Molekulare Medizin - Forschungsgruppe Börries
Veröffentlichungen
| Publications since 2021 | |||
| 2021 | Frey, P., Devisme, A., Rose, K. Schrempp, M, Freihen, V, Andrieux, G, Boerries, M, Hecht, A, SMAD4 mutations do not preclude epithelial–mesenchymal transition in colorectal cancer. Oncogene (2021). 2021/12/03, SN 1476-5594, https://doi.org/10.1038/s41388-021-02128-2. | ||
| Benedikt Westphalen C, Bokemeyer C, Büttner R, Fröhling S, Gaidzik VI, Glimm H, Hacker UT, Heinemann V, Illert AL, Keilholz U, Kindler T, Kirschner M, Schilling B, Siveke JT, Schroeder T, Tischler V, Wagner S, Weichert W, Zips D, Loges S; Working Group Molecular Diagnostics and Therapy. Börries M, Peters C, Et al. Corrigendum to "Conceptual framework for precision cancer medicine in Germany: Consensus statement of the Deutsche Krebshilfe working group 'Molecular Diagnostics and Therapy'" [European Journal of Cancer 135 (2020) 1-7]. Eur J Cancer. 2021 Dec 22:S0959-8049(21)01224-7. doi: 10.1016/j.ejca.2021.11.014. Epub ahead of print. Erratum for: Eur J Cancer. 2020 Aug;135:1-7. PMID: 34953660. | |||
| Spohr C, Poggio T, Andrieux G, Schönberger K, Cabezas-Wallscheid N, Boerries M, Halbach S, Illert AL, Brummer T. Gab2 deficiency prevents Flt3-ITD driven acute myeloid leukemia in vivo. Leukemia. 2021 Dec 13. doi: 10.1038/s41375-021-01490-0. Epub ahead of print. PMID: 34903841. | |||
| Dierks C, Seufert J, Aumann K, Ruf J, Klein C, Kiefer S, Rassner M, Boerries M, Zielke A, la Rosee P, Meyer PT, Kroiss M, Weißenberger C, Schumacher T, Metzger P, Weiss H, Smaxwil C, Laubner K, Duyster J, von Bubnoff N, Miething C, Thomusch O. Combination of Lenvatinib and Pembrolizumab Is an Effective Treatment Option for Anaplastic and Poorly Differentiated Thyroid Carcinoma. Thyroid. 2021 Jul;31(7):1076-1085. doi: 10.1089/thy.2020.0322. Epub 2021 Apr 15. PMID: 33509020; PMCID: PMC8290324. | |||
| Osswald L, Hamarsheh S, Uhl FM, Andrieux G, Klein C, Dierks C, Duquesne S, Braun LM, Schmitt-Graeff A, Duyster J, Boerries M, Brummer T, Zeiser R. Oncogenic Kras-G12D activation in the non-hematopoietic bone marrow microenvironment causes myelodysplastic syndrome in mice. Mol Cancer Res. 2021 Jun 4:molcanres.0275.2020. doi: 10.1158/1541-7786.MCR-20-0275. Epub ahead of print. PMID: 34088868. | |||
| Hoefflin R, Lazarou A, Hess ME, Reiser M, Wehrle J, Metzger P, Frey AV, Becker H, Aumann K, Berner K, Boeker M, Buettner N, Dierks C, Duque-Afonso J, Eisenblaetter M, Erbes T, Fritsch R, Ge IX, Geißler AL, Grabbert M, Heeg S, Heiland DH, Hettmer S, Kayser G, Keller A, Kleiber A, Kutilina A, Mehmed L, Meiss F, Poxleitner P, Rawluk J, Ruf J, Schäfer H, Scherer F, Shoumariyeh K, Tzschach A, Peters C, Brummer T, Werner M, Duyster J, Lassmann S, Miething C, Boerries M, Illert AL, von Bubnoff N. Transitioning the Molecular Tumor Board from Proof of Concept to Clinical Routine: A German Single-Center Analysis. Cancers (Basel). 2021 Mar 8;13(5):1151. doi: 10.3390/cancers13051151. Pubmed33800365. | |||
| 2020 | Ketterer S, Mitschke J, Ketscher A, Schlimpert M, Reichardt W, Baeuerle N, Hess ME, Metzger P, Boerries M, Peters C, Kammerer B, Brummer T, Steinberg F, Reinheckel T. Cathepsin D deficiency in mammary epithelium transiently stalls breast cancer by interference with mTORC1 signaling. Nat Commun. 2020 Oct 12;11(1):5133. doi: 10.1038/s41467-020-18935-2. Pubmed33046706 | ||
| Kozyra EJ, Pastor VB, Lefkopoulos S, Sahoo SS, Busch H, Voss RK, Erlacher M, Lebrecht D, Szvetnik EA, Hirabayashi S, Pasaulienė R, Pedace L, Tartaglia M, Klemann C, Metzger P, Boerries M, Catala A, Hasle H, de Haas V, Kállay K, Masetti R, De Moerloose B, Dworzak M, Schmugge M, Smith O, Starý J, Mejstrikova E, Ussowicz M, Morris E, Singh P, Collin M, Derecka M, Göhring G, Flotho C, Strahm B, Locatelli F, Niemeyer CM, Trompouki E, Wlodarski MW; European Working Group of MDS in Childhood (EWOG-MDS). Synonymous GATA2 mutations result in selective loss of mutated RNA and are common in patients with GATA2 deficiency. Leukemia. 2020 Oct;34(10):2673-2687. doi: 10.1038/s41375-020-0899-5. Pubmed32555368 | |||
| Wenzel J, Rose K, Haghighi EB, Lamprecht C, Rauen G, Freihen V, Kesselring R, Boerries M, Hecht A. Oncogene. Loss of the nuclear Wnt pathway effector TCF7L2 promotes migration and invasion of human colorectal cancer cells. Oncogene2020 May;39(19):3893-3909. doi: 10.1038/s41388-020-1259-7. Pubmed32203164 | |||
| Freihen V, Rönsch K, Mastroianni J, Frey P, Rose K, Boerries M, Zeiser R, Busch H, Hecht A. SNAIL1 employs β-Catenin-LEF1 complexes to control colorectal cancer cell invasion and proliferation. Int J Cancer. 146 (8), 2229-2242 2020 Apr 15. doi: 10.1002/ijc.32644. Pubmed31463973 | |||
