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Molekulare Medizin

Veröffentlichungen vor 2010

Molekulare Medizin - All Publications
2009 Schlatter R, Schmich K, Avalos Vizcarra I, Scheurich P, Sauter T, Borner C, Ederer M, Merfort I, Sawodny O. ON/OFF and beyond--a boolean model of apoptosis. PLoS Comput Biol. 2009 Dec;5(12):e1000595. Pubmed20011108
Bessler WG, Puce K, vor dem Esche U, Kirschning C, Huber M. Immunomodulating effects of OM-89, a bacterial extract from Escherichia coli, in murine and human leukocytes. Arzneimittelforschung. 2009;59(11):571-7. Pubmed20066966
  Xiao K, Jehle F, Peters C, Reinheckel T, Schirmer RH, Dandekar T. CA/C1 peptidases of the malaria parasites Plasmodium falciparum and P. berghei and their mammalian hosts--a bioinformatical analysis. Biol Chem. 2009 Nov;390(11):1185-97. Pubmed19663681
  Zimmermann S, Biniossek ML, Maurer C, Münzer P, Pantic M, Veelken H, Martens UM. Proteomic profiling in distinct cellular compartments of tumor cells reveals p53-dependent upregulation of S100A6 upon induction of telomere dysfunction. Proteomics. 2009 Nov;9(22):5175-87. PMID: Pubmed19834903
  Lindenboim L, Blacher E, Borner C, Stein R. Regulation of stress-induced nuclear protein redistribution: a new function of Bax and Bak uncoupled from Bcl-x(L). Cell Death Differ. 2009 Oct 9. Pubmed19816507
Sugita S, Horie S, Nakamura O, Maruyama K, Takase H, Usui Y, Takeuchi M, Ishidoh K, Koike M, Uchiyama Y, Peters C, Yamamoto Y, Mochizuki M. Acquisition of T regulatory function in cathepsin L-inhibited T cells by eye-derived CTLA-2alpha during inflammatory conditions. J Immunol. 2009 Oct 15;183(8):5013-22. Pubmed19801522
  Schuy S, Schäfer E, Yoder NC, Kumar K, Vogel R, Janshoff A. Lipopeptides derived from HIV and SIV mimicking the prehairpin intermediate of gp41 on solid supported lipid bilayers. J Struct Biol. 2009 Oct;168(1):125-36. Pubmed19406246
  Beinfeld MC, Funkelstein L, Foulon T, Cadel S, Kitagawa K, Toneff T, Reinheckel T, Peters C, Hook V. Cathepsin L plays a major role in cholecystokinin production in mouse brain cortex and in pituitary AtT-20 cells: protease gene knockout and inhibitor studies. Peptides. 2009 Oct;30(10):1882-91. Pubmed19589362
  Philippi N, Walter D, Schlatter R, Ferreira KS, Ederer M, Sawodny O, Timmer J, Borner C, Dandekar T. Modeling system states in liver cells: Survival, apoptosis and their modifications in response to viral infection. BMC Syst Biol. 2009 Sep 22;3(1):97. Pubmed19772631
  Baudot AD, Jeandel PY, Mouska X, Maurer U, Tartare-Deckert S, Raynaud SD, Cassuto JP, Ticchioni M, Deckert M. The tyrosine kinase Syk regulates the survival of chronic lymphocytic leukemia B cells through PKCdelta and proteasome-dependent regulation of Mcl-1 expression. Oncogene. 2009 Sep 17;28(37):3261-73. Pubmed19581935
Wolf AM, Eller K, Zeiser R, Dürr C, Gerlach UV, Sixt M, Markut L, Gastl G, Rosenkranz AR, Wolf D. The sphingosine 1-phosphate receptor agonist FTY720 potently inhibits regulatory T cell proliferation in vitro and in vivo. J Immunol. 2009 Sep 15;183(6):3751-60. Pubmed19692647
  Olson JA, Zeiser R, Beilhack A, Goldman JJ, Negrin RS. Tissue-specific homing and expansion of donor NK cells in allogeneic bone marrow transplantation. J Immunol. 2009 Sep 1;183(5):3219-28. Pubmed19657090
  Jost PJ, Grabow S, Gray D, McKenzie MD, Nachbur U, Huang DC, Bouillet P, Thomas HE, Borner C, Silke J, Strasser A, Kaufmann T. XIAP discriminates between type I and type II FAS-induced apoptosis. Nature. 2009 Aug 20;460(7258):1035-9. Pubmed19626005
  Galluzzi L, Aaronson SA, Abrams J, Alnemri ES, Andrews DW, Baehrecke EH, Bazan NG, Blagosklonny MV, Blomgren K, Borner C, Bredesen DE, Brenner C, Castedo M, Cidlowski JA, Ciechanover A, Cohen GM, De Laurenzi V, De Maria R, Deshmukh M, Dynlacht BD, El-Deiry WS, Flavell RA, Fulda S, Garrido C, Golstein P, Gougeon ML, Green DR, Gronemeyer H, Hajnóczky G, Hardwick JM, Hengartner MO, Ichijo H, Jäättelä M, Kepp O, Kimchi A, Klionsky DJ, Knight RA, Kornbluth S, Kumar S, Levine B, Lipton SA, Lugli E, Madeo F, Malomi W, Marine JC, Martin SJ, Medema JP, Mehlen P, Melino G, Moll UM, Morselli E, Nagata S, Nicholson DW, Nicotera P, Nuñez G, Oren M, Penninger J, Pervaiz S, Peter ME, Piacentini M, Prehn JH, Puthalakath H, Rabinovich GA, Rizzuto R, Rodrigues CM, Rubinsztein DC, Rudel T, Scorrano L, Simon HU, Steller H, Tschopp J, Tsujimoto Y, Vandenabeele P, Vitale I, Vousden KH, Youle RJ, Yuan J, Zhivotovsky B, Kroemer G. Guidelines for the use and interpretation of assays for monitoring cell death in higher eukaryotes. Cell Death Differ. 2009 Aug;16(8):1093-107. Review. Pubmed19373242
  Hook VY, Kindy M, Reinheckel T, Peters C, Hook G. Genetic cathepsin B deficiency reduces beta-amyloid in transgenic mice expressing human wild-type amyloid precursor protein. Biochem Biophys Res Commun. 2009 Aug 21;386(2):284-8. Pubmed19501042
  Ye S, Huber T, Vogel R, Sakmar TP. FTIR analysis of GPCR activation using azido probes. Nat Chem Biol. 2009 Jun;5(6):397-9. Pubmed19396177
  Vreemann A, Qu H, Mayer K, Andersen LB, Stefana MI, Wehner S, Lysson M, Farcas AM, Peters C, Reinheckel T, Kalff J, Brix K. Cathepsin B release from rodent intestine mucosa due to mechanical injury results in extracellular matrix damage in early post-traumatic phases.Biol Chem. 2009 May-Jun;390(5-6):481-92. Pubmed19335208
  Anel A, Bleackley C, Borner C, Golstein P, Krammer PH, Müllbacher A, Pardo J, Simon MM, Trapani JA. EMBO workshop on cytotoxicity, cell death and the immune system. Cell Death Differ. 2009 May;16(5):790-3. No abstract available. Pubmed19369941
  Zeiser R, Maas K, Youssef S, Dürr C, Steinman L, Negrin RS. Regulation of different inflammatory diseases by impacting the mevalonate pathway. Immunology. 2009 May;127(1):18-25. Review. Pubmed19191903
  Caglic D, Kosec G, Bojic L, Reinheckel T, Turk V, Turk B. Murine and human cathepsin B exhibit similar properties: possible implications for drug discovery. Biol Chem. 2009 Feb;390(2):175-9. Erratum in: Biol Chem. 2009 May-Jun;390(5-6):517. Pubmed19040356
  Pardo J, Aguilo JI, Anel A, Martin P, Joeckel L, Borner C, Wallich R, Müllbacher A, Froelich CJ, Simon MM. The biology of cytotoxic cell granule exocytosis pathway: granzymes have evolved to induce cell death and inflammation. Microbes Infect. 2009 Apr;11(4):452-9. Review. Pubmed19249384
  Zeiser R, Zerweck A, Bertz H, Finke J. Allogeneic hematopoietic cell transplantation for t-AML following liver transplantation from the same haploidentical donor. Bone Marrow Transplant. 2009 Apr;43(7):589-90. No abstract available. Pubmed18978821
Schuy S, Schäfer E, Yoder NC, Hobe S, Kumar K, Vogel R, Janshoff A. Coiled-coil lipopeptides mimicking the prehairpin intermediate of glycoprotein gp41. Angew Chem Int Ed Engl. 2009;48(4):751-4. No abstract available. Pubmed19090512
  Lüdeke S, Mahalingam M, Vogel R. Rhodopsin activation switches in a native membrane environment. Photochem Photobiol. 2009 Mar-Apr;85(2):437-41. Review. Pubmed19267869
  Shen ZJ, Esnault S, Schinzel A, Borner C, Malter JS. The peptidyl-prolyl isomerase Pin1 facilitates cytokine-induced survival of eosinophils by suppressing Bax activation. Nat Immunol. 2009 Mar;10(3):257-65. Pubmed19182807
  Zimmermann S, Biniossek ML, Pantic M, Pfeifer D, Veelken H, Martens UM. Proteomic profiling of tumor cells after induction of telomere dysfunction. Proteomics. 2009 Feb;9(3):521-34. Pubmed19132685
  Ryppa C, Mann-Steinberg H, Biniossek ML, Satchi-Fainaro R, Kratz F. In vitro and in vivo evaluation of a paclitaxel conjugate with the divalent peptide E-[c(RGDfK)2] that targets integrin alpha v beta 3. Int J Pharm. 2009 Feb 23;368(1-2):89-97. Pubmed18992308
Ajaj KA, Biniossek ML, Kratz F. Development of protein-binding bifunctional linkers for a new generation of dual-acting prodrugs. Bioconjug Chem. 2009 Feb;20(2):390-6. Pubmed19199576
  Schwinté P, Gärtner W, Sharda S, Mroginski MA, Hildebrandt P, Siebert F. The photoreactions of recombinant phytochrome CphA from the cyanobacterium Calothrix PCC7601: a low-temperature UV-Vis and FTIR study. Photochem Photobiol. 2009 Jan-Feb;85(1):239-49. Pubmed18764898
  Ai WZ, Hou JZ, Zeiser R, Czerwinski D, Negrin RS, Levy R. Follicular lymphoma B cells induce the conversion of conventional CD4+ T cells to T-regulatory cells. Int J Cancer. 2009 Jan 1;124(1):239-44. Pubmed18814264
  Wilson SR, Peters C, Saftig P, Brömme D. Cathepsin K activity-dependent regulation of osteoclast actin ring formation and bone resorption. J Biol Chem. 2009 Jan 23;284(4):2584-92. Pubmed19028686
  Vogel, S., Kiefer, T., Raulf, N., Sterz, K., Manoharan, A. & Borner, C. Mechanisms of Bax/Bak activation: is there any light at the end of the tunnel? Gastroenterology and Hepatology from Bed to Bench 2, S11-S18.(2009).
2008 Funkelstein L, Toneff T, Mosier C, Hwang SR, Beuschlein F, Lichtenauer UD, Reinheckel T, Peters C, Hook V. Major Role of Cathepsin L for Producing the Peptide Hormones ACTH, {beta}-Endorphin, and {alpha}-MSH, Illustrated by Protease Gene Knockout and Expression. J BiolChem. 2008 Dec19; 283(51):356529. Pubmed18849346
  Walter D, Schmich K, Vogel S, Pick R, Kaufmann T, Hochmuth FC, Haber A, Neubert K, McNelly S, von Weizsäcker F, Merfort I, Maurer U, Strasser A, Borner C. Switch from type II to I Fas/CD95 death signaling on in vitro culturing of primary hepatocytes. Hepatology. 2008 Dec;48(6):1942-53. Pubmed19003879
  Mahalingam M, Martínez-Mayorga K, Brown MF, Vogel R. Two protonation switches control rhodopsin activation in membranes.Proc Natl Acad Sci U S A. 2008 Nov 18;105(46):17795-800. Pubmed18997017
Ryppa C, Mann-Steinberg H, Satchi-Fainaro R, Biniossek ML, Kratz F. In vitro and in vivo evaluation of a paclitaxel conjugate with the divalent peptide E-[c(RGDfK)(2)] that targets integrin alpha(v)beta(3). Int J Pharm. 2008 Oct 17. Pubmed18992308
  Urban C, Rhême C, Maerz S, Berg B, Pick R, Nitschke R, Borner C. Apoptosis induced by Semliki Forest virus is RNA replication dependent and mediated via Bak. Cell Death Differ. 2008 Sep;15(9):1396-407. Pubmed18437160
  Jiang X, Zaitseva E, Schmidt M, Siebert F, Engelhard M, Schlesinger R, Ataka K, Vogel R, Heberle Resolving voltage-dependent structural changes of a membrane photoreceptor by surface-enhanced IR difference spectroscopy. J. Proc Natl Acad Sci U S A. 2008 Aug 26;105(34):12113-7. Pubmed18719097
Halle A, Hornung V, Petzold GC, Stewart CR, Monks BG, Reinheckel T, Fitzgerald KA, Latz E, Moore KJ, Golenbock DT. The NALP3 inflammasome is involved in the innate immune response to amyloid-beta. Nat Immunol. 2008 Aug;9(8):857-65.Pubmed18604209
Schurigt U, Sevenich L, Vannier C, Gajda M, Schwinde A, Werner F, Stahl A, von Elverfeldt D, Becker AK, Bogyo M, Peters C, Reinheckel T. Trial of the cysteine cathepsin inhibitor JPM-OEt on early and advanced mammary cancer stages in the MMTV-PyMT-transgenic mouse model. Biol Chem. 2008 Aug;389(8):1067-74.Pubmed18710344
Denayer T, Locker M, Borday C, Deroo T, Janssens S, Hecht A, van Roy F, Perron M, Vleminckx K. Canonical Wnt signaling controls proliferation of retinal stem/progenitor cells in postembryonic Xenopus eyes. Stem Cells. 2008 Aug;26(8):2063-74. Pubmed18556512
  Ryppa C, Mann-Steinberg H, Fichtner I, Weber H, Satchi-Fainaro R, Biniossek ML, Kratz F. In vitro and in vivo evaluation of doxorubicin conjugates with the divalent peptide E-[c(RGDfK)2] that targets integrin alphavbeta3. Bioconjug Chem. 2008 Jul;19(7):1414-22. 26.Pubmed18578486
  Funkelstein L, Toneff T, Hwang SR, Reinheckel T, Peters C, Hook V. Cathepsin L participates in the production of neuropeptide Y in secretory vesicles, demonstrated by protease gene knockout and expression. J Neurochem. 2008 Jul;106(1):384-91. Pubmed18410501
  Funkelstein L, Toneff T, Hwang SR, Reinheckel T, Peters C, Hook V. Cathepsin L participates in the production of neuropeptide Y in secretory vesicles, demonstrated by protease gene knockout and expression. J Neurochem. 2008 Jul;106(1):384-91. Pubmed18410501
  Vasiljeva O, Korovin M, Gajda M, Brodoefel H, Bojic L, Krüger A, Schurigt U, Sevenich L, Turk B, Peters C, Reinheckel T. Reduced tumour cell proliferation and delayed development of high-grade mammary carcinomas in cathepsin B-deficient mice. Oncogene. 2008 Jul 10;27(30):4191-9. Pubmed18345026
  Vogel R, Mahalingam M, Lüdeke S, Huber T, Siebert F, Sakmar TP. Functional role of the "ionic lock"--an interhelical hydrogen-bond network in family A heptahelical receptors. J Mol Biol. 2008 Jul 18;380(4):648-55. Pubmed18554610
  Schuy S, Faiss S, Yoder NC, Kalsani V, Kumar K, Janshoff A, Vogel R. Structure and thermotropic phase behavior of fluorinated phospholipid bilayers: a combined attenuated total reflection FTIR spectroscopy and imaging ellipsometry study. J Phys Chem B. 2008 Jul 17;112(28):8250-6. Pubmed18563929
