovi-Akue D, Frick M, Roesslein M, Egger L, Humar M, Hoetzel A, Schmidt R, Borner C, Pahl HL, Geiger KK, Pannen BH.
Volatile anesthetics induce caspase-dependent, mitochondria-mediated apoptosis in human T lymphocytes in vitro.
Anesthesiology. 2005 Jun;102(6):1147-57. Pubmed15915027
2004 Lindenboim L, Schlipf S, Kaufmann T, Borner C, Stein R.
Bcl-x(S) induces an NGF-inhibitable cytochrome c release.
Exp Cell Res. 2004 Jul 15;297(2):392-403. Pubmed15212942
  Schinzel A, Kaufmann T, Borner C.
Bcl-2 family members: intracellular targeting, membrane-insertion, and changes in subcellular localization.
Biochim Biophys Acta. 2004 Mar 1;1644(2-3):95-105. Pubmed14996494
  Schinzel A, Kaufmann T, Schuler M, Martinalbo J, Grubb D, Borner C.
Conformational control of Bax localization and apoptotic activity by Pro168.
J Cell Biol. 2004 Mar 29;164(7):1021-32. Pubmed15037603
  Kaufmann T, Schinzel A, Borner C.
Bcl-w(edding) with mitochondria.
Trends Cell Biol. 2004 Jan;14(1):8-12. Pubmed14729175 
2003 Egger L, Schneider J, Rheme C, Tapernoux M, Hacki J, Borner C.
Serine proteases mediate apoptosis-like cell death and phagocytosis under caspase-inhibiting conditions.
Cell Death Differ. 2003 Oct;10(10):1188-1203. Pubmed14502242
  McCaw SE, Schneider J, Liao EH, Zimmermann W, Gray-Owen SD.
Immunoreceptor tyrosine-based activation motif phosphorylation during engulfment of Neisseria gonorrhoeae by the neutrophil-restricted CEACAM3 (CD66d) receptor.
Mol Microbiol. 2003 Aug;49(3):623-37. Pubmed12864848
  Huber TB, Hartleben B, Kim J, Schmidts M, Schermer B, Keil A, Egger L, Lecha RL, Borner C, Pavenstädt H, Shaw A, Walz G, Benzing T.
Nephrin and CD2AP associate with phosphoinositide 3-OH kinase and stimulate AKT-dependent signaling.
Mol Cell Biol. 2003 Jul;23(14):4917-28. Pubmed12832477
  Gianinazzi C, Grandgirard D, Imboden H, Egger L, Meli DN, Bifrare YD, Joss PC, Tauber MG, Borner C, Leib SL.
Caspase-3 mediates hippocampal apoptosis in pneumococcal meningitis.
Acta Neuropathol (Berl) 2003 May;105(5):499-507. Pubmed12677451
  Kaufmann T, Schlipf S, Sanz J, Neubert K, Stein R, Borner C.
Characterization of the signal that directs Bcl-x(L), but not Bcl-2, to the mitochondrial outer membrane.
J Cell Biol 2003 Jan 6;160(1):53-64. Pubmed12515824
  Borner C.
The Bcl-2 protein family: sensors and checkpoints for life-or-death decisions.
Mol Immunol 2003 Jan;39(11):615-47, Pubmed12493639
2002 Schempp CM, Kirkin V, Simon-Haarhaus B, Kersten A, Kiss J, Termeer CC, Gilb B, Kaufmann T, Borner C, Sleeman JP, Simon JC.
Inhibition of tumour cell growth by hyperforin, a novel anticancer drug from St. John's wort that acts by induction of apoptosis.
Oncogene 2002 Feb 14;21(8):1242-50. Pubmed11850844
  Billker O, Popp A, Brinkmann V, Wenig G, Schneider J, Caron E, Meyer TF. Distinct mechanisms of internalization of Neisseria gonorrhoeae by members of the CEACAM receptor family involving Rac1- and Cdc42-dependent and -independent pathways.
EMBO J 2002 Feb 15;21(4):560-571. Pubmed11847104 http://emboj.oupjournals.org/cgi/reprint/21/4/560.pdf
2001 Lindenboim L, Borner C, Stein R.
Bcl-x(S) can form homodimers and heterodimers and its apoptotic activity requires localization of Bcl-x(S) to the mitochondria and its BH3 and loop domains. 