| Ruan X, Johnson GR, Bierschenk I, Nitschke R, Boerries M, Busch H, Murphy RF. Image-derived models of cell organization changes during differentiation and drug treatments. Mol Biol Cell. 2020 Mar 19;31(7):655-666. doi: 10.1091/mbc.E19-02-0080. Pubmed31774723 | |||
| Sánchez-González I, Bobien A, Molnar C, Schmid S, Strotbek M, Boerries M, Busch H, Olayioye M. miR-149 Suppresses Breast Cancer Metastasis by Blocking Paracrine Interactions With Macrophages. Cancer Res. 2020 Mar 15;80(6):1330-1341. doi: 10.1158/0008-5472.CAN-19-1934. Pubmed31911555 | |||
| 2019 | Dittmann J, Haydn T, Metzger P, Ward GA, Boerries M, Vogler M, Fulda S. Next-generation hypomethylating agent SGI-110 primes acute myeloid leukemia cells to IAP antagonist by activating extrinsic and intrinsic apoptosis pathways.Cell Death Differ. 2019 Dec 12. doi: 10.1038/s41418-019-0465-8. Pubmed31831875 [Epub ahead of print] | ||
| Ohse S, Boerries M, Busch H. November 11, 2019. Blind normalization of public high-throughput databases. PeerJ Computer Science 5:e231 doi.org/10.7717/peerj-cs.231 | |||
| Beyes S, Andrieux G, Schrempp M, Aicher D, Wenzel J, Antón-García P, Boerries M, Hecht A. Genome-wide mapping of DNA-binding sites identifies stemness-related genes as directly repressed targets of SNAIL1 in colorectal cancer cells. Oncogene. 2019 Oct;38(40):6647-6661. doi: 10.1038/s41388-019-0905-4. Epub 2019 Aug 7. Pubmed31391555 | |||
| Leichsenring J, Horak P, Kreutzfeldt S, Heining C, Christopoulos P, Volckmar AL, Neumann O, Kirchner M, Ploeger C, Budczies J, Heilig CE, Hutter B, Fröhlich M, Uhrig S, Kazdal D, Allgäuer M, Harms A, Rempel E, Lehmann U, Thomas M, Pfarr N, Azoitei N, Bonzheim I, Marienfeld R, Möller P, Werner M, Fend F, Boerries M, von Bubnoff N, Lassmann S, Longerich T, Bitzer M, Seufferlein T, Malek N, Weichert W, Schirmacher P, Penzel R, Endris V, Brors B, Klauschen F, Glimm H, Fröhling S, Stenzinger A. Variant Classification in Precision Oncology. Int J Cancer. 2019 Dec 1;145(11):2996-3010. doi: 10.1002/ijc.32358. Epub 2019 May 21. Pubmed31008532 | |||
| Gladilin E, Ohse S, Boerries M, Busch H, Xu C, Schneider M, Meister M, Eils R. TGFβ-induced cytoskeletal remodeling mediates elevation of cell stiffness and invasiveness in NSCLC. Sci Rep. 2019 May 21;9(1):7667. doi: 10.1038/s41598-019-43409-x. Pubmed31113982 | |||
| Schumacher D, Andrieux G, Boehnke K, Keil M, Silvestri A, Silvestrov M, Keilholz U, Haybaeck J, Erdmann G, Sachse C, Templin M, Hoffmann J, Boerries M, Schäfer R, Regenbrecht CRA. Heterogeneous pathway activation and drug response modelled in colorectal-tumor-derived 3D cultures. PLoS Genet. 2019 Mar 29;15(3):e1008076. doi: 10.1371/journal.pgen.1008076. eCollection 2019 Mar. Pubmed30925167 | |||
| Ohmer M, Tzivelekidis T, Niedenführ N, Volceanov-Hahn L, Barth S, Vier J, Börries M, Busch H, Kook L, Biniossek ML, Schilling O, Kirschnek S, Häcker G. Infection of HeLa cells with Chlamydia trachomatis inhibits protein synthesis and causes multiple changes to host cell pathways. Cell Microbiol. 2019 Apr;21(4):e12993. doi: 10.1111/cmi.12993. Pubmed30551267 | |||
| Hillebrand LE, Wickberg SM, Gomez-Auli A, Follo M, Maurer J, Busch H, Boerries M, Reinheckel T. MMP14 empowers tumor-initiating breast cancer cells under hypoxic nutrient-depleted conditions. FASEB J. 2019 Mar;33(3):4124-4140. doi: 10.1096/fj.201801127R. Epub 2018 Dec 6. Pubmed30521382 | |||
| Wanner N, Vornweg J, Combes A, Wilson S, Plappert J, Rafflenbeul G, Puelles VG, Rahman RU, Liwinski T, Lindner S, Grahammer F, Kretz O, Wlodek ME, Romano T, Moritz KM, Boerries M, Busch H, Bonn S, Little MH, Bechtel-Walz W, Huber TB. DNA Methyltransferase 1 Controls Nephron Progenitor Cell Renewal and Differentiation. J Am Soc Nephrol. 2019 Jan;30(1):63-78. doi: 10.1681/ASN.2018070736. Epub 2018 Dec 5. Pubmed30518531 | |||
| Mastroianni J, Stickel N, Andrlová H, Hanke K, Melchinger W, Duquesne S, Schmidt D, Falk M, Andrieux G, Pfeifer D, Dierbach H, Schmitt-Graeff A, Meiss F, Boerries M, Zeiser R. miR-146a controls immune response in the melanoma microenvironment. Cancer Res. 2019 Jan 1;79(1):183-195. doi: 10.1158/0008-5472.CAN-18-1397. Epub 2018 Nov 13. Pubmed30425059 | |||
| 2018 | Klett H, Jürgensen L, Most P, Busch M, Günther F, Dobreva G, Leuschner F, Hassel D, Busch H, Boerries M. Delineating the Dynamic Transcriptome Response of mRNA and microRNA during Zebrafish Heart Regeneration. Biomolecules. 2018 Dec 28;9(1). pii: E11. doi: 10.3390/biom9010011. Pubmed30597924 | ||