  Schilling O, Overall CM. Proteome-derived, database-searchable peptide libraries for identifying protease cleavage sites. Nat Biotechnol. 2008 Jun;26(6):685-94. Pubmed18500335
  Standfuss J, Zaitseva E, Mahalingam M, Vogel R. Structural impact of the E113Q counterion mutation on the activation and deactivation pathways of the G protein-coupled receptor rhodopsin. J Mol Biol. 2008 Jun 27;380(1):145-57. Pubmed18511075
  Harder J, Opitz OG, Brabender J, Olschewski M, Blum HE, Nomoto S, Usadel H.Quantitative promoter methylation analysis of hepatocellular carcinoma, cirrhotic and normal liver. Int J Cancer. 2008 Jun 15;122(12):2800-4. Pubmed18351580
  Götschel F, Kern C, Lang S, Sparna T, Markmann C, Schwager J, McNelly S, von Weizsäcker F, Laufer S, Hecht A, Merfort I Inhibition of GSK3 differentially modulates NFκB, CREB, AP-1 and β-catenin signaling in hepatocytes, but fails to to promote TNF-α -induced apoptosis. Exp. Cell. Res. 2008 April 1; 314 (6): 1351-1366Pubmed18261723
  Conus S, Perozzo R, Reinheckel T, Peters C, Scapozza L, Yousefi S, Simon HU. Caspase-8 is activated by cathepsin D initiating neutrophil apoptosis during the resolution of inflammation. J Exp Med. 2008 Mar 17;205(3):685-98. Pubmed18299403
  Pardo J, Wallich R, Martin P, Urban C, Rongvaux A, Flavell RA, Müllbacher A, Borner C, Simon MM. Granzyme B-induced cell death exerted by ex vivo CTL: discriminating requirements for cell death and some of its signs. Cell Death Differ. 2008 Mar;15(3):567-79. Pubmed18064039
  Pardo J, Wallich R, Martin P, Urban C, Rongvaux A, Flavell RA, Muellbacher A, Borner C, Simon MM. Granzyme B-induced cell death exerted by ex vivo CTL: discriminating requirements for cell death and some of its signs. Cell Death Differ. 2008 Mar;15(3):567-79. Epub 2007 Dec 7.Pubmed18064039
  Wolf P, Alt K, Bühler P, Katzenwadel A, Wetterauer U, Tacke M, Elsässer-Beile U. Anti-PSMA immunotoxin as novel treatment for prostate cancer? High and specific antitumor activity on human prostate xenograft tumors in SCID mice. Prostate. 2008 Feb 1;68(2):129-38. Pubmed18044731
  Zeiser R, Leveson-Gower DB, Zambricki EA, Kambham N, Beilhack A, Loh J, Hou JZ, Negrin RS. Differential impact of mammalian target of rapamycin inhibition on CD4+CD25+Foxp3+ regulatory T cells compared with conventional CD4+ T cells. Blood. 2008 Jan 1;111(1):453-62. Pubmed17967941
  Bühler P, Wolf P, Gierschner D, Schaber I, Katzenwadel A, Schultze-Seemann W, Wetterauer U, Tacke M, Swamy M, Schamel WW, Elsässer-Beile U. A bispecific diabody directed against prostate-specific membrane antigen and CD3 induces T-cell mediated lysis of prostate cancer cells. Cancer Immunol Immunother. 2008 Jan;57(1):43-52. Pubmed17579857
  Reinheckel, T., Gocheva, V., Peters, C., Joyce, J.A.:Roles of Cysteine Proteases in Tumor Progression: Analysis of Cysteine Cathepsin Knockout Mice in Cancer Models. In: D. Edwards et al. (eds.): The Cancer Degradome, Springer Science, cap. 15. 2008 / Buchbeitrag
2007 Wöhrle S, Wallmen B, Hecht A.:Differential control of Wnt target genes involves epigenetic mechanisms and selective promoter occupancy by TCFs. Mol Cell Biol. 2007 Dec;27(23):8164-8177 Pubmed17923689
  Bojic L, Petelin A, Stoka V, Reinheckel T, Peters C, Turk V, Turk B. Cysteine cathepsins are not involved in Fas/CD95 signalling in primary skin fibroblasts. FEBS Lett. 2007 Nov 13;581(27):5185-90. Pubmed1950288
  Spira D, Stypmann J, Tobin DJ, Petermann I, Mayer C, Haggemann S, Vasiljeva O, Günther T, Schüle R, Peters C, Reinheckel T. Cell type-specific functions of the lysosomal protease cathepsin L in the heart. J Biol Chem. 2007 Oct 17. Pubmed17942402
  Yamasaki R, Zhang J, Koshiishi I, Sastradipura Suniarti DF, Wu Z, Peters C, Schwake M, Uchiyama Y, Kira J, Saftig P, Utsumi H, Nakanishi H. Involvement of lysosomal storage-induced p38 MAP kinase activation in the overproduction of nitric oxide by microglia in cathepsin D-deficient mice.Mol Cell Neurosci. 2007 Aug;35(4):573-84. Pubmed17570679
  Yoder NC, Kalsani V, Schuy S, Vogel R, Janshoff A, Kumar K. Nanoscale patterning in mixed fluorocarbon-hydrocarbon phospholipid bilayers. J Am Chem Soc. 2007 Jul 25;129(29):9037-43. Pubmed17602478
  Colell A, Ricci JE, Tait S, Milasta S, Maurer U, Bouchier-Hayes L,
Fitzgerald P, Guio-Carrion A, Waterhouse NJ, Li CW, Mari B, Barbry P, Newmeyer DD, Beere HM, Green DR. GAPDH and autophagy preserve survival after apoptotic cytochrome c release in the absence of caspase activation. Cell. 2007 Jun 1;129(5):983-97. Pubmed17540177
  Tiwari N, Garbi N, Reinheckel T, Moldenhauer G, Hämmerling GJ, Momburg F. A transporter associated with antigen-processing independent vacuolar pathway for the MHC class I-mediated presentation of endogenous transmembrane proteins..J Immunol. 2007 Jun 15;178(12):7932-42. Pubmed17548631
  Sanjuán Szklarz LK, Kozjak-Pavlovic V, Voegtle FN, Chacinska A, Milenkovic D, Vogel S, Dürr M, Westermann B, Guiard B, Martinou JC, Borner C, Pfanner N, Meisinger C. Preprotein transport machineries of yeast mitochondrial outer membrane are not required for Bax-induced release of intermembrane space proteins. J Mol Biol. 2007 Apr 20;368(1):44-54. Pubmed17335847
  Kitamoto S, Sukhova GK, Sun J, Yang M, Libby P, Love V, Duramad P, Sun C, Zhang Y, Yang X, Peters C, Shi GP. Cathepsin L deficiency reduces diet-induced atherosclerosis in low-density lipoprotein receptor-knockout mice. Circulation. 2007 Apr 17;115(15):2065-75. Epub 2007 Apr 2. Pubmed17404153
  Bartl FJ, Vogel R. Structural and functional properties of metarhodopsin III: recent spectroscopic studies on deactivation pathways of rhodopsin. Phys Chem Chem Phys. 2007 Apr 14;9(14):1648-58. Review. Pubmed17396175
  Vasiljeva O, Reinheckel T, Peters C, Turk D, Turk V, Turk B. Emerging roles of cysteine cathepsins in disease and their potential as drug targets. Curr Pharm Des. 2007;13(4):387-403. Pubmed17311556
  Vogel R, Sakmar TP, Sheves M, Siebert F. Coupling of protonation switches during rhodopsin activation. Photochem Photobiol. 2007 Mar-Apr;83(2):286-92. Review. Pubmed17576345
  Vogel R, Martell S, Mahalingam M, Engelhard M, Siebert F. Interaction of a G protein-coupled receptor with a G protein-derived peptide induces structural changes in both peptide and receptor: a Fourier-transform infrared study using isotopically labeled peptides. J Mol Biol. 2007 Mar 9;366(5):1580-8. Pubmed17217962
  Hirsch C, Campano LM, Wohrle S, Hecht A. Canonical Wnt signaling transiently stimulates proliferation and enhances neurogenesis in neonatal neural progenitor cultures. Exp Cell Res. 2007 Feb 1;313(3):572-87. Pubmed17198701
2006 Rocken C, Fandrich M, Stix B, Tannert A, Hortschansky P, Reinheckel T, Saftig P, Kahne T, Menard R, Ancsin JB, Buhling F. Cathepsin protease activity modulates amyloid load in extracerebral amyloidosis. J Pathol. 2006 Dec;210(4):478-87. Pubmed17068745
  Sciortino MT, Perri D, Medici MA, Grelli S, Serafino A, Borner C, Mastino A. Role of Bcl-2 expression for productive herpes simplex virus 2 replication. Virology. 2006 Dec 5-20;356(1-2):136-46.
  Schepsky A, Bruser K, Gunnarsson GJ, Goodall J, Hallsson JH, Goding CR, Steingrimsson E, Hecht A. The microphthalmia-associated transcription factor Mitf interacts with beta-catenin to determine target gene expression. Mol Cell Biol. 2006 Dec;26(23):8914-27.
Klingmuller U, Bauer A, Bohl S, Nickel PJ, Breitkopf K, Dooley S, Zellmer S, Kern C, Merfort I, Sparna T, Donauer J, Walz G, Geyer M, Kreutz C, Hermes M, Gotschel F, Hecht A, Walter D, Egger L, Neubert K, Borner C, Brulport M, Schormann W, Sauer C, Baumann F, Preiss R, MacNelly S, Godoy P, Wiercinska E, Ciuclan L, Edelmann J, Zeilinger K, Heinrich M, Zanger UM, Gebhardt R, Maiwald T, Heinrich R, Timmer J, von Weizsacker F, Hengstler JG. Primary mouse hepatocytes for systems biology approaches: a standardized in vitro system for modelling of signal transduction pathways. Syst Biol (Stevenage). 2006 Nov;153(6):433-47. Pubmed17186705
  Waterkamp DA, Muller OJ, Ying Y, Trepel M, Kleinschmidt JA.
Isolation of targeted AAV2 vectors from novel virus display libraries. J Gene Med. 2006 Nov;8(11):1307-19. Pubmed16955542
  Modlich U, Bohne J, Schmidt M, von Kalle C, Knoss S, Schambach A, Baum C. Cell-culture assays reveal the importance of retroviral vector design for insertional genotoxicity. Blood. 2006 Oct 15;108(8):2545-53. Pubmed16825499
  Charvet C, Canonigo AJ, Becart S, Maurer U, Miletic AV, Swat W, Deckert M, Altman A. Vav1 promotes T cell cycle progression by linking TCR/CD28 costimulation to FOXO1 and p27kip1 expression. J Immunol. 2006 Oct 15;177(8):5024-31. Pubmed17015685
Baran K, Ciccone A, Peters C, Yagita H, Bird PI, Villadangos JA, Trapani JA. Cytotoxic T lymphocytes from cathepsin B-deficient mice survive normally in vitro and in vivo after encountering and killing target cells. J Biol Chem. 2006 Oct 13;281(41):30485-91. Pubmed16914553
  Perez-Amodio S, Jansen DC, Schoenmaker T, Vogels IM, Reinheckel T, Hayman AR, Cox TM, Saftig P, Beertsen W, Everts V. Calvarial osteoclasts express a higher level of tartrate-resistant acid phosphatase than long bone osteoclasts and activation does not depend on cathepsin K or L activity. Calcif Tissue Int. 2006 Oct;79(4):245-54. Pubmed17033726
  Worsham DN, Schuesler T, von Kalle C, Pan D. In vivo gene transfer into adult stem cells in unconditioned mice by in situ delivery of a lentiviral vector. Mol Ther. 2006 Oct;14(4):514-24. Pubmed16893684
  Binder M, Otto F, Mertelsmann R, Veelken H, Trepel M.
The epitope recognized by rituximab. Blood. 2006 Sep15;108(6):1975-8. Pubmed16705086
  Everts V, Korper W, Hoeben KA, Jansen ID, Bromme D, Cleutjens KB, Heeneman S, Peters C, Reinheckel T, Saftig P, Beertsen W.
Osteoclastic bone degradation and the role of different cysteine proteinases and matrix metalloproteinases: differences between calvaria and long bone. J Bone Miner Res. 2006 Sep;21(9):1399-408. Pubmed16939398
  Fischer M, Schmidt M, Klingenberg S, Eaves CJ, von Kalle C, Glimm H.
Short-term repopulating cells with myeloid potential in human mobilized peripheral blood do not have a side population (SP) phenotype. Blood. 2006 Sep 15;108(6):2121-3.
  Ekert PG, Jabbour AM, Manoharan A, Heraud JE, Yu J, Pakusch M, Michalak EM, Kelly PN, Callus B, Kiefer T, Verhagen A, Silke J, Strasser A, Borner C, Vaux DL. Cell death provoked by loss of Interleukin-3 signalling is independent of Bad, Bim, and PI3 Kinase, but depends in part on Puma. Blood. 2006 Sep 1;108(5):1461-8. Pubmed16705087
  Mollmann H, Nef HM, Kostin S, von Kalle C, Pilz I, Weber M, Schaper J, Hamm CW, Elsasser A. Bone marrow-derived cells contribute to infarct remodelling.Cardiovasc Res. 2006 Sep 1;71(4):661-71. Pubmed16854401
  Borner C. In memoriam of a prominent composer of the Bcl-2 family symphony. Cell Death Differ. 2006 Aug;13(8):1248-9. Pubmed16838034
  Klingmüller, U. Bauer, A., Breitkopf, K., Bohl, S., Dooley, S., Zellmer, S., Kern, C., Merfort, I., Sparna, T., Donauer, J., Walz, G., Geyer, M., Kreutz, C., Hermes, M., Walter, D., Egger, L., Neubert, K., Borner, C., Götschel, F., Hecht, A., Brulport, M., Schormann, W., Sauer, C., Baumann, F., Preiss, R., Illes, P., Nickel, P. J., MacNelly, S., Godoy, P., Wiercinska, E., Ciuclan, L., Zeilinger, K., Heinrich, M., Zanger, U. M., Reuss, M., Bader, A., Gebhardt, R., Maiwald, T., Timmer, J., von Weizsäcker, F., und Hengstler, J. G. “Primary mouse hepatocytes for systems biology approaches: a standardized in vitro system for modelling of signal transduction pathways”.IEE Proc. Systems Biology, 153, 433-447. Pubmed17186705
  Manoharan A, Kiefer T, Leist S, Schrader K, Urban C, Walter D, Maurer U, Borner C. Identification of a 'genuine' mammalian homolog of nematodal CED-4: is the hunt over or do we need better guns? Cell Death Differ. 2006 Aug;13(8):1310-7. Pubmed16691212
  Pardo, J., Urban, C., Galvez, E. M., Müller U., Kwon-Chung, J., Lobigs, M., Müllbacher, A. Wallich, R., Borner, C. & Simon, M. Bak is key in gliotoxin-induced apoptosis and a critical host factor of A. fumigatus virulence in mice. J. Cell Biology, Pubmed16893972
  Sevenich L, Pennacchio LA, Peters C, Reinheckel T. Human cathepsin L rescues the neurodegeneration and lethality in cathepsin B/L double-deficient mice. Biol Chem. 2006 Jul;387(7):885-91. Pubmed16913838
  Cheng T, Hitomi K, van Vlijmen-Willems IM, de Jongh GJ, Yamamoto K, Nishi K, Watts C, Reinheckel T, Schalkwijk J, Zeeuwen PL. Cystatin M/E is a high affinity inhibitor of cathepsin V and cathepsin L by a reactive site that is distinct from the legumain-binding site. A novel clue for the role of cystatin M/E in epidermal cornification.
J Biol Chem. 2006 Jun 9;281(23):15893-9. Pubmed16565075
  Petermann I, Mayer C, Stypmann J, Biniossek ML, Tobin DJ, Engelen MA, Dandekar T, Grune T, Schild L, Peters C, Reinheckel T.
Lysosomal, cytoskeletal, and metabolic alterations in cardiomyopathy of cathepsin L knockout mice. FASEB J. 2006 Jun;20(8):1266-8. Pubmed16636100