Cell Death Differ 2001 Sep;8(9):933-942. Pubmed11526448
2000 Conus S, Rossé T, Borner C.
Failure of Bcl-2 family members to interact with Apaf-1 in normal and apoptotic cells. 
Cell Death Differ 2000 Oct;7(10):947-954. Pubmed11279541
  Foyouzi-Youssefi R, Arnaudeau S, Borner C, Kelley WL, Tschopp J, Lew DP, Demaurex N, Krause KH.
Bcl-2 decreases the free Ca2+ concentration within the endoplasmic reticulum.
Proc Natl Acad Sci U S A 2000 May 23;97(11):5723-8
http://www.pnas.org/cgi/content/full/97/11/5723
  Häcki J, Egger L, Monney L, Conus S, Rossé T, Fellay I, Borner C.
Apoptotic crosstalk between the endoplasmic reticulum and mitochondria controlled by Bcl-2.
Oncogene 2000 May 4;19(19):2286-95. Pubmed10822379
  Conus S, Kaufmann T, Fellay I, Otter I, Rossé T, Borner C.
Bcl-2 is a monomeric protein: prevention of homodimerization by structural constraints.
EMBO J 2000 Apr 3;19(7):1534-44. Pubmed10747022
  Vieira O, Escargueil-Blanc I, Jürgens G, Borner C, Almeida L, Salvayre R, Negre-Salvayre A.
Oxidized LDLs alter the activity of the ubiquitin-proteasome pathway: potential role in oxidized LDL-induced apoptosis.
FASEB J 2000 Mar;14(3):532-42
http://www.fasebj.org/cgi/content/abstract/14/3/532
1999 Sugimoto C, Fujieda S, Seki M, Sunaga H, Fan GK, Tsuzuki H, Borner C, Saito H, Matsukawa S.
Apoptosis-promoting gene (bax) transfer potentiates sensitivity of squamous cell carcinoma to cisplatin in vitro and in vivo.
Int J Cancer 1999 Sep 9;82(6):860-7. Pubmed10446454
  Borner C, Schlagbauer Wadl H, Fellay I, Selzer E, Polterauer P, Jansen B.
Mutated N-ras upregulates Bcl-2 in human melanoma in vitro and in SCID mice.
Melanoma Res 1999 Aug;9(4):347-50. Pubmed10504052
  Borner C, Monney L.
Apoptosis without caspases: an inefficient molecular guillotine?
Cell Death Differ 1999 Jun;6(6):497-507. Pubmed10381652
  Borner C, Monney L, Olivier R, Rossé T, Häcki J, Conus S.
Life and death in a medieval atmosphere.
Cell Death Differ 1999 Feb;6(2):201-6. Pubmed10200567
1998 Grandgirard D, Studer E, Monney L, Belser T, Fellay I, Borner C, Michel MR.
Alphaviruses induce apoptosis in Bcl-2-overexpressing cells: evidence for a caspase-mediated, proteolytic inactivation of Bcl-2.
EMBO J 1998 Aug 10;17(5):1268-78
http://www.emboj.org/cgi/content/full/17/5/1268
  Monney L, Otter I, Olivier R, Ozer HL, Haas AL, Omura S, Borner C.
Defects in the ubiquitin pathway induce caspase-independent apoptosis blocked by Bcl-2.
J Biol Chem 1998 Mar 13;273(11):6121-31
http://www.jbc.org/cgi/content/full/273/11/6121
  Otter I, Conus S, Ravn U, Rager M, Olivier R, Monney L, Fabbro D, Borner C.
The binding properties and biological activities of Bcl-2 and Bax in cells exposed to apoptotic stimuli.
J Biol Chem 1998 Mar 13;273(11):6110-20
http://www.jbc.org/cgi/content/full/273/11/6110
  Monney L, Olivier R, Otter I, Jansen B, Poirier GG, Borner C.
Role of an acidic compartment in tumor-necrosis-factor-alpha-induced production of ceramide, activation of caspase-3 and apoptosis.