| Hoefflin, R.,Geißler, A.-L., Fritsch, R., Claus, R.,,Wehrle, J., Metzger, P., Reiser, M., Mehmed, L., Fauth, L., Heiland, D.H., Erbes, T., Stock, F.,,Csanadi, A., Miething, C., Weddeling, B., Meiss, F., von Bubnoff, D., Dierks, C., Ge, I., Brass, V., Heeg, S., Schäfer, H., Boeker, M., Rawluk, J., Botzenhart, E.M., Kayser, G., Hettmer, S., Busch, H., Peters, C., Werner, M., Duyster, J., Brummer, T., Boerries, M., Lassmann, S. and von Bubnoff, N. (2018). Personalized clinical decision making through implementation of a Molecular Tumorboard – a German single centre experience. JCO Precision Oncology, DOI: 10.1200/PO.18.00105 JCO Precision Oncology - published online August 16, 2018 | |||
| Saporito-Magriñá CM, Musacco-Sebio RN, Andrieux G, Kook L, Orrego MT, Tuttolomondo MV, Desimone MF, Boerries M, Borner C, Repetto MG. Copper-induced cell death and the protective role of glutathione: the implication of impaired protein folding rather than oxidative stress. Metallomics. 2018 Dec 12;10(12):1743-1754. doi: 10.1039/c8mt00182k. Pubmed30311620 | |||
| He Y, Thriene K, Boerries M, Hausser I, Franzke CW, Busch H, Dengjel J, Has C. Constitutional absence of epithelial integrin α3 impacts the composition of the cellular microenvironment of ILNEB keratinocytes. Matrix Biol. 2018 Dec;74:62-76. doi: 10.1016/j.matbio.2018.07.001. Epub 2018 Jul 3. Pubmed30466509 | |||
| Yakulov TA, Todkar AP, Slanchev K, Wiegel J, Bona A, Groß M, Scholz A, Hess I, Wurditsch A, Grahammer F, Huber TB, Lecaudey V, Bork T, Hochrein J, Boerries M, Leenders J, de Tullio P, Jouret F, Kramer-Zucker A, Walz G. CXCL12 and MYC control energy metabolism to support adaptive responses after kidney injury. Nat Commun. 2018 Sep 10;9(1):3660. doi: 10.1038/s41467-018-06094-4. Pubmed30202007 | |||
| Haun F, Neumann S, Peintner L, Wieland K, Habicht J, Schwan C, Østevold K, Koczorowska MM, Biniossek M, Kist M, Busch H, Boerries M, Davis RJ, Maurer U, Schilling O, Aktories K, Borner C. Identification of a novel anoikis signalling pathway using the fungal virulence factor gliotoxin. Nat Commun. 2018 Aug 30;9(1):3524. doi: 10.1038/s41467-018-05850-w. Pubmed30166526 | |||
| Viau A, Bienaimé F, Lukas K, Todkar AP, Knoll M, Yakulov TA, Hofherr A, Kretz O, Helmstädter M, Reichardt W, Braeg S, Aschman T, Merkle A, Pfeifer D, Dumit VI, Gubler MC, Nitschke R, Huber TB, Terzi F, Dengjel J, Grahammer F, Köttgen M, Busch H, Boerries M, Walz G, Triantafyllopoulou A, Kuehn EW. Cilia-localized LKB1 regulates chemokine signaling, macrophage recruitment, and tissue homeostasis in the kidney. EMBO J. 2018 Aug 1;37(15). pii: e98615. doi: 10.15252/embj.201798615. Epub 2018 Jun 19. Pubmed29925518 | |||
| Koszinowski S, La Padula V, Edlich F, Krieglstein K, Busch H, Boerries M. Bid Expression Network Controls Neuronal Cell Fate During Avian Ciliary Ganglion Development. Front Physiol. 2018 Jun 29;9:797. doi: 10.3389/fphys.2018.00797. eCollection 2018. Pubmed30008673 | |||
| Prokosch HU, Acker T, Bernarding J, Binder H, Boeker M, Boerries M, Daumke P, Ganslandt T, Hesser J, Höning G, Neumaier M, Marquardt K, Renz H, Rothkötter HJ, Schade-Brittinger C, Schmücker P, Schüttler J, Sedlmayr M, Serve H, Sohrabi K, Storf H. MIRACUM: Medical Informatics in Research and Care in University Medicine.Methods Inf Med. 2018 Jul;57(S 01):e82-e91. doi: 10.3414/ME17-02-0025. Epub 2018 Jul 17. Pubmed30016814 | |||
| Rinschen MM, Gödel M, Grahammer F, Zschiedrich S, Helmstädter M, Kretz O, Zarei M, Braun DA, Dittrich S, Pahmeyer C, Schroder P, Teetzen C, Gee H, Daouk G, Pohl M, Kuhn E, Schermer B, Küttner V, Boerries M, Busch H, Schiffer M, Bergmann C, Krüger M, Hildebrandt F, Dengjel J, Benzing T, Huber TB. A Multi-layered Quantitative In Vivo Expression Atlas of the Podocyte Unravels Kidney Disease Candidate Genes. Cell Rep. 2018 May 22;23(8):2495-2508. doi: 10.1016/j.celrep.2018.04.059. Pubmed29791858 | |||
| Klett H, Balavarca Y, Toth R, Gigic B, Habermann N, Scherer D, Schrotz-King P, Ulrich A, Schirmacher P, Herpel E, Brenner H, Ulrich C, Michels KB, Busch H, Boerries M. Robust prediction of gene regulation in colorectal cancer tissues from DNA methylation profiles. Epigenetics. 2018;13(4):386-397. doi: 10.1080/15592294.2018.1460034. Epub 2018 May 3. Pubmed29697014] | |||
| Hinderer M, Boerries M, Boeker M, Neumaier M, Loubal FP, Acker T, Brunner M, Prokosch HU, Christoph J. Implementing Pharmacogenomic Clinical Decision Support into German Hospitals. Stud Health Technol Inform. 2018;247:870-874. Pubmed29678085 | |||
