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Molekulare Medizin - AG Biniossek, Massenspektrometrie - Peptidanalytik und Proteinanalytik (Proteomics) - Publikationen
2017 Koczorowska MM, Friedemann C, Geiger K, Follo M, Biniossek ML, Schilling O. Differential effect of TGFβ on the proteome of cancer associated fibroblasts and cancer epithelial cells in a co-culture approach - a short report. Cell Oncol (Dordr). 2017 Aug 14. doi: 10.1007/s13402-017-0344-6. Pubmed28808957 [Epub ahead of print]
  Shahinian JH, Mayer B, Tholen S, Brehm K, Biniossek ML, Füllgraf H, Kiefer S, Heizmann U, Heilmann C, Rüter F, Grapow M, Reuthebuch OT, Eckstein F, Beyersdorf F, Schilling O, Siepe M. Proteomics highlights decrease of matricellular proteins in left ventricular assist device therapy†. Eur J Cardiothorac Surg. 2017 Jun 1;51(6):1063-1071. doi: 10.1093/ejcts/ezx023. Pubmed28329269
  Paireder M, Tholen S, Porodko A, Biniossek ML, Mayer B, Novinec M, Schilling O, Mach L. The papain-like cysteine proteinases NbCysP6 and NbCysP7 are highly processive enzymes with substrate specificities complementary to Nicotiana benthamiana cathepsin B. Biochim Biophys Acta. 2017 Apr;1865(4):444-452. doi: 10.1016/j.bbapap.2017.02.007. Pubmed28188928]
2016 Rupp T, Langlois B, Koczorowska MM, Radwanska A, Sun Z, Hussenet T, Lefebvre O, Murdamoothoo D, Arnold C, Klein A, Biniossek ML, Hyenne V, Naudin E, Velazquez-Quesada I, Schilling O, Van Obberghen-Schilling E, Orend G. Tenascin-C Orchestrates Glioblastoma Angiogenesis by Modulation of Pro- and Anti-angiogenic Signaling. Cell Rep. 2016 Dec 6;17(10):2607-2619. doi: 10.1016/j.celrep.2016.11.012. Pubmed27926865
  Sigloch FC, Knopf JD, Weißer J, Gomez-Auli A, Biniossek ML, Petrera A, Schilling O. Proteomic analysis of silenced cathepsin B expression suggests non-proteolytic cathepsin B functionality. Biochim Biophys Acta. 2016 Nov;1863(11):2700-2709. doi: 10.1016/j.bbamcr.2016.08.005. Epub 2016 Aug 12. Pubmed27526672
  Fascellaro G, Petrera A, Lai ZW, Nanni P, Grossmann J, Burger S, Biniossek ML, Gomez-Auli A, Schilling O, Imkamp F. Comprehensive Proteomic Analysis of Nitrogen Starved Mycobacterium smegmatis Δpup Reveals the Impact of Pupylation on Nitrogen Stress Response. J Proteome Res. 2016 Aug 5;15(8):2812-25. doi: 10.1021/acs.jproteome.6b00378. Epub 2016 Jul 25. Pubmed27378031
  Paireder M, Mehofer U, Tholen S, Porodko A, Schähs P, Maresch D, Biniossek ML, van der Hoorn RA, Lenarcic B, Novinec M, Schilling O, Mach L. The death enzyme CP14 is a unique papain-like cysteine proteinase with a pronounced S2 subsite selectivity. Arch Biochem Biophys. 2016 Aug 1;603:110-7. doi: 10.1016/j.abb.2016.05.017. Epub 2016 May 28. Pubmed27246477
  Biniossek ML, Niemer M, Maksimchuk K, Mayer B, Fuchs J, Huesgen PF, McCafferty DG, Turk B, Fritz G, Mayer J, Haecker G, Mach L, Schilling O. Identification of Protease Specificity by Combining Proteome-Derived Peptide Libraries and Quantitative Proteomics. Mol Cell Proteomics. 2016 Jul;15(7):2515-24. doi: 10.1074/mcp.O115.056671. Epub 2016 Apr 27. Pubmed27122596