Montini E, Cesana D, Schmidt M, Sanvito F, Ponzoni M, Bartholomae C, Sergi Sergi L, Benedicenti F, Ambrosi A, Di Serio C, Doglioni C, von Kalle C, Naldini L. Hematopoietic stem cell gene transfer in a tumor-prone mouse model uncovers low genotoxicity of lentiviral vector integration.Nat Biotechnol. 2006 Jun;24(6):687-96. Pubmed16732270

  Nowrouzi A, Dittrich M, Klanke C, Heinkelein M, Rammling M, Dandekar T, von Kalle C, Rethwilm A. Genome-wide mapping of foamy virus vector integrations into a human cell line. J Gen Virol. 2006 May;87(Pt 5):1339-47. Pubmed16603537
  Kim S, Xu X, Hecht A, Boyer TG. Mediator is a transducer of Wnt/beta-catenin signaling. J Biol Chem. 2006 May19;281(20): 14066-75. Pubmed16565090
  Schambach A, Galla M, Modlich U, Will E, Chandra S, Reeves L, Colbert M, Williams DA, von Kalle C, Baum C. Lentiviral vectors pseudotyped with murine ecotropic envelope: increased biosafety and convenience in preclinical research. Exp Hematol. 2006 May;34(5):588-92. Pubmed16647564
  Seggewiss R, Pittaluga S, Adler RL, Guenaga FJ, Ferguson C, Pilz IH, Ryu B, Sorrentino BP, Young WS 3rd, Donahue RE, von Kalle C, Nienhuis AW, Dunbar CE. Acute myeloid leukemia is associated with retroviral gene transfer to hematopoietic progenitor cells in a rhesus macaque. Blood. 2006 May 15;107(10):3865-7. Pubmed16439674
  Vasiljeva O, Papazoglou A, Kruger A, Brodoefel H, Korovin M, Deussing J, Augustin N, Nielsen BS, Almholt K, Bogyo M, Peters C, Reinheckel T. Tumor cell-derived and macrophage-derived cathepsin B promotes progression and lung metastasis of mammary cancer. Cancer Res. 2006 May 15;66(10):5242-50. Pubmed16707449
  Thakar J, Schleinkofer K, Borner C, Dandekar T. RIP death domain structural interactions implicated in TNF-mediated proliferation and survival. Proteins. 2006 May 15;63(3):413-23. Pubmed16470584
  Hajitou A, Trepel M, Lilley CE, Soghomonyan S, Alauddin MM, Marini FC 3rd, Restel BH, Ozawa MG, Moya CA, Rangel R, Sun Y, Zaoui K, Schmidt M, von Kalle C, Weitzman MD, Gelovani JG, Pasqualini R, Arap W. A hybrid vector for ligand-directed tumor targeting and molecular imaging. Cell. 2006 Apr 21;125(2):385-98. Pubmed16630824
  Ott MG, Schmidt M, Schwarzwaelder K, Stein S, Siler U, Koehl U, Glimm H, Kuhlcke K, Schilz A, Kunkel H, Naundorf S, Brinkmann A, Deichmann A, Fischer M, Ball C, Pilz I, Dunbar C, Du Y, Jenkins NA, Copeland NG, Luthi U, Hassan M, Thrasher AJ, Hoelzer D, von Kalle C, Seger R, Grez M. Correction of X-linked chronic granulomatous disease by gene therapy, augmented by insertional activation of MDS1-EVI1, PRDM16 or SETBP1. Nat Med. 2006 Apr;12(4):401-9. Pubmed16582916
  Woods NB, Bottero V, Schmidt M, von Kalle C, Verma IM. Gene therapy: therapeutic gene causing lymphoma. Nature. 2006 Apr 27;440(7088):1123. Pubmed16641981
  Maurer U, Charvet C, Wagman AS, Dejardin E, Green DR. Glycogen synthase kinase-3 regulates mitochondrial outer membrane permeabilization and apoptosis by destabilization of MCL-1. Mol Cell. 2006 Mar 17;21(6):749-60.Pubmed16543145
  Gocheva V, Zeng W, Ke D, Klimstra D, Reinheckel T, Peters C, Hanahan D, Joyce JA. Distinct roles for cysteine cathepsin genes in multistage tumorigenesis. Genes Dev. 2006 Mar 1;20(5):543-56. Pubmed16481467
  Schulte U, Thumfart JO, Klocker N, Sailer CA, Bildl W, Biniossek M, Dehn D, Deller T, Eble S, Abbass K, Wangler T, Knaus HG, Fakler B.
The epilepsy-linked lgi1 protein assembles into presynaptic kv1 channels and inhibits inactivation by kvbeta1.
Neuron. 2006 Mar 2;49(5):697-706. Pubmed1650494
  Yanez-Munoz RJ, Balaggan KS, MacNeil A, Howe SJ, Schmidt M, Smith AJ, Buch P, MacLaren RE, Anderson PN, Barker SE, Duran Y, Bartholomae C, von Kalle C, Heckenlively JR, Kinnon C, Ali RR, Thrasher AJ. Effective gene therapy with nonintegrating lentiviral vectors. Nat Med. 2006 Mar;12(3):348-53. Pubmed16491086
2005 Darie CC, Biniossek ML, Gawinowicz MA, Milgrom Y, Thumfart JO, Jovine L, Litscher ES, Wassarman PM. Mass spectrometric evidence that proteolytic processing of rainbow trout egg vitelline envelope proteins takes place on the egg. J Biol Chem. 2005 Nov 11;280(45):37585-98. Pubmed16157586
Calmels B, Ferguson C, Laukkanen MO, Adler R, Faulhaber M, Kim HJ, Sellers S, Hematti P, Schmidt M, von Kalle C, Akagi K, Donahue RE, Dunbar CE. Recurrent retroviral vector integration at the MDS1-EVI1 locus in non-human primate hematopoietic cells. Blood. 2005 Oct 1;106(7):2530-3. Pubmed15933056
  Themis M, Waddington SN, Schmidt M, von Kalle C, Wang Y, Al-Allaf F, Gregory LG, Nivsarkar M, Themis M, Holder MV, Buckley SM, Dighe N, Ruthe AT, Mistry A, Bigger B, Rahim A, Nguyen TH, Trono D, Thrasher AJ, Coutelle C. Oncogenesis following delivery of a nonprimate lentiviral gene therapy vector to fetal and neonatal mice. Mol Ther. 2005 Oct;12(4):763-71. Pubmed16084128
  Glimm H, Schmidt M, Fischer M, Schwarzwaelder K, Wissler M, Klingenberg S, Prinz C, Waller CF, Lange W, Eaves CJ, von Kalle C.
Efficient marking of human cells with rapid but transient repopulating activity in autografted recipients. Blood. 2005 Aug 1;106(3):893-8. Pubmed15845903
  Reinheckel T, Hagemann S, Dollwet-Mack S, Martinez E, Lohmuller T, Zlatkovic G, Tobin DJ, Maas-Szabowski N, Peters C. The lysosomal cysteine protease cathepsin L regulates keratinocyte proliferation by control of growth factor recycling. J Cell Sci. 2005 Aug 1;118(Pt 15):3387-95. Pubmed16079282
  Lindenboim L, Kringel S, Braun T, Borner C, Stein R.
Bak but not Bax is essential for Bcl-xS-induced apoptosis.
Cell Death Differ. 2005 Jul;12(7):713-23. Pubmed15861188
  Podsakoff GM, Engel BC, Carbonaro DA, Choi C, Smogorzewska EM, Bauer G, Selander D, Csik S, Wilson K, Betts MR, Koup RA, Nabel GJ, Bishop K, King S, Schmidt M, von Kalle C, Church JA, Kohn DB.
Selective survival of peripheral blood lymphocytes in children with HIV-1 following delivery of an anti-HIV gene to bone marrow CD34(+) cells. Mol Ther. 2005 Jul;12(1):77-86. Pubmed15963923
  Loop T, Dovi-Akue D, Frick M, Roesslein M, Egger L, Humar M, Hoetzel A, Schmidt R, Borner C, Pahl HL, Geiger KK, Pannen BH.
Volatile anesthetics induce caspase-dependent, mitochondria-mediated apoptosis in human T lymphocytes in vitro.
Anesthesiology. 2005 Jun;102(6):1147-57. Pubmed15915027
  Modlich U, Kustikova OS, Schmidt M, Rudolph C, Meyer J, Li Z, Kamino K, von Neuhoff N, Schlegelberger B, Kuehlcke K, Bunting KD, Schmidt S, Deichmann A, von Kalle C, Fehse B, Baum C. Leukemias following retroviral transfer of multidrug resistance 1 (MDR1) are driven by combinatorial insertional mutagenesis. Blood. 2005 Jun 1;105(11):4235-46. Pubmed15713797
  Darie CC, Biniossek ML, Winter V, Mutschler B, Haehnel W. Isolation and structural characterization of the Ndh complex from mesophyll and bundle sheath chloroplasts of Zea mays. FEBS J. 2005 Jun;272(11):2705-16. Pubmed15943805
  Thrasher AJ, Hacein-Bey-Abina S, Gaspar HB, Blanche S, Davies EG, Parsley K, Gilmour K, King D, Howe S, Sinclair J, Hue C, Carlier F, von Kalle C, de Saint Basile G, le Deist F, Fischer A, Cavazzana-Calvo M.
Failure of SCID-X1 gene therapy in older patients. Blood. 2005 Jun 1;105(11):4255-7. Pubmed15687233
Henningsson F, Yamamoto K, Saftig P, Reinheckel T, Peters C, Knight SD, Pejler G. A role for cathepsin E in the processing of mast-cell carboxypeptidase A. J Cell Sci. 2005 May 1;118(Pt 9):2035-42. Pubmed15860733
Schmidt M, Hacein-Bey-Abina S, Wissler M, Carlier F, Lim A, Prinz C, Glimm H, Andre-Schmutz I, Hue C, Garrigue A, Le Deist F, Lagresle C, Fischer A, Cavazzana-Calvo M, von Kalle C. Clonal evidence for the transduction of CD34+ cells with lymphomyeloid differentiation potential and self-renewal capacity in the SCID-X1 gene therapy trial. Blood. 2005 Apr 1;105(7):2699-706. Pubmed15585650
Stemmler MP, Hecht A, Kemler R. E-cadherin intron 2 contains cis-regulatory elements essential for gene expression.Development. 2005 Mar;132(5):965-76. Pubmed15673570
Laukkanen MO, Kuramoto K, Calmels B, Takatoku M, von Kalle C, Donahue RE, Dunbar CE. Low-dose total body irradiation causes clonal fluctuation of primate hematopoietic stem and progenitor cells. Blood. 2005 Feb 1;105(3):1010-5. Pubmed15383461
Urbich C, Heeschen C, Aicher A, Sasaki KI, Bruhl T, Farhadi MR, Vajkoczy P, Hofmann WK, Peters C, Pennacchio LA, Abolmaali ND, Chavakis E, Reinheckel T, Zeiher AM, Dimmeler S. Cathepsin L is required for endothelial progenitor cell-induced neovascularization.
Nat Med. 2005 Feb;11(2):206-13. Pubmed15665831
  Yao VJ, Ozawa MG, Trepel M, Arap W, McDonald DM, Pasqualini R.
Targeting pancreatic islets with phage display assisted by laser pressure catapult microdissection. Am J Pathol. 2005 Feb;166(2):625-36. Pubmed15681844
  Milsom MD, Duxbury R, Gagen D, Humphries RK, Schmidt M, von-Kalle C, Fairbairn LJ. Overexpression of HOXB4 confers a myelo-erythroid differentiation delay in vitro. Leukemia. 2005 Jan;19(1):148-53. (Letter) Pubmed15496973
  Glimm H, Schmidt M, Fischer M, Klingenberg S, Lange W, Waller CF, Eaves CJ, von Kalle C. Evidence of similar effects of short-term culture on the initial repopulating activity of mobilized peripheral blood transplants assessed in NOD/SCID-beta2microglobulin(null) mice and in autografted patients. Exp Hematol. 2005 Jan;33(1):20-5. Pubmed15661394
2004 Hematti P, Hong BK, Ferguson C, Adler R, Hanawa H, Sellers S, Holt IE, Eckfeldt CE, Sharma Y, Schmidt M, von Kalle C, Persons DA, Billings EM, Verfaillie CM, Nienhuis AW, Wolfsberg TG, Dunbar CE, Calmels B. Distinct genomic integration of MLV and SIV vectors in primate hematopoietic stem and progenitor cells. PLoS Biol. 2004 Dec;2(12):e423. Pubmed15550989
  Gaspar HB, Parsley KL, Howe S, King D, Gilmour KC, Sinclair J, Brouns G, Schmidt M, Von Kalle C, Barington T, Jakobsen MA, Christensen HO, Al Ghonaium A, White HN, Smith JL, Levinsky RJ, Ali RR, Kinnon C, Thrasher AJ. Gene therapy of X-linked severe combined immunodeficiency by use of a pseudotyped gammaretroviral vector. Lancet. 2004 Dec 18;364(9452):2181-7. Pubmed15610804
  Hagemann S, Gunther T, Dennemarker J, Lohmuller T, Bromme D, Schule R, Peters C, Reinheckel T. The human cysteine protease cathepsin V can compensate for murine cathepsin L in mouse epidermis and hair follicles. Eur J Cell Biol. 2004 Dec;83(11-12):775-80. Pubmed15679121
  von Kalle C, Fehse B, Layh-Schmitt G, Schmidt M, Kelly P, Baum C.
Stem cell clonality and genotoxicity in hematopoietic cells: gene activation side effects should be avoidable. Semin Hematol. 2004 Oct;41(4):303-18. Pubmed15508116
  von Kalle C, Baum C, Williams DA. Lenti in red: progress in gene therapy for human hemoglobinopathies. J Clin Invest. 2004 Oct;114(7):889-91. Pubmed15467825
  Lindenboim L, Schlipf S, Kaufmann T, Borner C, Stein R.
Bcl-x(S) induces an NGF-inhibitable cytochrome c release.
Exp Cell Res. 2004 Jul 15;297(2):392-403. Pubmed15212942
  Wille A, Gerber A, Heimburg A, Reisenauer A, Peters C, Saftig P, Reinheckel T, Welte T, Buhling F. Cathepsin L is involved in cathepsin D processing and regulation of apoptosis in A549 human lung epithelial cells. Biol Chem. 2004 Jul;385(7):665-70. Pubmed15318816
  Fischer A, Abina SH, Thrasher A, von Kalle C, Cavazzana-Calvo M.
LMO2 and gene therapy for severe combined immunodeficiency.
N Engl J Med. 2004 Jun 10;350(24):2526-7; author reply 2526-7. (Comment) Pubmed15190153
  Darie CC, Biniossek ML, Jovine L, Litscher ES, Wassarman PM.
Structural Characterization of Fish Egg Vitelline Envelope Proteins by Mass Spectrometry. Biochemistry. 2004 Jun 15;43(23):7459-7478. Pubmed15182189
  Kuramoto K, Follmann DA, Hematti P, Sellers S, Agricola BA, Metzger ME, Donahue RE, von Kalle C, Dunbar CE. Effect of chronic cytokine therapy on clonal dynamics in nonhuman primates. Blood. 2004 Jun 1;103(11):4070-7. Pubmed14962906
  Hook V, Yasothornsrikul S, Greenbaum D, Medzihradszky KF, Troutner K, Toneff T, Bundey R, Logrinova A, Reinheckel T, Peters C, Bogyo M.
Cathepsin L and Arg/Lys aminopeptidase: a distinct prohormone processing pathway for the biosynthesis of peptide neurotransmitters and hormones. Biol Chem. 2004 Jun;385(6):473-80. Pubmed15255178
  Schinzel A, Kaufmann T, Borner C.
Bcl-2 family members: intracellular targeting, membrane-insertion, and changes in subcellular localization.
Biochim Biophys Acta. 2004 Mar 1;1644(2-3):95-105. Pubmed14996494
  Schinzel A, Kaufmann T, Schuler M, Martinalbo J, Grubb D, Borner C.
Conformational control of Bax localization and apoptotic activity by Pro168.
J Cell Biol. 2004 Mar 29;164(7):1021-32. Pubmed15037603
  Kiem HP, Sellers S, Thomasson B, Morris JC, Tisdale JF, Horn PA, Hematti P, Adler R, Kuramoto K, Calmels B, Bonifacino A, Hu J, von Kalle C, Schmidt M, Sorrentino B, Nienhuis A, Blau CA, Andrews RG, Donahue RE, Dunbar CE. Long-term clinical and molecular follow-up of large animals receiving retrovirally transduced stem and progenitor cells: no progression to clonal hematopoiesis or leukemia. Mol Ther. 2004 Mar;9(3):389-95. Pubmed15006605
  Faller D, Reinheckel T, Wenzler D, Hagemann S, Xiao K, Honerkamp J, Peters C, Dandekar T, Timmer J. An open source protein gel documentation system for proteome analyses. J Chem Inf Comput Sci. 2004 Jan-Feb;44(1):168-9. Pubmed14741024
  Baum C, von Kalle C, Staal FJ, Li Z, Fehse B, Schmidt M, Weerkamp F, Karlsson S, Wagemaker G, Williams DA. Chance or necessity? Insertional mutagenesis in gene therapy and its consequences.
Mol Ther. 2004 Jan;9(1):5-13. Pubmed14741772
  Kaufmann T, Schinzel A, Borner C.
Bcl-w(edding) with mitochondria.
Trends Cell Biol. 2004 Jan;14(1):8-12. Pubmed14729175 
2003 Schild L, Reinheckel T, Reiser M, Horn TF, Wolf G, Augustin W. 
Nitric oxide produced in rat liver mitochondria causes oxidative stress and impairment of respiration after transient hypoxia. 