| Klett H, Fuellgraf H, Levit-Zerdoun E, Hussung S, Kowar S, Küsters S, Bronsert P, Werner M, Wittel U, Fritsch R, Busch H, Boerries M. Identification and Validation of a Diagnostic and Prognostic Multi-Gene Biomarker Panel for Pancreatic Ductal Adenocarcinoma. Front Genet. 2018 Apr 5;9:108. doi: 10.3389/fgene.2018.00108. eCollection 2018. Pubmed29675033 | |||
| Schmidt N, Haydn T, Schneider I, Busch H, Boerries M, Fulda S. Smac mimetic induces an early wave of gene expression via NF-κB and AP-1 and a second wave via TNFR1 signaling. Cancer Lett. 2018 May 1;421:170-185. doi: 10.1016/j.canlet.2018.01.082. Pubmed29421152 | |||
| Leseva MN, Grand RJ, Klett H, Boerries M, Busch H, Binder AM, Michels KB. Differences in DNA Methylation and Functional Expression in Lactase Persistent and Non-persistent Individuals. Sci Rep. 2018 Apr 4;8(1):5649. doi: 10.1038/s41598-018-23957-4. Pubmed29618745 | |||
| Heiland DH, Gaebelein A, Boerries M, Woerner J, Pompe N, Franco P, Heynckes S, Bartholomä MD, Ó hAilín D, Carro MS, Prinz M, Weber S, Mader I, Delev D, Schnell O. Microenvironmental-derived Regulation of HIF-Signaling Drives Transcriptional Heterogeneity in Glioblastoma Multiforme. Mol Cancer Res. 2018 Apr;16(4):655-668. doi: 10.1158/1541-7786.MCR-17-0680. Pubmed29330292 | |||
| Mathew NR, Baumgartner F, Braun L, ......... Halbach S, Brummer T, ........ Andrieux G, Börries M, ....... Blazar BR, Zeiser R. Erratum: Sorafenib promotes graft-versus-leukemia activity in mice and humans through IL-15 production in FLT3-ITD-mutant leukemia cells. Nat Med. 2018 Mar;24(3):282-291. doi: 10.1038/nm.4484. Pubmed29634689 | |||
| Herr R, Halbach S, Heizmann M, Busch H, Boerries M, Brummer T. BRAF inhibition upregulates a variety of receptor tyrosine kinases and their downstream effector Gab2 in colorectal cancer cell lines. Oncogene. 2018 Mar;37(12):1576-1593. doi: 10.1038/s41388-017-0063-5. Pubmed29326440 | |||
| Prestipino A,...... Boerries M, Busch H, Halbach S, ......Brummer T, ... Zeiser R. Oncogenic JAK2V617F causes PD-L1 expression, mediating immune escape in myeloproliferative neoplasms. Sci Transl Med. 2018 Feb 21;10(429). pii: eaam7729. doi: 10.1126/scitranslmed.aam7729. Pubmed29467301 | |||
| Pastor VB, Sahoo S, Boklan J, Schwabe GC, Saribeyoglu E, Strahm B, Lebrecht D, Voss M, Bryceson YT, Erlacher M, Ehninger G, Niewisch M, Schlegelberger B, Baumann I, Achermann JC, Shimamura A, Hochrein J, Tedgård U, Nilsson L, Hasle H, Boerries M, Busch H, Niemeyer CM, Wlodarski MW. Constitutional SAMD9L mutations cause familial myelodysplastic syndrome and transient monosomy 7. Haematologica. 2018 Mar;103(3):427-437. doi: 10.3324/haematol.2017.180778. Epub 2017 Dec 7. Pubmed29217778 | |||
| 2017 | Lipka DB, Witte T, Toth R, Yang J, Wiesenfarth M, Nöllke P, Fischer A, Brocks D, Gu Z, Park J, Strahm B, Wlodarski M, Yoshimi A, Claus R, Lübbert M, Busch H, Boerries M, Hartmann M, Schönung M, Kilik U, Langstein J, Wierzbinska JA, Pabst C, Garg S, Catalá A, De Moerloose B, Dworzak M, Hasle H, Locatelli F, Masetti R, Schmugge M, Smith O, Stary J, Ussowicz M, van den Heuvel-Eibrink MM, Assenov Y, Schlesner M, Niemeyer C, Flotho C, Plass C. RAS-pathway mutation patterns define epigenetic subclasses in juvenile myelomonocytic leukemia. Nat Commun. 2017 Dec 19;8(1):2126. doi: 10.1038/s41467-017-02177-w. Pubmed29259247 | ||
| Jägle S, Busch H, Freihen V, Beyes S, Schrempp M, Boerries M, Hecht A. SNAIL1-mediated downregulation of FOXA proteins facilitates the inactivation of transcriptional enhancer elements at key epithelial genes in colorectal cancer cells. PLoS Genet. 2017 Nov 20;13(11):e1007109. doi: 10.1371/journal.pgen.1007109. eCollection 2017 Nov. Pubmed29155818 | |||
| Hettmer S, Andrieux G, Hochrein J, Kurz P, Rössler J, Lassmann S, Werner M, von Bubnoff N, Peters C, Koscielniak E, Sparber-Sauer M, Niemeyer C, Mentzel T, Busch H, Boerries M. Epithelioid hemangioendotheliomas of the liver and lung in children and adolescents. Pediatr Blood Cancer. 2017 Dec;64(12). doi: 10.1002/pbc.26675. Epub 2017 Jun 9. Review. Pubmed28598585 | |||
| Metzger E, Stepputtis SS, Strietz J, Preca BT, Urban S, Willmann D, Allen A, Zenk F, Iovino N, Bronsert P, Proske A, Follo M, Boerries M, Stickeler E, Xu J, Wallace MB, Stafford JA, Kanouni T, Maurer J, Schüle R. KDM4 inhibition targets breast cancer stem-like cells. Cancer Res. 2017 Nov 1;77(21):5900-5912. doi: 10.1158/0008-5472.CAN-17-1754. Pubmed28883001 | |||