  Lai ZW, Weisser J, Nilse L, Costa F, Keller E, Tholen M, Kizhakkedathu JN, Biniossek M, Bronsert P, Schilling O. Formalin-Fixed, Paraffin-Embedded Tissues as a Robust Source for the Profiling of Native and Protease-Generated Protein Amino Termini. Mol Cell Proteomics. 2016 Jun;15(6):2203-13. doi: 10.1074/mcp.O115.056515. Epub 2016 Apr 17. Pubmed27087653
  Tholen S, Wolf C, Mayer B, Knopf JD, Löffek S, Qian Y, Kizhakkedathu JN, Biniossek ML, Franzke CW, Schilling O. Skin Barrier Defects Caused by Keratinocyte-Specific Deletion of ADAM17 or EGFR Are Based on Highly Similar Proteome and Degradome Alterations. J Proteome Res.2016 May 6;15(5):1402-17. doi: 10.1021/acs.jproteome.5b00691. Pubmed27089454
  Lai ZW, Bolm L, Fuellgraf H, Biniossek ML, Makowiec F, Hopt UT, Werner M, Keck T, Bausch D, Sorio C, Scarpa A, Schilling O, Bronsert P, Wellner UF. Characterization of various cell lines from different ampullary cancer subtypes and cancer associated fibroblast-mediated responses. BMC Cancer. 2016 Mar 8;16(1):195. doi: 10.1186/s12885-016-2193-5. Pubmed26951071
  Gomez-Auli A, Hillebrand LE, Biniossek ML, Peters C, Reinheckel T, Schilling O. Impact of cathepsin B on the interstitial fluid proteome of murine breast cancers. Biochimie. 2016 Mar;122:88-98. doi: 10.1016/j.biochi.2015.10.009. Epub 2015 Oct 8. Pubmed26455267
  Koczorowska MM, Tholen S, Bucher F, Lutz L, Kizhakkedathu JN, De Wever O, Wellner UF, Biniossek ML, Stahl A, Lassmann S, Schilling O. Fibroblast activation protein-α, a stromal cell surface protease, shapes key features of cancer associated fibroblasts through proteome and degradome alterations. Mol Oncol. 2016 Jan;10(1):40-58. doi: 10.1016/j.molonc.2015.08.001. Epub 2015 Aug 11. Pubmed26304112
  Guo S, Skala W, Magdolen V, Briza P, Biniossek ML, Schilling O, Kellermann J, Brandstetter H, Goettig P. A Single glycan at the 99-loop of human kallikrein-related peptidase 2 regulates activation and enzymatic activity. J Biol Chem. 2016 Jan 8;291(2):593-604. doi: 10.1074/jbc.M115.691097. Epub 2015 Nov 18. Pubmed26582203
2015 Lim C, Gandhi S, Biniossek ML, Feng L, Schilling O, Urban S, Chen X. An Aminopeptidase in the Drosophila Testicular Niche Acts in Germline Stem Cell Maintenance and Spermatogonial Dedifferentiation. Cell Rep. 2015 Oct 13;13(2):315-25. doi: 10.1016/j.celrep.2015.09.001. Epub 2015 Oct 1. Pubmed26440886
  Dong F, Eibach M, Bartsch JW, Dolga AM, Schlomann U, Conrad C, Schieber S, Schilling O, Biniossek ML, Culmsee C, Strik H, Koller G, Carl B, Nimsky C. The metalloprotease-disintegrin ADAM8 contributes to temozolomide chemoresistance and enhanced invasiveness of human glioblastoma cells. Neuro Oncol. 2015 Nov;17(11):1474-85. doi: 10.1093/neuonc/nov042. Epub 2015 Mar 29. Pubmed25825051