Eur J Biochem 1998 Jan 15;251(1-2):295-303
http://www.blackwell-synergy.com/Journals/member/institutions/processfree2.asp? contentid=ejb.1998.23&filetype=abstracts&article=25391
  Rossé T, Olivier R, Monney L, Rager M, Conus S, Fellay I, Jansen B, Borner C.
Bcl-2 prolongs cell survival after Bax-induced release of cytochrome c.
Nature 1998 Jan 29;391(6666):496-9. Pubmed9461218
1997 Weinstein IB, Kahn SM, O'Driscoll K, Borner C, Bang D, Jiang W, Blackwood A, Nomoto K.
The role of protein kinase C in signal transduction, growth control and lipid metabolism.
Adv Exp Med Biol 1997;400A:313-21. Pubmed9547573
  Ye Q, Wei Y, Fischer R, Borner C, Berchtold MW.
Expression of calmodulin and calmodulin binding proteins in rat fibroblasts stably transfected with protein kinase C and oncogenes.
Biochim Biophys Acta 1997 Oct 30;1359(1):89-96. Pubmed9398089
  Olivier R, Otter I, Monney L, Wartmann M, Borner C.
Bcl-2 does not require Raf kinase activity for its death-protective function.
Biochem J 1997 May 15;324 ( Pt 1):75-83
http://www.biochemj.org/bj//324/0075/bj3240075.htm
  Pourzand C, Rossier G, Reelfs O, Borner C, Tyrrell RM.
Overxpression of Bcl-2 inhibits UVA-mediated immediate apoptosiinrat 6 fibroblasts: evidence for the involvement of Bcl-2 as an antioxidant.
Cancer Res 1997 Apr 15;57(8):1405-11. Pubmed9108435
1996 Borner C.
Diminished cell proliferation associated with the death-protective activity of Bcl-2.
J Biol Chem 1996 May 31;271(22):12695-8
http://www.jbc.org/cgi/content/full/271/22/12695
  Zhang J, Alter N, Reed JC, Borner C, Obeid LM, Hannun YA.
Bcl-2 interrupts the ceramide-mediated pathway of cell death.
Proc Natl Acad Sci U S A 1996 May 28;93(11):5325-8
http://www.pnas.org/cgi/reprint/93/11/5325
  Monney L, Otter I, Olivier R, Ravn U, Mirzasaleh H, Fellay I, Poirier GG, Borner C.
Bcl-2 overexpression blocks activation of the death protease CPP32/Yama/apopain.
Biochem Biophys Res Commun 1996 Apr 16;221(2):340-5. Pubmed8619857
1995 Schröter M, Lowin B, Borner C, Tschopp J.
Regulation of Fas(Apo-1/CD95)- and perforin-mediated lytic pathways of primary cytotoxic T lymphocytes by the protooncogene bcl-2.
Eur J Immunol 1995 Dec;25(12):3509-13. Pubmed8566045
  Borner C, Ueffing M, Jaken S, Parker PJ, Weinstein IB.
Two closely related isoforms of protein kinase C produce reciprocal effects on the growth of rat fibroblasts. Possible molecular mechanisms.
J Biol Chem 1995 Jan 6;270(1):78-86
http://www.jbc.org/cgi/content/full/270/1/78
1994 Kahn SM, O'Driscoll KR, Jiang W, Borner C, Xu DB, Blackwood MA, Zhang YJ, Nomoto K, Weinstein IB.
Suppression of mitogenic activity by stable expression of the regulatory domain of PKC beta.
Carcinogenesis 1994 Dec;15(12):2919-25. Pubmed8001256
  Borner C, Olivier R, Martinou I, Mattmann C, Tschopp J, Martinou JC.
Dissection of functional domains in Bcl-2 alpha by site-directed mutagenesis.
Biochem Cell Biol 1994 Nov-Dec;72(11-12):463-9. Pubmed7654319
  Borner C, Martinou I, Mattmann C, Irmler M, Schaerer E, Martinou JC, Tschopp J.
The protein bcl-2 alpha does not require membrane attachment, but two conserved domains to suppress apoptosis.
J Cell Biol 1994 Aug;126(4):1059-68. Pubmed8051205
1993 Peitsch MC, Borner C, Tschopp J.
Sequence similarity of phospholipase A2 activating protein and the G protein beta-subunits: a new concept of effector protein activation in signal transduction?