| Barrow TM, Klett H, Toth R, Böhm J, Gigic B, Habermann N, Scherer D, Schrotz-King P, Skender S, Abbenhardt-Martin C, Zielske L, Schneider M, Ulrich A, Schirmacher P, Herpel E, Brenner H, Busch H, Boerries M, Ulrich CM, Michels KB. Smoking is associated with hypermethylation of the APC 1A promoter in colorectal cancer: the ColoCare Study. J Pathol. 2017 Nov;243(3):366-375. doi: 10.1002/path.4955. Epub 2017 Sep 29 Pubmed28791728 | |||
| Lang S, Busch H, Boerries M, Brummer T, Timme S, Lassmann S, Aktories K, Schmidt G. Specific role of RhoC in tumor invasion and metastasis. Oncotarget. 2017 Sep 16;8(50):87364-87378. doi: 10.18632/oncotarget.20957. eCollection 2017 Oct 20. Pubmed29152087 | |||
| Panayotopoulou EG, Müller AK, Börries M, Busch H, Hu G, Lev S. Targeting of apoptotic pathways by SMAC or BH3 mimetics distinctly sensitizes paclitaxel-resistant triple negative breast cancer cells.Oncotarget. 2017 Jul 11;8(28):45088-45104. doi: 10.18632/oncotarget.15125. Pubmed28187446 | |||
| Andrlová H, Mastroianni J, Madl J, Kern JS, Melchinger W, Dierbach H, Wernet F, Follo M, Technau-Hafsi K, Has C, Mittapalli VR, Idzko M, Herr R, Brummer T, Ungefroren H, Busch H, Boerries M, Narr A, Ihorst G, Vennin C, Schmitt-Graeff A, Minguet S, Timpson P, Duyster J, Meiss F, Römer W, Zeiser R. Biglycan expression in the melanoma microenvironment promotes invasiveness via increased tissue stiffness inducing integrin-β1 expression. Oncotarget. 2017 Jun 27;8(26):42901-42916. doi: 10.18632/oncotarget.17160. Pubmed28476030 | |||
| Sulaimanov N, Klose M, Busch H, Boerries M. Understanding the mTOR signaling pathway via mathematical modeling. Wiley Interdiscip Rev Syst Biol Med. 2017 Jul;9(4). doi: 10.1002/wsbm.1379. Epub 2017 Feb 10. Pubmed28186392 Review | |||
| Pazzagli C, He Y, Busch H, Esser P, Kiritsi D, Gache Y, Bruckner-Tuderman L, Boerries M, Has C. Absence of the integrin α3 subunit induces an activated phenotype in human keratinocytes. J Invest Dermatol. 2017 Jun;137(6):1387-1391. doi: 10.1016/j.jid.2017.01.018. Epub 2017 Feb 3. Pubmed28163067 | |||
| Hinderer M, Boerries M, Haller F, Wagner S, Sollfrank S, Acker T, Prokosch HU, Christoph J. Supporting Molecular Tumor Boards in Molecular-Guided Decision-Making - The Current Status of Five German University Hospitals. Stud Health Technol Inform. 2017;236:48-54. Pubmed28508778 | |||
| Krebs AM, Mitschke J, Losada ML, Schmalhofer O, Boerries M, Busch H, Boettcher M, Mougiakakos D, Reichardt W, Bronsert P, Brunton VG, Pilarsky C, Winkler TH, Brabletz S, Stemmler MP, Brabletz T. The EMT-activator Zeb1 is a key factor for cell plasticity and promotes metastasis in pancreatic cancer. Nat Cell Biol. 2017 May;19(5):518-529. doi: 10.1038/ncb3513. Epub 2017 Apr 17. Pubmed28414315 | |||
| Strotbek M, Schmid S, Sànchez-Gonzàlez I, Boerries M, Busch H, Olayioye MA. miR-181 elevates Akt signaling by co-targeting PHLPP2 and INPP4B phosphatases in luminal breast cancer. Int J Cancer. 2017 May 15;140(10):2310-2320. doi: 10.1002/ijc.30661. Epub 2017 Mar 11. Pubmed28224609 | |||
| Nkuipou-Kenfack E, Schanstra JP, Bajwa S, Pejchinovski M, Vinel C, Dray C, Valet P, Bascands JL, Vlahou A, Koeck T, Borries M, Busch H, Bechtel-Walz W, Huber TB, Rudolph KL, Pich A, Mischak H, Zürbig P.The use of urinary proteomics in the assessment of suitability of mouse models for ageing. PLoS One. 2017 Feb 15;12(2):e0166875. doi: 10.1371/journal.pone.0166875. eCollection 2017 Feb 15. Pubmed28199320 | |||
| Adlung L, Kar S, Wagner MC, She B, Chakraborty S, Bao J, Lattermann S, Boerries M, Busch H, Wuchter P, Ho AD, Timmer J, Schilling M, Höfer T, Klingmüller U. Protein abundance of AKT and ERK pathway components governs cell type-specific regulation of proliferation. Mol Syst Biol. 2017 Jan 24;13(1):904. doi: 10.15252/msb.20167258. Pubmed28123004 | |||
| 2016 | Strietz J, Stepputtis SS, Preca BT, Vannier C, Kim MM, Castro DJ, Au Q, Boerries M, Busch H, Aza-Blanc P, Heynen-Genel S, Bronsert P, Kuster B, Stickeler E, Brabletz T, Oshima RG, Maurer J. ERN1 and ALPK1 inhibit differentiation of bi-potential tumor-initiating cells in human breast cancer. Oncotarget. 2016 Dec 13;7(50):83278-83293. doi: 10.18632/oncotarget.13086. Pubmed27829216 | ||
| He Y, Maier K, Leppert J, Hausser I, Schwieger-Briel A, Weibel L, Theiler M, Kiritsi D, Busch H, Boerries M, Hannula-Jouppi K, Heikkilä H, Tasanen K, Castiglia D, Zambruno G, Has C. Monoallelic Mutations in the Translation Initiation Codon of KLHL24 Cause Skin Fragility. Am J Hum Genet. 2016 Dec 1;99(6):1395-1404. doi: 10.1016/j.ajhg.2016.11.005. Pubmed27889062 | |||
| La Padula V, Staszewski O, Nestel S, Busch H, Boerries M, Roussa E, Prinz M, Krieglstein K. HSPB3 protein is expressed in motoneurons and induces their survival after lesion-induced degeneration. Exp Neurol. 2016 Dec;286:40-49. doi: 10.1016/j.expneurol.2016.08.014. Pubmed27567740 | |||