  Sigloch FC, Burk UC, Biniossek ML, Brabletz T, Schilling O. miR-200c dampens cancer cell migration via regulation of protein kinase A subunits. Oncotarget. 2015 Sep 15;6(27):23874-89. Pubmed26203557
  Knopf JD, Tholen S, Koczorowska MM, De Wever O, Biniossek ML, Schilling O. The Stromal Cell-Surface Protease Fibroblast Activation Protein-α Localizes to Lipid Rafts and is Recruited to Invadopodia. Biochim Biophys Acta. 2015 Oct;1853(10 Pt A):2515-25. doi: 10.1016/j.bbamcr.2015.07.013. Pubmed26209915
  Weißer J, Lai ZW, Bronsert P, Kuehs M, Drendel V, Timme S, Kuesters S, Jilg CA, Wellner UF, Lassmann S, Werner M, Biniossek ML, Schilling O. Quantitative proteomic analysis of formalin-fixed, paraffin-embedded clear cell renal cell carcinoma tissue using stable isotopic dimethylation of primary amines. BMC Genomics. 2015 Jul 29;16:559. doi: 10.1186/s12864-015-1768-x. Pubmed26220445
  Nilse L, Sigloch FC, Biniossek ML, Schilling O. Towards improved peptide feature detection in quantitative proteomics using stable isotope labelling. Proteomics Clin Appl. 2015 Aug;9(7-8):706-14. doi: 10.1002/prca.201400173 Pubmed25931027
  Lai ZW, Gomez-Auli A, Keller E, Mayer B, Biniossek M, Schilling O. Enrichment of protein N-termini by charge-reversal of internal peptides. Proteomics. 2015 Jul;15(14):2470-8. doi: 10.1002/pmic.201500023. Epub 2015 Jun 15. Pubmed26013158
  Schmidt Y, Biniossek M, Stark GB, Finkenzeller G, Simunovic F. Osteoblastic alkaline phosphatase mRNA is stabilized by binding to vimentin intermediary filaments. Biol Chem. 2015 Mar 1;396(3):253-60. doi: 10.1515/hsz-2014-0274. PMID: 25536665
  Kern U, Wischnewski V, Biniossek ML, Schilling O, Reinheckel T. Lysosomal protein turnover contributes to the acquisition of TGFβ-1 induced invasive properties of mammary cancer cells. Mol Cancer. 2015 Feb 15;14(1):39. doi: 10.1186/s12943-015-0313-5. Pubmed25744631
2014 Avci D, Fuchs S, Schrul B, Fukumori A, Breker M, Frumkin I, Chen CY, Biniossek ML, Kremmer E, Schilling O, Steiner H, Schuldiner M, Lemberg MK. The Yeast ER-Intramembrane Protease Ypf1 Refines Nutrient Sensing by Regulating Transporter Abundance. Mol Cell. 2014 Dec 4;56(5):630-40. doi: 10.1016/j.molcel.2014.10.012. Epub 2014 Nov 13. Pubmed25454947
  Bronsert P, Weißer J, Biniossek ML, Kuehs M, Mayer B, Drendel V, Timme S, Shahinian H, Küsters S, Wellner UF, Lassmann S, Werner M, Schilling O. Impact of Routinely Employed Procedures for Tissue Processing on the Proteomic Analysis of Formalin-Fixed Paraffin-Embedded Tissue. Proteomics Clin Appl. 2014 Oct;8(10):796-804. doi: 10.1002/prca.201300082. Epub 2014 Jul 24. Pubmed24888792
  Volceanov L, Herbst K, Biniossek M, Schilling O, Haller D, Nölke T, Subbarayal P, Rudel T, Zieger B, Häcker G. Septins Arrange F-Actin-Containing Fibers on the Chlamydia trachomatis Inclusion and Are Required for Normal Release of the Inclusion by Extrusion.