FASEB J. 2003 Dec;17(15):2194-201. Pubmed14656981
  Gao C, Kang EM, Kuramoto K, Agricola BA, Metzger M, von Kalle C, Donahue RE, Tisdale JF. Retrovirally transduced muscle-derived cells contribute to hematopoiesis at very low levels in the nonhuman primate model. Mol Ther. 2003 Dec;8(6):974-80. Pubmed14664800
  Strauch OF, Stypmann J, Reinheckel T, Martinez E, Haverkamp W, Peters C. Cardiac and ocular pathologies in a mouse model of mucopolysaccharidosis type VI. Pediatr Res. 2003 Nov;54(5):701-8. Pubmed12904606
  Shah S, Hecht A, Pestell R, Byers SW. Trans-repression of beta-Catenin Activity by Nuclear Receptors.  
J Biol Chem. 2003 Nov 28;278(48):48137-48145. Pubmed12972427
  Neff T, Horn PA, Peterson LJ, Thomasson BM, Thompson J, Williams DA, Schmidt M, Georges GE, von Kalle C, Kiem HP. Methylguanine methyltransferase-mediated in vivo selection and chemoprotection of allogeneic stem cells in a large-animal model. J Clin Invest. 2003 Nov;112(10):1581-8. Pubmed14617759
  Egger L, Schneider J, Rheme C, Tapernoux M, Hacki J, Borner C.
Serine proteases mediate apoptosis-like cell death and phagocytosis under caspase-inhibiting conditions.
Cell Death Differ. 2003 Oct;10(10):1188-1203. Pubmed14502242
  Hacein-Bey-Abina S, Von Kalle C, Schmidt M, McCormack MP, Wulffraat N, Leboulch P, Lim A, Osborne CS, Pawliuk R, Morillon E, Sorensen R, Forster A, Fraser P, Cohen JI, de Saint Basile G, Alexander I, Wintergerst U, Frebourg T, Aurias A, Stoppa-Lyonnet D, Romana S, Radford-Weiss I, Gross F, Valensi F, Delabesse E, Macintyre E, Sigaux F, Soulier J, Leiva LE, Wissler M, Prinz C, Rabbitts TH, Le Deist F, Fischer A, Cavazzana-Calvo M. LMO2-associated clonal T cell proliferation in two patients after gene therapy for SCID-X1.
Science. 2003 Oct 17;302(5644):415-9. Pubmed14564000
  Houseweart MK, Pennacchio LA, Vilaythong A, Peters C, Noebels JL, Myers RM. Cathepsin B but not cathepsins L or S contributes to the pathogenesis of Unverricht-Lundborg progressive myoclonus epilepsy (EPM1). J Neurobiol. 2003 Sep 15;56(4):315-27.
  Muller OJ, Kaul F, Weitzman MD, Pasqualini R, Arap W, Kleinschmidt JA, Trepel M. Random peptide libraries displayed on adeno-associated virus to select for targeted gene therapy vectors. 
Nat Biotechnol. 2003 Sep;21(9):1040-6. Pubmed12897791
  McCaw SE, Schneider J, Liao EH, Zimmermann W, Gray-Owen SD.
Immunoreceptor tyrosine-based activation motif phosphorylation during engulfment of Neisseria gonorrhoeae by the neutrophil-restricted CEACAM3 (CD66d) receptor.
Mol Microbiol. 2003 Aug;49(3):623-37. Pubmed12864848
  Yasothornsrikul S, Greenbaum D, Medzihradszky KF, Toneff T, Bundey R, Miller R, Schilling B, Petermann I, Dehnert J, Logvinova A, Goldsmith P, Neveu JM, Lane WS, Gibson B, Reinheckel T, Peters C, Bogyo M, Hook V. Cathepsin L in secretory vesicles functions as a prohormone-processing enzyme for production of the enkephalin peptide neurotransmitter. 
Proc Natl Acad Sci U S A. 2003 Aug 5;100(16):9590-5. Pubmed12869695
  Huber TB, Hartleben B, Kim J, Schmidts M, Schermer B, Keil A, Egger L, Lecha RL, Borner C, Pavenstädt H, Shaw A, Walz G, Benzing T.
Nephrin and CD2AP associate with phosphoinositide 3-OH kinase and stimulate AKT-dependent signaling.
Mol Cell Biol. 2003 Jul;23(14):4917-28. Pubmed12832477
  Lohmuller T, Wenzler D, Hagemann S, Kiess W, Peters C, Dandekar T, Reinheckel T. Toward computer-based cleavage site prediction of cysteine endopeptidases.  Biol Chem. 2003 Jun;384(6):899-909. Pubmed12887057
  Friedrichs B, Tepel C, Reinheckel T, Deussing J, von Figura K, Herzog V, Peters C, Saftig P, Brix K. Thyroid functions of mouse cathepsins B, K, and L. J Clin Invest. 2003 Jun;111(11):1733-45. Pubmed12782676
  Stemmler MP, Hecht A, Kinzel B, Kemler R. Analysis of regulatory elements of E-cadherin with reporter gene constructs in transgenic mouse embryos. Dev Dyn. 2003 Jun;227(2):238-45 Pubmed12761851
  Gianinazzi C, Grandgirard D, Imboden H, Egger L, Meli DN, Bifrare YD, Joss PC, Tauber MG, Borner C, Leib SL.
Caspase-3 mediates hippocampal apoptosis in pneumococcal meningitis.
Acta Neuropathol (Berl) 2003 May;105(5):499-507. Pubmed12677451
  Schmidt M, Glimm H, Wissler M, Hoffmann G, Olsson K, Sellers S, Carbonaro D, Tisdale JF, Leurs C, Hanenberg H, Dunbar CE, Kiem HP, Karlsson S, Kohn DB, Williams D, Von Kalle C. Efficient characterization of retro-, lenti-, and foamyvector-transduced cell populations by high-accuracy insertion site sequencing. Ann N Y Acad Sci. 2003 May;996:112-21. Pubmed12799289
  Leurs C, Jansen M, Pollok KE, Heinkelein M, Schmidt M, Wissler M, Lindemann D, Von Kalle C, Rethwilm A, Williams DA, Hanenberg H.
Comparison of three retroviral vector systems for transduction of nonobese diabetic/severe combined immunodeficiency mice repopulating human CD34+ cord blood cells. Hum Gene Ther. 2003 Apr 10;14(6):509-19. Pubmed12718762
  Schmidt M, Carbonaro DA, Speckmann C, Wissler M, Bohnsack J, Elder M, Aronow BJ, Nolta JA, Kohn DB, von Kalle C. Clonality analysis after retroviral-mediated gene transfer to CD34+ cells from the cord blood of ADA-deficient SCID neonates. Nat Med. 2003 Apr;9(4):463-8. Pubmed12640448
  Tamm I, Trepel M, Cardó-Vila M, Sun Y, Welsh K, Cabezas E, Swatterthwait A, Arap W, Reed JC, Pasqualini R. Peptides targeting caspase inhibitors. J Biol Chem. 2003 Apr 18;278(16):14401-5. Pubmed12538646
  Baum C, Düllmann J, Li Z, Fehse B, Meyer J, Williams DA, von Kalle C.
Side effects of retroviral gene transfer into hematopoietic stem cells. Blood. 2003 Mar 15;101(6):2099-114. Pubmed12511419
  Woods NB, Muessig A, Schmidt M, Flygare J, Olsson K, Salmon P, Trono D, von Kalle C, Karlsson S. Lentiviral vector transduction of NOD/SCID repopulating cells results in multiple vector integrations per transduced cell: risk of insertional mutagenesis.
Blood. 2003 Feb 15;101(4):1284-9. Pubmed12393514
  Hecht A, Stemmler MP. Identification of a promoter-specific transcriptional activation domain at the C terminus of the Wnt effector protein T-cell factor 4. J Biol Chem. 2003 Feb 7;278(6):3776-85. Pubmed12446687
  Hacein-Bey-Abina S, von Kalle C, Schmidt M, Le Deist F, Wulffraat N, McIntyre E, Radford I, Villeval JL, Fraser CC, Cavazzana-Calvo M, Fischer A. A serious adverse event after successful gene therapy for X-linked severe combined immunodeficiency. 
N Engl J Med. 2003 Jan 16;348(3):255-6. Pubmed12529469
  Borner C.
The Bcl-2 protein family: sensors and checkpoints for life-or-death decisions.
Mol Immunol 2003 Jan;39(11):615-47, Pubmed12493639
  Kaufmann T, Schlipf S, Sanz J, Neubert K, Stein R, Borner C.
Characterization of the signal that directs Bcl-x(L), but not Bcl-2, to the mitochondrial outer membrane.
J Cell Biol 2003 Jan 6;160(1):53-64. Pubmed12515824
  Baum C, von Kalle C. Gene therapy targeting hematopoietic cells: better not leave it to chance. Acta Haematol. 2003;110(2-3):107-9. Pubmed14583670
2002 Nishimura F, Naruishi H, Naruishi K, Yamada T, Sasaki J, Peters C, Uchiyama Y, Murayama Y. Cathepsin-L, a key molecule in the pathogenesis of drug-induced and I-cell disease-mediated gingival overgrowth: a study with cathepsin-L-deficient mice.  
Am J Pathol 2002 Dec;161(6):2047-52 Pubmed12466121
  Ailles L, Schmidt M, Santoni de Sio FR, Glimm H, Cavalieri S, Bruno S, Piacibello W, Von Kalle C, Naldini L. Molecular evidence of lentiviral vector-mediated gene transfer into human self-renewing, multi-potent, long-term NOD/SCID repopulating hematopoietic cells. 
Mol Ther 2002 Nov;6(5):615-26 Pubmed12409260
  Schmidt M, Zickler P, Hoffmann G, Haas S, Wissler M, Muessig A, Tisdale JF, Kuramoto K, Andrews RG, Wu T, Kiem HP, Dunbar CE, von Kalle C. Polyclonal long-term repopulating stem cell clones in a primate model. Blood 2002 Oct 15;100(8):2737-43 Pubmed12351380
  Neff T, Horn PA, Valli VE, Gown AM, Wardwell S, Wood BL, von Kalle C, Schmidt M, Peterson LJ, Morris JC, Richard RE, Clackson T, Kiem HP, Blau CA. Pharmacologically regulated in vivo selection in a large animal. Blood 2002 Sep 15;100(6):2026-31 Pubmed12200362
  Ebert DH, Deussing J, Peters C, Dermody TS. Cathepsin L and cathepsin B mediate reovirus disassembly in murine fibroblast cells. J Biol Chem 2002 Jul 5;277(27):24609-17 Pubmed11986312
  Glimm H, Tang P, Clark-Lewis I, von Kalle C, Eaves C. Ex vivo treatment of proliferating human cord blood stem cells with stroma-derived factor-1 enhances their ability to engraft NOD/SCID mice. 
Blood 2002 May 1;99(9):3454-7 Pubmed11964317
  Honey K, Nakagawa T, Peters C, Rudensky A. Cathepsin L regulates CD4+ T cell selection independently of its effect on invariant chain: a role in the generation of positively selecting peptide ligands.  
J Exp Med 2002 May 20;195(10):1349-58 Pubmed12021314
  Tobin DJ, Foitzik K, Reinheckel T, Mecklenburg L, Botchkarev VA, Peters C, Paus R. The lysosomal protease cathepsin L is an important regulator of keratinocyte and melanocyte differentiation during hair follicle morphogenesis and cycling. Am J Pathol 2002 May;160(5):1807-21 Pubmed12000732
  Li Z, Dullmann J, Schiedlmeier B, Schmidt M, von Kalle C, Meyer J, Forster M, Stocking C, Wahlers A, Frank O, Ostertag W, Kuhlcke K, Eckert HG, Fehse B, Baum C. Murine leukemia induced by retroviral gene marking. Science 2002 Apr 19;296(5567):497 Pubmed11964471
  Stypmann J, Glaser K, Roth W, Tobin DJ, Petermann I, Matthias R, Monnig G, Haverkamp W, Breithardt G, Schmahl W, Peters C, Reinheckel T. Dilated cardiomyopathy in mice deficient for the lysosomal cysteine peptidase cathepsin L. Proc Natl Acad Sci U S A 2002 Apr 30;99(9):6234-9, Pubmed11972068, http://www.pnas.org/cgi/content/full/99/9/6234
  Schmidt S, Bork P, Dandekar T. A versatile structural domain analysis server using profile weight matrices.  J Chem Inf Comput Sci 2002 Mar-Apr;42(2):405-7 Pubmed11911710
  Schuster S, Pfeiffer T, Moldenhauer F, Koch I, Dandekar T. Exploring the pathway structure of metabolism: decomposition into subnetworks and application to Mycoplasma pneumoniae.  Bioinformatics 2002 Feb;18(2):351-361, Pubmed11847093
  Nishioku T, Hashimoto K, Yamashita K, Liou SY, Kagamiishi Y, Maegawa H, Katsube N, Peters C, von Figura K, Saftig P, Katunuma N, Yamamoto K, Nakanishi H. Involvement of cathepsin E in exogenous antigen processing in primary cultured murine microglia.  
J Biol Chem 2002 Feb 15;277(7):4816-22 Pubmed11719510
  Billker O, Popp A, Brinkmann V, Wenig G, Schneider J, Caron E, Meyer TF. Distinct mechanisms of internalization of Neisseria gonorrhoeae by members of the CEACAM receptor family involving Rac1- and Cdc42-dependent and -independent pathways.
EMBO J 2002 Feb 15;21(4):560-571. Pubmed11847104 http://emboj.oupjournals.org/cgi/reprint/21/4/560.pdf
  Schempp CM, Kirkin V, Simon-Haarhaus B, Kersten A, Kiss J, Termeer CC, Gilb B, Kaufmann T, Borner C, Sleeman JP, Simon JC.
Inhibition of tumour cell growth by hyperforin, a novel anticancer drug from St. John's wort that acts by induction of apoptosis.
Oncogene 2002 Feb 14;21(8):1242-50. Pubmed11850844
  Deussing J, Kouadio M, Rehman S, Werber I, Schwinde A, Peters C. 
Identification and characterization of a dense cluster of placenta-specific cysteine peptidase genes and related genes on mouse chromosome 13.
Genomics 2002 Feb;79(2):225-40 Pubmed11829493
  Dandekar T, Sauerborn R. Comparative genome analysis and pathway reconstruction. Pharmacogenomics 2002; 3(2):243-254 Pubmed11972445
  Zwad O, Kubler B, Roth W, Scharf JG, Saftig P, Peters C, Braulke T. 
Decreased intracellular degradation of insulin-like growth factor binding protein-3 in cathepsin L-deficient fibroblasts.
FEBS Lett 2002 510(3), 211-215 Pubmed11801256
2001 Dandekar T, Du F, Schirmer RH, Schmidt S. Medical target prediction from genome sequence: combining different sequence analysis algorithms with expert knowledge and input from artificial intelligence approaches. Comput Chem 2001 Dec;26(1):15-21 Pubmed11765847
  Nishioku T, Hashimoto K, Yamashita K, Liou SY, Kagamiishi Y, Maegawa H, Katsube N, Peters C, von Figura K, Saftig P, Katunuma N, Yamamoto K, Nakanishi H. Involvement of cathepsin E in exogenous antigen processing in primary cultured murine microglia.  J Biol Chem 2001 Nov 21; Pubmed1171951
  Lindenboim L, Borner C, Stein R.
Bcl-x(S) can form homodimers and heterodimers and its apoptotic activity requires localization of Bcl-x(S) to the mitochondria and its BH3 and loop domains. 
Cell Death Differ 2001 Sep;8(9):933-942. Pubmed11526448
  Schmidt M, Glimm H, Lemke N, Muessig A, Speckmann C, Haas S, Zickler P, Hoffmann G, Von Kalle C. A model for the detection of clonality in marked hematopoietic stem cells. Ann N Y Acad Sci 2001 Jun;938:146-55; discussion 155-6 Pubmed11458502
  Glimm H, Tang P, Clark-Lewis I, von Kalle C., Eaves C. Ex vivo treatment of proliferating human cord blood stem cells with stroma-derived factor-1 enhances their ability to engraft NOD/SCID mice.  Blood 2002 May 1;99(9):3454-7 Pubmed11964317 http://www.bloodjournal.org/cgi/content/full/99/9/3454 
  Gilgenast O, Brandt-Nedelev B, Wiswedel I, Lippert H, Halangk W, Reinheckel T. Differential oxidative injury in extrapancreatic tissues during experimental pancreatitis: modification of lung proteins by 4- hydroxynonenal. Dig Dis Sci 2001 Apr;46(4):932-937 PubMed11330437
  Honey K, Duff M, Beers C, Brissette WH, Elliott EA, Peters C, Maric M, Cresswell P, Rudensky A. (2001) Cathepsin S regulates the expression of cathepsin L and the turnover of gamma-interferon-inducible lysosomal thiol reductase in B lymphocytes. J Biol Chem 276(25), 22573-8 Pubmed11306582