| Hillebrand LE, Bengsch F, Hochrein J, Hülsdünker J, Bender J, Follo M, Busch H, Boerries M, Reinheckel T. Proteolysis-a characteristic of tumor-initiating cells in murine metastatic breast cancer. Oncotarget. 2016 Sep 6;7(36):58244-58260. doi: 10.18632/oncotarget.11309. Pubmed27542270 | |||
| Lerchenmüller C, Heißenberg J, Damilano F, Bezzeridis VJ, Krämer I, Bochaton-Piallat ML, Hirschberg K, Busch M, Katus HA, Peppel K, Rosenzweig A, Busch H, Boerries M, Most P. S100A6 Regulates Endothelial Cell Cycle Progression by Attenuating Antiproliferative Signal Transducers and Activators of Transcription 1 Signaling. Arterioscler Thromb Vasc Biol. 2016 Sep;36(9):1854-67. doi: 10.1161/ATVBAHA.115.306415. Epub 2016 Jul 7.. Pubmed27386938 | |||
| Grahammer F, Wigge C, Schell C, Kretz O, Patrakka J, Schneider S, Klose M, Arnold SJ, Habermann A, Bräuniger R, Rinschen MM, Völker L, Bregenzer A, Rubbenstroth D, Boerries M, Kerjaschki D, Miner JH, Walz G, Benzing T, Fornoni A, Frangakis AS, Huber TB. A flexible, multilayered protein scaffold maintains the slit in between glomerular podocytes. JCI Insight. 2016 Jun 16;1(9). pii: e86177. Pubmed 27430022 | |||
| Fluhr S, Boerries M, Busch H, Symeonidi A, Witte T, Lipka DB, Mücke O, Nöllke P, Krombholz CF, Niemeyer CM, Plass C, Flotho C. CREBBP is a target of epigenetic, but not genetic, modification in juvenile myelomonocytic leukemia. Clin Epigenetics. 2016 May 5;8:50. doi: 10.1186/s13148-016-0216-3. eCollection 2016. Pubmed27158276 | |||
| Offermann B, Knauer S, Singh A, Fernández-Cachón ML, Klose M, Kowar S, Busch H, Boerries M. Boolean Modeling Reveals the Necessity of Transcriptional Regulation for Bistability in PC12 Cell Differentiation. Front Genet. 2016 Apr 14;7:44. doi: 10.3389/fgene.2016.00044. eCollection 2016. Pubmed27148350 | |||
| 2015 | Boerries M, Herr R, Brummer T, Busch H. Global gene expression profiling analysis reveals reduction of stemness after B-RAF inhibition in colorectal cancer cell lines. Genom Data. 2015 Apr 28;4:158-61. doi: 10.1016/j.gdata.2015.04.015. eCollection 2015 Jun. Pubmed26484206 | ||
| Koszinowski S, Boerries M, Busch H, Krieglstein K. RARβ regulates neuronal cell death and differentiation in the avian ciliary ganglion. Dev Neurobiol. 2015 Nov;75(11):1204-18. doi: 10.1002/dneu.22278. Epub 2015 Jun 12. Pubmed25663354 | |||
| Ahrens TD, Timme S, Hoeppner J, Ostendorp J, Hembach S, Follo M, Hopt UT, Werner M, Busch H, Boerries M, Lassmann S. Selective inhibition of esophageal cancer cells by combination of HDAC inhibitors and Azacytidine. Epigenetics. 2015 May 4;10(5):431-45. doi: 10.1080/15592294.2015.1039216. Pubmed25923331 | |||
| Kalfalah F, Seggewiß S, Walter R, Tigges J, Moreno-Villanueva M, Bürkle A, Ohse S, Busch H, Boerries M, Hildebrandt B, Royer-Pokora B, Boege F. Structural chromosome abnormalities, increased DNA strand breaks and DNA strand break repair deficiency in dermal fibroblasts from old female human donors. Aging (Albany NY). 2015 Feb;7(2):110-22. Pubmed25678531 | |||
| Herr R, Köhler M, Andrlova H, Weinberg F, Möller Y, Halbach S, Lutz L, Mastroianni J, Klose M, Bittermann N, Kowar S, Zeiser R, Olayioye MA, Lassmann S, Busch H, Boerries M, Brummer T. B-Raf inhibitors induce epithelial differentiation in BRAF-mutant colorectal cancer cells. Cancer Res. 2015 Jan 1;75(1):216-29. doi: 10.1158/0008-5472.CAN-13-3686. Epub 2014 Nov 7. PMID: 25381152 | |||
| 2014 | Waldera-Lupa DM, Kalfalah F, Florea AM, Sass S, Kruse F, Rieder V, Tigges J, Fritsche E, Krutmann J, Busch H, Boerries M, Meyer HE, Boege F, Theis F, Reifenberger G, Stühler K. Proteome-wide analysis reveals an age-associated cellular phenotype of in situ aged human fibroblasts. Aging (Albany NY). 2014 Oct;6(10):856-78. Pubmed25411231 | ||
| Bischoff A, Huck B, Keller B, Strotbek M, Schmid S, Boerries M, Busch H, Müller D, Olayioye MA. miR-149 functions as a tumor suppressor by controlling breast epithelial cell migration and invasion. Cancer Res. 2014 Sep 15;74(18):5256-65. doi: 10.1158/0008-5472.CAN-13-3319. Epub 2014 Jul 17. Pubmed25035394 | |||
| Grahammer F, Haenisch N, Steinhardt F, Sander L, Roerden M, Arnold F, Cordts T, Wanner N, Reichardt W, Kerjaschki D, Ruegg MA, Hall MN, Moulin P, Busch H, Boerries M, Walz G, Artunc F, Huber TB. mTORC1 maintains renal tubular homeostasis and is essential in response to ischemic stress. Proc Natl Acad Sci U S A. 2014 Jun 23. pii: 201402352. Pubmed24958889 | |||