MBio. 2014 Oct 7;5(5). pii: e01802-14. doi: 10.1128/mBio.01802-14. Pubmed25293760
  Videm P, Gunasekaran D, Schröder B, Mayer B, Biniossek ML, Schilling O. Automated peptide mapping and protein-topographical annotation of proteomics data.BMC Bioinformatics. 2014 Jun 19;15:207. doi: 10.1186/1471-2105-15-207. Pubmed24946880
  Tholen S, Biniossek ML, Gansz M, Ahrens TD, Schlimpert M, Kizhakkedathu JN, Reinheckel T, Schilling O. Double deficiency of cathepsins B and L results in massive secretome alterations and suggests a degradative cathepsin-MMP axis. Cell Mol Life Sci. 2014 Mar;71(5):899-916. doi: 10.1007/s00018-013-1406-1. Epub2013 Jun 29. Pubmed23811845
  Shahinian H, Loessner D, Biniossek ML, Kizhakkedathu JN, Clements JA, Magdolen V, Schilling O. Secretome and degradome profiling shows that Kallikrein-related peptidases 4, 5, 6, and 7 induce TGFβ-1 signaling in ovarian cancer cells. Mol Oncol. 2014 Feb;8(1):68-82. doi: 10.1016/j.molonc.2013.09.003. Epub 2013 Oct 1.. Pubmed24120346
2013 Biniossek ML, Lechel A, Rudolph KL, Martens UM, Zimmermann S. Quantitative proteomic profiling of tumor cell response to telomere dysfunction using isotope-coded protein labeling (ICPL) reveals interaction network of candidate senescence markers. J Proteomics. 2013 Oct 8;91:515-35. doi: 10.1016/j.jprot.2013.08.007. Epub 2013 Aug 19. Pubmed23969227
  Ploen D, Hafirassou ML, Himmelsbach K, Sauter D, Biniossek ML, Weiss TS, Baumert TF, Schuster C, Hildt E.TIP47 plays a crucial role in the life cycle of hepatitis C virus. J Hepatol. 2013 Jun;58(6):1081-8. doi: 10.1016/j.jhep.2013.01.022. Epub 2013 Jan 24. Pubmed 23354285
  Elfert S, Weise A, Bruser K, Biniossek ML, Jägle S, Senghaas N, Hecht A. Acetylation of human TCF4 (TCF7L2) proteins attenuates inhibition by the HBP1 repressor and induces a conformational change in the TCF4::DNA complex. PLoS One. 2013 Apr 15;8(4):e61867. doi: 10.1371/journal.pone.0061867. Print 2013. Pubmed23613959
  Tholen S, Biniossek ML, Gansz M, Gomez-Auli A, Werner F, Noel A, Kizhakkedathu JN, Boerries M, Busch H, Reinheckel T, Schilling O. Deletion of cysteine cathepsins B or L yields differential impacts on murine skin proteome and degradome. Mol Cell Proteomics. 2013 Mar;12(3):611-25. doi: 10.1074/mcp.M112.017962. Epub 2012 Dec 10. Pubmed23233448
2012 Biniossek ML, Schilling O. Enhanced identification of peptides lacking basic residues by LC-ESI-MS/MS analysis of singly charged peptides. Proteomics. 2012 May;12(9):1303-9. doi: 10.1002/pmic.201100569. Pubmed22589179
Vogel S, Raulf N, Bregenhorn S, Biniossek ML, Maurer U, Czabotar P, Borner C. Cytosolic Bax: Does it require binding proteins to keep its pro-apoptotic activity in check? J Biol Chem. 2012 Mar 16;287(12):9112-27. Epub 2012 Jan 25. Pubmed22277657
  Bildl W, Haupt A, Mueller CS, Biniossek ML, Thumfart JO, Hueber B, Fakler B, Schulte U. Extending The Dynamic Range Of Label-Free Mass Spectrometric Quantification Of Affinity Purifications. Mol Cell Proteomics. 2012 Feb;11(2):M111.007955. Epub 2011 Nov 8. PubMed22067099