Trends Biochem Sci 1993 Aug;18(8):292-3. Pubmed8236442
  Fabbro, D. & Borner, C. (1993) Protein kinase C.
Human protein data EMBL (A. Haeberli, ed.) VHC Verlags GmBH, Weinheim
  Weinstein, I. B., Borner, C., Guadagno Nichols, S., O'Driscoll, K., Cacace, A. & Fabbro, D. (1993) The roles of specific isoforms of protein kinase C (PKC) in growth control, oncogene-induced cell transformation, and differentiation (Review)
In: The pharmacology of cell differentiation. R. A. Rifkind (ed.); Elsevier Science Publishers, B. V., pp. 15-23.
  Kahn, S. M., O'Driscoll, K., Borner, C., Bang, D., Jiang, W., Blackwood, A., Nomoto, K. & Weinstein, I. B. (1993) Inhibition of diacylglycerol production in rat 6 cells that stably express only the regulatory domain of protein kinase CbI.
In: Advances in polyunsaturated fatty acid research. T. Yasugi, H. Nakamura, and M. Soma (eds.); Elsevier Science Publishers, B. V., pp. 45-50.
1992 Borner C, Guadagno Nichols S, Fabbro D, Weinstein IB.
Expression of four protein kinase C isoforms in rat fibroblasts. I. Distinct subcellular distribution and regulation by calcium and phorbol esters.
J Biol Chem 1992 Jun 25;267(18):12892-9. Pubmed1618787
  Borner C, Guadagno Nichols S, Hsiao WW, Fabbro D, Barr M, Weinstein IB.
Expression of four protein kinase C isoforms in rat fibroblasts. II. Differential alterations in ras-, src-, and fos-transformed cells.
J Biol Chem 1992 Jun 25;267(18):12900-10. Pubmed1618788
  Tulchin N, Ornstein L, Harpaz N, Guillem J, Borner C, O'Toole K.
c-myc protein distribution. Neoplastic tissues of the human colon.
Am J Pathol 1992 Mar;140(3):719-29. Pubmed1372161
  Guadagno Nichols S, Borner C, Weinstein IB.
Altered regulation of a major substrate of protein kinase C in rat 6 fibroblasts overproducing PKC beta I.
J Biol Chem 1992 Feb 5;267(4):2697-707. Pubmed1370830
  Fabbro D, Küng W, Costa SD, Borner C, Regenass U, Eppenberger U.
Involvement of protein kinase C in the growth regulation of human breast cancer cells.
Cancer Treat Res 1992;61:229-48. Pubmed1360235
  Borner, C. & Fabbro, D. (1992) PKC and Cellular Transformation (Review)
In: Protein kinase C: Current concepts and perspectives. R. Epand and D. Lester (eds.); Ellis Horwood Publisher, Sussex, England, pp. 296-352.
  O'Driscoll, K. R., Kahn, S. M., Borner, C. M., Jiang, W. & Weinstein, I. B. (1992) Studies on the role of protein kinase C in multistage carcinogenesis and their relevance to risk extrapolation (Review).
In: Oncogene and transgenic correlates of cancer risk assessments. C. Zervos (ed.); Plenum Press, New York, pp. 43-59.
1991 Borner C, Filipuzzi I, Weinstein IB, Imber R.
Failure of wild-type or a mutant form of protein kinase C-alpha to transform fibroblasts.
Nature 1991 Sep 5;353(6339):78-80. Pubmed1881450
  Fabbro, D., Küng, W., Costa, S. D., Borner, C., Regenass, U. & Eppenberger, U. (1991) Involvement of protein kinase C in the growth regulation of human breast cancer cells.
In: Genes, Oncogenes, and Hormones: Advances in Cellular and Molecular Biology of Breast Cancer. R. B. Dickson & M. E. Lippman (eds.); Kluwer Academic Publishers, Boston, pp. 229-248.
1990 Borner C, Guadagno Nichols S, Hsieh LL, Hsiao WL, Weinstein IB.
Transformation by a ras oncogene causes increased expression of protein kinase C-alpha and decreased expression of protein kinase C-epsilon.