| Timme S, Ihde S, Fichter CD, Waehle V, Bogatyreva L, Atanasov K, Kohler I, Schöpflin A, Geddert H, Faller G, Klimstra D, Tang L, Reinheckel T, Hauschke D, Busch H, Boerries M, Werner M, Lassmann S. STAT3 expression, activity and functional consequences of STAT3 inhibition in esophageal squamous cell carcinomas and Barrett's adenocarcinomas.Oncogene. 2014 Jun 19;33(25):3256-66. doi: 10.1038/onc.2013.298. Epub 2013 Aug 5. Pubmed23912451 | |||
| Rohde D, Schön C, Boerries M, Didrihsone I, Ritterhoff J, Kubatzky KF, Völkers M, Herzog N, Mähler M, Tsoporis JN, Parker TG, Linke B, Giannitsis E, Gao E, Peppel K, Katus HA, Most P. S100A1 is released from ischemic cardiomyocytes and signals myocardial damage via Toll-like receptor 4. EMBO Mol Med. 2014 May 15;6(6):778-94. doi: 10.15252/emmm.201303498. Pubmed24833748 | |||
| Kalfalah F, Sobek S, Bornholz B, Götz-Rösch C, Tigges J, Fritsche E, Krutmann J, Köhrer K, Deenen R, Ohse S, Boerries M, Busch H, Boege F. Inadequate mito-biogenesis in primary dermal fibroblasts from old humans is associated with impairment of PGC1A-independent stimulation. Exp Gerontol. 2014 Mar 31. pii: S0531-5565(14)00089-8. doi: 10.1016/j.exger.2014.03.017. Pubmed24699405 | |||
| Neumann J, Boerries M, Köhler R, Giaisi M, Krammer PH, Busch H, Li-Weber M. The natural anticancer compound rocaglamide selectively inhibits the G1-S-phase transition in cancer cells through the ATM/ATR-mediated Chk1/2 cell cycle checkpoints. Int J Cancer. 2014 Apr 15;134(8):1991-2002. doi: 10.1002/ijc.28521. Epub 2013 Oct 21. Pubmed24150948 | |||
| Ebeling S, Naumann K, Pollok S, Wardecki T, Vidal-Y-Sy S, Nascimento JM, Boerries M, Schmidt G, Brandner JM, Merfort I. From a traditional medicinal plant to a rational drug: understanding the clinically proven wound healing efficacy of birch bark extract. PLoS One. 2014 Jan 22;9(1):e86147. doi: 10.1371/journal.pone.0086147. eCollection 2014 Jan 22.Pubmed24465925 | |||
| 2013 | Fuellen G, Boerries M, Busch H, de Grey AD, Hahn U, Hiller T, Hoeflich A, Jansen L, Janssens GE, Kaleta C, Meinema AC, Schäuble S, Schofield PN, Smith B, Sühnel J, Vera J, Wagner W, Wönne EC, Wuttke D, Simm A. In-Silico-Approaches and the Role of Ontologies in Aging Research. Rejuvenation Res. 2013 Dec;16(6):540-6. doi: 10.1089/rej.2013.1517. Pubmed24188080 | ||
| Sprenger A, Weber S, Zarei M, Engelke R, Nascimento JM, Gretzmeier C, Hilpert M, Boerries M, Has C, Busch H, Bruckner-Tuderman L, Dengjel J. Consistency of the proteome in primary human keratinocytes with respect to gender, age, and skin localization. Mol Cell Proteomics. 2013 Sep;12(9):2509-21. doi: 10.1074/mcp.M112.025478. Epub 2013 May 30 Pubmed23722187 | |||
| Boerries M, Grahammer F, Eiselein S, Buck M, Meyer C, Goedel M, Bechtel W, Zschiedrich S, Pfeifer D, Laloë D, Arrondel C, Gonçalves S, Krüger M, Harvey SJ, Busch H, Dengjel J, Huber TB. Molecular fingerprinting of the podocyte reveals novel gene and protein regulatory networks. Kidney Int. 2013 Jun;83(6):1052-64. doi: 10.1038/ki.2012.487. Epub 2013 Jan 30 Pubmed23364521 | |||
| Busch H, Boerries M, Bao J, Hanke ST, Hiss M, Tiko T, Rensing SA. Network theory inspired analysis of time-resolved expression data reveals key players guiding P. patens stem cell development. PLoS One. 2013 Apr 18;8(4):e60494. doi: 10.1371/journal.pone.0060494. Print 2013. Pubmed23637751 | |||
| Küttner V, Mack C, Rigbolt KT, Kern JS, Schilling O, Busch H, Bruckner-Tuderman L, Dengjel J. Global remodelling of cellular microenvironment due to loss of collagen VII. Mol Syst Biol. 2013 Apr 16;9:657. doi: 10.1038/msb.2013.17. Pubmed23591773 | |||
| Tholen S, Biniossek ML, Gansz M, Gomez-Auli A, Werner F, Noel A, Kizhakkedathu JN, Boerries M, Busch H, Reinheckel T, Schilling O. Deletion of cysteine cathepsins B or L yields differential impacts on murine skin proteome and degradome. Mol Cell Proteomics. 2013 Mar;12(3):611-25. doi: 10.1074/mcp.M112.017962. Epub 2012 Dec 10. Pubmed23233448 | |||
| Weber S, Fernández-Cachón ML, Nascimento JM, Knauer S, Offermann B, Murphy RF, Boerries M, Busch H. Label-free detection of neuronal differentiation in cell populations using high-throughput live-cell imaging of PC12 cells. PLoS One. 2013;8(2):e56690. doi: 10.1371/journal.pone.0056690. Epub 2013 Feb 22. Pubmed23451069 | |||
| 2012 | Singh A, Nascimento JM, Kowar S, Busch H, Boerries M.Boolean approach to signalling pathway modelling in HGF-induced keratinocyte migration. Bioinformatics. 2012 Sep 15;28(18):i495-i501. doi: 10.1093/bioinformatics/bts410. Pubmed22962472 | ||