Nakanishi H, Zhang J, Koike M, Nishioku T, Okamoto Y, Kominami E, von Figura K, Peters C, Yamamoto K, Saftig P, Uchiyama Y. (2001) 
Involvement of nitric oxide released from microglia-macrophages in pathological changes of cathepsin D-deficient mice.
J Neurosci  21(19), 7526-33 Pubmed11567042

  Reinheckel T, Deussing J, Roth W, Peters C. Towards specific functions of lysosomal cysteine peptidases: phenotypes of mice deficient for cathepsin B or cathepsin L. Biol Chem 382(5), 735-41 Pubmed11517926
  Reinheckel T, Grune T. Regulation of the degradation of oxidized proteins. In: Nesaretnam K., Packer L. (Hrsg): Micronutrients and Health: Molecular Biological Mechanisms. AOCS Press, 2001; chap 17
  Schulz HU, Böhm AK, Halangk W, Lippert H, Reinheckel T.  Insertions-Deletions-Polymorphismus im humanen T6 Trypsinogen-Gen: Bedeutung für die Entwicklung einer chronischen Pankreatitis.  
In: ? Chirurgisches Forum 2001; 30:, 2001; 219-221
2000 Pross M, Schulz HU, Flechsig A, Manger T, Halangk W, Augustin W, Lippert H, Reinheckel T. 
Oxidative stress in lung tissue induced by CO(2) pneumoperitoneum in the rat. 