Cell Growth Differ 1990 Dec;1(12):653-60. Pubmed2288879
  Rotenberg SA, Krauss RS, Borner CM, Weinstein IB.
Characterization of a specific form of protein kinase C overproduced by a C3H 10T1/2 cell line.
Biochem J 1990 Feb 15;266(1):173-8. Pubmed2310371, Portland Press
  Krauss RS, Housey GM, Hsiao WL, Johnson MK, Rotenberg SA, Borner CM, Weinstein IB.
The role of protein kinase C in signal transduction and cellular transformation.
Prog Clin Biol Res 1990;340D:175-82, Review. Pubmed2196578
  Weinstein IB, Borner C, Krauss R, O'Driscoll K, Choi P, Moritomi M, Hoshina S, Hsieh L-L, Tchou-Wong K-M, Guadagno Nichols S, Ueffing M, Guillem J.
Pleiotropic effects of protein kinase C and the concept of carcinogenesis as a progressive disorder in signal transduction.
Adv in Second Messenger and Phosphoprotein Res 1990; 26:182-96.
  Kahn SM, Jiang W, Borner C, O'Driscoll K, Weinstein IB.
Construction of defined deletion mutants by thermal cycled fusion: Applications to protein kinase C.
Technique 1990; 2:27-30.
1989 Borner C, Filipuzzi I, Wartmann M, Eppenberger U, Fabbro D.
Biosynthesis and posttranslational modifications of protein kinase C in human breast cancer cells.
J Biol Chem 1989 Aug 15;264(23):13902-9. Pubmed2474538
1988 Borner C, Eppenberger U, Wyss R, Fabbro D.
Continuous synthesis of two protein-kinase-C-related proteins after down-regulation by phorbol esters.
Proc Natl Acad Sci U S A 1988 Apr;85(7):2110-4. Pubmed3353368
  Fabbro D, Mazurek N, Borner C, Conscience JF, Erne P.
Role of protein kinase C (PKC) in short- and long-term cellular responses: inhibition of agonist-mediated calcium transients and down-regulation of PKC.
J Cardiovasc Pharmacol 1988;12 Suppl 5:S73-9. Pubmed2469882
1987 Borner C, Wyss R, Regazzi R, Eppenberger U, Fabbro D.
Immunological quantitation of phospholipid/Ca2+-dependent protein kinase of human mammary carcinoma cells: inverse relationship to estrogen receptors.
Int J Cancer 1987 Sep 15;40(3):344-8. Pubmed3623717
  Wyss R, Fabbro D, Regazzi R, Borner C, Takahashi A, Eppenberger U.
Phorbol ester and epidermal growth factor receptors in human breast cancer.
Anticancer Res 1987 Jul-Aug;7(4B):721-7. Pubmed3499860
  Mazurek N, Regazzi R, Borner C, Wyss R, Conscience JF, Erne P, Eppenberger U, Fabbro D.
Altered protein kinase C in a mast cell variant defective in exocytosis.
Proc Natl Acad Sci U S A 1987 Mar;84(5):1277-81. Pubmed3493490
  Erne P, Mazurek N, Borner C, Conscience JF, Eppenberger U, Fabbro D.
Translocation of protein kinase C is not required to inhibit the antigen-induced increase of cytosolic calcium in a mast cell line.
Biochem Biophys Res Commun 1987 Feb 27;143(1):252-9. Pubmed3103618
  Fabbro D, Regazzi R, Costa SD, Borner C, Eppenberger U.
Protein kinase C desensitization by phorbol esters and its impact on growth of human breast cancer cells.
Year Book of Cancer 1987; 545-546.
1986 Regazzi R, Fabbro D, Costa SD, Borner C, Eppenberger U.
Effects of tumor promoters on growth and on cellular redistribution of phospholipid/Ca2+-dependent protein kinase in human breast cancer cells.
Int J Cancer 1986 May 15;37(5):731-7. Pubmed3084390
  Fabbro D, Regazzi R, Costa SD, Borner C, Eppenberger U.
Protein kinase C desensitization by phorbol esters and its impact on growth of human breast cancer cells.