2011 Biniossek ML, Nägler DK, Becker-Pauly C, Schilling O. Proteomic Identification of Protease Cleavage Sites Characterizes Prime and Non-prime Specificity of Cysteine Cathepsins B, L, and S. JProteome Res. 2011 Dec 2;10(12):5363-73. PubMed21967108
2010 Sprenger A, Küttner V, Biniossek ML, Gretzmeier C, Boerries M, Mack C, Has C, Bruckner-Tuderman L, Dengjel J. Comparative quantitation of proteome alterations induced by aging or immortalization in primary human fibroblasts and keratinocytes for clinical applications. Mol Biosyst. 2010 Sep;6(9):1579-82. Pubmed20454738
2009 Zimmermann S, Biniossek ML, Maurer C, Münzer P, Pantic M, Veelken H, Martens UM. Proteomic profiling in distinct cellular compartments of tumor cells reveals p53-dependent upregulation of S100A6 upon induction of telomere dysfunction. Proteomics. 2009 Nov;9(22):5175-87. PMID: Pubmed19834903
  Zimmermann S, Biniossek ML, Pantic M, Pfeifer D, Veelken H, Martens UM. Proteomic profiling of tumor cells after induction of telomere dysfunction. Proteomics. 2009 Feb;9(3):521-34. Pubmed19132685
  Ajaj KA, Biniossek ML, Kratz F. Development of protein-binding bifunctional linkers for a new generation of dual-acting prodrugs. Bioconjug Chem. 2009 Feb;20(2):390-6. Pubmed19199576
  Ryppa C, Mann-Steinberg H, Biniossek ML, Satchi-Fainaro R, Kratz F. In vitro and in vivo evaluation of a paclitaxel conjugate with the divalent peptide E-[c(RGDfK)2] that targets integrin alpha v beta 3. Int J Pharm. 2009 Feb 23;368(1-2):89-97. Pubmed18992308
2008 Ryppa C, Mann-Steinberg H, Fichtner I, Weber H, Satchi-Fainaro R, Biniossek ML, Kratz F. In vitro and in vivo evaluation of doxorubicin conjugates with the divalent peptide E-[c(RGDfK)2] that targets integrin alphavbeta3. Bioconjug Chem. 2008 Jul;19(7):1414-22. Epub 2008 Jun 26. Pubmed18578486
2006 Petermann I, Mayer C, Stypmann J, Biniossek ML, Tobin DJ, Engelen MA, Dandekar T, Grune T, Schild L, Peters C, Reinheckel T.
Lysosomal, cytoskeletal, and metabolic alterations in cardiomyopathy of cathepsin L knockout mice. FASEB J. 2006 Jun;20(8):1266-8. Pubmed16636100
Schulte U, Thumfart JO, Klocker N, Sailer CA, Bildl W, Biniossek M, Dehn D, Deller T, Eble S, Abbass K, Wangler T, Knaus HG, Fakler B.
The epilepsy-linked Igi1 protein assembles into presynaptic kv1 channels and inhibits inactivation by kvbeta1.
Neuron. 2006 Mar 2;49(5):697-706. Pubmed1650494
2005 Darie CC, Biniossek ML, Gawinowicz MA, Milgrom Y, Thumfart JO, Jovine L, Litscher ES, Wassarman PM. Mass spectrometric evidence that proteolytic processing of rainbow trout egg vitelline envelope proteins takes place on the egg. J Biol Chem. 2005 Nov 11;280(45):37585-98. Pubmed16157586
  Darie CC, Biniossek ML, Winter V, Mutschler B, Haehnel W. Isolation and structural characterization of the Ndh complex from mesophyll and bundle sheath chloroplasts of Zea mays. FEBS J. 2005 Jun;272(11):2705-16. Pubmed15943805
2004 Darie CC, Biniossek ML, Jovine L, Litscher ES, Wassarman PM.
Structural Characterization of Fish Egg Vitelline Envelope Proteins by Mass Spectrometry. Biochemistry. 2004 Jun 15;43(23):7459-7478. Pubmed15182189

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