Surg Endosc 2000 Dec;14(12):1180-4 Pubmed11148794
  Conus S, Rossé T, Borner C.
Failure of Bcl-2 family members to interact with Apaf-1 in normal and apoptotic cells. 
Cell Death Differ 2000 Oct;7(10):947-954. Pubmed11279541
  Bosse R, Kulmburg P, von Kalle C, Engelhardt M, Dwenger A, Rosenthal F, Schulz G. 
Production of stem-cell transplants according to good manufacturing practice. 
Ann Hematol 2000 Sep;79(9):469-76 PubMed 11043417
  Dandekar T, Huynen M, Regula JT, Ueberle B, Zimmermann CU, Andrade MA, Doerks T, Sanchez-Pulido L, Snel B, Suyama M, Yuan YP, Herrmann R, Bork P. 
Re-annotating the mycoplasma pneumoniae genome sequence: adding value, function and reading frames. 
Nucleic Acids Res. 2000 Sep 1;28(17):3278-88 Pubmed10954595
  Kenealy MR, Flouriot G, Sonntag-Buck V, Dandekar T, Brand H, Gannon F. 
The 3'-untranslated region of the human estrogen receptor alpha gene mediates rapid messenger ribonucleic acid turnover. 
Endocrinology. 2000 Aug;141(8):2805-13 Pubmed10919266
  Tribble G, Ahn YT, Lee J, Dandekar T, Jayaram M. 
DNA recognition, strand selectivity, and cleavage mode during integrase family site-specific recombination. 
J Biol Chem. 2000 Jul 21;275(29):22255-67 Pubmed10748094
  Foyouzi-Youssefi R, Arnaudeau S, Borner C, Kelley WL, Tschopp J, Lew DP, Demaurex N, Krause KH.
Bcl-2 decreases the free Ca2+ concentration within the endoplasmic reticulum.
Proc Natl Acad Sci U S A 2000 May 23;97(11):5723-8
  Häcki J, Egger L, Monney L, Conus S, Rossé T, Fellay I, Borner C.
Apoptotic crosstalk between the endoplasmic reticulum and mitochondria controlled by Bcl-2.
Oncogene 2000 May 4;19(19):2286-95. Pubmed10822379
  Reinheckel T, Ullrich O, Sitte N, Grune T. 
Differential impairment of 20S and 26S proteasome activities in human hematopoietic K562 cells during oxidative stress. 
Arch Biochem Biophys 2000 May 1;377(1):65-8 Pubmed10775442
  Conus S, Kaufmann T, Fellay I, Otter I, Rossé T, Borner C.
Bcl-2 is a monomeric protein: prevention of homodimerization by structural constraints.
EMBO J 2000 Apr 3;19(7):1534-44. Pubmed10747022
  Reinheckel T, Körn S, Möhring S, Augustin W, Halangk W, Schild L. 
Adaptation of protein carbonyl detection to the requirements of proteome analysis demonstrated for hypoxia/reoxygenation in isolated rat liver mitochondria. 
Arch Biochem Biophys 2000 Apr 1;376(1):59-65 Pubmed10729190
  Vieira O, Escargueil-Blanc I, Jürgens G, Borner C, Almeida L, Salvayre R, Negre-Salvayre A.
Oxidized LDLs alter the activity of the ubiquitin-proteasome pathway: potential role in oxidized LDL-induced apoptosis.
FASEB J 2000 Mar;14(3):532-42
  Schuster S, Fell DA, Dandekar T. 
A general definition of metabolic pathways useful for systematic organization and analysis of complex metabolic networks. 
Nat Biotechnol. 2000 Mar;18(3):326-32 Pubmed10700151
  Glimm H, Eisterer W, Lee K, Cashman J, Holyoake TL, Nicolini F, Shultz LD, von Kalle C, Eaves CJ. 
Previously undetected human hematopoietic cell populations with short-term repopulating activity selectively engraft NOD/SCID-beta2 microglobulin-null mice. 
J Clin Invest 2001 Jan;107(2):199-206 http://www.jci.org/cgi/content/full/107/2/199?view=full&pmid=11160136
  Pross M, Manger T, Reinheckel T, Mirow L, Kunz D, Lippert H. 
Endoscopic treatment of clinically symptomatic leaks of thoracic esophageal anastomoses. 
Gastrointest Endosc 2000 Jan;51(1):73-6 Pubmed10625803
  Deussing, J., von Olshausen, I., and Peters, C. (2000). 
Murine and Human Cathepsin Z: cDNA-cloning, characterization of the genes and chromosomal localization.
Biochim. Biophys. Acta 1491, 93-106 Pubmed10760573
  Deussing, J., Tisljar, K., Papazoglou, A., and Peters, C. (2000). 
Mouse Cathepsin F: cDNA cloning, genomic organization and chromosomal assignment of the gene.
Gene 251(2):165-73 Pubmed10876093
  Guicciardi, M.E., Deussing, J., Miyoshi, H., Bronk, S.F., Svingen, P.A., Peters, C., Kaufmann, S.H., and Gores, G.J. (2000) 
Cathepsin B contributes to TNF-alpha-mediated hepatocyte apoptosis by promoting mitochondrial release of cytochrome c.
J. Clin. Invest. 106, 1127-37 Pubmed11067865
  Halangk, W., Lerch, M.M., Brandt-Nedelev, B., Roth, W., Ruthenbuerger, M., Reinheckel, T., Domschke, W., Lippert, H., Peters, C., and Deussing, J. (2000). 
Role of cathepsin B in intracellular trypsinogen activation and the onset of acute pancreatitis.
 J. Clin. Invest. 106, 773-81 http://www.jci.org/cgi/content/full/106/6/773?view=full&pmid=10995788 Pubmed10995788
  Heinrich, M., Wickel, M., Winoto-Morbach, S., Schneider-Brachert, W., Weber, T., Brunner, J., Saftig, P., Peters, C., Krönke, M., and Schütze, S. (2000). 
Ceramide as an activator lipid of cathepsin D (Review).
Adv. Exp. Med. Biol. 477, 305-15 Pubmed10849758
  Hrabe de Angelis, M.H., Flaswinkel, H., Fuchs, H., Rathkolb, B., Soewarto, D., Marschall, S., Heffner, S., Pargent, W., Wuensch, K., Jung, M., Reis, A., Richter, T., Alessandrini, F., Jakob, T., Fuchs, E., Kolb, H., Kremmer, E., Schaeble, K., Rollinski, B., Roscher, A., Peters, C., Meitinger, T., Strom, T., Steckler, T., Holsboer, F., Klopstock T. Gekeler, F., Schindewolf, C., Jung, T., Avraham, K., Behrendt, H., Ring, J., Zimmer, A., Schughart, K., Pfeffer, K., Wolf, E., and Balling, R. (2000) 
Genome-wide, large-scale production of mutant mice by ENU mutagenesis.

Nat. Genet. 25, 444-7 Pubmed10932192
  Koike, M., Nakanishi, H., Saftig, P., Ezaki, J., Isahara, K., Ohsawa, Y., Schulz-Schaeffer, W., Watanabe, T., Waguri, S., Kametaka, S., Shibata, M., Yamamoto, K., Kominami, E., Peters, C., von Figura, K., and Uchiyama, Y. (2000). 
Cathepsin D deficiency induces lysosomal storage with ceroid lipofuscin in mouse CNS neurons.
J. Neurosci. 20, 6898-906 Pubmed10995834
  Moin, K., Demchik, L., Mai, J., Deussing, J., Peters, C., and Sloane, B.F. (2000). 
Observing proteases in living cells (Review).
Adv. Exp. Med. Biol. 477, 391-401 Pubmed10849765
  Roth, W., Deussing, J., Botchkarev, V.A., Pauly-Evers, M., Saftig, P., Hafner, A., Schmidt, P., Schmahl, W., Scherer, J., Anton-Lamprecht, I., von Figura, K., Paus, R., and Peters, C. (2000). 
Cathepsin L deficiency as molecular defect of furless: hyperproliferation of keratinocytes and pertubation of hair follicle cycling.
FASEB J., 14, 2075-86 Pubmed11023992
  Tatnell, P.J., Cook, M., Peters, C., and Kay, J. (2000) 
Molecular organization, expression and chromosomal localization of the mouse pronapsin gene.
Eur. J. Biochem. 267, 6921-30 Pubmed11082205
  Reinheckel T, Grune T, Davies KJ. 
The measurement of protein degradation in response to oxidative stress.
Methods Mol Biol 2000;99:49-60 Pubmed10909076
  Botchkareva, N.V., Botchkarev, V.A., Welker, P., Airaksinen, M., Roth, W., Suvanto, P., Müller-Röver, S., Hadshiew, I.M., Peters, C., and Paus, R. (2000). 
New roles for glial cell line-derived neurotrophic factor and neurturin: involvement in hair cycle control.
Am. J. Pathol. 156, 1041-53 Pubmed10702420
1999 Dandekar T, Schuster S, Snel B, Huynen M, Bork P. 
Pathway alignment: application to the comparative analysis of glycolytic enzymes. 

Biochem J. 1999 Oct 1;343 Pt 1:115-24 Pubmed10493919
  Nickel R, Ott C, Dandekar T, Leippe M. 
Pore-forming peptides of Entamoeba dispar. Similarity and divergence to amoebapores in structure, expression and activity. 

Eur J Biochem. 1999 Nov;265(3):1002-7 Pubmed10518795
  Struttmann T, Fabro M, Romieu G, de Roquefeuil G, Touchon J, Dandekar T, Ritchie K. 
Quality-of-life assessment in the old using the WHOQOL 100: differences between patients with senile dementia and patients with cancer. 
Int Psychogeriatr. 1999 Sep;11(3):273-9 Pubmed10547127
  Ullrich O, Reinheckel T, Sitte N, Grune T. 
Degradation of hypochlorite-damaged glucose-6-phosphate dehydrogenase by the 20S proteasome. 
Free Radic Biol Med 1999 Sep;27(5-6):487-92 Pubmed10490267
  Sugimoto C, Fujieda S, Seki M, Sunaga H, Fan GK, Tsuzuki H, Borner C, Saito H, Matsukawa S.
Apoptosis-promoting gene (bax) transfer potentiates sensitivity of squamous cell carcinoma to cisplatin in vitro and in vivo.
Int J Cancer 1999 Sep 9;82(6):860-7. Pubmed10446454
  Borner C, Schlagbauer Wadl H, Fellay I, Selzer E, Polterauer P, Jansen B.
Mutated N-ras upregulates Bcl-2 in human melanoma in vitro and in SCID mice.
Melanoma Res 1999 Aug;9(4):347-50. Pubmed10504052
  Huynen MA, Dandekar T, Bork P. 
Variation and evolution of the citric-acid cycle: a genomic perspective. 
Trends Microbiol. 1999 Jul;7(7):281-91. Review Pubmed10390638
  Borner C, Monney L.
Apoptosis without caspases: an inefficient molecular guillotine?
Cell Death Differ 1999 Jun;6(6):497-507. Pubmed10381652
  Ullrich O, Reinheckel T, Sitte N, Hass R, Grune T, Davies KJ. 
Poly-ADP ribose polymerase activates nuclear proteasome to degrade oxidatively damaged histones. 
Proc Natl Acad Sci U S A 1999 May 25;96(11):6223-8 http://www.pnas.org/cgi/content/full/96/11/6223
  Reinheckel T, Bohne M, Halangk W, Augustin W, Gollnick H. 
Evaluation of UVA-mediated oxidative damage to proteins and lipids in extracorporeal photoimmunotherapy. 
Photochem Photobiol 1999 May;69(5):566-70 Pubmed10333762
  Konig R, Dandekar T. 
Improving genetic algorithms for protein folding simulations by systematic crossover. 

Biosystems. 1999 Apr;50(1):17-25 Pubmed10235648
  Liu Z, Song D, Kramer A, Martin AC, Dandekar T, Schneider-Mergener J, Bautz EK, Dubel S. 
Fine mapping of the antigen-antibody interaction of scFv215, a recombinant antibody inhibiting RNA polymerase II from Drosophila melanogaster. 
J Mol Recognit. 1999 Mar-Apr;12(2):103-11 Pubmed10398401
  Keese MA, Saffrich R, Dandekar T, Becker K, Schirmer RH. 
Microinjected glutathione reductase crystals as indicators of the redox status in living cells. 
FEBS Lett. 1999 Mar 26;447(2-3):135-8 Pubmed10214933
  Borner C, Monney L, Olivier R, Rossé T, Häcki J, Conus S.
Life and death in a medieval atmosphere.
Cell Death Differ 1999 Feb;6(2):201-6. Pubmed10200567
  Schuster S, Dandekar T, Fell DA. 
Detection of elementary flux modes in biochemical networks: a promising tool for pathway analysis and metabolic engineering. 
Trends Biotechnol. 1999 Feb;17(2):53-60. Review Pubmed10087604
  Reinheckel T, Prause J, Nedelev B, Augustin W, Schulz HU, Lippert H, Halangk W. 
Oxidative stress affects pancreatic proteins during the early pathogenesis of rat caerulein pancreatitis. 
Digestion 1999 Jan-Feb;60(1):56-62 Pubmed9892799
  Heinrich, M., Wickel, M., Schneider-Brachert, W., Sandberg, C., Gahr, J., Schwandner, R., Weber, T., Brunner, J., Saftig, P., Peters, C., Brunner, J., Krönke, M., and Schütze, S. (1999). 
Cathepsin D targeted by acid sphingomyelinase-derived ceramide.
 EMBO J. 18, 5252-63 Pubmed10508159
  Tisljar, K., Deussing, J., and Peters, C. (1999). 
Cathepsin J, a novel murine cysteine protease of the papain family with a placenta-restricted expression.
FEBS Lett. 459, 299-304 Pubmed10526153
  Botchkarev, V.A., Botchkareva, N.V., Roth, W., Nakamura, M., Chen, L.-H., Herzog, W., Lindner, G., McMahon, J.A., Peters, C., Lauster, R., McMahon, A.P., and Paus, R. (1999). 
Noggin is a mesenchymally derived stimulator of hair follicle induction.
Nat. Cell Biol. 1, 158-64 Pubmed10559902