Biochem Biophys Res Commun 1986 Feb 26;135(1):65-73. Pubmed3513765
  Fabbro, D., Wyss, R., Borner, C. & Regazzi, R. (1986) Epidermal growth factor receptor and calcium/phospholipid-dependent protein kinase activities in human mammary tumor cells.
In: S. Eckhardt, J. H. Holzner, G. A. Nagel (eds.); Contributions to Oncology: Endocrine Therapy of Breast Cancer 23, 33-44, Karger, Basel.
 

 
Abstracts

1998 Borner, C., Monney, L., Olivier, R., Rossé, T., Conus, S. and Fellay, I. (1998)
Bcl-2 and Bax: the "good" and the "bad" for cell survival.
On behalf of the international STCS meeting on "Life and Death of a Cell", Sept 17-18, 1998, Fribourg, Switzerland
Anticancer Res 18, 4521.
  Borner, C., Olivier, R., Otter, I., Jansen, B., Poirier, G. G., and Monney, L. (1998)
Role of an acidic compartment in TNF-a-induced production of ceramide, activation of caspase-3 (CPP32) and apoptosis.
On behalf of the Annual Swiss Cancer Meeting, 28.8.97, St. Gallen, Switzerland, in"Recent Results in Cancer Research", Springer Publisher.
  Conus, S., Fellay, I., Otter, I., Rossé, T., Wartmann, M. & Borner, C. (1998)
Bcl-2 does not readily form homodimers.
On behalf of the international STCS meeting on "Life and Death of a Cell", Sept 17-18, 1998, Fribourg, Switzerland
Anticancer Res 18, 4524.
  Häcki, J., Monney, L., Conus, S., Rossé, T., Olivier, R., Baggiolini, M. & Borner, C. (1998)
Loss of procaspase-3 in response to the caspase inhibitor z-VAD-fmk.
On behalf of the international STCS meeting on "Life and Death of a Cell", Sept 17-18, 1998, Fribourg, Switzerland
Anticancer Res 18, 4533.
  Pourzand, C., Borner, C. & Tyrell, R. M. (1998)
Iron does not play a role in UVA-mediated immediate apoptosis in rat R6 fibroblasts.
On behalf of the international STCS meeting on "Life and Death of a Cell", Sept 17-18, 1998, Fribourg, Switzerland
Anticancer Res 18, 4548.
  Schlagbauer-Wadl, H., Wacheck, V., Borner, C., Fink, D., Mensik, C., Eichler, H.-G.,Wolff, K., Pehamberger, H. & Jansen, B. (1998)
Bcl-2 mediates chemoresistance in human melanoma.
On behalf of the international STCS meeting on "Life and Death of a Cell", Sept 17-18, 1998, Fribourg, Switzerland
Anticancer Res 18, 4552-4553.
  Schlagbauer-Wadl, H., Wacheck, V., Borner, C., Fink, D., Mensik, C., Eichler, H.-G.,Wolff, K., Pehamberger, H. & Jansen, B. (1998)
Bcl-2 mediates chemoresistance in human melanoma.
On behalf of the international STCS meeting on "Life and Death of a Cell", Sept 17-18, 1998, Fribourg, Switzerland
Anticancer Res 18, 4552-4553.
  Wacheck, V., Selzer, E., Mayer, B., Schlagbauer-Wadl, H., Borner, C., Wolff, K., Pehamberger, D., Eichler, H.-G. & Jansen, B. (1998)
Selective blockage of apoptosis pathways by Bcl-2.
On behalf of the international STCS meeting on "Life and Death of a Cell", Sept 17-18, 1998, Fribourg, Switzerland
Anticancer Res 18, 4561-4562.
  Grandgirard, D., Studer, E., Monney, L., Fellay, I., Belser, T., Borner, C. & Michel, M. R. (1998)
Regulation of alphavirus-induced death by Bcl-2.
On behalf of the international STCS meeting on "Life and Death of a Cell", Sept 17-18, 1998, Fribourg, Switzerland
Anticancer Res 18, 4531.
1996 Borner, C. (1996)
A lysosomal component required for cell death induced by tumor necrosis factor a.
28th Annual Meeting of the Swiss Society of Experimental Biology (USGEB), March 27-29, 1996, Zürich-Irchel
Experientia 52, p. A79, Birkhäuser.