| 2011 | Bachmann J, Raue A, Schilling M, Böhm ME, Kreutz C, Kaschek D, Busch H, Gretz N, Lehmann WD, Timmer J, Klingmüller U. . Division of labor by dual feedback regulators controls JAK2/STAT5 signaling over broad ligand range. Mol Syst Biol. 2011 Jul 19;7:516. doi: 10.1038/msb.2011.50. Pubmed21772264 | ||
| Mesecke S, Urlaub D, Busch H, Eils R, Watzl C. Integration of activating and inhibitory receptor signaling by regulated phosphorylation of Vav1 in immune cells. Sci Signal. 2011 May 31;4(175):ra36. doi: 10.1126/scisignal.2001325. Pubmed21632469 | |||
| Bhattacharya N, Diener S, Idler IS, Rauen J, Häbe S, Busch H, Habermann A, Zenz T, Döhner H, Stilgenbauer S, Mertens D. Nurse-like cells show deregulated expression of genes involved in immunocompetence. Br J Haematol. 2011 Aug;154(3):349-56. doi: 10.1111/j.1365-2141.2011.08747.x. Epub 2011 May 25. Pubmed21615384 | |||
| Heinemann A, He Y, Zimina E, Boerries M, Busch H, Chmel N, Kurz T, Bruckner-Tuderman L, Has C. Induction of phenotype modifying cytokines by FERMT1 mutations. Hum Mutat. 2011 Apr;32(4):397-406. doi: 10.1002/humu.21449. Epub 2011 Mar 1. Pubmed21309038 | |||
| 2010 | Maiwald T, Schneider A, Busch H, Sahle S, Gretz N, Weiss TS, Kummer U, Klingmüller U. Combining theoretical analysis and experimental data generation reveals IRF9 as a crucial factor for accelerating interferon α-induced early antiviral signalling. FEBS J. 2010 Nov;277(22):4741-54. doi: 10.1111/j.1742-4658.2010.07880.x. Epub 2010 Oct 21. Pubmed20964804 | ||
| Sprenger A, Küttner V, Biniossek ML, Gretzmeier C, Boerries M, Mack C, Has C, Bruckner-Tuderman L, Dengjel J. Comparative quantitation of proteome alterations induced by aging or immortalization in primary human fibroblasts and keratinocytes for clinical applications. Mol Biosyst. 2010 Sep;6(9):1579-82. doi: 10.1039/c003962d. Epub 2010 May 10. Pubmed20454738 | |||
| 2009 | Kraus C, Rohde D, Weidenhammer C, Qiu G, Pleger ST, Voelkers M, Boerries M, Remppis A, Katus HA, Most P. S100A1 in cardiovascular health and disease: closing the gap between basic science and clinical therapy. J Mol Cell Cardiol. 2009 Oct;47(4):445-55. doi: 10.1016/j.yjmcc.2009.06.003. Epub 2009 Jun 16. Review. Pubmed19538970 | ||
| 2008 | Busch H, Camacho-Trullio D, Rogon Z, Breuhahn K, Angel P, Eils R, Szabowski A. Gene network dynamics controlling keratinocyte migration. Mol Syst Biol. 2008;4:199. doi: 10.1038/msb.2008.36. Epub 2008 Jul 1. Pubmed18594517 | ||
| 2007 | Boerries M, Most P, Gledhill JR, Walker JE, Katus HA, Koch WJ, Aebi U, Schoenenberger CA. Ca2+ -dependent interaction of S100A1 with F1-ATPase leads to an increased ATP content in cardiomyocytes. Mol Cell Biol. 2007 Jun;27(12):4365-73. Epub 2007 Apr 16. Pubmed17438143 | ||
| 2006 | Glatt E, Busch H, Kaiser F, Zaikin A. Noise-memory induced excitability and pattern formation in oscillatory neural models. Phys Rev E Stat Nonlin Soft Matter Phys. 2006 Feb;73(2 Pt 2):026216. Epub 2006 Feb 22. Pubmed16605438 | ||
| 2005 | H. Busch, R. Eils. Systems Biology, in Encyclopedia of Molecular Cell Biology and Molecular Medicine, 14, 123, (2005) | ||
| Most P, Boerries M, Eicher C, Schweda C, Völkers M, Wedel T, Söllner S, Katus HA, Remppis A, Aebi U, Koch WJ, Schoenenberger CA. Distinct subcellular location of the Ca2+-binding protein S100A1 differentially modulates Ca2+-cycling in ventricular rat cardiomyocytes. J Cell Sci. 2005 Jan 15;118(Pt 2):421-31. Pubmed15654019 | |||
| 2004 | Most P, Pleger ST, Völkers M, Heidt B, Boerries M, Weichenhan D, Löffler E, Janssen PM, Eckhart AD, Martini J, Williams ML, Katus HA, Remppis A, Koch WJ. Cardiac adenoviral S100A1 gene delivery rescues failing myocardium. J Clin Invest. 2004 Dec;114(11):1550-63. Pubmed15578088 | ||
| H. Busch and M.-Th. Hütt. Scale-dependence of spatiotemporal filters inspired by cellular automata. Int. J. Bifurcation Chaos, 14, 1957, (2004) | |||
| 2003 | H. Busch, J. Garcia-Ojalvo, and F. Kaiser. Influence of spatiotemporal 1/f -noise on structure formation in excitable media. Proc. SPIE, 5114, 468, (2003). | ||
| Most P, Boerries M, Eicher C, Schweda C, Ehlermann P, Pleger ST, Loeffler E, Koch WJ, Katus HA, Schoenenberger CA, Remppis A. Extracellular S100A1 protein inhibits apoptosis in ventricular cardiomyocytes via activation of the extracellular signal-regulated protein kinase 1/2 (ERK1/2). J Biol Chem. 2003 Nov 28;278(48):48404-12. Epub 2003 Sep 6. Pubmed12960148 | |||
| Busch H, Kaiser F. Influence of spatiotemporally correlated noise on structure formation in excitable media. Phys Rev E Stat Nonlin Soft Matter Phys. 2003 Apr;67(4 Pt 1):041105. Epub 2003 Apr 25. Pubmed12786345 | |||