Villadangos, J.A., Bryant, R.A., Deussing, J., Driessen, C., Lennon-Dumenil, A.M., Riese, R.J., Roth, W., Saftig, P., Shi, G.P., Chapman, H.A., Peters, C., and Ploegh, H.L. (1999). 
Proteases involved in MHC class II antigen presentation. (Review).
Immunol. Rev. 172, 109-20 Pubmed10631941
1998 Grandgirard D, Studer E, Monney L, Belser T, Fellay I, Borner C, Michel MR.
Alphaviruses induce apoptosis in Bcl-2-overexpressing cells: evidence for a caspase-mediated, proteolytic inactivation of Bcl-2.
EMBO J 1998 Aug 10;17(5):1268-78
  Monney L, Otter I, Olivier R, Ozer HL, Haas AL, Omura S, Borner C.
Defects in the ubiquitin pathway induce caspase-independent apoptosis blocked by Bcl-2.
J Biol Chem 1998 Mar 13;273(11):6121-31
  Otter I, Conus S, Ravn U, Rager M, Olivier R, Monney L, Fabbro D, Borner C.
The binding properties and biological activities of Bcl-2 and Bax in cells exposed to apoptotic stimuli.
J Biol Chem 1998 Mar 13;273(11):6110-20
  Monney L, Olivier R, Otter I, Jansen B, Poirier GG, Borner C.
Role of an acidic compartment in tumor-necrosis-factor-alpha-induced production of ceramide, activation of caspase-3 and apoptosis.
Eur J Biochem 1998 Jan 15;251(1-2):295-303
http://www.blackwell-synergy.com/Journals/member/institutions/processfree2.asp? contentid=ejb.1998.23&filetype=abstracts&article=25391
  Rossé T, Olivier R, Monney L, Rager M, Conus S, Fellay I, Jansen B, Borner C.
Bcl-2 prolongs cell survival after Bax-induced release of cytochrome c.
Nature 1998 Jan 29;391(6666):496-9. Pubmed9461218
  Deussing, J., Roth, W., Saftig, P., Peters, C., Ploegh, H.L., and Villadangos, J.A. (1998). 
Cathepsins B and D are dispensable for major histocompatibility complex class II-mediated antigen presentation.
Proc. Natl. Acad. Sci. USA 95, 4516-21 Pubmed9539769

Nakagawa, T., Roth, W., Wong, P., Nelson, A., Farr, A., Deussing, J., Villadangos, J.A., Ploegh, H., Peters, C., and Rudensky, A. (1998). 
Cathepsin L: critical role in Ii degradation and CD4 T cell selection in the thymus.
 Science 280, 450-3   Pubmed9545226
  Tatnell, P.J., Roth, W., Deussing, J., Peters, C., and Kay, J. (1998). 
Mouse procathepsin E gene: molecular organisation and chromosomal localisation.
Biochim. Biophys. Acta 1398(1), 57-66 Pubmed9602058
  Wu, G. S., Saftig, P., Peters, C., and El-Deiry, W. S. (1998). 
Potential role for cathepsin D in p53-dependent tumor suppression and chemosensitivity.
Oncogene 16, 2177-83 Pubmed9619826
Deussing, J., Pauly-Evers, M., Roth, W., Saftig, P., and Peters, C. (1997). 
Manipulating the Mouse Genome (Review).
 Futura 12, 162-71 
  Deussing, J., Roth, W., Rommerskirch, W., Wiederanders, B., von Figura, K., and Peters, C. (1997). 
The genes of the lysosomal cysteine proteinases cathepsin B, H, L, and S map to different mouse chromosomes.
Mamm. Genome 8, 241-5 Pubmed9096102
  Saftig, P., Hartmann, D., Lüllmann-Rauch, R., Wolff, J., Evers, M., Köster, A., Hetman, M., von Figura, K., and Peters, C. (1997). 
Mice deficient in lysosomal acid phosphatase develop lysosomal storage in the kidney and central nervous system.
J. Biol. Chem. 272, 18628-35 Pubmed9228031
  Villadangos, J.A., Riese, R.J., Peters, C., Chapman, H.A., and Ploegh, H.L. (1997). 
Degradation of mouse invariant chain: roles of cathepsins S and D and the influence of major histocompatibility complex polymorphism.
J. Exp. Med. 186, 549-60 Pubmed9254653
  Ye Q, Wei Y, Fischer R, Borner C, Berchtold MW.
Expression of calmodulin and calmodulin binding proteins in rat fibroblasts stably transfected with protein kinase C and oncogenes.
Biochim Biophys Acta 1997 Oct 30;1359(1):89-96. Pubmed9398089
  Olivier R, Otter I, Monney L, Wartmann M, Borner C.
Bcl-2 does not require Raf kinase activity for its death-protective function.
Biochem J 1997 May 15;324 ( Pt 1):75-83
  Pourzand C, Rossier G, Reelfs O, Borner C, Tyrrell RM.
Overxpression of Bcl-2 inhibits UVA-mediated immediate apoptosiinrat 6 fibroblasts: evidence for the involvement of Bcl-2 as an antioxidant.
Cancer Res 1997 Apr 15;57(8):1405-11. Pubmed9108435
  Weinstein IB, Kahn SM, O'Driscoll K, Borner C, Bang D, Jiang W, Blackwood A, Nomoto K.
The role of protein kinase C in signal transduction, growth control and lipid metabolism.
Adv Exp Med Biol 1997;400A:313-21. Pubmed9547573
Braulke, T., Claussen, M., Saftig, P., Wendland, M., Neifer, K., Schmidt, B., Zapf, J., von Figura, K., and Peters, C. (1996). 
Proteolysis of IGFBPs by cathepsin D in vitro and in cathepsin D-deficient mice (Review).
Prog. Growth Factor Res. 6, 265-71 Pubmed8817669
  Evers, M., Saftig, P., Schmidt, P., Hafner, A., McLoghlin, D.B., Schmahl, W., Hess, B., von Figura, K., and Peters, C. (1996). 
Targeted disruption of the arylsulfatase B gene results in mice resembling the phenotype of mucopolysaccharidosis VI.
Proc. Natl. Acad. Sci. USA 93, 8214-9  Pubmed8710849
  Hess, B., Saftig, P., Hartmann, D., Coenen, R., Lüllmann-Rauch, R., Goebel, H. H., Evers, M., von Figura, K., D´Hooge, R., Nagels, G., DeDeyn, P., Peters, C., and Gieselmann, V. (1996). 
Phenotype of arylsulfatase A-deficient mice: relationship to human metachromatic leukodystrophy.
Proc. Natl. Acad. Sci. USA 93, 14821-6 Pubmed8962139
  Isbrandt, D., Hopwood, J.J., von Figura, K., and Peters, C. (1996). 
Two novel frameshift mutations causing premature stop codons in a patient with the severe form of Maroteaux-Lamy syndrome.
Hum. Mutat. 7, 361-3   Pubmed8723688
  Litjens, T., Brooks, D.A., Peters, C., Gibson, G.J., and Hopwood, J.J. (1996). 
Identification, expression, and biochemical characterization of N-acetylgalactosamine-4-sulfatase mutations and relationship with clinical phenotype in MPS-VI patients.
Am. J. Hum. Genet. 58, 1127-34 Pubmed8651289
  Saftig, P., Peters, C., von Figura, K., Craessaerts, K., van Leuven, F., and De Strooper, B. (1996). 
Amyloidogenic processing of human amyloid precursor protein in hippocampal neurons devoid of cathepsin D.
J. Biol. Chem. 271, 27241-4 Pubmed8910296
  Borner C.
Diminished cell proliferation associated with the death-protective activity of Bcl-2.
J Biol Chem 1996 May 31;271(22):12695-8
  Zhang J, Alter N, Reed JC, Borner C, Obeid LM, Hannun YA.
Bcl-2 interrupts the ceramide-mediated pathway of cell death.
Proc Natl Acad Sci U S A 1996 May 28;93(11):5325-8
  Monney L, Otter I, Olivier R, Ravn U, Mirzasaleh H, Fellay I, Poirier GG, Borner C.
Bcl-2 overexpression blocks activation of the death protease CPP32/Yama/apopain.
Biochem Biophys Res Commun 1996 Apr 16;221(2):340-5. Pubmed8619857
1995 Brooks, D.A., Robertson, D.A., Bindloss, C., Litjens, T., Anson, D.S., Peters, C., Morris, C.P., and Hopwood, J.J. (1995). 
Two site-directed mutations abrogate enzyme activity but have different effects on the conformation and cellular content of the N-acetylgalactosamine 4-sulphatase protein.
Biochem. J. 307, 457-463 Pubmed7733883
  Saftig, P., Hetman, M., Schmahl, W., Weber, K., Heine, L., Mossmann, H., Köster, A., Hess, B., Evers, M., von Figura, K., and Peters, C. (1995). 
Mice deficient for the lysosomal proteinase cathepsin D exhibit progressive atrophy of the intestinal mucosa and profound destruction of lymphoid cells.

EMBO J. 14, 3599-608   Pubmed7641679
  Schröter M, Lowin B, Borner C, Tschopp J.
Regulation of Fas(Apo-1/CD95)- and perforin-mediated lytic pathways of primary cytotoxic T lymphocytes by the protooncogene bcl-2.
Eur J Immunol 1995 Dec;25(12):3509-13. Pubmed8566045
  Borner C, Ueffing M, Jaken S, Parker PJ, Weinstein IB.
Two closely related isoforms of protein kinase C produce reciprocal effects on the growth of rat fibroblasts. Possible molecular mechanisms.
J Biol Chem 1995 Jan 6;270(1):78-86
1994 Arlt, G., Brooks, D.A., Isbrandt, D., Hopwood, J.J., Bielicki, J., Bradford, T.M., Bindloss-Petherbridge, C.A., von Figura, K., and Peters, C. (1994). 
Juvenile form of mucopolysaccharidosis VI (Maroteaux-Lamy syndrome). A C-terminal extension causes instability but increases catalytic efficiency of arylsulfatase B.
J. Biol. Chem. 269, 9638-43 Pubmed8144552
  von Figura, K., Hille-Rehfeld, A., Lehmann, L., Peters, C., and Prill, V.  
Signal-Mediated Targeting of Lysosomal Membrane Glycoproteins (Review).
44. Colloquium Mosbach 1993, DNA Replication and the Cell Cycle, Springer-Verlag Berlin Heidelberg pp. 33-44
  Hetman, M., Perschl, A., Saftig, P., von Figura, K., and Peters, C. (1994). 
Mouse cathepsin D gene: molecular organization, characterization of the promoter, and chromosomal localization.
DNA Cell Biol. 13, 419-27 Pubmed8011168
  Isbrandt, D., Arlt, G., Brooks, D.A., Hopwood, J.J., von Figura, K., and Peters, C. (1994). 
Mucopolysaccharidosis VI (Maroteaux-Lamy syndrome): six unique arylsulfatase B gene alleles causing variable disease phenotypes.
Am. J. Hum. Genet. 54, 454-63 Pubmed8116615
  Peters, C., and von Figura, K. (1994). 
Biogenesis of lysosomal membranes (Review).
FEBS Lett. 346, 108-14 Pubmed8206148
  Voskoboeva, E., Isbrandt, D., von Figura, K., Krasnopolskaya, X., and Peters, C. (1994). 
Four novel mutant alleles of the arylsulfatase B gene in two patients with intermediate form of mucopolysaccharidosis VI (Maroteaux-Lamy Syndrome).