  Monney, L., and Borner, C. (1996)
Bcl-2 protects from cell death induced by a toxic overload of aberrant protein.
28th Annual Meeting of the Swiss Society of Experimental Biology (USGEB), March 27-29, 1996, Zürich-Irchel
Experientia 52, p. A79, Birkhäuser.
  Olivier, R., Martinou, I., Martinou, J.-C., and Borner, C. (1996)
Chimera between Bcl-2 and Bax: a tool to dissect domains for survival and death.
28th Annual Meeting of the Swiss Society of Experimental Biology (USGEB), March 27-29, 1996, Zürich-Irchel
Experientia 52, p. A79, Birkhäuser.
  Otter, I., and Borner, C. (1996)
Analysis of proteins that bind to Bcl-2 during apoptotic stresses.
28th Annual Meeting of the Swiss Society of Experimental Biology (USGEB), March 27-29, 1996, Zürich-Irchel
Experientia 52, p. A79, Birkhäuser.
  Otter, I., and Borner, C. (1996)
Analysis of proteins that bind to Bcl-2 during apoptotic stresses.
The life and death of a cell, 4th IUBMB Conference, Edinburgh, July 14-17, 1996
Biochemical Society Transactions 24, p. 600S
  Wartmann, M., Olivier, R., Otter, I., Monney, L., and Borner, C. (1996)
Bcl-2 confers cell death protection via a R-ras- and Raf-independent pathway.
The life and death of a cell, 4th IUBMB Conference, Edinburgh, July 14-17, 1996
Biochemical Society Transactions 24, p. 598S
1995 Borner, C. (1995)
Bcl-2 slows down the proliferation of eukaryotic and prokaryotic cells.
27th Annual Meeting of the Swiss Society of Experimental Biology (USGEB), March 30 & 31, 1995, Fribourg
Experientia 51, p. A88, Birkhäuser.
  Favre, D. & Borner, C. (1995)
Impact of the survival factor Bcl-2 on protein turnover.
27th Annual Meeting of the Swiss Society of Experimental Biology (USGEB), March 30 & 31, 1995, Fribourg
Experientia 51, p. A88, Birkhäuser.
  Olivier, R., Otter, I., and Borner, C. (1995)
The interaction of Bcl-2 with the raf-signalling pathway.
27th Annual Meeting of the Swiss Society of Experimental Biology (USGEB), March 30 & 31, 1995, Fribourg
Experientia 51, p. A88, Birkhäuser.
  Otter, I., and Borner, C. (1995)
Identification of proteins which interact with the survival factor Bcl-2.
27th Annual Meeting of the Swiss Society of Experimental Biology (USGEB), March 30 & 31, 1995, Fribourg
Experientia 51, p. A88, Birkhäuser.
1994 Borner, C., Martinou, I., Mattmann, C., Imber, M., Schaerer, E., Martinou,J.-C. & Tschopp, J. (1994)
Bcl-2 does not require membrane attachment for its survival activity.
26th Annual Meeting of the Swiss Society of Experimental Biology (USGEB), March 17 & 18, 1994, Bern.
Experientia 50, p. A3, Birkhäuser.
1993 Borner, C., Ueffing, M. & Weinstein. I. B. (1993)
Opposing impact of two PKC isoforms on cell growth and transformation.
In: Keystone Symposia on Molecular and Cellular Biology,
J. Cellular Biochemistry, Supplement 17A, p. 264.
1992 Borner, C., Guadagno Nichols, S., Fabbro, D., Hsiao, W., Barr, M. & Weinstein, I. B. (1992)
Expression of PKC isoforms in rat fibroblasts.
24th Annual Meeting of the Swiss Society of Experimental Biology (USGEB), March 19 & 20, 1992, Basle.
Experientia 48, p. A30, Birkhäuser.
1991 Borner, C., Guadagno Nichols, S., Hsiao, W.-W. L. & Weinstein, I. B. (1991)
Increased expression of PKCa and decreased expression of PKCe in cells transformed by ras, fos or src oncogenes.