Hum. Genet. 93, 259-64 Pubmed8125475
  Kahn SM, O'Driscoll KR, Jiang W, Borner C, Xu DB, Blackwood MA, Zhang YJ, Nomoto K, Weinstein IB.
Suppression of mitogenic activity by stable expression of the regulatory domain of PKC beta.
Carcinogenesis 1994 Dec;15(12):2919-25. Pubmed8001256
  Borner C, Olivier R, Martinou I, Mattmann C, Tschopp J, Martinou JC.
Dissection of functional domains in Bcl-2 alpha by site-directed mutagenesis.
Biochem Cell Biol 1994 Nov-Dec;72(11-12):463-9. Pubmed7654319
  Borner C, Martinou I, Mattmann C, Irmler M, Schaerer E, Martinou JC, Tschopp J.
The protein bcl-2 alpha does not require membrane attachment, but two conserved domains to suppress apoptosis.
J Cell Biol 1994 Aug;126(4):1059-68. Pubmed8051205
1993 Brömme, D., Bonneau, P.R., Lachance, P., Wiederanders, B., Kirschke, H., Peters, C., Thomas, D.Y., Storer, A.C., and Vernet, T. (1993). 
Functional expression of human cathepsin S in Saccharomyces cerevisiae: purification and characterization of the recombinant enzyme.
J. Biol. Chem. 268, 4832-8 Pubmed8444861
  Köster, A., Saftig, P., Matzner, U., von Figura, K., Peters, C., and Pohlmann, R. (1993). 
Targeted disruption of the M(r) 46,000 mannose 6-phosphate receptor gene in mice results in misrouting of lysosomal proteins.
EMBO J. 12, 5219-23 Pubmed8262064
  Modaressi, S., Rupp, K., von Figura, K., and Peters, C. (1993). 
Structure of the human arylsulfatase B gene.
Biol. Chem. Hoppe Seyler 374, 327-35 Pubmed7687847
  Prill, V., Lehmann, L., von Figura, K., and Peters, C. (1993). 
The cytoplasmic tail of lysosomal acid phosphatase contains overlapping but distinct signals for basolateral sorting and rapid internalization in polarized MDCK cells.
EMBO J. 12, 2181-93 Pubmed8491206
  Peitsch MC, Borner C, Tschopp J.
Sequence similarity of phospholipase A2 activating protein and the G protein beta-subunits: a new concept of effector protein activation in signal transduction?
Trends Biochem Sci 1993 Aug;18(8):292-3. Pubmed8236442
  Fabbro, D. & Borner, C. (1993) Protein kinase C.
Human protein data EMBL (A. Haeberli, ed.) VHC Verlags GmBH, Weinheim
  Weinstein, I. B., Borner, C., Guadagno Nichols, S., O'Driscoll, K., Cacace, A. & Fabbro, D. (1993) The roles of specific isoforms of protein kinase C (PKC) in growth control, oncogene-induced cell transformation, and differentiation (Review)
In: The pharmacology of cell differentiation. R. A. Rifkind (ed.); Elsevier Science Publishers, B. V., pp. 15-23.
  Kahn, S. M., O'Driscoll, K., Borner, C., Bang, D., Jiang, W., Blackwood, A., Nomoto, K. & Weinstein, I. B. (1993) Inhibition of diacylglycerol production in rat 6 cells that stably express only the regulatory domain of protein kinase CbI.
In: Advances in polyunsaturated fatty acid research. T. Yasugi, H. Nakamura, and M. Soma (eds.); Elsevier Science Publishers, B. V., pp. 45-50.
1992 Anson, D.S., Taylor, J.A., Bielicki, J., Harper, G.S., Peters, C., Gibson, G.J., and Hopwood, J.J. (1992). 
Correction of human mucopolysaccharidosis type VI fibroblasts with recombinant N-acetylgalactosamine- 4-sulphatase.
Biochem. J. 284, 789-94 Pubmed1320379
  Bresciani, R., Peters, C., and von Figura, K. (1992). 
Lysosomal acid phosphatase is not involved in the dephosphorylation of mannose 6-phosphate containing lysosomal proteins.
Eur. J. Cell Biol. 58, 57-61 Pubmed1353723
  Hille, A., Klumperman, J., Geuze, H.J., Peters, C., Brodsky, F.M., and von Figura, K. (1992). 
Lysosomal acid phosphatase is internalized via clathrin-coated pits.
 Eur. J. Cell Biol. 59, 106-15 Pubmed1468434
  Lehmann, L.E., Eberle, W., Krull, S., Prill, V., Schmidt, B., Sander, C., von Figura, K., and Peters, C. (1992). 
The internalization signal in the cytoplasmic tail of lysosomal acid phosphatase consists of the hexapeptide PGYRHV.  
EMBO J. 11, 4391-4399 Pubmed1425575
  Litjens, T., Morris, C.P., Robertson, E.F., Peters, C., von Figura, K., and Hopwood, J.J. (1992). 
An N-acetylgalactosamine- 4-sulfatase mutation (delta G238) results in a severe Maroteaux-Lamy phenotype.
Hum. Mutat. 1, 397-402  Pubmed1301949
  Peters, C., Braun, M., Weber, B., Wendland, M., Schmidt, B., Pohlmann, R., Waheed, A. and von Figura, K. (1992). 
The nineteen amino acid cytoplasmic tail of lysosomal acid phosphatase contains an endocytosis signal necessary and sufficient for targeting to lysosomes (Review).
in: Endocytosis. Ed.: P.J. Courtoy. NATO ASI Series, Vol. H 62, Springer-Verlag Berlin Heidelberg. 
  Wiederanders, B., Brömme, D., Kirschke, H., von Figura, K., Schmidt, B., and Peters, C. (1992). 
Phylogenetic conservation of cysteine proteinases. Cloning and expression of a cDNA coding for human cathepsin S.
J. Biol. Chem. 267, 13708-13 Pubmed1377692
  Borner C, Guadagno Nichols S, Fabbro D, Weinstein IB.
Expression of four protein kinase C isoforms in rat fibroblasts. I. Distinct subcellular distribution and regulation by calcium and phorbol esters.
J Biol Chem 1992 Jun 25;267(18):12892-9. Pubmed1618787
  Borner C, Guadagno Nichols S, Hsiao WW, Fabbro D, Barr M, Weinstein IB.
Expression of four protein kinase C isoforms in rat fibroblasts. II. Differential alterations in ras-, src-, and fos-transformed cells.
J Biol Chem 1992 Jun 25;267(18):12900-10. Pubmed1618788
  Tulchin N, Ornstein L, Harpaz N, Guillem J, Borner C, O'Toole K.
c-myc protein distribution. Neoplastic tissues of the human colon.
Am J Pathol 1992 Mar;140(3):719-29. Pubmed1372161
  Guadagno Nichols S, Borner C, Weinstein IB.
Altered regulation of a major substrate of protein kinase C in rat 6 fibroblasts overproducing PKC beta I.
J Biol Chem 1992 Feb 5;267(4):2697-707. Pubmed1370830
  Fabbro D, Küng W, Costa SD, Borner C, Regenass U, Eppenberger U.
Involvement of protein kinase C in the growth regulation of human breast cancer cells.
Cancer Treat Res 1992;61:229-48. Pubmed1360235
  Borner, C. & Fabbro, D. (1992) PKC and Cellular Transformation (Review)
In: Protein kinase C: Current concepts and perspectives. R. Epand and D. Lester (eds.); Ellis Horwood Publisher, Sussex, England, pp. 296-352.
  O'Driscoll, K. R., Kahn, S. M., Borner, C. M., Jiang, W. & Weinstein, I. B. (1992) Studies on the role of protein kinase C in multistage carcinogenesis and their relevance to risk extrapolation (Review).
In: Oncogene and transgenic correlates of cancer risk assessments. C. Zervos (ed.); Plenum Press, New York, pp. 43-59.
1991 Eberle, W., Sander, C., Klaus, W., Schmidt, B., von Figura, K., and Peters, C. (1991). 
The essential tyrosine of the internalization signal in lysosomal acid phosphatase is part of a beta turn.
Cell 67, 1203-9 Pubmed1760845
  Peters, C., Rommerskirch, W., Modaressi, S., and von Figura, K. (1991). 
Restoration of arylsulfatase B activity in human mucopolysaccharidosis- type-VI fibroblasts by retroviral-vector-mediated gene transfer.
Biochem. J. 276, 499-504 Pubmed1904721
  Rommerskirch, W., Fluharty, A.L., Peters, C., von Figura, K., and Gieselmann, V. (1991). 
Restoration of arylsulfatase A activity in human-metachromatic- leukodystrophy fibroblasts via retroviral-vector-mediated gene transfer.
 Biochem. J. 280, 459-61 Pubmed1684103
  Wicker, G., Prill, V., Brooks, D., Gibson, G., Hopwood, J., von Figura, K., and Peters, C. (1991). 
Mucopolysaccharidosis VI (Maroteaux-Lamy Syndrome): An intermediate clinical phenotype caused by substitution of valine for glycine at position 137 of arylsulfatase B.
J. Biol. Chem. 266, 21386-91 Pubmed1718978 
  Borner C, Filipuzzi I, Weinstein IB, Imber R.
Failure of wild-type or a mutant form of protein kinase C-alpha to transform fibroblasts.
Nature 1991 Sep 5;353(6339):78-80. Pubmed1881450
  Fabbro, D., Küng, W., Costa, S. D., Borner, C., Regenass, U. & Eppenberger, U. (1991) Involvement of protein kinase C in the growth regulation of human breast cancer cells.
In: Genes, Oncogenes, and Hormones: Advances in Cellular and Molecular Biology of Breast Cancer. R. B. Dickson & M. E. Lippman (eds.); Kluwer Academic Publishers, Boston, pp. 229-248.
1990 Peters, C., Braun, M., Weber, B., Wendland, M., Schmidt, B., Pohlmann, R., Waheed, A., and von Figura, K. (1990). 
Targeting of a lysosomal membrane protein: a tyrosine-containing endocytosis signal in the cytoplasmic tail of lysosomal acid phosphatase is necessary and sufficient for targeting to lysosomes.
  EMBO J. 9, 3497-506 Pubmed2209556
  Peters, C., Schmidt, B., Rommerskirch, W., Rupp, K., Zühlsdorf, M., Vingron, M., Meyer, H.E., Pohlmann, R., and von Figura, K. (1990). 
Phylogenetic conservation of arylsulfatases. cDNA cloning and expression of human arylsulfatase B.
J. Biol. Chem. 265, 3374-81 Pubmed2303452
  Borner C, Guadagno Nichols S, Hsieh LL, Hsiao WL, Weinstein IB.
Transformation by a ras oncogene causes increased expression of protein kinase C-alpha and decreased expression of protein kinase C-epsilon.
Cell Growth Differ 1990 Dec;1(12):653-60. Pubmed2288879
  Rotenberg SA, Krauss RS, Borner CM, Weinstein IB.
Characterization of a specific form of protein kinase C overproduced by a C3H 10T1/2 cell line.
Biochem J 1990 Feb 15;266(1):173-8. Pubmed2310371, Portland Press
  Krauss RS, Housey GM, Hsiao WL, Johnson MK, Rotenberg SA, Borner CM, Weinstein IB.
The role of protein kinase C in signal transduction and cellular transformation.
Prog Clin Biol Res 1990;340D:175-82, Review. Pubmed2196578
  Weinstein IB, Borner C, Krauss R, O'Driscoll K, Choi P, Moritomi M, Hoshina S, Hsieh L-L, Tchou-Wong K-M, Guadagno Nichols S, Ueffing M, Guillem J.
Pleiotropic effects of protein kinase C and the concept of carcinogenesis as a progressive disorder in signal transduction.
Adv in Second Messenger and Phosphoprotein Res 1990; 26:182-96.
  Kahn SM, Jiang W, Borner C, O'Driscoll K, Weinstein IB.
Construction of defined deletion mutants by thermal cycled fusion: Applications to protein kinase C.
Technique 1990; 2:27-30.
1989 Peters, C., Geier, C., Pohlmann, R., Waheed, A., von Figura, K., Roiko, K., Virkkunen, P., Henttu, P., and Vihko, P. (1989). 
High degree of homology between primary structure of human lysosomal acid phosphatase and human prostatic acid phosphatase.
Biol. Chem. Hoppe Seyler 370, 177-81 Pubmed2706086
  Peters, C., Kruse, U., Pollwein, R., Grzeschik, K.H., and Sippel, A.E. (1989). The human lysozyme gene. Sequence organization and chromosomal localization. 
Eur. J. Biochem. 182, 507-16 Pubmed2546758
  Borner C, Filipuzzi I, Wartmann M, Eppenberger U, Fabbro D.
Biosynthesis and posttranslational modifications of protein kinase C in human breast cancer cells.
J Biol Chem 1989 Aug 15;264(23):13902-9. Pubmed2474538
1988 Bonifer, C., Hecht, A., Peters, C., and Sippel. A.E. (1988). 
Rat antibodies as probes for the characterization of progesterone receptor A and B proteins from laying hen oviduct cytosol.
Biochim. Biophys. Acta 968, 96-108 Pubmed3337848
  Borner C, Eppenberger U, Wyss R, Fabbro D.
Continuous synthesis of two protein-kinase-C-related proteins after down-regulation by phorbol esters.
Proc Natl Acad Sci U S A 1988 Apr;85(7):2110-4. Pubmed3353368
  Fabbro D, Mazurek N, Borner C, Conscience JF, Erne P.
Role of protein kinase C (PKC) in short- and long-term cellular responses: inhibition of agonist-mediated calcium transients and down-regulation of PKC.
J Cardiovasc Pharmacol 1988;12 Suppl 5:S73-9. Pubmed2469882
1987 Peters, C., Sippel, A.E., Vingron, M., and Klempnauer K.H. (1987). 
Drosophila and vertebrate myb proteins share two conserved regions, one of which functions as a DNA-binding domain.
EMBO J. 6, 3085-90 Pubmed3121304
  Borner C, Wyss R, Regazzi R, Eppenberger U, Fabbro D.
Immunological quantitation of phospholipid/Ca2+-dependent protein kinase of human mammary carcinoma cells: inverse relationship to estrogen receptors.
Int J Cancer 1987 Sep 15;40(3):344-8. Pubmed3623717
  Wyss R, Fabbro D, Regazzi R, Borner C, Takahashi A, Eppenberger U.
Phorbol ester and epidermal growth factor receptors in human breast cancer.
Anticancer Res 1987 Jul-Aug;7(4B):721-7. Pubmed3499860
  Mazurek N, Regazzi R, Borner C, Wyss R, Conscience JF, Erne P, Eppenberger U, Fabbro D.
Altered protein kinase C in a mast cell variant defective in exocytosis.
Proc Natl Acad Sci U S A 1987 Mar;84(5):1277-81. Pubmed3493490
  Erne P, Mazurek N, Borner C, Conscience JF, Eppenberger U, Fabbro D.
Translocation of protein kinase C is not required to inhibit the antigen-induced increase of cytosolic calcium in a mast cell line.
Biochem Biophys Res Commun 1987 Feb 27;143(1):252-9. Pubmed3103618
  Fabbro D, Regazzi R, Costa SD, Borner C, Eppenberger U.
Protein kinase C desensitization by phorbol esters and its impact on growth of human breast cancer cells.
Year Book of Cancer 1987; 545-546.
1986 Regazzi R, Fabbro D, Costa SD, Borner C, Eppenberger U.
Effects of tumor promoters on growth and on cellular redistribution of phospholipid/Ca2+-dependent protein kinase in human breast cancer cells.
Int J Cancer 1986 May 15;37(5):731-7. Pubmed3084390
  Fabbro D, Regazzi R, Costa SD, Borner C, Eppenberger U.
Protein kinase C desensitization by phorbol esters and its impact on growth of human breast cancer cells.
Biochem Biophys Res Commun 1986 Feb 26;135(1):65-73. Pubmed3513765
  Fabbro, D., Wyss, R., Borner, C. & Regazzi, R. (1986) Epidermal growth factor receptor and calcium/phospholipid-dependent protein kinase activities in human mammary tumor cells.
In: S. Eckhardt, J. H. Holzner, G. A. Nagel (eds.); Contributions to Oncology: Endocrine Therapy of Breast Cancer 23, 33-44, Karger, Basel.
1981 Peters, C., Schwermann, J., Schmidt, A., and Buddecke, E. (1981). 
Phosphate ester groups in proteoglycans from bovine nasal cartilage.
Biochim. Biophys. Acta 673, 270-8 Pubmed7225419


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