In: UCLA Symposia on Molecular and Cellular Biology,
J. Cellular Biochemistry, Supplement 15B, p. 148.
  Guadagno, S. N., Borner, C., & Weinstein. I. B. (1991)
Regulation of the MARCKS protein in cell lines which overexpress PKCbI.
In: UCLA Symposia on Molecular and Cellular Biology,
J. Cellular Biochemistry, Supplement 15B, p. 163
  Gazetas, P., Borner, C., Ueffing, M., Pocsidio, J., Logerfo, P. & Weinstein, I. B. (1991)
Elevated levels of PKA activity in human breast cancer.
In: UCLA Symposia on Molecular and Cellular Biology,
J. Cellular Biochemistry, Supplement 15B, p. 154
  O'Driscoll, K., Kahn, S. M., Borner, C., Jiang, W. & Weinstein, I. B. (1991)
Stable expression of regulatory domain deletion mutants of PKCbI in rat fibroblasts.
In: UCLA Symposia on Molecular and Cellular Biology,
J. Cellular Biochemistry, Supplement 15B, p. 163
  Fabbro, D., Wolf, M., Filipuzzi, I., Borner, C., Imber, R., Meyer, T. & Matter, A. (1991)
Effects of staurosporine and derivatives on PKC.
In: UCLA Symposia on Molecular and Cellular Biology,
J. Cellular Biochemistry, Supplement 15B, p. 152
1990 Borner, C., Nichols, S., Hsieh, L. L., Hsiao, W.-L.W. & Weinstein, I. B. (1990)
Differential expression of protein kinase C isoforms during multistep carcinogenesis.
In: UCLA Symposia on Molecular and Cellular Biology,
J. Cellular Biochemistry, Supplement 14B, p. 285.
1988 Borner, C., Filipuzzi, I., Eppenberger, U. & Fabbro, D. (1988)
Biosynthesis and posttranslational modifications of protein kinase C in human breast cancer cells.
20th Annual Meeting of the Swiss Society for Experimental Biology (USGEB), March 10 & 11, Interlaken.
Experientia 44, p. A1-A98, Birkhäuser
1986 Fabbro, D., Regazzi, R., Costa, S. D., Borner, C. & Eppenberger, U. (1986)
Protein kinase C desensitization by phorbol esters and its impact on growth of human breast cancer cells.
1st International Congress on Cancer and Hormones, Endocrinology and Malignancy, Basic and Clinical Issue, April 22-27, Rome, Italy.
Anticancer Res 6 (3), part A

 
Articles in newspapers

1998

Mort cellulaire: découverte à Fribourg. Le Nouveau Quotidien, 3.2.98, text by press communication

  Mort des cellules: une découverte à Fribourg. La Gruyère, 3.2.98, text by press communication
  Universität Freiburg: Wie sterben Zellen? Freiburger Nachrichten, 3.2.98, text by press communication
  Université: La mort des cellules est mieux comprise. La Liberté, 3.2.98, text by press communication
  Sterben, um leben zu koennen: Journal Universitas Friburgensis, 3/98, text by Christoph Borner
  A l'Université, des biochimistes cernent le mystère des cellules immortelles et au péril de l'organisme, des cellules refusent de mourir. Pourquoi?
La Liberté, 26.3.98, text by Jean Ammann, journalist
  Vos lettres, Recherche contre le cancer (pour le combat de l'initiative sur le génie génétique). La Liberté, 25.4.98, text by Christoph Borner
  Fribourg, 300 chercheurs de 21 pays vont parler de la mort de la cellule. Captivant. La Liberté, 16.9.98, text by Pierre-André Sieber, journalist
  Universität: Kolloquium zum Zelltod. Freiburger Nachrichten, 18.9.98, text by press communication
  Cellules: mourir pour que l'organisme puisse vivre. Le Journal du Cancer de la Ligue Suisse Contre le Cancer, Oct 1998. text by Christiane Kuhn, journalist

 
Radio

1998 Interview about the article "Bcl-2 prolongs cell survival after Bax-induced release of cytochrome c Nature , 391, 496-499" in the french-speaking and german-speaking local radios of Fribourg/Freiburg. January 29, 1998
 

Interview about "Est-ce que vous voulez devenir 120 ans?" in the local Fribourg radio "Radio de quartier". September 26, 1998

 
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